This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017] See more...

Aliases for ZNF292 Gene

Aliases for ZNF292 Gene

  • Zinc Finger Protein 292 2 3 4 5
  • BA393I2.3 2 3
  • KIAA0530 2 4
  • ZFP292 2 3
  • Zn-15 2 3
  • Putative Protein Product Of Nbla00365 3
  • 16 Zinc-Finger Domain Protein 3
  • Nbla00365 3
  • ZNF292 5
  • MRD63 3
  • MRD64 3
  • ZN-16 3
  • Zn-16 2

External Ids for ZNF292 Gene

Previous GeneCards Identifiers for ZNF292 Gene

  • GC06P087913
  • GC06P087932
  • GC06P087857
  • GC06P087859
  • GC06P087920
  • GC06P085081

Summaries for ZNF292 Gene

Entrez Gene Summary for ZNF292 Gene

  • This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]

GeneCards Summary for ZNF292 Gene

ZNF292 (Zinc Finger Protein 292) is a Protein Coding gene. Diseases associated with ZNF292 include Intellectual Developmental Disorder, Autosomal Dominant 64 and Disease Of Mental Health. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is RLF.

UniProtKB/Swiss-Prot Summary for ZNF292 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF292 Gene

Genomics for ZNF292 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF292 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF292 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF292

Top Transcription factor binding sites by QIAGEN in the ZNF292 gene promoter:
  • AML1a
  • AREB6
  • CREB
  • deltaCREB
  • Evi-1
  • Gfi-1
  • HFH-1
  • N-Myc
  • Pax-4a

Genomic Locations for ZNF292 Gene

Latest Assembly
chr6:87,152,833-87,265,943
(GRCh38/hg38)
Size:
113,111 bases
Orientation:
Plus strand

Previous Assembly
chr6:87,865,283-87,975,661
(GRCh37/hg19 by Entrez Gene)
Size:
110,379 bases
Orientation:
Plus strand

chr6:87,862,551-87,973,914
(GRCh37/hg19 by Ensembl)
Size:
111,364 bases
Orientation:
Plus strand

Genomic View for ZNF292 Gene

Genes around ZNF292 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF292 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF292 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF292 Gene

Proteins for ZNF292 Gene

  • Protein details for ZNF292 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60281-ZN292_HUMAN
    Recommended name:
    Zinc finger protein 292
    Protein Accession:
    O60281
    Secondary Accessions:
    • Q5W0B2
    • Q7Z3L7
    • Q9H8G3
    • Q9H8J4

    Protein attributes for ZNF292 Gene

    Size:
    2723 amino acids
    Molecular mass:
    304816 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14622.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF292 Gene

    Alternative splice isoforms for ZNF292 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF292 Gene

Post-translational modifications for ZNF292 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF292 Gene

Domains & Families for ZNF292 Gene

Gene Families for ZNF292 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF292 Gene

Suggested Antigen Peptide Sequences for ZNF292 Gene

GenScript: Design optimal peptide antigens:
  • ZNF292 protein (Q6P495_HUMAN)
  • Zinc finger protein 292 (ZN292_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60281

UniProtKB/Swiss-Prot:

ZN292_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF292: view

Function for ZNF292 Gene

Molecular function for ZNF292 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF292 Gene

Gene Ontology (GO) - Molecular Function for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF292: view
genes like me logo Genes that share phenotypes with ZNF292: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF292

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF292 Gene

Localization for ZNF292 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF292 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF292 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF292: view

Pathways & Interactions for ZNF292 Gene

PathCards logo

SuperPathways for ZNF292 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF292: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF292 Gene

Drugs & Compounds for ZNF292 Gene

No Compound Related Data Available

Transcripts for ZNF292 Gene

mRNA/cDNA for ZNF292 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF292

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF292 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3:
SP4: - - - - - - - - - -
SP5: - - - - - - -

Relevant External Links for ZNF292 Gene

GeneLoc Exon Structure for
ZNF292

Expression for ZNF292 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF292 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF292 Gene

This gene is overexpressed in Retina (46.3), Liver, secretome (11.7), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF292 Gene



Protein tissue co-expression partners for ZNF292 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF292

SOURCE GeneReport for Unigene cluster for ZNF292 Gene:

Hs.485892

Evidence on tissue expression from TISSUES for ZNF292 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF292: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF292 Gene

Orthologs for ZNF292 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF292 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF292 29 30
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF292 29 30
  • 93.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF292 29 30
  • 91.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp292 29
  • 85.23 (n)
Mouse
(Mus musculus)
Mammalia Zfp292 29 16 30
  • 84.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF292 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF292 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF292 29 30
  • 73.43 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF292 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf292 29
  • 59.47 (n)
Str.7312 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.9913 29
Zebrafish
(Danio rerio)
Actinopterygii znf292b 30
  • 32 (a)
OneToMany
znf292a 30
  • 31 (a)
OneToMany
Species where no ortholog for ZNF292 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF292 Gene

ENSEMBL:
Gene Tree for ZNF292 (if available)
TreeFam:
Gene Tree for ZNF292 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF292: view image
Alliance of Genome Resources:
Additional Orthologs for ZNF292

Paralogs for ZNF292 Gene

Paralogs for ZNF292 Gene

(3) SIMAP similar genes for ZNF292 Gene using alignment to 7 proteins:

  • ZN292_HUMAN
  • E5RFE6_HUMAN
  • E5RJG2_HUMAN
  • H0YAU0_HUMAN
  • H0YB79_HUMAN
  • J3KNV1_HUMAN
  • Q6P495_HUMAN

Pseudogenes.org Pseudogenes for ZNF292 Gene

genes like me logo Genes that share paralogs with ZNF292: view

Variants for ZNF292 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF292 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
1013515 Likely Pathogenic: not provided 87,255,750(+) TAATG/T
NM_015021.3(ZNF292):c.2124_2127del (p.Asn708fs)
FRAMESHIFT
932591 Uncertain Significance: not provided 87,259,301(+) ACATT/A
NM_015021.3(ZNF292):c.5675_5678del (p.Ile1892fs)
FRAMESHIFT
975785 Likely Benign: Intellectual disability 87,258,959(+) C/T
NM_015021.3(ZNF292):c.5330C>T (p.Ser1777Phe)
MISSENSE
977380 Uncertain Significance: Seizures 87,254,888(+) A/G
NM_015021.3(ZNF292):c.1259A>G (p.Glu420Gly)
MISSENSE
981386 Uncertain Significance: Intellectual disability; Neurodevelopmental disorder; Autosomal dominant intellectual developmental disorder 64 87,215,999(+) C/T
NM_015021.3(ZNF292):c.265C>T (p.Arg89Ter)
NONSENSE,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF292 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF292 Gene

Variant ID Type Subtype PubMed ID
esv2759453 CNV loss 17122850
esv2763585 CNV gain 21179565
esv3303905 CNV mobile element insertion 20981092
esv3327111 CNV insertion 20981092
nsv604114 CNV loss 21841781

Variation tolerance for ZNF292 Gene

Residual Variation Intolerance Score: 8.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF292 Gene

Human Gene Mutation Database (HGMD)
ZNF292
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF292
Leiden Open Variation Database (LOVD)
ZNF292

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF292 Gene

Disorders for ZNF292 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF292 Gene - From: OMI, CVR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF292

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF292: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF292 Gene

Publications for ZNF292 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  2. De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder. (PMID: 31723249) Mirzaa GM … Bamshad MJ (Genetics in medicine : official journal of the American College of Medical Genetics 2020) 3 72
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 40
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3

Products for ZNF292 Gene

Sources for ZNF292 Gene