The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010] See more...

Aliases for ZNF300 Gene

Aliases for ZNF300 Gene

  • Zinc Finger Protein 300 2 3 4 5
  • Kruppel-Like Zinc Finger Protein 3
  • ZNF300 5

External Ids for ZNF300 Gene

Previous GeneCards Identifiers for ZNF300 Gene

  • GC21U990107
  • GC05M150303
  • GC05M150254
  • GC05M145419

Summaries for ZNF300 Gene

Entrez Gene Summary for ZNF300 Gene

  • The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

GeneCards Summary for ZNF300 Gene

ZNF300 (Zinc Finger Protein 300) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF782.

UniProtKB/Swiss-Prot Summary for ZNF300 Gene

Gene Wiki entry for ZNF300 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF300 Gene

Genomics for ZNF300 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF300 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF300 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF300

Top Transcription factor binding sites by QIAGEN in the ZNF300 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • HNF-1
  • HNF-1A
  • NF-Y
  • NF-YA
  • NF-YB
  • Pbx1a

Genomic Locations for ZNF300 Gene

Genomic Locations for ZNF300 Gene
chr5:150,892,958-150,904,983
(GRCh38/hg38)
Size:
12,026 bases
Orientation:
Minus strand
chr5:150,273,954-150,284,545
(GRCh37/hg19)
Size:
10,592 bases
Orientation:
Minus strand

Genomic View for ZNF300 Gene

Genes around ZNF300 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF300 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF300 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF300 Gene

Proteins for ZNF300 Gene

  • Protein details for ZNF300 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RE9-ZN300_HUMAN
    Recommended name:
    Zinc finger protein 300
    Protein Accession:
    Q96RE9
    Secondary Accessions:
    • A8MY91
    • B3KU35
    • B4DU78
    • F5GWS1
    • Q06DQ3
    • Q17RP3
    • Q5H9N5

    Protein attributes for ZNF300 Gene

    Size:
    604 amino acids
    Molecular mass:
    68743 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).
    SequenceCaution:
    • Sequence=EAW61702.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF300 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF300 Gene

Post-translational modifications for ZNF300 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF300 Gene

No data available for DME Specific Peptides for ZNF300 Gene

Domains & Families for ZNF300 Gene

Gene Families for ZNF300 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF300 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF300 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 300 (ZN300_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RE9

UniProtKB/Swiss-Prot:

ZN300_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF300: view

Function for ZNF300 Gene

Molecular function for ZNF300 Gene

UniProtKB/Swiss-Prot Function:
Has a transcriptional repressor activity.

Phenotypes From GWAS Catalog for ZNF300 Gene

Gene Ontology (GO) - Molecular Function for ZNF300 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 20585888
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23665872
GO:0043565 sequence-specific DNA binding IDA 20585888
genes like me logo Genes that share ontologies with ZNF300: view
genes like me logo Genes that share phenotypes with ZNF300: view

Animal Model Products

CRISPR Products

miRNA for ZNF300 Gene

miRTarBase miRNAs that target ZNF300

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF300

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF300 Gene

Localization for ZNF300 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF300 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF300 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF300 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23665872
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZNF300: view

Pathways & Interactions for ZNF300 Gene

genes like me logo Genes that share pathways with ZNF300: view

Pathways by source for ZNF300 Gene

2 Reactome pathways for ZNF300 Gene
1 KEGG pathway for ZNF300 Gene

Gene Ontology (GO) - Biological Process for ZNF300 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 20585888
genes like me logo Genes that share ontologies with ZNF300: view

No data available for SIGNOR curated interactions for ZNF300 Gene

Drugs & Compounds for ZNF300 Gene

No Compound Related Data Available

Transcripts for ZNF300 Gene

mRNA/cDNA for ZNF300 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF300

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF300 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: - - - - -
SP7: - -
SP8:

Relevant External Links for ZNF300 Gene

GeneLoc Exon Structure for
ZNF300

Expression for ZNF300 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF300 Gene

Protein differential expression in normal tissues from HIPED for ZNF300 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF300 Gene



Protein tissue co-expression partners for ZNF300 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF300

SOURCE GeneReport for Unigene cluster for ZNF300 Gene:

Hs.134885

mRNA Expression by UniProt/SwissProt for ZNF300 Gene:

Q96RE9-ZN300_HUMAN
Tissue specificity: Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly expressed in testis.

Evidence on tissue expression from TISSUES for ZNF300 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with ZNF300: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF300 Gene

Orthologs for ZNF300 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF300 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF300 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF300 30 31
  • 89.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF300 30 31
  • 87.74 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta BG:DS04929.3 32
  • 44 (a)
CG11902 32
  • 33 (a)
Species where no ortholog for ZNF300 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF300 Gene

ENSEMBL:
Gene Tree for ZNF300 (if available)
TreeFam:
Gene Tree for ZNF300 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF300: view image

Paralogs for ZNF300 Gene

Paralogs for ZNF300 Gene

(535) SIMAP similar genes for ZNF300 Gene using alignment to 3 proteins:

  • ZN300_HUMAN
  • F8WE31_HUMAN
  • J3KQF6_HUMAN
genes like me logo Genes that share paralogs with ZNF300: view

Variants for ZNF300 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF300 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
771385 Benign: not provided 150,896,590(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
771386 Benign: not provided 150,896,726(-) A/C MISSENSE_VARIANT,INTRON_VARIANT
776080 Benign: not provided 150,896,165(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
787296 Benign: not provided 150,896,549(-) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT
rs1988688 - p.Gln336His

Additional dbSNP identifiers (rs#s) for ZNF300 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF300 Gene

Variant ID Type Subtype PubMed ID
dgv10114n54 CNV loss 21841781
dgv5817n100 CNV loss 25217958
esv2759386 CNV loss 17122850
esv2760955 CNV loss 21179565
nsv10760 CNV loss 18304495
nsv428129 CNV loss 18775914
nsv482091 CNV loss 20164927
nsv968263 CNV duplication 23825009

Variation tolerance for ZNF300 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF300 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF300

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF300 Gene

Disorders for ZNF300 Gene

Additional Disease Information for ZNF300

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF300 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF300 Gene

Publications for ZNF300 Gene

  1. Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis. (PMID: 17541838) Cao Y … Wu M (DNA sequence : the journal of DNA sequencing and mapping 2007) 3 4 23
  2. Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300. (PMID: 14746915) Gou D … Li W (Biochimica et biophysica acta 2004) 2 3 4
  3. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W … Huang Z (Cellular and molecular life sciences : CMLS 2013) 3 4
  4. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZNF300 Gene

  • Signalway Proteins for ZNF300

Sources for ZNF300 Gene