Aliases for ZNF324 Gene

Aliases for ZNF324 Gene

  • Zinc Finger Protein 324 2 3 5
  • Zinc Finger Protein ZF5128 3 4
  • Zinc Finger Protein 324A 3 4
  • ZNF324A 3 4
  • ZF5128 3

External Ids for ZNF324 Gene

Previous GeneCards Identifiers for ZNF324 Gene

  • GC00U990856
  • GC19P063654
  • GC19P063670
  • GC19P059042
  • GC19P059049
  • GC19P055287
  • GC19P059066
  • GC19P059081
  • GC19P059098
  • GC19P059135
  • GC19P059191
  • GC19P059231
  • GC19P059280
  • GC19P058459

Summaries for ZNF324 Gene

GeneCards Summary for ZNF324 Gene

ZNF324 (Zinc Finger Protein 324) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF324B.

UniProtKB/Swiss-Prot Summary for ZNF324 Gene

  • May be involved in transcriptional regulation. May be involved in regulation of cell proliferation.

Additional gene information for ZNF324 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF324 Gene

Genomics for ZNF324 Gene

GeneHancer (GH) Regulatory Elements for ZNF324 Gene

Promoters and enhancers for ZNF324 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF324 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF324 gene promoter:
  • AP-1
  • ATF-2
  • Bach2
  • c-Jun
  • HSF2
  • NF-1

Genomic Locations for ZNF324 Gene

Genomic Locations for ZNF324 Gene
chr19:58,467,045-58,475,436
(GRCh38/hg38)
Size:
8,392 bases
Orientation:
Plus strand
chr19:58,978,412-58,984,945
(GRCh37/hg19)
Size:
6,534 bases
Orientation:
Plus strand

Genomic View for ZNF324 Gene

Genes around ZNF324 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF324 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF324 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF324 Gene

Proteins for ZNF324 Gene

  • Protein details for ZNF324 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75467-Z324A_HUMAN
    Recommended name:
    Zinc finger protein 324A
    Protein Accession:
    O75467
    Secondary Accessions:
    • B3KRX1

    Protein attributes for ZNF324 Gene

    Size:
    553 amino acids
    Molecular mass:
    61104 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF324 Gene

Post-translational modifications for ZNF324 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF324 Gene

No data available for DME Specific Peptides for ZNF324 Gene

Domains & Families for ZNF324 Gene

Gene Families for ZNF324 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF324 Gene

Suggested Antigen Peptide Sequences for ZNF324 Gene

GenScript: Design optimal peptide antigens:
  • ZNF324 protein (Q96I98_HUMAN)
  • Zinc finger protein ZF5128 (Z324A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75467

UniProtKB/Swiss-Prot:

Z324A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF324: view

Function for ZNF324 Gene

Molecular function for ZNF324 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May be involved in regulation of cell proliferation.
UniProtKB/Swiss-Prot Induction:
Induced at the early stage of T cell activation. Regulated at the transcriptional level during the cell cycle. Induced at a maximum level in the S phase.

Phenotypes From GWAS Catalog for ZNF324 Gene

Gene Ontology (GO) - Molecular Function for ZNF324 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF324: view
genes like me logo Genes that share phenotypes with ZNF324: view

Animal Model Products

CRISPR Products

miRNA for ZNF324 Gene

miRTarBase miRNAs that target ZNF324

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF324 Gene

Localization for ZNF324 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF324 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF324 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF324 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF324: view

Pathways & Interactions for ZNF324 Gene

genes like me logo Genes that share pathways with ZNF324: view

Pathways by source for ZNF324 Gene

2 Reactome pathways for ZNF324 Gene
1 KEGG pathway for ZNF324 Gene

Gene Ontology (GO) - Biological Process for ZNF324 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF324: view

No data available for SIGNOR curated interactions for ZNF324 Gene

Drugs & Compounds for ZNF324 Gene

No Compound Related Data Available

Transcripts for ZNF324 Gene

mRNA/cDNA for ZNF324 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF324 Gene

No ASD Table

Relevant External Links for ZNF324 Gene

GeneLoc Exon Structure for
ZNF324
ECgene alternative splicing isoforms for
ZNF324

Expression for ZNF324 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF324 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF324 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF324 Gene



Protein tissue co-expression partners for ZNF324 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF324 Gene:

ZNF324

SOURCE GeneReport for Unigene cluster for ZNF324 Gene:

Hs.515660

mRNA Expression by UniProt/SwissProt for ZNF324 Gene:

O75467-Z324A_HUMAN
Tissue specificity: Expressed at high levels in the spleen, thymus, and PBMC, at low levels in the prostate, ovary, small intestine, colon (mucosal lining), placenta, lung, and pancreas, and very weakly expressed in the liver and kidney.

Evidence on tissue expression from TISSUES for ZNF324 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF324: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF324 Gene

Orthologs for ZNF324 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF324 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF324 32
  • 96.44 (n)
-- 33
  • 81 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia ZNF324 32
  • 79.75 (n)
-- 33
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF324 32
  • 77.52 (n)
-- 33
  • 68 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp324 17 33 32
  • 75.89 (n)
rat
(Rattus norvegicus)
Mammalia Zfp324 32
  • 75.71 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-199m13.2 33
  • 34 (a)
ManyToMany
si:dkey-238o14.6 33
  • 34 (a)
ManyToMany
si:dkey-199m13.8 33
  • 32 (a)
ManyToMany
si:dkey-233e3.4 33
  • 32 (a)
ManyToMany
BX640547.1 33
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta zfh1 33
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zag-1 33
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 7 (a)
OneToMany
Species where no ortholog for ZNF324 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF324 Gene

ENSEMBL:
Gene Tree for ZNF324 (if available)
TreeFam:
Gene Tree for ZNF324 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF324: view image

Paralogs for ZNF324 Gene

Paralogs for ZNF324 Gene

(522) SIMAP similar genes for ZNF324 Gene using alignment to 3 proteins:

  • Z324A_HUMAN
  • F5H1K2_HUMAN
  • M0R1C8_HUMAN
genes like me logo Genes that share paralogs with ZNF324: view

Variants for ZNF324 Gene

Sequence variations from dbSNP and Humsavar for ZNF324 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000430399 -- 58,475,937(+) G/C
rs1000441917 -- 58,467,921(+) C/T 5_prime_UTR_variant, intron_variant
rs1000787520 -- 58,472,452(+) A/G 3_prime_UTR_variant
rs1000955127 -- 58,472,706(+) A/T 3_prime_UTR_variant
rs1001156533 -- 58,468,776(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF324 Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
esv3556698 CNV deletion 23714750
nsv1057077 CNV gain 25217958
nsv1116353 CNV deletion 24896259
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv833888 CNV loss 17160897
nsv952156 CNV deletion 24416366

Variation tolerance for ZNF324 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF324 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF324

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF324 Gene

Disorders for ZNF324 Gene

Additional Disease Information for ZNF324

No disorders were found for ZNF324 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF324 Gene

Publications for ZNF324 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. Nucleotide sequence and cell cycle-associated differential expression of ZF5128, a novel Kruppel type zinc finger protein gene. (PMID: 11779640) Rue SW … Kim YH (Biochimica et biophysica acta 2001) 3 4 56
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for ZNF324 Gene

Sources for ZNF324 Gene