Aliases for ZNF285 Gene

Aliases for ZNF285 Gene

  • Zinc Finger Protein 285 2 3 4 5
  • Zinc Finger Protein 285A 2 3 4
  • ZNF285A 3 4
  • ZNF285 5

External Ids for ZNF285 Gene

Previous HGNC Symbols for ZNF285 Gene

  • ZNF285A

Previous GeneCards Identifiers for ZNF285 Gene

  • GC00U990660
  • GC19U900206
  • GC19M049578
  • GC19M044886
  • GC19M041321

Summaries for ZNF285 Gene

GeneCards Summary for ZNF285 Gene

ZNF285 (Zinc Finger Protein 285) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF287.

UniProtKB/Swiss-Prot Summary for ZNF285 Gene

Additional gene information for ZNF285 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF285 Gene

Genomics for ZNF285 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF285 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF285 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF285

Genomic Locations for ZNF285 Gene

Genomic Locations for ZNF285 Gene
chr19:44,382,298-44,401,608
(GRCh38/hg38)
Size:
19,311 bases
Orientation:
Minus strand
chr19:44,886,459-44,905,777
(GRCh37/hg19)
Size:
19,319 bases
Orientation:
Minus strand

Genomic View for ZNF285 Gene

Genes around ZNF285 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF285 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF285 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF285 Gene

Proteins for ZNF285 Gene

  • Protein details for ZNF285 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NJ3-ZN285_HUMAN
    Recommended name:
    Zinc finger protein 285
    Protein Accession:
    Q96NJ3
    Secondary Accessions:
    • Q17RJ3
    • Q6B0A8
    • Q6ISR5

    Protein attributes for ZNF285 Gene

    Size:
    590 amino acids
    Molecular mass:
    68261 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF285 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF285 Gene

Post-translational modifications for ZNF285 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF285 Gene

Domains & Families for ZNF285 Gene

Gene Families for ZNF285 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF285 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF285 Gene

GenScript: Design optimal peptide antigens:
  • ZNF285A protein (B7ZLR9_HUMAN)
  • ZNF285A protein (Q6B0D6_HUMAN)
  • Zinc finger protein ZNF285 (Q86WM0_HUMAN)
  • Zinc finger protein 285A (ZN285_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96NJ3

UniProtKB/Swiss-Prot:

ZN285_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF285: view

Function for ZNF285 Gene

Molecular function for ZNF285 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF285 Gene

Gene Ontology (GO) - Molecular Function for ZNF285 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF285: view

Phenotypes for ZNF285 Gene

genes like me logo Genes that share phenotypes with ZNF285: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF285

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF285 Gene

Localization for ZNF285 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF285 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF285 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF285 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF285: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF285 Gene

Pathways & Interactions for ZNF285 Gene

genes like me logo Genes that share pathways with ZNF285: view

Pathways by source for ZNF285 Gene

2 Reactome pathways for ZNF285 Gene
1 KEGG pathway for ZNF285 Gene

Gene Ontology (GO) - Biological Process for ZNF285 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF285: view

No data available for SIGNOR curated interactions for ZNF285 Gene

Drugs & Compounds for ZNF285 Gene

No Compound Related Data Available

Transcripts for ZNF285 Gene

mRNA/cDNA for ZNF285 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF285

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF285 Gene

No ASD Table

Relevant External Links for ZNF285 Gene

GeneLoc Exon Structure for
ZNF285

Expression for ZNF285 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF285 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF285

SOURCE GeneReport for Unigene cluster for ZNF285 Gene:

Hs.709428

Evidence on tissue expression from TISSUES for ZNF285 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF285: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF285 Gene

Orthologs for ZNF285 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF285 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF285 30 31
  • 98.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF285 31
  • 75 (a)
OneToOne
Species where no ortholog for ZNF285 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF285 Gene

ENSEMBL:
Gene Tree for ZNF285 (if available)
TreeFam:
Gene Tree for ZNF285 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF285: view image

Paralogs for ZNF285 Gene

(515) SIMAP similar genes for ZNF285 Gene using alignment to 5 proteins:

  • ZN285_HUMAN
  • K7EIK6_HUMAN
  • K7EQE9_HUMAN
  • K7ERT5_HUMAN
  • Q86WM0_HUMAN

Pseudogenes.org Pseudogenes for ZNF285 Gene

genes like me logo Genes that share paralogs with ZNF285: view

Variants for ZNF285 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF285 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12610859 - p.Arg536Gly
rs2571089 - p.Asn208Ser

Additional dbSNP identifiers (rs#s) for ZNF285 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF285 Gene

Variant ID Type Subtype PubMed ID
dgv3605n100 CNV loss 25217958
esv2421963 CNV deletion 20811451
esv25060 CNV loss 19812545
esv2663330 CNV deletion 23128226
esv2758764 CNV loss 17122850
esv2763206 CNV loss 21179565
esv3644482 CNV loss 21293372
nsv1055278 CNV loss 25217958
nsv1061350 CNV loss 25217958
nsv1062330 CNV loss 25217958
nsv442465 CNV loss 18776908
nsv515911 CNV loss 19592680
nsv579855 CNV loss 21841781
nsv579856 CNV gain 21841781
nsv817849 CNV loss 17921354
nsv960852 CNV duplication 23825009
nsv9734 CNV gain+loss 18304495

Variation tolerance for ZNF285 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.62; 94.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF285 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF285

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF285 Gene

Disorders for ZNF285 Gene

No disorders were found for ZNF285 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF285 Gene

Publications for ZNF285 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. (PMID: 23049088) Meng W … Malecaze F (Investigative ophthalmology & visual science 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF285 Gene

Sources for ZNF285 Gene