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Aliases for ZNF311 Gene

Aliases for ZNF311 Gene

  • Zinc Finger Protein 311 2 3 3 5
  • Zinc Finger Protein Zfp-31 4
  • Zinc Finger Protein Zfp31 3
  • ZFP31 4
  • Zf31 3

External Ids for ZNF311 Gene

Previous GeneCards Identifiers for ZNF311 Gene

  • GC06M029025
  • GC06M029070
  • GC06M028962
  • GC06M028772

Summaries for ZNF311 Gene

GeneCards Summary for ZNF311 Gene

ZNF311 (Zinc Finger Protein 311) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF354A.

UniProtKB/Swiss-Prot for ZNF311 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF311 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF311 Gene

Genomics for ZNF311 Gene

GeneHancer (GH) Regulatory Elements for ZNF311 Gene

Promoters and enhancers for ZNF311 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029005 Promoter/Enhancer 1.4 Ensembl ENCODE 661.7 +0.0 21 1.2 HDGF SMAD1 ATF1 ARNT YY1 ETS1 POLR2B E2F8 ATF7 GTF2B ZNF311 ZKSCAN4 ZKSCAN3 ZKSCAN8 ZSCAN9 ZSCAN12 TRIM27 HLA-K HLA-U HLA-H
GH06J028079 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.4 +925.0 924962 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF165 LOC102724889 ZKSCAN8 ZNF603P ZKSCAN3 ZSCAN12 ZKSCAN4 ZSCAN9 ZNF311 PGBD1
GH06J029845 Enhancer 0.9 ENCODE 68.3 -839.9 -839911 0.2 FOXA2 KLF7 FOS KLF13 SP3 JUNB ZNF662 SREBF1 ZNF658 KDM1A MDC1 HCG18 ZNF311 HLA-H PPP1R10 HLA-A PRR3 HCG4 ZNRD1ASP TRIM39
GH06J028353 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 22 +650.2 650169 4.7 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZSCAN31 ZNF603P ZKSCAN8 ZKSCAN3 ZSCAN12 ZSCAN9 ZKSCAN4 ZNF311 ZSCAN23 OR2B7P
GH06J028977 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 22.7 +25.3 25253 6.5 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D TRE-CTC1-6 TRF-GAA1-2 ZKSCAN3 ZKSCAN8 ZKSCAN4 TRIM27 ZSCAN12 HLA-K ZSCAN9 ZNF311
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF311 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF311 gene promoter:
  • ER-alpha

Genomic Locations for ZNF311 Gene

Genomic Locations for ZNF311 Gene
10,844 bases
Minus strand
10,532 bases
Minus strand

Genomic View for ZNF311 Gene

Genes around ZNF311 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF311 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF311 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZNF311 Gene

  • Protein details for ZNF311 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 311
    Protein Accession:
    Secondary Accessions:
    • A2BFK5
    • B0S7Y4
    • Q92971

    Protein attributes for ZNF311 Gene

    666 amino acids
    Molecular mass:
    76322 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB16812.1; Type=Frameshift; Positions=396, 408; Evidence={ECO:0000305};

neXtProt entry for ZNF311 Gene

Post-translational modifications for ZNF311 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF311 Gene

Domains & Families for ZNF311 Gene

Gene Families for ZNF311 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF311 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF311: view

Function for ZNF311 Gene

Molecular function for ZNF311 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF311 Gene

Gene Ontology (GO) - Molecular Function for ZNF311 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF311: view
genes like me logo Genes that share phenotypes with ZNF311: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF311

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF311 Gene

Localization for ZNF311 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF311 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF311 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF311 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF311: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF311 Gene

Pathways & Interactions for ZNF311 Gene

SuperPathways for ZNF311 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF311: view

Pathways by source for ZNF311 Gene

2 Reactome pathways for ZNF311 Gene

Interacting Proteins for ZNF311 Gene

Gene Ontology (GO) - Biological Process for ZNF311 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF311: view

No data available for SIGNOR curated interactions for ZNF311 Gene

Drugs & Compounds for ZNF311 Gene

No Compound Related Data Available

Transcripts for ZNF311 Gene

mRNA/cDNA for ZNF311 Gene

Unigene Clusters for ZNF311 Gene

Zinc finger protein 311:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF311

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF311 Gene

No ASD Table

Relevant External Links for ZNF311 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF311 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF311 Gene

Protein differential expression in normal tissues from HIPED for ZNF311 Gene

This gene is overexpressed in Rectum (55.6) and Urinary Bladder (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF311 Gene

Protein tissue co-expression partners for ZNF311 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF311 Gene:


SOURCE GeneReport for Unigene cluster for ZNF311 Gene:


Evidence on tissue expression from TISSUES for ZNF311 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF311: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF311 Gene

Orthologs for ZNF311 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF311 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF311 34 33
  • 99.45 (n)
(Bos Taurus)
Mammalia ZNF311 34
  • 75 (a)
(Canis familiaris)
Mammalia ZNF311 34 33
  • 67.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta topi 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea unc-98 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for ZNF311 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF311 Gene

Gene Tree for ZNF311 (if available)
Gene Tree for ZNF311 (if available)
Evolutionary constrained regions (ECRs) for ZNF311: view image

Paralogs for ZNF311 Gene

Paralogs for ZNF311 Gene

(470) SIMAP similar genes for ZNF311 Gene using alignment to 2 proteins:

  • ZN311_HUMAN
  • L0R8L7_HUMAN
genes like me logo Genes that share paralogs with ZNF311: view

Variants for ZNF311 Gene

Sequence variations from dbSNP and Humsavar for ZNF311 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000085829 -- 29,003,780(-) A/T intron_variant
rs1000486984 -- 29,007,350(-) G/A/T upstream_transcript_variant
rs1000509969 -- 28,997,729(-) G/T intron_variant
rs1000871080 -- 29,001,584(-) T/G intron_variant
rs1000975135 -- 29,002,353(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF311 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
esv2314693 CNV deletion 18987734
esv2609234 CNV deletion 19546169
esv2677483 CNV deletion 23128226
esv2731756 CNV deletion 23290073
esv2731757 CNV deletion 23290073
esv4265 CNV loss 18987735
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074388 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv349494 CNV deletion 16902084
nsv830622 CNV gain 17160897

Variation tolerance for ZNF311 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF311 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF311 Gene

Disorders for ZNF311 Gene

Additional Disease Information for ZNF311

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF311 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF311 Gene

Publications for ZNF311 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  2. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PMID: 18309376) Lee HS … Gregersen PK (Molecular medicine (Cambridge, Mass.) 2008) 3 44 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Computer sequence analysis of human highly conserved zinc finger modules. (PMID: 10520746) Petroni D … Comi P (DNA sequence : the journal of DNA sequencing and mapping 1998) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF311 Gene

Sources for ZNF311 Gene

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