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This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
ZNF292 (Zinc Finger Protein 292) is a Protein Coding gene. Diseases associated with ZNF292 include Alacrima, Achalasia, And Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is RLF.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF292 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF292 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF292 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp292 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Zfp292 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNF292 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF292 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZNF292 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZNF292 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf292 30 |
|
||
Str.7312 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.9913 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | znf292b 31 |
|
OneToMany | |
znf292a 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
690394 | Uncertain Significance: not provided | 87,261,499(+) | C/G | MISSENSE_VARIANT | |
711035 | Benign: not provided | 87,258,353(+) | T/C | MISSENSE_VARIANT | |
712558 | Benign: not provided | 87,258,547(+) | G/C | MISSENSE_VARIANT | |
716870 | Benign: not provided | 87,258,571(+) | G/A | MISSENSE_VARIANT | |
736552 | Likely Benign: not provided | 87,260,778(+) | A/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759453 | CNV | loss | 17122850 |
esv2763585 | CNV | gain | 21179565 |
esv3303905 | CNV | mobile element insertion | 20981092 |
esv3327111 | CNV | insertion | 20981092 |
nsv604114 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alacrima, achalasia, and mental retardation syndrome |
|