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Aliases for ZNF30 Gene

Aliases for ZNF30 Gene

  • Zinc Finger Protein 30 2 3 4 5
  • Zinc Finger Protein 30 (KOX 28) 2 3
  • Zinc Finger Protein KOX28 3 4
  • KOX28 3 4

External Ids for ZNF30 Gene

Previous GeneCards Identifiers for ZNF30 Gene

  • GC19U990098
  • GC19M035883
  • GC19P040111
  • GC19P040112
  • GC19P040109
  • GC19P035417
  • GC19P031925

Summaries for ZNF30 Gene

GeneCards Summary for ZNF30 Gene

ZNF30 (Zinc Finger Protein 30) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF571.

UniProtKB/Swiss-Prot for ZNF30 Gene

Additional gene information for ZNF30 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF30 Gene

Genomics for ZNF30 Gene

GeneHancer (GH) Regulatory Elements for ZNF30 Gene

Promoters and enhancers for ZNF30 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J034926 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 627 +0.3 298 2 ZFX SIX5 NKRF POLR2A MLLT1 ZNF121 ZSCAN21 ZBTB7A SP7 ELF1 ZNF30 ZNF30-AS1 ARHGAP33 GC19P037324
GH19J035246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 60.3 +321.4 321351 4.1 ZNF473 MTA3 SP1 CTCF ZFX CC2D1A ELF3 MNT SIX5 CBFA2T2 LSR HAUS5 TMEM147-AS1 ZNF599 KMT2B RBM42 KIAA0355 ZNF792 ZNF30 ZNF302
GH19J035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.7 +977.2 977155 13 ZNF473 ZNF652 SP1 ZFX CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ZNF121 NFKBID TYROBP HCST ENSG00000280194 ZNF567 TMEM147-AS1 ZNF790 ZNF566 ZNF529 ZNF260
GH19J034961 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.9 +36.5 36464 4.5 ZNF473 CC2D1A ZFX ELF3 CBFA2T2 ZNF148 NKRF RERE NFIB ZSCAN21 ZNF792 GC19M039188 ZNF599 ZNF30 TMEM147-AS1 LSM14A PROSER3 ZNF302 ENSG00000267049 KMT2B
GH19J034972 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 43 +46.3 46296 0.8 ZNF473 ZNF652 SP1 CC2D1A ELF3 CTCF NKRF ZNF121 ZSCAN21 AHR TMEM147-AS1 HAUS5 ZNF599 ENSG00000267049 PROSER3 KMT2B LSM14A ZNF30 KIAA0355 ZNF792
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF30 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF30 Gene

Genomic Locations for ZNF30 Gene
chr19:34,926,903-34,945,172
(GRCh38/hg38)
Size:
18,270 bases
Orientation:
Plus strand
chr19:35,417,807-35,436,076
(GRCh37/hg19)
Size:
18,270 bases
Orientation:
Plus strand

Genomic View for ZNF30 Gene

Genes around ZNF30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF30 Gene

Proteins for ZNF30 Gene

  • Protein details for ZNF30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17039-ZNF30_HUMAN
    Recommended name:
    Zinc finger protein 30
    Protein Accession:
    P17039
    Secondary Accessions:
    • A5PLP1
    • A8K320
    • B4DIC0
    • Q6N068

    Protein attributes for ZNF30 Gene

    Size:
    623 amino acids
    Molecular mass:
    71417 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF30 Gene

Post-translational modifications for ZNF30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF30 Gene

Domains & Families for ZNF30 Gene

Gene Families for ZNF30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF30 Gene

Suggested Antigen Peptide Sequences for ZNF30 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX28 (ZNF30_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17039

UniProtKB/Swiss-Prot:

ZNF30_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF30: view

Function for ZNF30 Gene

Molecular function for ZNF30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 30 (KOX28) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF30 Gene

Gene Ontology (GO) - Molecular Function for ZNF30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF30: view
genes like me logo Genes that share phenotypes with ZNF30: view

Animal Model Products

CRISPR Products

miRNA for ZNF30 Gene

miRTarBase miRNAs that target ZNF30

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF30

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF30 Gene

Localization for ZNF30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF30 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF30: view

Pathways & Interactions for ZNF30 Gene

genes like me logo Genes that share pathways with ZNF30: view

Pathways by source for ZNF30 Gene

2 Reactome pathways for ZNF30 Gene
1 KEGG pathway for ZNF30 Gene

Gene Ontology (GO) - Biological Process for ZNF30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF30: view

No data available for SIGNOR curated interactions for ZNF30 Gene

Drugs & Compounds for ZNF30 Gene

No Compound Related Data Available

Transcripts for ZNF30 Gene

mRNA/cDNA for ZNF30 Gene

Unigene Clusters for ZNF30 Gene

Zinc finger protein 30:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF30

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF30 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for ZNF30 Gene

GeneLoc Exon Structure for
ZNF30
ECgene alternative splicing isoforms for
ZNF30

Expression for ZNF30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF30 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF30 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF30 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF30 Gene



Protein tissue co-expression partners for ZNF30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF30 Gene:

ZNF30

SOURCE GeneReport for Unigene cluster for ZNF30 Gene:

Hs.657402

Evidence on tissue expression from TISSUES for ZNF30 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ZNF30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF30 Gene

Orthologs for ZNF30 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF30 35 34
  • 98.87 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF383 35
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487020 34
  • 50.72 (n)
Species where no ortholog for ZNF30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF30 Gene

ENSEMBL:
Gene Tree for ZNF30 (if available)
TreeFam:
Gene Tree for ZNF30 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF30: view image

Paralogs for ZNF30 Gene

Paralogs for ZNF30 Gene

(485) SIMAP similar genes for ZNF30 Gene using alignment to 3 proteins:

  • ZNF30_HUMAN
  • L8E9Q4_HUMAN
  • V9GYJ2_HUMAN
genes like me logo Genes that share paralogs with ZNF30: view

Variants for ZNF30 Gene

Sequence variations from dbSNP and Humsavar for ZNF30 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000067119 -- 34,924,173(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000138655 -- 34,925,486(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000174088 -- 34,943,080(+) T/G intron_variant
rs1000247261 -- 34,942,725(+) G/C intron_variant
rs1000254528 -- 34,937,001(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF30 Gene

Variant ID Type Subtype PubMed ID
esv2760536 CNV gain 21179565
esv3644224 CNV loss 21293372
nsv1131422 CNV deletion 24896259
nsv523802 CNV loss 19592680

Variation tolerance for ZNF30 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.95; 94.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF30

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF30 Gene

Disorders for ZNF30 Gene

Additional Disease Information for ZNF30

No disorders were found for ZNF30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF30 Gene

Publications for ZNF30 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF30 Gene

Sources for ZNF30 Gene

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