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Aliases for ZNF322 Gene

Aliases for ZNF322 Gene

  • Zinc Finger Protein 322 2 3 5
  • Zinc Finger Protein 322A 2 3 4
  • Zinc Finger Protein 489 2 3 4
  • Zinc Finger Protein 388 3 4
  • HLA Complex Group 12 2 3
  • ZNF322A 3 4
  • ZNF388 3 4
  • ZNF489 3 4
  • HCG12 3

External Ids for ZNF322 Gene

Previous HGNC Symbols for ZNF322 Gene

  • ZNF489
  • ZNF388
  • HCG12
  • ZNF322A

Previous GeneCards Identifiers for ZNF322 Gene

  • GC00U990845
  • GC06M026636

Summaries for ZNF322 Gene

Entrez Gene Summary for ZNF322 Gene

  • ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF322 Gene

ZNF322 (Zinc Finger Protein 322) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF629.

UniProtKB/Swiss-Prot for ZNF322 Gene

  • Involved in transcriptional regulation as an activator.

Additional gene information for ZNF322 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF322 Gene

Genomics for ZNF322 Gene

GeneHancer (GH) Regulatory Elements for ZNF322 Gene

Promoters and enhancers for ZNF322 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I026658 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 577.8 +0.2 152 2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF213 ZNF207 ZNF322 GUSBP2 BTN2A3P GC06P027085
GH06I027126 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 48.3 -478.3 -478270 23 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC HIST1H2AH GC06P027140 HIST1H2AG HIST1H4I HIST1H2BJ HIST1H2BK ZKSCAN8 ABT1 HMGN4 BTN2A1
GH06I026222 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 53.7 +434.9 434887 5.1 PKNOX1 ARNT ZNF493 SIN3A FEZF1 YY1 ETS1 ZNF121 ZNF213 ELK1 HIST1H3E ABT1 ZNF322 GUSBP2 BTN2A2 BTN2A1 HMGN4 HCG11 BTN2A3P HIST1H2AE
GH06I027494 Enhancer 1.3 Ensembl ENCODE 85.4 -835.9 -835897 1.7 FEZF1 ZNF213 E2F8 ZNF143 SP3 ZFP41 MEF2D SSRP1 ZNF610 RCOR2 TRS-AGA2-3 ZSCAN12 ZSCAN23 ZKSCAN8 PGBD1 ZNF322 ZKSCAN3 ZSCAN9 ZNF391 ENSG00000261839
GH06I026341 Enhancer 1.5 Ensembl ENCODE dbSUPER 48.5 +317.6 317562 1.6 MLX YBX1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 NFYC MEF2D ABT1 BTN2A3P ZNF322 BTN2A2 HMGN4 BTN3A2 BTN2A1 GUSBP2 TRIM38 HIST1H1D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF322 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF322 Gene

Genomic Locations for ZNF322 Gene
25,370 bases
Minus strand

Genomic View for ZNF322 Gene

Genes around ZNF322 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF322 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF322 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF322 Gene

Proteins for ZNF322 Gene

  • Protein details for ZNF322 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 322
    Protein Accession:
    Secondary Accessions:
    • A8K1X3
    • Q0VDH6
    • Q6B0G2
    • Q86W72
    • Q9H5I9

    Protein attributes for ZNF322 Gene

    402 amino acids
    Molecular mass:
    46941 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF322 Gene

Post-translational modifications for ZNF322 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF322 Gene

Domains & Families for ZNF322 Gene

Gene Families for ZNF322 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF322 Gene


Suggested Antigen Peptide Sequences for ZNF322 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF322: view

Function for ZNF322 Gene

Molecular function for ZNF322 Gene

UniProtKB/Swiss-Prot Function:
Involved in transcriptional regulation as an activator.

Phenotypes From GWAS Catalog for ZNF322 Gene

Gene Ontology (GO) - Molecular Function for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF322: view
genes like me logo Genes that share phenotypes with ZNF322: view

Animal Model Products

miRNA for ZNF322 Gene

miRTarBase miRNAs that target ZNF322
Targeted motifs for ZNF322 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF322
  • Consensus sequence: GAGCCTGGTACTGWGCCTGR Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF322 Gene

Localization for ZNF322 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF322 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF322 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF322: view

Pathways & Interactions for ZNF322 Gene

SuperPathways for ZNF322 Gene

No Data Available

Interacting Proteins for ZNF322 Gene

Gene Ontology (GO) - Biological Process for ZNF322 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF322: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF322 Gene

Drugs & Compounds for ZNF322 Gene

No Compound Related Data Available

Transcripts for ZNF322 Gene

Unigene Clusters for ZNF322 Gene

Zinc finger protein 322:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF322 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for ZNF322 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF322 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF322 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF322 Gene:


SOURCE GeneReport for Unigene cluster for ZNF322 Gene:


mRNA Expression by UniProt/SwissProt for ZNF322 Gene:

Tissue specificity: Ubiquitous. Highly expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for ZNF322 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF322: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF322 Gene

Orthologs for ZNF322 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF322 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF322A 33 34
  • 99.75 (n)
(Bos Taurus)
Mammalia MGC157324 34
  • 94 (a)
ZNF322A 33
  • 92.95 (n)
(Canis familiaris)
Mammalia ZNF322 33 34
  • 92.21 (n)
(Rattus norvegicus)
Mammalia Zfp322a 33
  • 88.97 (n)
(Mus musculus)
Mammalia Zfp322a 33 16 34
  • 88.59 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
(Gallus gallus)
Aves -- 34
  • 38 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 35 (a)
-- 34
  • 33 (a)
-- 34
  • 32 (a)
ZNF302 34
  • 32 (a)
-- 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
Species where no ortholog for ZNF322 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF322 Gene

Gene Tree for ZNF322 (if available)
Gene Tree for ZNF322 (if available)

Paralogs for ZNF322 Gene

Paralogs for ZNF322 Gene

(477) SIMAP similar genes for ZNF322 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF322: view

Variants for ZNF322 Gene

Sequence variations from dbSNP and Humsavar for ZNF322 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000185747 -- 26,646,322(-) T/C intron_variant
rs1000379769 -- 26,638,933(-) C/G intron_variant
rs1000501612 -- 26,660,576(-) G/A upstream_transcript_variant
rs1000705620 -- 26,654,148(-) A/G intron_variant
rs1000725726 -- 26,646,026(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF322 Gene

Variant ID Type Subtype PubMed ID
esv2658606 CNV deletion 23128226
esv2731731 CNV deletion 23290073
esv3608410 CNV loss 21293372
nsv10803 CNV loss 18304495
nsv349022 CNV deletion 16902084
nsv471635 CNV gain 15918152
nsv5231 CNV deletion 18451855
nsv823460 CNV loss 20364138
nsv830613 CNV gain 17160897
nsv965691 CNV duplication 23825009

Variation tolerance for ZNF322 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF322 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF322 Gene

Disorders for ZNF322 Gene

Additional Disease Information for ZNF322

No disorders were found for ZNF322 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF322 Gene

Publications for ZNF322 Gene

  1. ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (PMID: 15555580) Li Y … Liu M (Biochemical and biophysical research communications 2004) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression. (PMID: 28581525) Liao SY … Wang YC (Oncogene 2017) 3 58
  5. Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer. (PMID: 26279304) Jen J … Wang YC (Oncogene 2016) 3 58

Products for ZNF322 Gene

Sources for ZNF322 Gene

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