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Aliases for ZNF283 Gene

Aliases for ZNF283 Gene

  • Zinc Finger Protein 283 2 3 5
  • Zinc Finger Protein HZF19 3 4
  • Zinc Finger Protein 41 3
  • HZF19 3
  • HZF41 3

External Ids for ZNF283 Gene

Previous GeneCards Identifiers for ZNF283 Gene

  • GC00U990662
  • GC19P049007
  • GC19P049023
  • GC19P049016
  • GC19P044272

Summaries for ZNF283 Gene

GeneCards Summary for ZNF283 Gene

ZNF283 (Zinc Finger Protein 283) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF571.

UniProtKB/Swiss-Prot for ZNF283 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF283 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF283 Gene

Genomics for ZNF283 Gene

GeneHancer (GH) Regulatory Elements for ZNF283 Gene

Promoters and enhancers for ZNF283 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043826 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 622.5 +0.2 182 1.6 ATF1 ZNF493 ARID4B SIN3A DMAP1 YY1 ETS1 ZNF121 ZNF766 ELK1 ZNF283 LYPD5 ZNF45 ZNF225 ZNF180 ZNF234 MRPS15P2 ZNF224 ZNF227 ZNF155
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 124.5 -47.4 -47390 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 94.3 +285.7 285709 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF112 ZNF224 ZNF226
GH19I044206 Promoter/Enhancer 1.6 Ensembl ENCODE 112 +380.4 380442 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF302 ZNF227 ZNF45 ZNF180 ZNF225 ZNF224 ZNF283 ZNF223 ZNF226 ZNF235 ZNF112
GH19I044164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 76.5 +338.0 337958 1.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF226 ZNF45 ZNF180 ZNF225 ZNF155 ZNF224 ZNF227 ZNF284 ZNF234 ZNF112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF283 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF283 gene promoter:

Genomic Locations for ZNF283 Gene

Genomic Locations for ZNF283 Gene
chr19:43,827,292-43,852,017
(GRCh38/hg38)
Size:
24,726 bases
Orientation:
Plus strand
chr19:44,331,444-44,353,307
(GRCh37/hg19)

Genomic View for ZNF283 Gene

Genes around ZNF283 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF283 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF283 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF283 Gene

Proteins for ZNF283 Gene

  • Protein details for ZNF283 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7M2-ZN283_HUMAN
    Recommended name:
    Zinc finger protein 283
    Protein Accession:
    Q8N7M2
    Secondary Accessions:
    • B4DGZ5
    • B7WP04
    • Q6RFR9
    • Q86WM6

    Protein attributes for ZNF283 Gene

    Size:
    679 amino acids
    Molecular mass:
    77942 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05251.1; Type=Miscellaneous discrepancy; Note=Compared to the genome, the sequence lacks 6 bp for unexplained reasons.; Evidence={ECO:0000305};

neXtProt entry for ZNF283 Gene

Post-translational modifications for ZNF283 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF283 Gene

Domains & Families for ZNF283 Gene

Gene Families for ZNF283 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF283 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7M2

UniProtKB/Swiss-Prot:

ZN283_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF283: view

Function for ZNF283 Gene

Molecular function for ZNF283 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF283 Gene

Gene Ontology (GO) - Molecular Function for ZNF283 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF283: view

Phenotypes for ZNF283 Gene

GenomeRNAi human phenotypes for ZNF283:
genes like me logo Genes that share phenotypes with ZNF283: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF283 Gene

Localization for ZNF283 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF283 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF283 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF283 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF283: view

Pathways & Interactions for ZNF283 Gene

SuperPathways for ZNF283 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF283 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF283: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF283 Gene

Drugs & Compounds for ZNF283 Gene

No Compound Related Data Available

Transcripts for ZNF283 Gene

Unigene Clusters for ZNF283 Gene

Zinc finger protein 283:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF283 Gene

No ASD Table

Relevant External Links for ZNF283 Gene

GeneLoc Exon Structure for
ZNF283
ECgene alternative splicing isoforms for
ZNF283

Expression for ZNF283 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF283 Gene

Protein differential expression in normal tissues from HIPED for ZNF283 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF283 Gene



Protein tissue co-expression partners for ZNF283 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF283 Gene:

ZNF283

SOURCE GeneReport for Unigene cluster for ZNF283 Gene:

Hs.652513

mRNA Expression by UniProt/SwissProt for ZNF283 Gene:

Q8N7M2-ZN283_HUMAN
Tissue specificity: Detected in prostate, testis, and pancreas.

Evidence on tissue expression from TISSUES for ZNF283 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF283: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF283 Gene

Orthologs for ZNF283 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF283 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF283 33 34
  • 96.76 (n)
cow
(Bos Taurus)
Mammalia ZNF283 33 34
  • 90.06 (n)
dog
(Canis familiaris)
Mammalia ZNF283 33 34
  • 86.11 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 46 (a)
OneToMany
Species where no ortholog for ZNF283 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF283 Gene

ENSEMBL:
Gene Tree for ZNF283 (if available)
TreeFam:
Gene Tree for ZNF283 (if available)

Paralogs for ZNF283 Gene

(607) SIMAP similar genes for ZNF283 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF283: view

Variants for ZNF283 Gene

Sequence variations from dbSNP and Humsavar for ZNF283 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000006143 -- 43,833,091(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000010560 -- 43,838,153(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000083483 -- 43,837,786(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000165739 -- 43,843,194(+) A/T 5_prime_UTR_variant, intron_variant
rs1000217692 -- 43,842,865(+) A/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF283 Gene

Variant ID Type Subtype PubMed ID
nsv458710 CNV loss 19166990
nsv524460 CNV loss 19592680
nsv579853 CNV loss 21841781
nsv978826 CNV duplication 23825009

Variation tolerance for ZNF283 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.43; 96.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF283 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF283

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF283 Gene

Disorders for ZNF283 Gene

Additional Disease Information for ZNF283

No disorders were found for ZNF283 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF283 Gene

Publications for ZNF283 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K … Easton DF (Nature genetics 2013) 3 58

Products for ZNF283 Gene

Sources for ZNF283 Gene

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