Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
ZNF287 (Zinc Finger Protein 287) is a Protein Coding gene. Diseases associated with ZNF287 include Nanophthalmos. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF426.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0042035 | regulation of cytokine biosynthetic process | IEA | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF287 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF287 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp287 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ZNF287 30 |
|
||
ZNF135 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Zfp287 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6654 32 |
|
|
|
CG2120 32 |
|
|
|||
CG8301 32 |
|
|
|||
CG10543 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | Y55F3AM.14 32 |
|
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920744 | Uncertain Significance: Malignant tumor of prostate | 16,553,049(-) | C/G | MISSENSE_VARIANT | |
rs7224723 | - | p.Lys281Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2715702 | CNV | deletion | 23290073 |
esv3640103 | CNV | gain | 21293372 |
nsv1063764 | CNV | loss | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
nanophthalmos |
|
|