Aliases for ZNF296 Gene

Aliases for ZNF296 Gene

  • Zinc Finger Protein 296 2 3 4 5
  • Zinc Finger Protein 342 2 3 4
  • ZNF342 3 4
  • ZFP296 3 4

External Ids for ZNF296 Gene

Previous HGNC Symbols for ZNF296 Gene

  • ZNF342

Previous GeneCards Identifiers for ZNF296 Gene

  • GC00U990682
  • GC19U900558
  • GC19M050267
  • GC19M045574
  • GC19M042004

Summaries for ZNF296 Gene

GeneCards Summary for ZNF296 Gene

ZNF296 (Zinc Finger Protein 296) is a Protein Coding gene. An important paralog of this gene is ZNF653.

UniProtKB/Swiss-Prot Summary for ZNF296 Gene

Additional gene information for ZNF296 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF296 Gene

Genomics for ZNF296 Gene

GeneHancer (GH) Regulatory Elements for ZNF296 Gene

Promoters and enhancers for ZNF296 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF296 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF296 gene promoter:
  • FAC1
  • MZF-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-5
  • Roaz
  • Spz1
  • STAT3

Genomic Locations for ZNF296 Gene

Genomic Locations for ZNF296 Gene
chr19:45,071,500-45,076,587
(GRCh38/hg38)
Size:
5,088 bases
Orientation:
Minus strand
chr19:45,574,758-45,579,846
(GRCh37/hg19)
Size:
5,089 bases
Orientation:
Minus strand

Genomic View for ZNF296 Gene

Genes around ZNF296 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF296 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF296 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF296 Gene

Proteins for ZNF296 Gene

  • Protein details for ZNF296 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUU4-ZN296_HUMAN
    Recommended name:
    Zinc finger protein 296
    Protein Accession:
    Q8WUU4

    Protein attributes for ZNF296 Gene

    Size:
    475 amino acids
    Molecular mass:
    50810 Da
    Quaternary structure:
    • Interacts with KLF4.

neXtProt entry for ZNF296 Gene

Post-translational modifications for ZNF296 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF296 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF296 Gene

Domains & Families for ZNF296 Gene

Gene Families for ZNF296 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF296 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF296 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 342 (ZN296_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WUU4

UniProtKB/Swiss-Prot:

ZN296_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF296: view

Function for ZNF296 Gene

Molecular function for ZNF296 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional corepressor with KLF4.

Phenotypes From GWAS Catalog for ZNF296 Gene

Gene Ontology (GO) - Molecular Function for ZNF296 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with ZNF296: view
genes like me logo Genes that share phenotypes with ZNF296: view

Animal Models for ZNF296 Gene

MGI Knock Outs for ZNF296:

Animal Model Products

CRISPR Products

miRNA for ZNF296 Gene

miRTarBase miRNAs that target ZNF296

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF296

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF296 Gene

Localization for ZNF296 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF296 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF296 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF296 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF296: view

Pathways & Interactions for ZNF296 Gene

PathCards logo

SuperPathways for ZNF296 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF296 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0007283 spermatogenesis ISS,IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF296: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF296 Gene

Drugs & Compounds for ZNF296 Gene

No Compound Related Data Available

Transcripts for ZNF296 Gene

mRNA/cDNA for ZNF296 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF296

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF296 Gene

No ASD Table

Relevant External Links for ZNF296 Gene

GeneLoc Exon Structure for
ZNF296
ECgene alternative splicing isoforms for
ZNF296

Expression for ZNF296 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF296 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF296 Gene

This gene is overexpressed in Serum (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF296 Gene



Protein tissue co-expression partners for ZNF296 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF296 Gene:

ZNF296

SOURCE GeneReport for Unigene cluster for ZNF296 Gene:

Hs.192237

Evidence on tissue expression from TISSUES for ZNF296 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZNF296: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF296 Gene

Orthologs for ZNF296 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF296 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF296 33 32
  • 93.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF296 33 32
  • 85.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF296 33 32
  • 84.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp296 17 33 32
  • 73.84 (n)
rat
(Rattus norvegicus)
Mammalia Zfp296 32
  • 73.56 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF296 33
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 20 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii znf296 33
  • 18 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9650 33
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13H6.1 33
  • 14 (a)
OneToMany
Species where no ortholog for ZNF296 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF296 Gene

ENSEMBL:
Gene Tree for ZNF296 (if available)
TreeFam:
Gene Tree for ZNF296 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF296: view image

Paralogs for ZNF296 Gene

(2) SIMAP similar genes for ZNF296 Gene using alignment to 1 proteins:

  • ZN296_HUMAN
genes like me logo Genes that share paralogs with ZNF296: view

Variants for ZNF296 Gene

Sequence variations from dbSNP and Humsavar for ZNF296 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000032922 -- 45,073,654(-) G/A intron_variant
rs1000141476 -- 45,077,508(-) G/T upstream_transcript_variant
rs1000186948 -- 45,072,770(-) A/C intron_variant
rs1000654308 -- 45,073,152(-) A/G intron_variant
rs1000657357 -- 45,078,132(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF296 Gene

Variant ID Type Subtype PubMed ID
nsv953587 CNV deletion 24416366

Variation tolerance for ZNF296 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF296 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF296

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF296 Gene

Disorders for ZNF296 Gene

Additional Disease Information for ZNF296

No disorders were found for ZNF296 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF296 Gene

Publications for ZNF296 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas. (PMID: 14633674) Hong C … Costello JF (Cancer research 2003) 2 3 56
  3. Cloning, structure, expression analysis, and assignment to mouse chromosome 7 of the gene Zfp296 encoding a zinc finger protein. (PMID: 11063263) Dear TN (Mammalian genome : official journal of the International Mammalian Genome Society 2000) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. (PMID: 28977666) Hoffmeister H … Längst G (Nucleic acids research 2017) 3 56

Products for ZNF296 Gene

Sources for ZNF296 Gene