Aliases for ZNF282 Gene

Aliases for ZNF282 Gene

  • Zinc Finger Protein 282 2 3 4 5
  • HUB1 2 3 4
  • HTLV-I U5RE-Binding Protein 1 3 4
  • HUB-1 3 4
  • HTLV-I U5 Repressive Element-Binding Protein 1 3
  • ZNF282 5

External Ids for ZNF282 Gene

Previous GeneCards Identifiers for ZNF282 Gene

  • GC07P147139
  • GC07P148207
  • GC07P148284
  • GC07P148216
  • GC07P148330
  • GC07P148523
  • GC07P148892
  • GC07P142969

Summaries for ZNF282 Gene

GeneCards Summary for ZNF282 Gene

ZNF282 (Zinc Finger Protein 282) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF48.

UniProtKB/Swiss-Prot Summary for ZNF282 Gene

  • Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.

Additional gene information for ZNF282 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF282 Gene

Genomics for ZNF282 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF282 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF282 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF282

Top Transcription factor binding sites by QIAGEN in the ZNF282 gene promoter:
  • AML1a
  • AREB6
  • c-Myc
  • Ik-3
  • Max1
  • NRSF form 1
  • NRSF form 2
  • Olf-1
  • Pax-4a

Genomic Locations for ZNF282 Gene

Genomic Locations for ZNF282 Gene
chr7:149,195,495-149,226,243
(GRCh38/hg38)
Size:
30,749 bases
Orientation:
Plus strand
chr7:148,892,577-148,923,339
(GRCh37/hg19)
Size:
30,763 bases
Orientation:
Plus strand

Genomic View for ZNF282 Gene

Genes around ZNF282 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF282 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF282 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF282 Gene

Proteins for ZNF282 Gene

  • Protein details for ZNF282 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDV7-ZN282_HUMAN
    Recommended name:
    Zinc finger protein 282
    Protein Accession:
    Q9UDV7
    Secondary Accessions:
    • B4DRI5
    • O43691
    • Q6DKK0

    Protein attributes for ZNF282 Gene

    Size:
    671 amino acids
    Molecular mass:
    74295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24380.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF282 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF282 Gene

Post-translational modifications for ZNF282 Gene

  • Ubiquitination at Lys228
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF282 Gene

No data available for DME Specific Peptides for ZNF282 Gene

Domains & Families for ZNF282 Gene

Gene Families for ZNF282 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF282 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF282 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79181, highly similar to Zinc finger protein 282 (B4DRI5_HUMAN)
  • ZNF282 protein (Q05BY5_HUMAN)
  • ZNF282 protein (Q7Z2V4_HUMAN)
  • HTLV-I U5RE-binding protein 1 (ZN282_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UDV7

UniProtKB/Swiss-Prot:

ZN282_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF282: view

Function for ZNF282 Gene

Molecular function for ZNF282 Gene

UniProtKB/Swiss-Prot Function:
Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.

Phenotypes From GWAS Catalog for ZNF282 Gene

Gene Ontology (GO) - Molecular Function for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0008270 zinc ion binding NAS 9396811
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF282: view
genes like me logo Genes that share phenotypes with ZNF282: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF282

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF282 Gene

Localization for ZNF282 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF282 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF282 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF282: view

Pathways & Interactions for ZNF282 Gene

genes like me logo Genes that share pathways with ZNF282: view

Pathways by source for ZNF282 Gene

2 Reactome pathways for ZNF282 Gene
1 KEGG pathway for ZNF282 Gene

Gene Ontology (GO) - Biological Process for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 9396811
GO:0045892 negative regulation of transcription, DNA-templated TAS 9396811
genes like me logo Genes that share ontologies with ZNF282: view

No data available for SIGNOR curated interactions for ZNF282 Gene

Drugs & Compounds for ZNF282 Gene

No Compound Related Data Available

Transcripts for ZNF282 Gene

mRNA/cDNA for ZNF282 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF282

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF282 Gene

No ASD Table

Relevant External Links for ZNF282 Gene

GeneLoc Exon Structure for
ZNF282

Expression for ZNF282 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF282 Gene

Protein differential expression in normal tissues from HIPED for ZNF282 Gene

This gene is overexpressed in Adipocyte (35.8) and Pancreatic juice (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF282 Gene



Protein tissue co-expression partners for ZNF282 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF282

SOURCE GeneReport for Unigene cluster for ZNF282 Gene:

Hs.729056

mRNA Expression by UniProt/SwissProt for ZNF282 Gene:

Q9UDV7-ZN282_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF282 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF282: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF282 Gene

Orthologs for ZNF282 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF282 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF282 30 31
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF282 30 31
  • 91.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF282 30 31
  • 87.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp282 30 17 31
  • 86.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp282 30
  • 86.09 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF282 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF282 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 56 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia ZNF282 31
  • 45 (a)
OneToOne
Species where no ortholog for ZNF282 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF282 Gene

ENSEMBL:
Gene Tree for ZNF282 (if available)
TreeFam:
Gene Tree for ZNF282 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF282: view image

Paralogs for ZNF282 Gene

(321) SIMAP similar genes for ZNF282 Gene using alignment to 4 proteins:

  • ZN282_HUMAN
  • B4DRI5_HUMAN
  • Q05BY5_HUMAN
  • Q7Z2V4_HUMAN
genes like me logo Genes that share paralogs with ZNF282: view

Variants for ZNF282 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF282 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1202418 - p.Met273Val

Additional dbSNP identifiers (rs#s) for ZNF282 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF282 Gene

Variant ID Type Subtype PubMed ID
dgv11712n54 CNV loss 21841781
nsv465196 CNV loss 19166990
nsv518773 CNV loss 19592680

Variation tolerance for ZNF282 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF282 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF282

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF282 Gene

Disorders for ZNF282 Gene

Additional Disease Information for ZNF282

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF282 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF282 Gene

Publications for ZNF282 Gene

  1. HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. (PMID: 9396811) Okumura K … Igarashi H (Nucleic acids research 1997) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF282 Gene

Sources for ZNF282 Gene