Aliases for ZNF286B Gene

Aliases for ZNF286B Gene

  • Zinc Finger Protein 286B (Pseudogene) 2 3 5
  • Putative Zinc Finger Protein 286B 3 4
  • Zinc Finger 286C Pseudogene 2 3
  • Zinc Finger Protein 590 2 3
  • ZNF286C 3 4
  • ZNF286L 3 4
  • Zinc Finger Protein 286-Like 2
  • Zinc Finger Protein 286B 2
  • Forkhead Box O3B 3
  • FOXO3B 3
  • ZNF590 3

External Ids for ZNF286B Gene

Previous HGNC Symbols for ZNF286B Gene

  • ZNF286L
  • ZNF286C

Previous GeneCards Identifiers for ZNF286B Gene

  • GC17U900825
  • GC17M018511
  • GC17M018561

Summaries for ZNF286B Gene

GeneCards Summary for ZNF286B Gene

ZNF286B (Zinc Finger Protein 286B (Pseudogene)) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF286A.

UniProtKB/Swiss-Prot Summary for ZNF286B Gene

Additional gene information for ZNF286B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF286B Gene

Genomics for ZNF286B Gene

GeneHancer (GH) Regulatory Elements for ZNF286B Gene

Promoters and enhancers for ZNF286B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF286B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF286B gene promoter:
  • aMEF-2
  • Evi-1
  • MEF-2A
  • MRF-2
  • Olf-1
  • POU2F1
  • POU2F1a
  • SEF-1 (1)
  • Spz1
  • STAT3

Genomic Locations for ZNF286B Gene

Genomic Locations for ZNF286B Gene
chr17:18,658,429-18,682,259
(GRCh38/hg38)
Size:
23,831 bases
Orientation:
Minus strand
chr17:18,561,742-18,585,575
(GRCh37/hg19)
Size:
23,834 bases
Orientation:
Minus strand

Genomic View for ZNF286B Gene

Genes around ZNF286B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF286B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF286B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF286B Gene

Proteins for ZNF286B Gene

  • Protein details for ZNF286B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG31-Z286B_HUMAN
    Recommended name:
    Putative zinc finger protein 286B
    Protein Accession:
    P0CG31

    Protein attributes for ZNF286B Gene

    Size:
    522 amino acids
    Molecular mass:
    59572 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF286B Gene

Post-translational modifications for ZNF286B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF286B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ZNF286B Gene

Domains & Families for ZNF286B Gene

Gene Families for ZNF286B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF286B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF286B Gene

GenScript: Design optimal peptide antigens:
  • Putative zinc finger protein 286B (Z286B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG31

UniProtKB/Swiss-Prot:

Z286B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF286B: view

Function for ZNF286B Gene

Molecular function for ZNF286B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF286B Gene

Gene Ontology (GO) - Molecular Function for ZNF286B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF286B: view

Phenotypes for ZNF286B Gene

genes like me logo Genes that share phenotypes with ZNF286B: view

Animal Model Products

CRISPR Products

Transcription Factor Targets for ZNF286B Gene

Selected GeneGlobe predicted Target genes for ZNF286B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for ZNF286B Gene

Localization for ZNF286B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF286B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF286B gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF286B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF286B: view

Pathways & Interactions for ZNF286B Gene

PathCards logo

SuperPathways for ZNF286B Gene

No Data Available

Interacting Proteins for ZNF286B Gene

Gene Ontology (GO) - Biological Process for ZNF286B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF286B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF286B Gene

Drugs & Compounds for ZNF286B Gene

No Compound Related Data Available

Transcripts for ZNF286B Gene

mRNA/cDNA for ZNF286B Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF286B Gene

No ASD Table

Relevant External Links for ZNF286B Gene

GeneLoc Exon Structure for
ZNF286B
ECgene alternative splicing isoforms for
ZNF286B

Expression for ZNF286B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF286B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF286B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of ZNF286B Gene:

ZNF286B

SOURCE GeneReport for Unigene cluster for ZNF286B Gene:

Hs.534279
genes like me logo Genes that share expression patterns with ZNF286B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF286B Gene

Orthologs for ZNF286B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF286B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF286A 33
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 33
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF286A 33
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp286 33
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 59 (a)
OneToMany
Species where no ortholog for ZNF286B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF286B Gene

ENSEMBL:
Gene Tree for ZNF286B (if available)
TreeFam:
Gene Tree for ZNF286B (if available)

Paralogs for ZNF286B Gene

Paralogs for ZNF286B Gene

(513) SIMAP similar genes for ZNF286B Gene using alignment to 5 proteins:

  • Z286B_HUMAN
  • I3L365_HUMAN
  • I3L3U3_HUMAN
  • J3KS91_HUMAN
  • J3QKZ1_HUMAN

Pseudogenes.org Pseudogenes for ZNF286B Gene

genes like me logo Genes that share paralogs with ZNF286B: view

Variants for ZNF286B Gene

Sequence variations from dbSNP and Humsavar for ZNF286B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000253512 -- 18,678,729(-) G/A intron_variant
rs1000436850 -- 18,672,562(-) C/T intron_variant
rs1000678739 -- 18,667,002(-) /C intron_variant
rs1000763966 -- 18,660,364(-) C/G non_coding_transcript_variant
rs1000853660 -- 18,677,118(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF286B Gene

Variant ID Type Subtype PubMed ID
dgv3111n100 CNV gain 25217958
dgv564e214 CNV gain 21293372
esv3572454 CNV gain 25503493
esv3640158 CNV loss 21293372
esv3640159 CNV gain 21293372
nsv1057803 CNV loss 25217958
nsv1060744 CNV gain 25217958
nsv499818 OTHER inversion 21111241
nsv523721 CNV gain 19592680
nsv827913 CNV gain 20364138
nsv833389 CNV gain 17160897
nsv9504 CNV gain+loss 18304495
nsv962277 CNV duplication 23825009

Variation tolerance for ZNF286B Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.28; 98.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF286B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF286B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF286B Gene

Disorders for ZNF286B Gene

Additional Disease Information for ZNF286B

No disorders were found for ZNF286B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF286B Gene

Publications for ZNF286B Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 56
  2. A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene. (PMID: 29925039) Santo EE … Paik J (Gene 2018) 3 56
  3. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 43 56
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 43 56
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D … Mitchell GF (BMC medical genetics 2007) 43 56

Products for ZNF286B Gene

Sources for ZNF286B Gene