Aliases for ZNF283 Gene

Aliases for ZNF283 Gene

  • Zinc Finger Protein 283 2 3 4 5
  • Zinc Finger Protein HZF19 3 4
  • Zinc Finger Protein 41 3
  • HZF19 3
  • HZF41 3

External Ids for ZNF283 Gene

Previous GeneCards Identifiers for ZNF283 Gene

  • GC00U990662
  • GC19P049007
  • GC19P049023
  • GC19P049016
  • GC19P044272

Summaries for ZNF283 Gene

GeneCards Summary for ZNF283 Gene

ZNF283 (Zinc Finger Protein 283) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF331.

UniProtKB/Swiss-Prot Summary for ZNF283 Gene

Additional gene information for ZNF283 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF283 Gene

Genomics for ZNF283 Gene

GeneHancer (GH) Regulatory Elements for ZNF283 Gene

Promoters and enhancers for ZNF283 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF283 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF283 gene promoter:
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF283 Gene

Genomic Locations for ZNF283 Gene
24,726 bases
Plus strand
21,864 bases
Plus strand

Genomic View for ZNF283 Gene

Genes around ZNF283 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF283 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF283 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF283 Gene

Proteins for ZNF283 Gene

  • Protein details for ZNF283 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 283
    Protein Accession:
    Secondary Accessions:
    • B4DGZ5
    • B7WP04
    • Q6RFR9
    • Q86WM6

    Protein attributes for ZNF283 Gene

    679 amino acids
    Molecular mass:
    77942 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence lacks 6 bp for unexplained reasons.; Evidence={ECO:0000305};

neXtProt entry for ZNF283 Gene

Post-translational modifications for ZNF283 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF283 Gene

Domains & Families for ZNF283 Gene

Gene Families for ZNF283 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF283 Gene

Suggested Antigen Peptide Sequences for ZNF283 Gene

GenScript: Design optimal peptide antigens:
  • ZNF283 protein (Q4G0N1_HUMAN)
  • Zinc finger protein 41 (Q6RFR4_HUMAN)
  • Zinc finger protein HZF19 (ZN283_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF283: view

Function for ZNF283 Gene

Molecular function for ZNF283 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF283 Gene

Gene Ontology (GO) - Molecular Function for ZNF283 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF283: view

Phenotypes for ZNF283 Gene

genes like me logo Genes that share phenotypes with ZNF283: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF283 Gene

Localization for ZNF283 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF283 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF283 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF283 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF283: view

Pathways & Interactions for ZNF283 Gene

PathCards logo

SuperPathways for ZNF283 Gene

genes like me logo Genes that share pathways with ZNF283: view

Pathways by source for ZNF283 Gene

1 KEGG pathway for ZNF283 Gene

Interacting Proteins for ZNF283 Gene

Gene Ontology (GO) - Biological Process for ZNF283 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF283: view

No data available for SIGNOR curated interactions for ZNF283 Gene

Drugs & Compounds for ZNF283 Gene

No Compound Related Data Available

Transcripts for ZNF283 Gene

mRNA/cDNA for ZNF283 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF283 Gene

No ASD Table

Relevant External Links for ZNF283 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF283 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF283 Gene

Protein differential expression in normal tissues from HIPED for ZNF283 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF283 Gene

Protein tissue co-expression partners for ZNF283 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF283 Gene:


SOURCE GeneReport for Unigene cluster for ZNF283 Gene:


mRNA Expression by UniProt/SwissProt for ZNF283 Gene:

Tissue specificity: Detected in prostate, testis, and pancreas.

Evidence on tissue expression from TISSUES for ZNF283 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF283: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF283 Gene

Orthologs for ZNF283 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF283 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF283 33 32
  • 96.76 (n)
(Bos Taurus)
Mammalia ZNF283 33 32
  • 90.06 (n)
(Canis familiaris)
Mammalia ZNF283 33 32
  • 86.11 (n)
(Monodelphis domestica)
Mammalia -- 33
  • 46 (a)
Species where no ortholog for ZNF283 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF283 Gene

Gene Tree for ZNF283 (if available)
Gene Tree for ZNF283 (if available)
Evolutionary constrained regions (ECRs) for ZNF283: view image

Paralogs for ZNF283 Gene

Paralogs for ZNF283 Gene

(607) SIMAP similar genes for ZNF283 Gene using alignment to 7 proteins:

  • ZN283_HUMAN
  • K7EJ77_HUMAN
  • K7EL69_HUMAN
  • K7ES18_HUMAN
  • Q4G0N1_HUMAN
genes like me logo Genes that share paralogs with ZNF283: view

Variants for ZNF283 Gene

Sequence variations from dbSNP and Humsavar for ZNF283 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000006143 -- 43,833,091(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000010560 -- 43,838,153(+) C/A/T 5_prime_UTR_variant, intron_variant
rs1000083483 -- 43,837,786(+) T/A 5_prime_UTR_variant, intron_variant
rs1000165739 -- 43,843,194(+) A/T 5_prime_UTR_variant, intron_variant
rs1000217692 -- 43,842,865(+) A/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF283 Gene

Variant ID Type Subtype PubMed ID
nsv458710 CNV loss 19166990
nsv524460 CNV loss 19592680
nsv579853 CNV loss 21841781
nsv978826 CNV duplication 23825009

Variation tolerance for ZNF283 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.43; 96.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF283 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF283 Gene

Disorders for ZNF283 Gene

Additional Disease Information for ZNF283

No disorders were found for ZNF283 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF283 Gene

Publications for ZNF283 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 3 4 56
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 56
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56

Products for ZNF283 Gene

Sources for ZNF283 Gene