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Aliases for ZNF32 Gene

Aliases for ZNF32 Gene

  • Zinc Finger Protein 32 2 3 3 5
  • Zinc Finger Protein 32 (KOX 30) 2 3
  • Zinc Finger Protein KOX30 3 4
  • C2H2-546 3 4
  • KOX30 3 4

External Ids for ZNF32 Gene

Previous GeneCards Identifiers for ZNF32 Gene

  • GC10M043428
  • GC10M043607
  • GC10M043914
  • GC10M043423
  • GC10M043338
  • GC10M043459
  • GC10M044139
  • GC10M040666

Summaries for ZNF32 Gene

GeneCards Summary for ZNF32 Gene

ZNF32 (Zinc Finger Protein 32) is a Protein Coding gene. An important paralog of this gene is ZFP1.

UniProtKB/Swiss-Prot for ZNF32 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF32 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF32 Gene

Genomics for ZNF32 Gene

GeneHancer (GH) Regulatory Elements for ZNF32 Gene

Promoters and enhancers for ZNF32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J043647 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 481 2.4 PKNOX1 ATF1 ZFP64 SIN3A ZNF48 YY1 ETS1 ZNF766 ZNF416 ZNF207 LOC105378274 ZNF32 ZNF32-AS2 BMS1 ENSG00000273008 ZNF32-AS3 GC10M043601
GH10J043392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.9 +247.2 247189 18.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HNRNPF RASGEF1A BMS1 EIF3LP2 ZNF32-AS2 HNRNPA3P1 ZNF37BP ZNF33B ZNF32-AS1 ZNF32
GH10J043605 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 +42.2 42216 1.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 ETS1 POLR2B GLIS2 CAP1P2 ZNF485 ZNF32 PIR33135 GC10M043601
GH10J043689 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.5 -41.1 -41098 1.9 PKNOX1 ATF1 ZNF133 SIN3A ZNF2 YY1 ETS1 ZNF121 GLIS2 ELK1 ZNF32 CXCL12 PIR60234 GC10M043601 ENSG00000228426
GH10J043671 Enhancer 0.7 ENCODE 11.6 -22.9 -22946 0.2 CTCF CLOCK RB1 ERF ZNF2 THRB RAD21 RARA ZNF143 SMC3 ZNF32 CXCL12 LINC00619 ENSG00000228426 PIR60234 GC10M043601 ZNF32-AS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF32 gene promoter:
  • LCR-F1
  • HNF-3beta
  • FOXO4
  • C/EBPalpha
  • LyF-1

Genomic Locations for ZNF32 Gene

Genomic Locations for ZNF32 Gene
chr10:43,643,859-43,648,878
(GRCh38/hg38)
Size:
5,020 bases
Orientation:
Minus strand
chr10:44,139,307-44,144,326
(GRCh37/hg19)
Size:
5,020 bases
Orientation:
Minus strand

Genomic View for ZNF32 Gene

Genes around ZNF32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF32 Gene

Proteins for ZNF32 Gene

  • Protein details for ZNF32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17041-ZNF32_HUMAN
    Recommended name:
    Zinc finger protein 32
    Protein Accession:
    P17041
    Secondary Accessions:
    • Q92951

    Protein attributes for ZNF32 Gene

    Size:
    273 amino acids
    Molecular mass:
    31029 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF32 Gene

neXtProt entry for ZNF32 Gene

Post-translational modifications for ZNF32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF32 Gene

No data available for DME Specific Peptides for ZNF32 Gene

Domains & Families for ZNF32 Gene

Gene Families for ZNF32 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF32 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17041

UniProtKB/Swiss-Prot:

ZNF32_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF32: view

Function for ZNF32 Gene

Molecular function for ZNF32 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 32 (KOX30) (C2H2 type,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF32: view
genes like me logo Genes that share phenotypes with ZNF32: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF32

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF32 Gene

Localization for ZNF32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF32 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF32: view

Pathways & Interactions for ZNF32 Gene

SuperPathways for ZNF32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF32: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF32 Gene

Drugs & Compounds for ZNF32 Gene

No Compound Related Data Available

Transcripts for ZNF32 Gene

mRNA/cDNA for ZNF32 Gene

Unigene Clusters for ZNF32 Gene

Zinc finger protein 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF32

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF32 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for ZNF32 Gene

GeneLoc Exon Structure for
ZNF32
ECgene alternative splicing isoforms for
ZNF32

Expression for ZNF32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF32 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF32 Gene



Protein tissue co-expression partners for ZNF32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF32 Gene:

ZNF32

SOURCE GeneReport for Unigene cluster for ZNF32 Gene:

Hs.522885

Evidence on tissue expression from TISSUES for ZNF32 Gene

  • Nervous system(4.6)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with ZNF32: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF32 Gene

Orthologs for ZNF32 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF32 34 33
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF32 34 33
  • 93.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF32 34 33
  • 93.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp637 33
  • 90.44 (n)
mouse
(Mus musculus)
Mammalia Zfp637 16 34 33
  • 87.99 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332864 33
  • 52.02 (n)
CABZ01081748.1 34
  • 42 (a)
ManyToMany
si:dkeyp-53d3.6 34
  • 40 (a)
ManyToMany
zgc:175008 34
  • 39 (a)
ManyToMany
si:dkey-77p23.2 34
  • 38 (a)
ManyToMany
si:dkey-262g12.7 34
  • 37 (a)
ManyToMany
CR788316.4 34
  • 37 (a)
ManyToMany
CABZ01015530.1 34
  • 37 (a)
ManyToMany
BX649328.1 34
  • 36 (a)
ManyToMany
si:ch73-266f23.3 34
  • 35 (a)
ManyToMany
si:ch211-161m3.4 34
  • 35 (a)
ManyToMany
si:dkey-77f5.14 34
  • 34 (a)
ManyToMany
CABZ01071909.3 34
  • 32 (a)
ManyToMany
si:dkey-240n22.8 34
  • 31 (a)
ManyToMany
si:dkey-77f5.15 34
  • 29 (a)
ManyToMany
CABZ01081749.1 34
  • 28 (a)
ManyToMany
si:ch73-57f22.2 34
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BG:DS02740.8 35
  • 33 (a)
CG4730 34
  • 16 (a)
ManyToMany
rgr 34
  • 9 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03D4.4 34
  • 15 (a)
OneToMany
Species where no ortholog for ZNF32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF32 Gene

ENSEMBL:
Gene Tree for ZNF32 (if available)
TreeFam:
Gene Tree for ZNF32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF32: view image

Paralogs for ZNF32 Gene

Paralogs for ZNF32 Gene

(552) SIMAP similar genes for ZNF32 Gene using alignment to 1 proteins:

  • ZNF32_HUMAN
genes like me logo Genes that share paralogs with ZNF32: view

Variants for ZNF32 Gene

Sequence variations from dbSNP and Humsavar for ZNF32 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000943663 -- 43,648,362(-) G/A 5_prime_UTR_variant, intron_variant
rs1001261314 -- 43,646,949(-) T/C 5_prime_UTR_variant, intron_variant
rs1001313897 -- 43,648,560(-) A/C 5_prime_UTR_variant, intron_variant
rs1001861571 -- 43,645,139(-) A/G intron_variant
rs1002009110 -- 43,651,340(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF32 Gene

Variant ID Type Subtype PubMed ID
esv2437420 CNV deletion 19546169

Variation tolerance for ZNF32 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF32

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF32 Gene

Disorders for ZNF32 Gene

Additional Disease Information for ZNF32

No disorders were found for ZNF32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF32 Gene

Publications for ZNF32 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells. (PMID: 9475118) Drew PD … Becker KG (Journal of neurovirology 1997) 3 4 58
  4. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. (PMID: 8500793) Cannizzaro LA … Thiesen HJ (Human genetics 1993) 3 22 58
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58

Products for ZNF32 Gene

Sources for ZNF32 Gene

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