Aliases for ZNF318 Gene

Aliases for ZNF318 Gene

  • Zinc Finger Protein 318 2 3 4 5
  • Endocrine Regulatory Protein 3 4
  • Testicular Zinc Finger 3
  • Endocrine Regulator 3
  • HRIHFB2436 3
  • ZFP318 3
  • TZF 3

External Ids for ZNF318 Gene

Previous GeneCards Identifiers for ZNF318 Gene

  • GC06M043280
  • GC06M043332
  • GC06M043346
  • GC06M043394
  • GC06M043022

Summaries for ZNF318 Gene

GeneCards Summary for ZNF318 Gene

ZNF318 (Zinc Finger Protein 318) is a Protein Coding gene. Among its related pathways are Androgen receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot Summary for ZNF318 Gene

  • [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.
  • [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.

Gene Wiki entry for ZNF318 Gene

Additional gene information for ZNF318 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF318 Gene

Genomics for ZNF318 Gene

GeneHancer (GH) Regulatory Elements for ZNF318 Gene

Promoters and enhancers for ZNF318 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF318 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF318

Top Transcription factor binding sites by QIAGEN in the ZNF318 gene promoter:
  • AhR
  • Arnt
  • GR
  • GR-alpha
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-kappaB1
  • Pax-5

Genomic Locations for ZNF318 Gene

Genomic Locations for ZNF318 Gene
chr6:43,307,134-43,369,647
(GRCh38/hg38)
Size:
62,514 bases
Orientation:
Minus strand
chr6:43,274,872-43,337,216
(GRCh37/hg19)
Size:
62,345 bases
Orientation:
Minus strand

Genomic View for ZNF318 Gene

Genes around ZNF318 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF318 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF318 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF318 Gene

Proteins for ZNF318 Gene

  • Protein details for ZNF318 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VUA4-ZN318_HUMAN
    Recommended name:
    Zinc finger protein 318
    Protein Accession:
    Q5VUA4
    Secondary Accessions:
    • O94796
    • Q4G0E4
    • Q8NEM6
    • Q9UNU8
    • Q9Y2W9

    Protein attributes for ZNF318 Gene

    Size:
    2279 amino acids
    Molecular mass:
    251112 Da
    Quaternary structure:
    • Homodimer. Heterodimer of isoform 1 and isoform 2. Isoform 1 and isoform 2 interact with AR.
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    SequenceCaution:
    • Sequence=AAD17298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD47387.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH98434.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 1214.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF318 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF318 Gene

Post-translational modifications for ZNF318 Gene

  • Glycosylation at Asn1603
  • Ubiquitination at Lys1866
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ZN318_HUMAN (2091)

Other Protein References for ZNF318 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF318 Gene

Domains & Families for ZNF318 Gene

Gene Families for ZNF318 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF318 Gene

Blocks:
  • Zn-finger, U1-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF318 Gene

GenScript: Design optimal peptide antigens:
  • Endocrine regulatory protein (ZN318_HUMAN)
genes like me logo Genes that share domains with ZNF318: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF318 Gene

Function for ZNF318 Gene

Molecular function for ZNF318 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division.

Phenotypes From GWAS Catalog for ZNF318 Gene

Gene Ontology (GO) - Molecular Function for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0042803 protein homodimerization activity IEA,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF318: view
genes like me logo Genes that share phenotypes with ZNF318: view

Animal Models for ZNF318 Gene

MGI Knock Outs for ZNF318:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF318

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF318 Gene

Localization for ZNF318 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF318 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF318 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF318: view

Pathways & Interactions for ZNF318 Gene

PathCards logo

SuperPathways for ZNF318 Gene

genes like me logo Genes that share pathways with ZNF318: view

Pathways by source for ZNF318 Gene

1 BioSystems pathway for ZNF318 Gene

Gene Ontology (GO) - Biological Process for ZNF318 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IEA,ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS,IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with ZNF318: view

No data available for SIGNOR curated interactions for ZNF318 Gene

Drugs & Compounds for ZNF318 Gene

(1) Drugs for ZNF318 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZNF318 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF318: view

Transcripts for ZNF318 Gene

mRNA/cDNA for ZNF318 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF318

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF318 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5: - - - -

Relevant External Links for ZNF318 Gene

GeneLoc Exon Structure for
ZNF318

Expression for ZNF318 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF318 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF318 Gene

This gene is overexpressed in Pancreas (15.4), Serum (14.2), Synovial fluid (12.6), and Testis (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF318 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF318

SOURCE GeneReport for Unigene cluster for ZNF318 Gene:

Hs.509718

mRNA Expression by UniProt/SwissProt for ZNF318 Gene:

Q5VUA4-ZN318_HUMAN
Tissue specificity: Expressed in endocrine tissue.

Evidence on tissue expression from TISSUES for ZNF318 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF318: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF318 Gene

Orthologs for ZNF318 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF318 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF318 31 30
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF318 31 30
  • 88.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF318 31 30
  • 88.05 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp318 30
  • 82.47 (n)
mouse
(Mus musculus)
Mammalia Zfp318 17 31 30
  • 82.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 63 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF318 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF318 31
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF318 31
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU571336.2 31
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9776 31
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
CSA.4713 31
  • 26 (a)
OneToMany
Species where no ortholog for ZNF318 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF318 Gene

ENSEMBL:
Gene Tree for ZNF318 (if available)
TreeFam:
Gene Tree for ZNF318 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF318: view image

Paralogs for ZNF318 Gene

No data available for Paralogs for ZNF318 Gene

Variants for ZNF318 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF318 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs141660717 A breast cancer sample p.Asn812Ser
VAR_036057 A breast cancer sample p.Gly1274Arg
rs10948072 - p.Thr1292Ile
rs1459675 - p.Val1797Ala
rs34541323 - p.Ser407Ile

Additional dbSNP identifiers (rs#s) for ZNF318 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF318 Gene

Variant ID Type Subtype PubMed ID
esv2629858 CNV deletion 19546169
esv26917 CNV loss 19812545
esv3571028 CNV loss 25503493
esv3571029 CNV loss 25503493
nsv1017398 CNV gain 25217958
nsv1142461 CNV tandem duplication 24896259
nsv348832 CNV insertion 16902084
nsv970116 CNV duplication 23825009

Variation tolerance for ZNF318 Gene

Residual Variation Intolerance Score: 0.687% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF318 Gene

Human Gene Mutation Database (HGMD)
ZNF318
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF318

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF318 Gene

Disorders for ZNF318 Gene

Additional Disease Information for ZNF318

No disorders were found for ZNF318 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF318 Gene

Publications for ZNF318 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  2. Opposite effects of alternative TZF spliced variants on androgen receptor. (PMID: 16446156) Tao RH … Takayanagi R (Biochemical and biophysical research communications 2006) 3 23 54
  3. A zinc finger protein TZF is a novel corepressor of androgen receptor. (PMID: 15882980) Ishizuka M … Hagiwara H (Biochemical and biophysical research communications 2005) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54

Products for ZNF318 Gene

Sources for ZNF318 Gene