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Aliases for ZNF284 Gene

Aliases for ZNF284 Gene

  • Zinc Finger Protein 284 2 3 4 5
  • ZNF284L 3 4

External Ids for ZNF284 Gene

Previous GeneCards Identifiers for ZNF284 Gene

  • GC00U990661
  • GC19P049252
  • GC19P049268
  • GC19U900427
  • GC19P044578
  • GC19P041008
  • GC19P044580

Summaries for ZNF284 Gene

GeneCards Summary for ZNF284 Gene

ZNF284 (Zinc Finger Protein 284) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF225.

UniProtKB/Swiss-Prot for ZNF284 Gene

Additional gene information for ZNF284 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF284 Gene

Genomics for ZNF284 Gene

GeneHancer (GH) Regulatory Elements for ZNF284 Gene

Promoters and enhancers for ZNF284 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044071 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 621.7 0.0 -43 2.6 ELF3 SIX5 POLR2A MLLT1 ZNF121 ZNF687 ZSCAN21 AHR ZBTB7A YY1 ZNF284 ZNF45 ZNF225 ZNF223 ZNF227 ZNF180 ZNF283 ZNF226 ZNF235 ZNF112
GH19J043773 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 149.8 -292.2 -292176 12.3 ZNF473 CC2D1A ZFX CTCF ELF3 ZKSCAN8 CBFA2T2 ZNF148 NKRF MLLT1 KCNN4 ZNF45 ZNF180 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF283 ZNF234
GH19J043901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 127.3 -170.5 -170543 2.4 SIX5 ZNF687 ZSCAN21 MCM2 ZBTB7A YY1 SP7 ZNF174 ZNF548 CREM ZNF221 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284
GH19J044740 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 89 +677.5 677527 18.7 SP1 ZNF652 ZFX CC2D1A ELF3 ZKSCAN8 CBFA2T2 ZNF148 NKRF MLLT1 BCL3 ZNF45 ZNF224 ZNF155 ZNF284 ZNF180 ZNF225 ZNF234 CLASRP ZNF235
GH19J044164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 106 +93.1 93057 2.8 SP1 ELF3 SIX5 NKRF POLR2A CEBPG GTF2F1 ZSCAN21 BACH1 TFE3 ZNF226 ZNF45 ZNF180 ZNF225 ZNF155 ZNF224 ZNF234 ZNF227 ZNF284 CLASRP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF284 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF284 gene promoter:
  • C/EBPalpha
  • NCX

Genomic Locations for ZNF284 Gene

Genomic Locations for ZNF284 Gene
chr19:44,072,144-44,089,613
(GRCh38/hg38)
Size:
17,470 bases
Orientation:
Plus strand
chr19:44,576,297-44,593,766
(GRCh37/hg19)
Size:
17,470 bases
Orientation:
Plus strand

Genomic View for ZNF284 Gene

Genes around ZNF284 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF284 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF284 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF284 Gene

Proteins for ZNF284 Gene

  • Protein details for ZNF284 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VY69-ZN284_HUMAN
    Recommended name:
    Zinc finger protein 284
    Protein Accession:
    Q2VY69
    Secondary Accessions:
    • Q86WM1

    Protein attributes for ZNF284 Gene

    Size:
    593 amino acids
    Molecular mass:
    69019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF284 Gene

Post-translational modifications for ZNF284 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF284 Gene

No data available for DME Specific Peptides for ZNF284 Gene

Domains & Families for ZNF284 Gene

Gene Families for ZNF284 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF284 Gene

Suggested Antigen Peptide Sequences for ZNF284 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 284 (ZN284_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2VY69

UniProtKB/Swiss-Prot:

ZN284_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF284: view

Function for ZNF284 Gene

Molecular function for ZNF284 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF284 Gene

Gene Ontology (GO) - Molecular Function for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF284: view
genes like me logo Genes that share phenotypes with ZNF284: view

Animal Model Products

CRISPR Products

miRNA for ZNF284 Gene

miRTarBase miRNAs that target ZNF284

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF284 - Now 50% OFF >
  • * ZNF284 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF284 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF284 Gene

Localization for ZNF284 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF284 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF284 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF284: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF284 Gene

Pathways & Interactions for ZNF284 Gene

PathCards logo

SuperPathways for ZNF284 Gene

genes like me logo Genes that share pathways with ZNF284: view

Pathways by source for ZNF284 Gene

1 KEGG pathway for ZNF284 Gene

Interacting Proteins for ZNF284 Gene

Gene Ontology (GO) - Biological Process for ZNF284 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF284: view

No data available for SIGNOR curated interactions for ZNF284 Gene

Drugs & Compounds for ZNF284 Gene

No Compound Related Data Available

Transcripts for ZNF284 Gene

mRNA/cDNA for ZNF284 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ZNF284 Gene

Zinc finger protein 284:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF284 - Now 50% OFF >
  • * ZNF284 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF284 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF284 Gene

No ASD Table

Relevant External Links for ZNF284 Gene

GeneLoc Exon Structure for
ZNF284
ECgene alternative splicing isoforms for
ZNF284

Expression for ZNF284 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF284 Gene

Protein differential expression in normal tissues from HIPED for ZNF284 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF284 Gene



Protein tissue co-expression partners for ZNF284 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF284 Gene:

ZNF284

SOURCE GeneReport for Unigene cluster for ZNF284 Gene:

Hs.445395

mRNA Expression by UniProt/SwissProt for ZNF284 Gene:

Q2VY69-ZN284_HUMAN
Tissue specificity: Expressed in lung, liver, pancreas and thymus. Lower expression in heart, placenta, spleen, prostate, ovary, small intestine and colon. No expression seen in brain, skeletal muscle, kidney, testis and peripheral blood leukocyte.

Evidence on tissue expression from TISSUES for ZNF284 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF284: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF284 Gene

Orthologs for ZNF284 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF284 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF284 35 34
  • 99.46 (n)
OneToOne
Species where no ortholog for ZNF284 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF284 Gene

ENSEMBL:
Gene Tree for ZNF284 (if available)
TreeFam:
Gene Tree for ZNF284 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF284: view image

Paralogs for ZNF284 Gene

Paralogs for ZNF284 Gene

(390) SIMAP similar genes for ZNF284 Gene using alignment to 1 proteins:

  • ZN284_HUMAN
genes like me logo Genes that share paralogs with ZNF284: view

Variants for ZNF284 Gene

Sequence variations from dbSNP and Humsavar for ZNF284 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000180108 -- 44,077,932(+) C/T intron_variant
rs1000290482 -- 44,071,366(+) T/C upstream_transcript_variant
rs1000326383 -- 44,071,348(+) C/A upstream_transcript_variant
rs1000585405 -- 44,071,092(+) C/T upstream_transcript_variant
rs1000765663 -- 44,088,845(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF284 Gene

Variant ID Type Subtype PubMed ID
esv3556442 CNV deletion 23714750
nsv833840 CNV gain 17160897
nsv978827 CNV duplication 23825009

Variation tolerance for ZNF284 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.53; 92.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF284 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF284

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF284 Gene

Disorders for ZNF284 Gene

Additional Disease Information for ZNF284

No disorders were found for ZNF284 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF284 Gene

Publications for ZNF284 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 2 3 4 58
  2. Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L). (PMID: 16817023) Yin G … Mao Y (Molecular biology reports 2006) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for ZNF284 Gene

Sources for ZNF284 Gene

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