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This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017] See more...
Aliases for ZNF292 Gene
Aliases for ZNF292 Gene
External Ids for ZNF292 Gene
- HGNC: 18410
- Entrez Gene: 23036
- Ensembl: ENSG00000188994
- OMIM: 616213
- UniProtKB: O60281
Previous GeneCards Identifiers for ZNF292 Gene
- GC06P087913
- GC06P087932
- GC06P087857
- GC06P087859
- GC06P087920
- GC06P085081
Summaries for ZNF292 Gene
-
This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
GeneCards Summary for ZNF292 Gene
ZNF292 (Zinc Finger Protein 292) is a Protein Coding gene. Diseases associated with ZNF292 include Alacrima, Achalasia, And Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is RLF.
UniProtKB/Swiss-Prot Summary for ZNF292 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF292 Gene
- HGNC(18410)
- Entrez Gene(23036)
- Ensembl(ENSG00000188994)
- OMIM(616213)
- UniProtKB(O60281)
- Open Targets Platform(ENSG00000188994)
- Monarch Initiative
- Search for ZNF292 at DataMed
- Search for ZNF292 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF292 Gene
Genomics for ZNF292 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF292 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF292 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF292
- Top Transcription factor binding sites by QIAGEN in the ZNF292 gene promoter:
-
- AML1a
- AREB6
- CREB
- deltaCREB
- Evi-1
- Gfi-1
- HFH-1
- N-Myc
- Pax-4a
Genomic Locations for ZNF292 Gene
Genomic Locations for ZNF292 Gene
- chr6:87,152,833-87,265,943
- (GRCh38/hg38)
- Size:
- 113,111 bases
- Orientation:
- Plus strand
- chr6:87,862,551-87,973,914
- (GRCh37/hg19)
- Size:
- 111,364 bases
- Orientation:
- Plus strand
Genomic View for ZNF292 Gene
Genes around ZNF292 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q14.3 by HGNC
- 6q14.3 by Entrez Gene
- 6q14.3 by Ensembl
ZNF292 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF292 Gene
Proteins for ZNF292 Gene
-
Protein details for ZNF292 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60281-ZN292_HUMAN
- Recommended name:
- Zinc finger protein 292
- Protein Accession:
- O60281
- Q5W0B2
- Q7Z3L7
- Q9H8G3
- Q9H8J4
Protein attributes for ZNF292 Gene
- Size:
- 2723 amino acids
- Molecular mass:
- 304816 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14622.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ZNF292 Gene
Post-translational modifications for ZNF292 Gene
Other Protein References for ZNF292 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ZNF292 Antibody
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- Invitrogen Antibodies for ZNF292 (AFLGC-ZNF292)
-
Boster Bio Antibodies for ZNF292
Protein Products
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- Novus Biologicals proteins for ZNF292
No data available for DME Specific Peptides for ZNF292 Gene
Domains & Families for ZNF292 Gene
Gene Families for ZNF292 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF292 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF292 Gene
- GenScript: Design optimal peptide antigens:
-
- ZNF292 protein (Q6P495_HUMAN)
- Zinc finger protein 292 (ZN292_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60281- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF292 Gene
Molecular function for ZNF292 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF292 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IBA | 21873635 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF292 Gene
- GenomeRNAi human phenotypes for ZNF292:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF292 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF292
miRNA for ZNF292 Gene
- miRTarBase miRNAs that target ZNF292
-
- hsa-miR-335-5p (MIRT018531)
- hsa-miR-21-5p (MIRT030961)
- hsa-miR-196a-3p (MIRT408854)
- hsa-miR-7153-5p (MIRT532943)
- hsa-miR-146b-5p (MIRT532944)
- hsa-miR-146a-5p (MIRT532945)
- hsa-miR-3925-5p (MIRT532946)
- hsa-miR-3120-3p (MIRT532947)
- hsa-miR-32-3p (MIRT532948)
- hsa-miR-1273g-3p (MIRT682925)
- hsa-miR-7703 (MIRT682926)
- hsa-miR-6720-5p (MIRT682927)
- hsa-miR-6512-3p (MIRT682928)
- hsa-miR-661 (MIRT682929)
- hsa-miR-6860 (MIRT682930)
- hsa-miR-612 (MIRT682931)
- hsa-miR-5189-5p (MIRT682932)
- hsa-miR-3187-5p (MIRT682933)
- hsa-miR-1285-3p (MIRT682934)
- hsa-miR-4793-3p (MIRT682935)
- hsa-miR-766-3p (MIRT682936)
- hsa-miR-939-3p (MIRT682937)
- hsa-miR-6849-3p (MIRT682938)
- hsa-miR-508-5p (MIRT682939)
- hsa-miR-200a-3p (MIRT682940)
- hsa-miR-141-3p (MIRT682941)
- hsa-miR-6873-3p (MIRT717467)
- hsa-miR-4795-3p (MIRT717468)
- hsa-miR-6817-3p (MIRT717469)
- hsa-miR-7110-3p (MIRT717470)
- hsa-miR-3675-3p (MIRT717471)
- hsa-miR-7151-5p (MIRT717472)
- hsa-miR-5003-3p (MIRT717473)
miRNA Products
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for ZNF292
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF292 Gene
Localization for ZNF292 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF292 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nuclear membrane (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
Pathways & Interactions for ZNF292 Gene
Interacting Proteins for ZNF292 Gene
GPS-Prot Interaction Network for ZNF292
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF292 Gene
Transcripts for ZNF292 Gene
mRNA/cDNA for ZNF292 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000339907 8287 nts (view in UCSC)
- ENST00000369577 12341 nts (view in UCSC)
- ENST00000369578 1732 nts (view in UCSC)
- ENST00000392985 1096 nts (view in UCSC)
- ENST00000466062 838 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF292 - Select products 50% OFF >
- * ZNF292 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF292
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF292
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF292
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF292
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF292 - Select products 50% OFF >
- * ZNF292 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF292
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - |
Relevant External Links for ZNF292 Gene
- GeneLoc Exon Structure for
- ZNF292
Expression for ZNF292 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
- Hematopoietic Bone Marrow
- Eye (Sensory Organs)
This gene is overexpressed in Retina (46.3), Liver, secretome (11.7), and Platelet (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF292 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF292
SOURCE GeneReport for Unigene cluster for ZNF292 Gene:
Hs.485892Evidence on tissue expression from TISSUES for ZNF292 Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for ZNF292
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF292 Gene
Orthologs for ZNF292 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF292 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF292 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF292 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp292 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Zfp292 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZNF292 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF292 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZNF292 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZNF292 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf292 30 |
|
||
| Str.7312 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9913 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | znf292b 31 |
|
OneToMany | |
| znf292a 31 |
|
OneToMany |
- Species where no ortholog for ZNF292 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZNF292 Gene
- ENSEMBL:
- Gene Tree for ZNF292 (if available)
- TreeFam:
- Gene Tree for ZNF292 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF292: view image
Paralogs for ZNF292 Gene
(3) SIMAP similar genes for ZNF292 Gene using alignment to 7 proteins:
- ZN292_HUMAN
- E5RFE6_HUMAN
- E5RJG2_HUMAN
- H0YAU0_HUMAN
- H0YB79_HUMAN
- J3KNV1_HUMAN
- Q6P495_HUMAN
Pseudogenes.org Pseudogenes for ZNF292 Gene
Variants for ZNF292 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF292 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 690394 | Uncertain Significance: not provided | 87,261,499(+) | C/G | MISSENSE_VARIANT | |
| 711035 | Benign: not provided | 87,258,353(+) | T/C | MISSENSE_VARIANT | |
| 712558 | Benign: not provided | 87,258,547(+) | G/C | MISSENSE_VARIANT | |
| 716870 | Benign: not provided | 87,258,571(+) | G/A | MISSENSE_VARIANT | |
| 736552 | Likely Benign: not provided | 87,260,778(+) | A/G | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759453 | CNV | loss | 17122850 |
| esv2763585 | CNV | gain | 21179565 |
| esv3303905 | CNV | mobile element insertion | 20981092 |
| esv3327111 | CNV | insertion | 20981092 |
| nsv604114 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
8.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.17;
69.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF292 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF292 Gene
Disorders for ZNF292 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alacrima, achalasia, and mental retardation syndrome |
|
Search ZNF292 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF292
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF292 Gene
Publications for ZNF292 Gene
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
- An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3
ExternalLinks
Products for ZNF292 Gene
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- antibodies-online: Show 4 available ZNF292 Antibodies ranked by validation data
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- Boster Bio Antibodies for ZNF292
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Sources for ZNF292 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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