Aliases for ZNF324B Gene

Aliases for ZNF324B Gene

  • Zinc Finger Protein 324B 2 3 4 5
  • FLJ45850 2
  • ZNF324B 5

External Ids for ZNF324B Gene

Previous GeneCards Identifiers for ZNF324B Gene

  • GC19P063657
  • GC19P059047
  • GC19P059051
  • GC19P055271
  • GC19P059068
  • GC19P059080
  • GC19P059097
  • GC19P059134
  • GC19P059190
  • GC19P059230
  • GC19P059279
  • GC19P058419
  • GC19P058420
  • GC19P058424
  • GC19P058789

Summaries for ZNF324B Gene

GeneCards Summary for ZNF324B Gene

ZNF324B (Zinc Finger Protein 324B) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF324.

UniProtKB/Swiss-Prot Summary for ZNF324B Gene

Additional gene information for ZNF324B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF324B Gene

Genomics for ZNF324B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF324B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF324B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF324B

Top Transcription factor binding sites by QIAGEN in the ZNF324B gene promoter:
  • AP-1
  • ATF-2
  • Bach2
  • c-Jun
  • HSF2
  • NF-1
  • NF-1/L

Genomic Locations for ZNF324B Gene

Genomic Locations for ZNF324B Gene
chr19:58,451,611-58,457,833
(GRCh38/hg38)
Size:
6,223 bases
Orientation:
Plus strand
chr19:58,962,971-58,969,200
(GRCh37/hg19)
Size:
6,230 bases
Orientation:
Plus strand

Genomic View for ZNF324B Gene

Genes around ZNF324B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF324B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF324B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF324B Gene

Proteins for ZNF324B Gene

  • Protein details for ZNF324B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AW86-Z324B_HUMAN
    Recommended name:
    Zinc finger protein 324B
    Protein Accession:
    Q6AW86
    Secondary Accessions:
    • B2RTZ6
    • Q6ZMX8
    • Q6ZS42

    Protein attributes for ZNF324B Gene

    Size:
    544 amino acids
    Molecular mass:
    60602 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF324B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF324B Gene

Post-translational modifications for ZNF324B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF324B Gene

No data available for DME Specific Peptides for ZNF324B Gene

Domains & Families for ZNF324B Gene

Gene Families for ZNF324B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF324B Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF324B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 324B (Z324B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6AW86

UniProtKB/Swiss-Prot:

Z324B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF324B: view

Function for ZNF324B Gene

Molecular function for ZNF324B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF324B Gene

Gene Ontology (GO) - Molecular Function for ZNF324B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF324B: view
genes like me logo Genes that share phenotypes with ZNF324B: view

Animal Model Products

CRISPR Products

miRNA for ZNF324B Gene

miRTarBase miRNAs that target ZNF324B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF324B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF324B Gene

Localization for ZNF324B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF324B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF324B gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF324B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF324B: view

Pathways & Interactions for ZNF324B Gene

genes like me logo Genes that share pathways with ZNF324B: view

Pathways by source for ZNF324B Gene

2 Reactome pathways for ZNF324B Gene
1 KEGG pathway for ZNF324B Gene

Gene Ontology (GO) - Biological Process for ZNF324B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF324B: view

No data available for SIGNOR curated interactions for ZNF324B Gene

Drugs & Compounds for ZNF324B Gene

No Compound Related Data Available

Transcripts for ZNF324B Gene

mRNA/cDNA for ZNF324B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF324B

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF324B Gene

No ASD Table

Relevant External Links for ZNF324B Gene

GeneLoc Exon Structure for
ZNF324B

Expression for ZNF324B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF324B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF324B

SOURCE GeneReport for Unigene cluster for ZNF324B Gene:

Hs.186970

Evidence on tissue expression from TISSUES for ZNF324B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF324B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF324B Gene

Orthologs for ZNF324B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF324B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF324B 30 31
  • 98.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 65 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 61 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Zfp324 31
  • 59 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 6 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-238o14.6 31
  • 34 (a)
ManyToMany
si:dkey-199m13.2 31
  • 33 (a)
ManyToMany
si:dkey-233e3.4 31
  • 32 (a)
ManyToMany
si:dkey-199m13.8 31
  • 31 (a)
ManyToMany
BX640547.1 31
  • 29 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta zfh1 31
  • 6 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea zag-1 31
  • 12 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 8 (a)
OneToMany
Species where no ortholog for ZNF324B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF324B Gene

ENSEMBL:
Gene Tree for ZNF324B (if available)
TreeFam:
Gene Tree for ZNF324B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF324B: view image

Paralogs for ZNF324B Gene

Paralogs for ZNF324B Gene

(496) SIMAP similar genes for ZNF324B Gene using alignment to 6 proteins:

  • Z324B_HUMAN
  • C9JTQ8_HUMAN
  • M0R090_HUMAN
  • M0R0B1_HUMAN
  • M0R1X9_HUMAN
  • M0R3B5_HUMAN
genes like me logo Genes that share paralogs with ZNF324B: view

Variants for ZNF324B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF324B Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12611254 - p.Ser63Gly

Additional dbSNP identifiers (rs#s) for ZNF324B Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF324B Gene

Variant ID Type Subtype PubMed ID
esv3556698 CNV deletion 23714750
nsv1057077 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833888 CNV loss 17160897
nsv952155 CNV deletion 24416366

Variation tolerance for ZNF324B Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF324B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF324B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF324B Gene

Disorders for ZNF324B Gene

No disorders were found for ZNF324B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF324B Gene

Publications for ZNF324B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3

Products for ZNF324B Gene

Sources for ZNF324B Gene