Aliases for ZNF3 Gene

Aliases for ZNF3 Gene

  • Zinc Finger Protein 3 2 3 4 5
  • Zinc Finger Protein HZF3.1 3 4
  • Zinc Finger Protein HF.12 3 4
  • Zinc Finger Protein KOX25 3 4
  • KOX25 3 4
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein 3 (A8-51) 2
  • Zfp113 3
  • A8-51 3
  • HF.12 3
  • PP838 3

External Ids for ZNF3 Gene

Previous GeneCards Identifiers for ZNF3 Gene

  • GC07M098196
  • GC07M099259
  • GC07M099272
  • GC07M099306
  • GC07M099499
  • GC07M099661
  • GC07M094297

Summaries for ZNF3 Gene

GeneCards Summary for ZNF3 Gene

ZNF3 (Zinc Finger Protein 3) is a Protein Coding gene. Diseases associated with ZNF3 include Selective Igg Deficiency Disease. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is ZFP28.

UniProtKB/Swiss-Prot Summary for ZNF3 Gene

Gene Wiki entry for ZNF3 Gene

Additional gene information for ZNF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF3 Gene

Genomics for ZNF3 Gene

GeneHancer (GH) Regulatory Elements for ZNF3 Gene

Promoters and enhancers for ZNF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100076 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 512.2 +2.4 2445 6.7 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC ZNF3 lnc-MCM7-2 AP4M1 ZSCAN21 SRRT GIGYF1 MBLAC1 STAG3L5P PPP1R35 ZSCAN25
GH07J100427 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 93.1 -350.4 -350445 11.2 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G USF1 PPP1R35 MEPCE ZCWPW1 piR-33055 SRRT ZSCAN25 GIGYF1 TRIM4 ZNF3 ZNF655
GH07J100148 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 61.8 -66.8 -66768 2.7 NRF1 POLR2G USF1 SP1 PHF8 PHB2 FOS ZNF639 ZBTB5 ZIC2 HSALNG0059969 LAMTOR4 ZSCAN25 TRIM4 ZNF3 AP4M1 ZNF655 PTCD1 GIGYF1 SRRT
GH07J100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 57.3 -594.4 -594444 8.6 FOXK2 HNRNPK ZNF217 EP300 NRF1 MYC POLR2G USF1 SP1 BCLAF1 GNB2 GIGYF1 TRIM4 ZNF3 SRRT PPP1R35 STAG3L5P PCOLCE AP4M1 ZAN
GH07J100475 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 53.3 -395.2 -395227 4.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A POLR2G SP1 ZNF639 ZNF10 TSC22D4 ZSCAN25 SRRT TRIM4 ZNF655 PILRA ZNF3 GIGYF1 AP4M1 PPP1R35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF3

Top Transcription factor binding sites by QIAGEN in the ZNF3 gene promoter:
  • C/EBPbeta
  • Elk-1
  • FOXF2
  • MyoD
  • NF-AT1
  • Pax-4a
  • Pax-6
  • POU2F1
  • POU2F1a
  • SEF-1 (1)

Genomic Locations for ZNF3 Gene

Genomic Locations for ZNF3 Gene
chr7:100,063,847-100,082,548
(GRCh38/hg38)
Size:
18,702 bases
Orientation:
Minus strand
chr7:99,661,653-99,680,171
(GRCh37/hg19)
Size:
18,519 bases
Orientation:
Minus strand

Genomic View for ZNF3 Gene

Genes around ZNF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF3 Gene

Proteins for ZNF3 Gene

  • Protein details for ZNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17036-ZNF3_HUMAN
    Recommended name:
    Zinc finger protein 3
    Protein Accession:
    P17036
    Secondary Accessions:
    • D6W5U0
    • P13683
    • Q9HBR4
    • Q9NNX8
    • Q9NXJ1
    • Q9UC15
    • Q9UC16

    Protein attributes for ZNF3 Gene

    Size:
    446 amino acids
    Molecular mass:
    50916 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF3 Gene

Post-translational modifications for ZNF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF3 Gene

Domains & Families for ZNF3 Gene

Gene Families for ZNF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF3 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 3 (A8-51) (A4D2A4_HUMAN)
  • Zinc finger protein 3 (A8-51) (Q86U76_HUMAN)
  • Zinc finger protein KOX25 (ZNF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17036

UniProtKB/Swiss-Prot:

ZNF3_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF3: view

Function for ZNF3 Gene

Molecular function for ZNF3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cell differentiation and/or proliferation.
GENATLAS Biochemistry:
zinc finger protein 3 (A8-51)

Phenotypes From GWAS Catalog for ZNF3 Gene

Gene Ontology (GO) - Molecular Function for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 2288909
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 18255255
genes like me logo Genes that share ontologies with ZNF3: view
genes like me logo Genes that share phenotypes with ZNF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF3

Clone Products

  • Addgene plasmids for ZNF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF3 Gene

Localization for ZNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF3: view

Pathways & Interactions for ZNF3 Gene

genes like me logo Genes that share pathways with ZNF3: view

Pathways by source for ZNF3 Gene

2 Reactome pathways for ZNF3 Gene
1 KEGG pathway for ZNF3 Gene

Gene Ontology (GO) - Biological Process for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0045321 leukocyte activation NAS 2288909
genes like me logo Genes that share ontologies with ZNF3: view

No data available for SIGNOR curated interactions for ZNF3 Gene

Drugs & Compounds for ZNF3 Gene

No Compound Related Data Available

Transcripts for ZNF3 Gene

mRNA/cDNA for ZNF3 Gene

22 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF3

Clone Products

  • Addgene plasmids for ZNF3

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - - -

Relevant External Links for ZNF3 Gene

GeneLoc Exon Structure for
ZNF3

Expression for ZNF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF3 Gene



Protein tissue co-expression partners for ZNF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF3

SOURCE GeneReport for Unigene cluster for ZNF3 Gene:

Hs.435302

Evidence on tissue expression from TISSUES for ZNF3 Gene

  • Intestine(4.2)
  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF3 Gene

Orthologs for ZNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF3 31 30
  • 99.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF3 31
  • 94 (a)
OneToOne
LOC489848 30
  • 91.8 (n)
cow
(Bos Taurus)
Mammalia ZNF3 31 30
  • 88.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp113 17 31 30
  • 86.85 (n)
rat
(Rattus norvegicus)
Mammalia Zfp113 30
  • 86.07 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF3 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 31
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF3 Gene

ENSEMBL:
Gene Tree for ZNF3 (if available)
TreeFam:
Gene Tree for ZNF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF3: view image

Paralogs for ZNF3 Gene

Paralogs for ZNF3 Gene

(547) SIMAP similar genes for ZNF3 Gene using alignment to 8 proteins:

  • ZNF3_HUMAN
  • A4D2A4_HUMAN
  • C9J5S8_HUMAN
  • C9JE35_HUMAN
  • C9JIW8_HUMAN
  • C9JK31_HUMAN
  • F8WA60_HUMAN
  • Q86U76_HUMAN