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Aliases for ZNF292 Gene

Aliases for ZNF292 Gene

  • Zinc Finger Protein 292 2 3 3 5
  • Putative Protein Product Of Nbla00365 3
  • 16 Zinc-Finger Domain Protein 3
  • Nbla00365 3
  • BA393I2.3 3
  • KIAA0530 4
  • ZFP292 3
  • ZN-16 3
  • Zn-15 3

External Ids for ZNF292 Gene

Previous GeneCards Identifiers for ZNF292 Gene

  • GC06P087913
  • GC06P087932
  • GC06P087857
  • GC06P087859
  • GC06P087920
  • GC06P085081

Summaries for ZNF292 Gene

Entrez Gene Summary for ZNF292 Gene

  • This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]

GeneCards Summary for ZNF292 Gene

ZNF292 (Zinc Finger Protein 292) is a Protein Coding gene. Diseases associated with ZNF292 include Alacrima, Achalasia, And Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is RLF.

UniProtKB/Swiss-Prot for ZNF292 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF292 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF292 Gene

Genomics for ZNF292 Gene

GeneHancer (GH) Regulatory Elements for ZNF292 Gene

Promoters and enhancers for ZNF292 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J087151 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 761.3 +1.6 1567 6.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF292 ENSG00000272008 RARS2 SLC35A1 RCN1P1 TAF13P1 ST13P16 SMIM8 LINC01590 ORC3
GH06J087472 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.5 +320.3 320349 2.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 SLC35A1 ZNF292 RARS2 ENSG00000272008 ORC3 C6orf163 GC06P087489 ENSG00000213204
GH06J087321 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 31.5 +169.8 169847 1.4 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 SMIM8 LINC01590 C6orf163 ZNF292 SLC35A1 GJB7
GH06J087697 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.5 +547.5 547524 6.6 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D AKIRIN2 GC06M087700 SLC35A1 ENSG00000272008 ORC3 ZNF292 LINC01590 RARS2 SMIM8 GC06P087659
GH06J087912 Enhancer 0.7 dbSUPER 77.5 +759.7 759732 1.1 ZFP64 ZNF140 ZNF266 ZNF697 ZNF664 ZNF213 RBAK ZNF433 ZNF202 ZNF680 ZNF292 RARS2 SLC35A1 LINC01590 C6orf163 LOC105377882 ENSG00000271114
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF292 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF292 gene promoter:

Genomic Locations for ZNF292 Gene

Genomic Locations for ZNF292 Gene
111,364 bases
Plus strand

Genomic View for ZNF292 Gene

Genes around ZNF292 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF292 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF292 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF292 Gene

Proteins for ZNF292 Gene

  • Protein details for ZNF292 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 292
    Protein Accession:
    Secondary Accessions:
    • Q5W0B2
    • Q7Z3L7
    • Q9H8G3
    • Q9H8J4

    Protein attributes for ZNF292 Gene

    2723 amino acids
    Molecular mass:
    304816 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14622.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Frameshift; Positions=637; Evidence={ECO:0000305}; Sequence=CAD97823.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZNF292 Gene

    Alternative splice isoforms for ZNF292 Gene


neXtProt entry for ZNF292 Gene

Post-translational modifications for ZNF292 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF292 Gene

Domains & Families for ZNF292 Gene

Gene Families for ZNF292 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF292 Gene


Suggested Antigen Peptide Sequences for ZNF292 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF292: view

Function for ZNF292 Gene

Molecular function for ZNF292 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF292 Gene

Gene Ontology (GO) - Molecular Function for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF292: view
genes like me logo Genes that share phenotypes with ZNF292: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF292

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF292 Gene

Localization for ZNF292 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF292 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF292 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF292: view

Pathways & Interactions for ZNF292 Gene

SuperPathways for ZNF292 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF292 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF292: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF292 Gene

Drugs & Compounds for ZNF292 Gene

No Compound Related Data Available

Transcripts for ZNF292 Gene

Unigene Clusters for ZNF292 Gene

Zinc finger protein 292:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF292

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF292 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP4: - - - - - - - - - -
SP5: - - - - - - -

Relevant External Links for ZNF292 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF292 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF292 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF292 Gene

This gene is overexpressed in Retina (46.3), Liver, secretome (11.7), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF292 Gene

Protein tissue co-expression partners for ZNF292 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF292 Gene:


SOURCE GeneReport for Unigene cluster for ZNF292 Gene:


Evidence on tissue expression from TISSUES for ZNF292 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF292: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF292 Gene

Orthologs for ZNF292 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF292 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF292 34 33
  • 99.56 (n)
(Canis familiaris)
Mammalia ZNF292 34 33
  • 93.42 (n)
(Bos Taurus)
Mammalia ZNF292 34 33
  • 91.05 (n)
(Rattus norvegicus)
Mammalia Zfp292 33
  • 85.23 (n)
(Mus musculus)
Mammalia Zfp292 16 34 33
  • 84.76 (n)
(Monodelphis domestica)
Mammalia ZNF292 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF292 34
  • 70 (a)
(Gallus gallus)
Aves ZNF292 34 33
  • 73.43 (n)
(Anolis carolinensis)
Reptilia ZNF292 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf292 33
  • 59.47 (n)
Str.7312 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9913 33
(Danio rerio)
Actinopterygii znf292b 34
  • 32 (a)
znf292a 34
  • 31 (a)
Species where no ortholog for ZNF292 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF292 Gene

Gene Tree for ZNF292 (if available)
Gene Tree for ZNF292 (if available)
Evolutionary constrained regions (ECRs) for ZNF292: view image

Paralogs for ZNF292 Gene

Paralogs for ZNF292 Gene

(3) SIMAP similar genes for ZNF292 Gene using alignment to 7 proteins:

  • ZN292_HUMAN
  • H0YB79_HUMAN
  • Q6P495_HUMAN Pseudogenes for ZNF292 Gene

genes like me logo Genes that share paralogs with ZNF292: view

Variants for ZNF292 Gene

Sequence variations from dbSNP and Humsavar for ZNF292 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs879255403 uncertain-significance, not specified 87,259,665(+) AGAG/AG coding_sequence_variant, frameshift
rs1000003309 -- 87,165,883(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000016124 -- 87,163,363(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000046648 -- 87,204,849(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000048723 -- 87,219,177(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF292 Gene

Variant ID Type Subtype PubMed ID
esv2759453 CNV loss 17122850
esv2763585 CNV gain 21179565
esv3303905 CNV mobile element insertion 20981092
esv3327111 CNV insertion 20981092
nsv604114 CNV loss 21841781

Variation tolerance for ZNF292 Gene

Residual Variation Intolerance Score: 8.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF292 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF292 Gene

Disorders for ZNF292 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF292 Gene - From: ClinVar

Disorder Aliases PubMed IDs
alacrima, achalasia, and mental retardation syndrome
  • aamr
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF292

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF292: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF292 Gene

Publications for ZNF292 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Frameshift mutations of a tumor suppressor gene ZNF292 in gastric and colorectal cancers with high microsatellite instability. (PMID: 27150435) Lee JH … Lee SH (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF292 Gene

Sources for ZNF292 Gene

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