Aliases for ZNF317 Gene

Aliases for ZNF317 Gene

  • Zinc Finger Protein 317 2 3 4 5
  • KRAB-Containing Zinc Finger Protein 317 3
  • KIAA1588 4
  • ZNF317 5

External Ids for ZNF317 Gene

Previous GeneCards Identifiers for ZNF317 Gene

  • GC19P009372
  • GC19P009473
  • GC19P009096
  • GC19P009113
  • GC19P009115
  • GC19P009116
  • GC19P009251
  • GC19P008832

Summaries for ZNF317 Gene

GeneCards Summary for ZNF317 Gene

ZNF317 (Zinc Finger Protein 317) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot Summary for ZNF317 Gene

  • May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Additional gene information for ZNF317 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF317 Gene

Genomics for ZNF317 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF317 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF317 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF317

Top Transcription factor binding sites by QIAGEN in the ZNF317 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • CREB
  • FosB
  • Fra-1
  • JunB
  • JunD
  • LUN-1
  • PPAR-gamma2

Genomic Locations for ZNF317 Gene

Genomic Locations for ZNF317 Gene
chr19:9,140,395-9,163,424
(GRCh38/hg38)
Size:
23,030 bases
Orientation:
Plus strand
chr19:9,251,056-9,274,100
(GRCh37/hg19)
Size:
23,045 bases
Orientation:
Plus strand

Genomic View for ZNF317 Gene

Genes around ZNF317 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF317 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF317 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF317 Gene

Proteins for ZNF317 Gene

  • Protein details for ZNF317 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PQ6-ZN317_HUMAN
    Recommended name:
    Zinc finger protein 317
    Protein Accession:
    Q96PQ6
    Secondary Accessions:
    • Q6DCA9
    • Q96PM0
    • Q96PM1
    • Q96PT2
    • Q9HCI4

    Protein attributes for ZNF317 Gene

    Size:
    595 amino acids
    Molecular mass:
    67959 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF317 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF317 Gene

Post-translational modifications for ZNF317 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF317 Gene

No data available for DME Specific Peptides for ZNF317 Gene

Domains & Families for ZNF317 Gene

Gene Families for ZNF317 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF317 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF317 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57774, moderately similar to Zinc finger protein 317 (B4E279_HUMAN)
  • Zinc finger protein 317 (ZN317_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96PQ6

UniProtKB/Swiss-Prot:

ZN317_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF317: view

Function for ZNF317 Gene

Molecular function for ZNF317 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.

Phenotypes From GWAS Catalog for ZNF317 Gene

Gene Ontology (GO) - Molecular Function for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF317: view
genes like me logo Genes that share phenotypes with ZNF317: view

Animal Model Products

CRISPR Products

miRNA for ZNF317 Gene

miRTarBase miRNAs that target ZNF317
Targeted motifs for ZNF317 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF317
  • Consensus sequence: GTCWGCTGTYYCTCT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF317

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF317 Gene

Localization for ZNF317 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF317 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF317 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,HDA 21630459
genes like me logo Genes that share ontologies with ZNF317: view

Pathways & Interactions for ZNF317 Gene

genes like me logo Genes that share pathways with ZNF317: view

Pathways by source for ZNF317 Gene

2 Reactome pathways for ZNF317 Gene
1 KEGG pathway for ZNF317 Gene

Gene Ontology (GO) - Biological Process for ZNF317 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF317: view

No data available for SIGNOR curated interactions for ZNF317 Gene

Drugs & Compounds for ZNF317 Gene

No Compound Related Data Available

Transcripts for ZNF317 Gene

mRNA/cDNA for ZNF317 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF317

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF317 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8:
SP9: - - -
SP10:

Relevant External Links for ZNF317 Gene

GeneLoc Exon Structure for
ZNF317

Expression for ZNF317 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF317 Gene

Protein differential expression in normal tissues from HIPED for ZNF317 Gene

This gene is overexpressed in Liver (57.6) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF317 Gene



Protein tissue co-expression partners for ZNF317 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF317

SOURCE GeneReport for Unigene cluster for ZNF317 Gene:

Hs.465829

mRNA Expression by UniProt/SwissProt for ZNF317 Gene:

Q96PQ6-ZN317_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.

Evidence on tissue expression from TISSUES for ZNF317 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF317: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF317 Gene

Orthologs for ZNF317 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF317 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF317 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF317 30 31
  • 85.38 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF317 30 31
  • 83.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp317 30
  • 80.15 (n)
Mouse
(Mus musculus)
Mammalia Zfp317 30 17 31
  • 79.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 38 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF557 31
  • 35 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG8388 32
  • 28 (a)
Species where no ortholog for ZNF317 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF317 Gene

ENSEMBL:
Gene Tree for ZNF317 (if available)
TreeFam:
Gene Tree for ZNF317 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF317: view image

Paralogs for ZNF317 Gene

Paralogs for ZNF317 Gene

(468) SIMAP similar genes for ZNF317 Gene using alignment to 3 proteins:

  • ZN317_HUMAN
  • K7EKT9_HUMAN
  • K7ERD6_HUMAN

Pseudogenes.org Pseudogenes for ZNF317 Gene

genes like me logo Genes that share paralogs with ZNF317: view

Variants for ZNF317 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF317 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs3752199 - p.Gln19His

Additional dbSNP identifiers (rs#s) for ZNF317 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF317 Gene

Variant ID Type Subtype PubMed ID
esv27422 CNV loss 19812545
esv275448 CNV gain+loss 21479260
esv2762024 CNV gain 21179565
esv3556002 CNV deletion 23714750
nsv1056401 CNV gain 25217958
nsv1059554 CNV gain 25217958
nsv1160583 CNV deletion 26073780
nsv138312 CNV deletion 16902084
nsv2408 CNV deletion 18451855
nsv2411 CNV deletion 18451855
nsv509720 CNV insertion 20534489

Variation tolerance for ZNF317 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF317 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF317

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF317 Gene

Disorders for ZNF317 Gene

No disorders were found for ZNF317 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF317 Gene

Publications for ZNF317 Gene

  1. Molecular cloning and characterization of a KRAB-containing zinc finger protein, ZNF317, and its isoforms. (PMID: 11688974) Takashima H … Sawada K (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for ZNF317 Gene

Sources for ZNF317 Gene