Aliases for ZNF286A Gene

Aliases for ZNF286A Gene

  • Zinc Finger Protein 286A 2 3 4 5
  • ZNF286 3 4
  • Zinc Finger Protein ZNF286 3
  • Zinc Finger Protein 286 2
  • KIAA1874 4

External Ids for ZNF286A Gene

Previous HGNC Symbols for ZNF286A Gene

  • ZNF286

Previous GeneCards Identifiers for ZNF286A Gene

  • GC17P015544
  • GC17P015602
  • GC17P015478
  • GC17P015701

Summaries for ZNF286A Gene

GeneCards Summary for ZNF286A Gene

ZNF286A (Zinc Finger Protein 286A) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ENSG00000255104.

UniProtKB/Swiss-Prot Summary for ZNF286A Gene

Additional gene information for ZNF286A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF286A Gene

Genomics for ZNF286A Gene

GeneHancer (GH) Regulatory Elements for ZNF286A Gene

Promoters and enhancers for ZNF286A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF286A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF286A

Top Transcription factor binding sites by QIAGEN in the ZNF286A gene promoter:
  • Evi-1
  • FOXL1
  • MRF-2
  • Olf-1
  • POU2F1
  • POU2F1a
  • PPAR-gamma2
  • RREB-1
  • SEF-1 (1)
  • STAT3

Genomic Locations for ZNF286A Gene

Genomic Locations for ZNF286A Gene
chr17:15,699,577-15,720,787
(GRCh38/hg38)
Size:
21,211 bases
Orientation:
Plus strand
chr17:15,602,891-15,648,092
(GRCh37/hg19)
Size:
45,202 bases
Orientation:
Plus strand

Genomic View for ZNF286A Gene

Genes around ZNF286A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF286A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF286A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF286A Gene

Proteins for ZNF286A Gene

  • Protein details for ZNF286A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT8-Z286A_HUMAN
    Recommended name:
    Zinc finger protein 286A
    Protein Accession:
    Q9HBT8
    Secondary Accessions:
    • B4DKF9
    • Q96JF3

    Protein attributes for ZNF286A Gene

    Size:
    521 amino acids
    Molecular mass:
    60175 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47503.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF286A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF286A Gene

Post-translational modifications for ZNF286A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF286A Gene

Domains & Families for ZNF286A Gene

Gene Families for ZNF286A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF286A Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF286A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34940 fis, clone NT2RP7006886, highly similar to Zinc finger protein 286 (A1A525_HUMAN)
  • Zinc finger protein 286A (Z286A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBT8

UniProtKB/Swiss-Prot:

Z286A_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF286A: view

Function for ZNF286A Gene

Molecular function for ZNF286A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF286A Gene

Gene Ontology (GO) - Molecular Function for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF286A: view
genes like me logo Genes that share phenotypes with ZNF286A: view

Animal Model Products

CRISPR Products

miRNA for ZNF286A Gene

miRTarBase miRNAs that target ZNF286A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF286A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF286A Gene

Localization for ZNF286A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF286A Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF286A: view

No data available for Subcellular locations from COMPARTMENTS for ZNF286A Gene

Pathways & Interactions for ZNF286A Gene

genes like me logo Genes that share pathways with ZNF286A: view

Pathways by source for ZNF286A Gene

2 Reactome pathways for ZNF286A Gene
1 KEGG pathway for ZNF286A Gene

Interacting Proteins for ZNF286A Gene

;

Gene Ontology (GO) - Biological Process for ZNF286A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF286A: view

No data available for SIGNOR curated interactions for ZNF286A Gene

Drugs & Compounds for ZNF286A Gene

No Compound Related Data Available

Transcripts for ZNF286A Gene

mRNA/cDNA for ZNF286A Gene

14 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF286A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF286A Gene

No ASD Table

Relevant External Links for ZNF286A Gene

GeneLoc Exon Structure for
ZNF286A

Expression for ZNF286A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF286A Gene

Protein differential expression in normal tissues from HIPED for ZNF286A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF286A Gene



Protein tissue co-expression partners for ZNF286A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF286A

SOURCE GeneReport for Unigene cluster for ZNF286A Gene:

Hs.585799

Evidence on tissue expression from TISSUES for ZNF286A Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF286A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF286A Gene

Orthologs for ZNF286A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF286A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF286A 31 30
  • 99.55 (n)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF286A 30
  • 91.54 (n)
-- 31
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF286A 31 30
  • 85.45 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp286 17 31 30
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Zfp286a 30
  • 83.17 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
OneToMany
Species where no ortholog for ZNF286A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF286A Gene

ENSEMBL:
Gene Tree for ZNF286A (if available)
TreeFam:
Gene Tree for ZNF286A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF286A: view image

Paralogs for ZNF286A Gene

Paralogs for ZNF286A Gene

(549) SIMAP similar genes for ZNF286A Gene using alignment to 12 proteins:

  • Z286A_HUMAN
  • A1A525_HUMAN
  • A8MTT8_HUMAN
  • B4DKF9_HUMAN
  • J3KRD3_HUMAN
  • J3KRF9_HUMAN
  • J3KRV6_HUMAN
  • J3KSJ1_HUMAN
  • J3KSW0_HUMAN
  • J3QQV4_HUMAN
  • K7ENW2_HUMAN
  • K7EQ88_HUMAN
genes like me logo Genes that share paralogs with ZNF286A: view

Variants for ZNF286A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF286A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs3760299 - p.Tyr90His

Additional dbSNP identifiers (rs#s) for ZNF286A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF286A Gene

Variant ID Type Subtype PubMed ID
dgv3107n100 CNV gain 25217958
nsv1132447 CNV duplication 24896259
nsv457695 CNV gain 19166990
nsv515999 CNV loss 19592680
nsv518620 CNV loss 19592680
nsv520426 CNV loss 19592680
nsv522564 CNV loss 19592680
nsv574462 CNV gain 21841781
nsv827899 CNV gain 20364138
nsv962262 CNV duplication 23825009

Variation tolerance for ZNF286A Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF286A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF286A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF286A Gene

Disorders for ZNF286A Gene

Additional Disease Information for ZNF286A

No disorders were found for ZNF286A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF286A Gene

Publications for ZNF286A Gene

No publications were found for ZNF286A Gene.

Products for ZNF286A Gene

Sources for ZNF286A Gene