ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008] See more...

Aliases for ZNF322 Gene

Aliases for ZNF322 Gene

  • Zinc Finger Protein 322 2 3 4 5
  • Zinc Finger Protein 322A 2 3 4
  • Zinc Finger Protein 489 2 3 4
  • Zinc Finger Protein 388 3 4
  • HLA Complex Group 12 2 3
  • ZNF322A 3 4
  • ZNF388 3 4
  • ZNF489 3 4
  • HCG12 3

External Ids for ZNF322 Gene

Previous HGNC Symbols for ZNF322 Gene

  • ZNF489
  • ZNF388
  • HCG12
  • ZNF322A

Previous GeneCards Identifiers for ZNF322 Gene

  • GC00U990845
  • GC06M026636
  • GC06M026767
  • GC06M026810
  • GC06M026638
  • GC06M026683
  • GC06M026723

Summaries for ZNF322 Gene

Entrez Gene Summary for ZNF322 Gene

  • ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF322 Gene

ZNF322 (Zinc Finger Protein 322) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot Summary for ZNF322 Gene

  • Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).

Additional gene information for ZNF322 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF322 Gene

Genomics for ZNF322 Gene

GeneHancer (GH) Regulatory Elements for ZNF322 Gene

Promoters and enhancers for ZNF322 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF322 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF322 Gene

Genomic Locations for ZNF322 Gene
chr6:26,634,383-26,659,752
(GRCh38/hg38)
Size:
25,370 bases
Orientation:
Minus strand
chr6:26,634,611-26,659,980
(GRCh37/hg19)
Size:
25,370 bases
Orientation:
Minus strand

Genomic View for ZNF322 Gene

Genes around ZNF322 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF322 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF322 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF322 Gene

Proteins for ZNF322 Gene

  • Protein details for ZNF322 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U7Q0-ZN322_HUMAN
    Recommended name:
    Zinc finger protein 322
    Protein Accession:
    Q6U7Q0
    Secondary Accessions:
    • A8K1X3
    • Q0VDH6
    • Q6B0G2
    • Q86W72
    • Q9H5I9

    Protein attributes for ZNF322 Gene

    Size:
    402 amino acids
    Molecular mass:
    46941 Da
    Quaternary structure:
    • Interacts with POU5F1.
    Miscellaneous:
    • Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process.
    SequenceCaution:
    • Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF322 Gene

Post-translational modifications for ZNF322 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF322 Gene

Domains & Families for ZNF322 Gene

Gene Families for ZNF322 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF322 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF322 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 489 (Z322A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6U7Q0

UniProtKB/Swiss-Prot:

ZN322_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF322: view

Function for ZNF322 Gene

Molecular function for ZNF322 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).

Phenotypes From GWAS Catalog for ZNF322 Gene

Gene Ontology (GO) - Molecular Function for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0035326 enhancer binding IEA --
genes like me logo Genes that share ontologies with ZNF322: view
genes like me logo Genes that share phenotypes with ZNF322: view

Animal Model Products

CRISPR Products

miRNA for ZNF322 Gene

miRTarBase miRNAs that target ZNF322
Targeted motifs for ZNF322 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF322
  • Consensus sequence: GAGCCTGGTACTGWGCCTGR Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF322

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF322 Gene

Localization for ZNF322 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF322 Gene

Cytoplasm. Nucleus. Note=Mainly found in the nucleus. {ECO:0000269 PubMed:15555580}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF322 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF322: view

Pathways & Interactions for ZNF322 Gene

PathCards logo

SuperPathways for ZNF322 Gene

No Data Available

Interacting Proteins for ZNF322 Gene

Gene Ontology (GO) - Biological Process for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:1902459 positive regulation of stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with ZNF322: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF322 Gene

Drugs & Compounds for ZNF322 Gene

No Compound Related Data Available

Transcripts for ZNF322 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF322

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF322 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for ZNF322 Gene

GeneLoc Exon Structure for
ZNF322
ECgene alternative splicing isoforms for
ZNF322

Expression for ZNF322 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF322 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF322 Gene:

ZNF322

SOURCE GeneReport for Unigene cluster for ZNF322 Gene:

Hs.126280

mRNA Expression by UniProt/SwissProt for ZNF322 Gene:

Q6U7Q0-ZN322_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for ZNF322 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF322: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF322 Gene

Orthologs for ZNF322 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF322 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF322A 33 32
  • 99.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MGC157324 33
  • 94 (a)
OneToOne
ZNF322A 32
  • 92.95 (n)
dog
(Canis familiaris)
Mammalia ZNF322 33 32
  • 92.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp322a 32
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Zfp322a 17 33 32
  • 88.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 38 (a)
ManyToMany
-- 33
  • 36 (a)
ManyToMany
-- 33
  • 35 (a)
ManyToMany
-- 33
  • 35 (a)
ManyToMany
-- 33
  • 33 (a)
ManyToMany
ZNF302 33
  • 32 (a)
ManyToMany
-- 33
  • 32 (a)
ManyToMany
-- 33
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF322 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF322 Gene

ENSEMBL:
Gene Tree for ZNF322 (if available)
TreeFam:
Gene Tree for ZNF322 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF322: view image

Paralogs for ZNF322 Gene

Paralogs for ZNF322 Gene

(477) SIMAP similar genes for ZNF322 Gene using alignment to 2 proteins:

  • ZN322_HUMAN
  • C9JP13_HUMAN
genes like me logo Genes that share paralogs with ZNF322: view

Variants for ZNF322 Gene

Sequence variations from dbSNP and Humsavar for ZNF322 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000185747 -- 26,646,322(-) T/C intron_variant
rs1000379769 -- 26,638,933(-) C/G intron_variant
rs1000501612 -- 26,660,576(-) G/A upstream_transcript_variant
rs1000705620 -- 26,654,148(-) A/G intron_variant
rs1000725726 -- 26,646,026(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF322 Gene

Variant ID Type Subtype PubMed ID
esv2658606 CNV deletion 23128226
esv2731731 CNV deletion 23290073
esv3608410 CNV loss 21293372
nsv10803 CNV loss 18304495
nsv349022 CNV deletion 16902084
nsv471635 CNV gain 15918152
nsv5231 CNV deletion 18451855
nsv823460 CNV loss 20364138
nsv830613 CNV gain 17160897
nsv965691 CNV duplication 23825009

Variation tolerance for ZNF322 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF322 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF322

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF322 Gene

Disorders for ZNF322 Gene

Additional Disease Information for ZNF322

No disorders were found for ZNF322 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF322 Gene

Publications for ZNF322 Gene

  1. ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (PMID: 15555580) Li Y … Liu M (Biochemical and biophysical research communications 2004) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322. (PMID: 28880489) Hu X … Huang C (Cell biology international 2018) 3 56
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 56

Products for ZNF322 Gene

Sources for ZNF322 Gene