ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002] See more...

Aliases for ZNF320 Gene

Aliases for ZNF320 Gene

  • Zinc Finger Protein 320 2 3 4 5
  • ZFPL 2 3
  • Zinc Finger Protein Like 3
  • Zinc Finger Gene 320 3
  • DKFZp686G16228 2
  • ZNF320 5

External Ids for ZNF320 Gene

Previous GeneCards Identifiers for ZNF320 Gene

  • GC19U990298
  • GC19M058071
  • GC19M053379
  • GC19M049706

Summaries for ZNF320 Gene

Entrez Gene Summary for ZNF320 Gene

  • ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF320 Gene

ZNF320 (Zinc Finger Protein 320) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot Summary for ZNF320 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF320 Gene

Genomics for ZNF320 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF320 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J052896 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 644.9 +0.3 312 2.8 SP1 KDM1A POLR2A LARP7 GABPA PKNOX1 SMAD5 NR2C1 HDAC1 SOX6 ZNF320 ZNF468 lnc-ZNF468-2 FJ601684-238 lnc-ZNF320-1 lnc-ERVV-1-2
GH19J052879 Promoter 0.3 EPDnew 600.4 +17.8 17810 0.1 ZNF320 FJ601684-238 ENSG00000283695 ZNF468 lnc-ZNF320-1 lnc-ERVV-1-2
GH19J053517 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 28.9 -622.3 -622276 5.6 ZNF221 SP1 HNRNPL CREB1 PRDM10 REST ZNF629 SIX5 LEF1 IKZF1 ZNF331 lnc-ZNF331-1 ZNF83 ZNF347 ZNF137P LENG8-AS1 PRPF31 ZNF160 ZNF677 ZNF761
GH19J052856 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 12.4 +40.4 40427 2.6 SP1 PRDM10 POLR2A BACH1 TARDBP PRDM1 RBFOX2 HDAC1 SCRT2 KMT2B ZNF468 ZNF28 ZNF320 MN298114-111 lnc-ERVV-1-2 lnc-ZNF320-1 ZNF600
GH19J051926 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 +970.1 970126 2.8 CREB1 CTCF PRDM10 ZNF629 TFE3 SIX5 IKZF1 ZNF692 NFRKB JUND ZNF613 lnc-ZNF613-3 ZNF615 ZNF611 ZNF649 ENSG00000269483 ZNF577 ZNF880 ZNF83 ZNF137P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF320 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF320

Top Transcription factor binding sites by QIAGEN in the ZNF320 gene promoter:
  • Ik-1

Genomic Locations for ZNF320 Gene

Genomic Locations for ZNF320 Gene
chr19:52,859,491-52,897,727
(GRCh38/hg38)
Size:
38,237 bases
Orientation:
Minus strand
chr19:53,367,043-53,400,946
(GRCh37/hg19)
Size:
33,904 bases
Orientation:
Minus strand

Genomic View for ZNF320 Gene

Genes around ZNF320 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF320 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF320 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF320 Gene

Proteins for ZNF320 Gene

  • Protein details for ZNF320 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RRD8-ZN320_HUMAN
    Recommended name:
    Zinc finger protein 320
    Protein Accession:
    A2RRD8
    Secondary Accessions:
    • Q8NDR6

    Protein attributes for ZNF320 Gene

    Size:
    509 amino acids
    Molecular mass:
    59326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF320 Gene

Post-translational modifications for ZNF320 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF320 Gene

Domains & Families for ZNF320 Gene

Gene Families for ZNF320 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF320 Gene

Suggested Antigen Peptide Sequences for ZNF320 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 320 (ZN320_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A2RRD8

UniProtKB/Swiss-Prot:

ZN320_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF320: view

Function for ZNF320 Gene

Molecular function for ZNF320 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF320 Gene

Gene Ontology (GO) - Molecular Function for ZNF320 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF320: view
genes like me logo Genes that share phenotypes with ZNF320: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF320

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF320 Gene

Localization for ZNF320 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF320 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF320 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF320 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF320: view

Pathways & Interactions for ZNF320 Gene

genes like me logo Genes that share pathways with ZNF320: view

Pathways by source for ZNF320 Gene

2 Reactome pathways for ZNF320 Gene
1 KEGG pathway for ZNF320 Gene

Gene Ontology (GO) - Biological Process for ZNF320 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF320: view

No data available for SIGNOR curated interactions for ZNF320 Gene

Drugs & Compounds for ZNF320 Gene

No Compound Related Data Available

Transcripts for ZNF320 Gene

mRNA/cDNA for ZNF320 Gene

6 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF320

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF320 Gene

No ASD Table

Relevant External Links for ZNF320 Gene

GeneLoc Exon Structure for
ZNF320

Expression for ZNF320 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF320 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF320 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF320

SOURCE GeneReport for Unigene cluster for ZNF320 Gene:

Hs.369632

mRNA Expression by UniProt/SwissProt for ZNF320 Gene:

A2RRD8-ZN320_HUMAN
Tissue specificity: Expressed at high levels in placenta, pancreas, kidney and heart, and at lower levels in liver, skeletal muscle and brain.

Evidence on tissue expression from TISSUES for ZNF320 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF320: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF320 Gene

Orthologs for ZNF320 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF320 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF320 30 31
  • 98.95 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 46 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 37 (a)
ManyToMany
Species where no ortholog for ZNF320 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF320 Gene

ENSEMBL:
Gene Tree for ZNF320 (if available)
TreeFam:
Gene Tree for ZNF320 (if available)

Paralogs for ZNF320 Gene

Paralogs for ZNF320 Gene

(510) SIMAP similar genes for ZNF320 Gene using alignment to 7 proteins:

  • ZN320_HUMAN
  • M0QX96_HUMAN
  • M0QZA2_HUMAN
  • M0R0Z8_HUMAN
  • M0R1K6_HUMAN
  • M0R2L4_HUMAN
  • M0R2Z6_HUMAN

Pseudogenes.org Pseudogenes for ZNF320 Gene

genes like me logo Genes that share paralogs with ZNF320: view

Variants for ZNF320 Gene

Additional dbSNP identifiers (rs#s) for ZNF320 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF320 Gene

Variant ID Type Subtype PubMed ID
esv2678383 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718799 CNV deletion 23290073
esv2718803 CNV deletion 23290073
esv2718804 CNV deletion 23290073
esv3644726 CNV loss 21293372
esv3644727 CNV gain 21293372
esv3644728 CNV loss 21293372
esv3893234 CNV gain 25118596
nsv1057118 CNV gain 25217958
nsv1060163 CNV loss 25217958
nsv1064234 CNV gain 25217958
nsv1066098 CNV loss 25217958
nsv1066762 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv458747 CNV gain 19166990
nsv458752 CNV loss 19166990
nsv524151 CNV gain 19592680
nsv525329 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580034 CNV gain 21841781
nsv580045 CNV loss 21841781
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009

Variation tolerance for ZNF320 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF320 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF320

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF320 Gene

Disorders for ZNF320 Gene

UniProtKB/Swiss-Prot

ZN320_HUMAN
  • Note=A chromosomal aberration involving ZNF320 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with BRWD2/WDR11. {ECO:0000269 PubMed:11536051}.

Additional Disease Information for ZNF320

No disorders were found for ZNF320 Gene.

No data available for MalaCards and Genatlas for ZNF320 Gene

Publications for ZNF320 Gene

  1. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. (PMID: 11536051) Chernova OB … Cowell JK (Oncogene 2001) 2 3 4
  2. Genome-wide association study of Alzheimer's disease with psychotic symptoms. (PMID: 22005930) Hollingworth P … Williams J (Molecular psychiatry 2012) 3 41
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF320 Gene

Sources for ZNF320 Gene