This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF287 Gene

Aliases for ZNF287 Gene

  • Zinc Finger Protein 287 2 3 4 5
  • ZKSCAN13 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 13 3 4
  • ZSCAN45 2 3
  • ZNF287 5

External Ids for ZNF287 Gene

Previous GeneCards Identifiers for ZNF287 Gene

  • GC17M016816
  • GC17M017565
  • GC17M016397
  • GC17M016655
  • GC17M016395
  • GC17M016320
  • GC17M016453
  • GC17M016550
  • GC17M016551
  • GC17M016554

Summaries for ZNF287 Gene

Entrez Gene Summary for ZNF287 Gene

  • This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF287 Gene

ZNF287 (Zinc Finger Protein 287) is a Protein Coding gene. Diseases associated with ZNF287 include Nanophthalmos. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF426.

UniProtKB/Swiss-Prot Summary for ZNF287 Gene

Additional gene information for ZNF287 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF287 Gene

Genomics for ZNF287 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF287 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF287 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF287

Top Transcription factor binding sites by QIAGEN in the ZNF287 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • CUTL1
  • HNF-3beta
  • NF-AT
  • NF-AT1
  • Nkx2-2
  • Pax-2
  • Pax-2a
  • SEF-1 (1)

Genomic Locations for ZNF287 Gene

Genomic Locations for ZNF287 Gene
chr17:16,546,689-16,569,212
(GRCh38/hg38)
Size:
22,524 bases
Orientation:
Minus strand
chr17:16,453,631-16,472,520
(GRCh37/hg19)
Size:
18,890 bases
Orientation:
Minus strand

Genomic View for ZNF287 Gene

Genes around ZNF287 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF287 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF287 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF287 Gene

Proteins for ZNF287 Gene

  • Protein details for ZNF287 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT7-ZN287_HUMAN
    Recommended name:
    Zinc finger protein 287
    Protein Accession:
    Q9HBT7
    Secondary Accessions:
    • Q6IAG1

    Protein attributes for ZNF287 Gene

    Size:
    761 amino acids
    Molecular mass:
    88339 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG09702.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI01488.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI13364.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF287 Gene

Post-translational modifications for ZNF287 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF287 Gene

Domains & Families for ZNF287 Gene

Gene Families for ZNF287 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF287 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF287 Gene

GenScript: Design optimal peptide antigens:
  • ZNF287 protein (Q6PEZ3_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 13 (ZN287_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBT7

UniProtKB/Swiss-Prot:

ZN287_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF287: view

Function for ZNF287 Gene

Molecular function for ZNF287 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF287 Gene

Gene Ontology (GO) - Molecular Function for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF287: view
genes like me logo Genes that share phenotypes with ZNF287: view

Animal Models for ZNF287 Gene

MGI Knock Outs for ZNF287:
  • Zfp287 Zfp287<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZNF287 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF287

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF287 Gene

Localization for ZNF287 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF287 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF287 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF287: view

Pathways & Interactions for ZNF287 Gene

PathCards logo

SuperPathways for ZNF287 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF287: view

Pathways by source for ZNF287 Gene

2 Reactome pathways for ZNF287 Gene

Gene Ontology (GO) - Biological Process for ZNF287 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042035 regulation of cytokine biosynthetic process IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF287: view

No data available for SIGNOR curated interactions for ZNF287 Gene

Drugs & Compounds for ZNF287 Gene

No Compound Related Data Available

Transcripts for ZNF287 Gene

mRNA/cDNA for ZNF287 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF287

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF287 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: -

Relevant External Links for ZNF287 Gene

GeneLoc Exon Structure for
ZNF287

Expression for ZNF287 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF287 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF287

SOURCE GeneReport for Unigene cluster for ZNF287 Gene:

Hs.99724

Evidence on tissue expression from TISSUES for ZNF287 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF287: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF287 Gene

Orthologs for ZNF287 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF287 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF287 30 31
  • 99.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF287 30 31
  • 91.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp287 30
  • 85.97 (n)
Cow
(Bos Taurus)
Mammalia ZNF287 30
  • 85.34 (n)
ZNF135 31
  • 43 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp287 30 17 31
  • 83.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
-- 31
  • 39 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6654 32
  • 40 (a)
CG2120 32
  • 36 (a)
CG8301 32
  • 32 (a)
CG10543 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 32
  • 36 (a)
Species where no ortholog for ZNF287 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF287 Gene

ENSEMBL:
Gene Tree for ZNF287 (if available)
TreeFam:
Gene Tree for ZNF287 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF287: view image

Paralogs for ZNF287 Gene

(426) SIMAP similar genes for ZNF287 Gene using alignment to 3 proteins:

  • ZN287_HUMAN
  • C9JAV4_HUMAN
  • Q6PEZ3_HUMAN
genes like me logo Genes that share paralogs with ZNF287: view

Variants for ZNF287 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF287 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs193920744 Uncertain Significance: Malignant tumor of prostate 16,553,049(-) C/G MISSENSE_VARIANT
rs7224723 - p.Lys281Thr

Additional dbSNP identifiers (rs#s) for ZNF287 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF287 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV deletion 23290073
esv3640103 CNV gain 21293372
nsv1063764 CNV loss 25217958

Variation tolerance for ZNF287 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF287 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF287

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF287 Gene

Disorders for ZNF287 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF287 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nanophthalmos
  • nanophthalmia
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF287: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF287 Gene

Publications for ZNF287 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3
  3. Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma. (PMID: 25288879) Yang R … Qin ZS (Cancer informatics 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4

Products for ZNF287 Gene

Sources for ZNF287 Gene