Aliases for ZNF3 Gene

Aliases for ZNF3 Gene

  • Zinc Finger Protein 3 2 3 4 5
  • KOX25 2 3 4
  • Zinc Finger Protein HZF3.1 3 4
  • Zinc Finger Protein HF.12 3 4
  • Zinc Finger Protein KOX25 3 4
  • Zfp113 2 3
  • A8-51 2 3
  • HF.12 2 3
  • PP838 2 3
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein 3 (A8-51) 2
  • FLJ20216 2
  • ZNF3 5

External Ids for ZNF3 Gene

Previous GeneCards Identifiers for ZNF3 Gene

  • GC07M098196
  • GC07M099259
  • GC07M099272
  • GC07M099306
  • GC07M099499
  • GC07M099661
  • GC07M094297

Summaries for ZNF3 Gene

GeneCards Summary for ZNF3 Gene

ZNF3 (Zinc Finger Protein 3) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot Summary for ZNF3 Gene

Gene Wiki entry for ZNF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF3 Gene

Genomics for ZNF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF3

Top Transcription factor binding sites by QIAGEN in the ZNF3 gene promoter:
  • C/EBPbeta
  • Elk-1
  • FOXF2
  • MyoD
  • NF-AT1
  • Pax-4a
  • Pax-6
  • POU2F1
  • POU2F1a
  • SEF-1 (1)

Genomic Locations for ZNF3 Gene

Genomic Locations for ZNF3 Gene
chr7:100,063,837-100,082,577
(GRCh38/hg38)
Size:
18,741 bases
Orientation:
Minus strand
chr7:99,661,653-99,680,171
(GRCh37/hg19)
Size:
18,519 bases
Orientation:
Minus strand

Genomic View for ZNF3 Gene

Genes around ZNF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF3 Gene

Proteins for ZNF3 Gene

  • Protein details for ZNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17036-ZNF3_HUMAN
    Recommended name:
    Zinc finger protein 3
    Protein Accession:
    P17036
    Secondary Accessions:
    • D6W5U0
    • P13683
    • Q9HBR4
    • Q9NNX8
    • Q9NXJ1
    • Q9UC15
    • Q9UC16

    Protein attributes for ZNF3 Gene

    Size:
    446 amino acids
    Molecular mass:
    50916 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF3 Gene

Post-translational modifications for ZNF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF3 Gene

Domains & Families for ZNF3 Gene

Gene Families for ZNF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF3 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 3 (A8-51) (A4D2A4_HUMAN)
  • Zinc finger protein 3 (A8-51) (Q86U76_HUMAN)
  • Zinc finger protein KOX25 (ZNF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17036

UniProtKB/Swiss-Prot:

ZNF3_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF3: view

Function for ZNF3 Gene

Molecular function for ZNF3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cell differentiation and/or proliferation.
GENATLAS Biochemistry:
zinc finger protein 3 (A8-51)

Phenotypes From GWAS Catalog for ZNF3 Gene

Gene Ontology (GO) - Molecular Function for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 2288909
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 18255255
GO:0008270 zinc ion binding NAS 2288909
genes like me logo Genes that share ontologies with ZNF3: view
genes like me logo Genes that share phenotypes with ZNF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF3 Gene

Localization for ZNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF3: view

Pathways & Interactions for ZNF3 Gene

genes like me logo Genes that share pathways with ZNF3: view

Pathways by source for ZNF3 Gene

2 Reactome pathways for ZNF3 Gene
1 KEGG pathway for ZNF3 Gene

Gene Ontology (GO) - Biological Process for ZNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0045321 leukocyte activation NAS 2288909
genes like me logo Genes that share ontologies with ZNF3: view

No data available for SIGNOR curated interactions for ZNF3 Gene

Drugs & Compounds for ZNF3 Gene

No Compound Related Data Available

Transcripts for ZNF3 Gene

mRNA/cDNA for ZNF3 Gene

22 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF3

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - - -

Relevant External Links for ZNF3 Gene

GeneLoc Exon Structure for
ZNF3

Expression for ZNF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF3 Gene



Protein tissue co-expression partners for ZNF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF3

SOURCE GeneReport for Unigene cluster for ZNF3 Gene:

Hs.435302

Evidence on tissue expression from TISSUES for ZNF3 Gene

  • Skin(4.5)
  • Intestine(4.4)
  • Nervous system(4.3)
  • Spleen(2.7)
  • Lung(2.7)
  • Lymph node(2.6)
  • Bone marrow(2.5)
  • Heart(2.1)
  • Kidney(2.1)
  • Muscle(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with ZNF3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF3 Gene

Orthologs for ZNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF3 30 31
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF3 31
  • 94 (a)
OneToOne
LOC489848 30
  • 91.8 (n)
Cow
(Bos Taurus)
Mammalia ZNF3 30 31
  • 88.12 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp113 30 17 31
  • 86.85 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp113 30
  • 86.07 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF3 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 26 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ZFP92 31
  • 46 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF3 Gene

ENSEMBL:
Gene Tree for ZNF3 (if available)
TreeFam:
Gene Tree for ZNF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF3: view image

Paralogs for ZNF3 Gene

Paralogs for ZNF3 Gene

(547) SIMAP similar genes for ZNF3 Gene using alignment to 8 proteins:

  • ZNF3_HUMAN
  • A4D2A4_HUMAN
  • C9J5S8_HUMAN
  • C9JE35_HUMAN
  • C9JIW8_HUMAN
  • C9JK31_HUMAN
  • F8WA60_HUMAN
  • Q86U76_HUMAN

Pseudogenes.org Pseudogenes for ZNF3 Gene

genes like me logo Genes that share paralogs with ZNF3: view

Variants for ZNF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF3 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs11550034 - p.Ile102Thr

Additional dbSNP identifiers (rs#s) for ZNF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781

Variation tolerance for ZNF3 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 75.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF3 Gene

Disorders for ZNF3 Gene

No disorders were found for ZNF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF3 Gene

Publications for ZNF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. (PMID: 1945843) Rosati M … Grimaldi G (Nucleic acids research 1991) 3 4
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4
  5. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PMID: 3380682) Pannuti A … Lania L (Nucleic acids research 1988) 3 4

Products for ZNF3 Gene