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Aliases for ZNF282 Gene

Aliases for ZNF282 Gene

  • Zinc Finger Protein 282 2 3 3 5
  • HTLV-I U5RE-Binding Protein 1 3 4
  • HUB-1 3 4
  • HUB1 3 4
  • HTLV-I U5 Repressive Element-Binding Protein 1 3

External Ids for ZNF282 Gene

Previous GeneCards Identifiers for ZNF282 Gene

  • GC07P147139
  • GC07P148207
  • GC07P148284
  • GC07P148216
  • GC07P148330
  • GC07P148523
  • GC07P148892
  • GC07P142969

Summaries for ZNF282 Gene

GeneCards Summary for ZNF282 Gene

ZNF282 (Zinc Finger Protein 282) is a Protein Coding gene. Diseases associated with ZNF282 include T-Cell Leukemia. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF398.

UniProtKB/Swiss-Prot for ZNF282 Gene

  • Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5-TCCACCCC-3 sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.

Additional gene information for ZNF282 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF282 Gene

Genomics for ZNF282 Gene

GeneHancer (GH) Regulatory Elements for ZNF282 Gene

Promoters and enhancers for ZNF282 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J149194 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.9 +1.0 958 3.1 HDGF SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF282 ZNF212 RN7SL521P ZNF398 ZNF425 ZNF783
GH07J149143 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 52.3 -48.9 -48938 7 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 POLR2B ZNF398 ZNF425 GC07P149147 GC07P149148 ZNF783 ZNF282 ZNF212 ENSG00000271664 LOC155060 ZNF767P
GH07J149124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.5 -68.6 -68636 3.8 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 ZNF398 ZNF425 GC07M149126 RN7SL521P ZNF786 ZNF212 ZNF783 ENSG00000271664 ZNF282 ZNF767P
GH07J148882 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39 -311.6 -311615 3.6 HNRNPUL1 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B EZH2 GC07P148885 ZNF783 ZNF398 ENSG00000271664 ZNF212 ZNF282 ZNF767P LOC155060 ZNF777
GH07J149622 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 38.9 +428.9 428927 3.8 HDGF CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF767P ZNF783 ZNF212 ZNF398 ENSG00000271664 ZNF282 ZNF746 LOC155060 ZNF777 CUL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF282 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF282 gene promoter:
  • Pax-4a
  • NRSF form 2
  • NRSF form 1
  • AML1a
  • Max1
  • Ik-3
  • c-Myc
  • Olf-1
  • AREB6

Genomic Locations for ZNF282 Gene

Genomic Locations for ZNF282 Gene
chr7:149,195,462-149,226,248
(GRCh38/hg38)
Size:
30,787 bases
Orientation:
Plus strand
chr7:148,892,577-148,923,339
(GRCh37/hg19)
Size:
30,763 bases
Orientation:
Plus strand

Genomic View for ZNF282 Gene

Genes around ZNF282 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF282 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF282 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF282 Gene

Proteins for ZNF282 Gene

  • Protein details for ZNF282 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDV7-ZN282_HUMAN
    Recommended name:
    Zinc finger protein 282
    Protein Accession:
    Q9UDV7
    Secondary Accessions:
    • B4DRI5
    • O43691
    • Q6DKK0

    Protein attributes for ZNF282 Gene

    Size:
    671 amino acids
    Molecular mass:
    74295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24380.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF282 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF282 Gene

Post-translational modifications for ZNF282 Gene

  • Ubiquitination at isoforms=2228
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF282 Gene

No data available for DME Specific Peptides for ZNF282 Gene

Domains & Families for ZNF282 Gene

Gene Families for ZNF282 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF282 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UDV7

UniProtKB/Swiss-Prot:

ZN282_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF282: view

Function for ZNF282 Gene

Molecular function for ZNF282 Gene

UniProtKB/Swiss-Prot Function:
Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5-TCCACCCC-3 sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.

Phenotypes From GWAS Catalog for ZNF282 Gene

Gene Ontology (GO) - Molecular Function for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9396811
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF282: view
genes like me logo Genes that share phenotypes with ZNF282: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF282 Gene

Localization for ZNF282 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF282 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF282 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF282: view

Pathways & Interactions for ZNF282 Gene

SuperPathways for ZNF282 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF282: view

Pathways by source for ZNF282 Gene

2 Reactome pathways for ZNF282 Gene

Interacting Proteins for ZNF282 Gene

Gene Ontology (GO) - Biological Process for ZNF282 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 9396811
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045892 negative regulation of transcription, DNA-templated TAS 9396811
genes like me logo Genes that share ontologies with ZNF282: view

No data available for SIGNOR curated interactions for ZNF282 Gene

Drugs & Compounds for ZNF282 Gene

No Compound Related Data Available

Transcripts for ZNF282 Gene

mRNA/cDNA for ZNF282 Gene

Unigene Clusters for ZNF282 Gene

Zinc finger protein 282:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF282 Gene

No ASD Table

Relevant External Links for ZNF282 Gene

GeneLoc Exon Structure for
ZNF282
ECgene alternative splicing isoforms for
ZNF282

Expression for ZNF282 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF282 Gene

Protein differential expression in normal tissues from HIPED for ZNF282 Gene

This gene is overexpressed in Adipocyte (35.8) and Pancreatic juice (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF282 Gene



Protein tissue co-expression partners for ZNF282 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF282 Gene:

ZNF282

SOURCE GeneReport for Unigene cluster for ZNF282 Gene:

Hs.729056

mRNA Expression by UniProt/SwissProt for ZNF282 Gene:

Q9UDV7-ZN282_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF282 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF282: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF282 Gene

Orthologs for ZNF282 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF282 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF282 34 33
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF282 34 33
  • 91.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF282 34 33
  • 87.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp282 16 34 33
  • 86.34 (n)
rat
(Rattus norvegicus)
Mammalia Zfp282 33
  • 86.09 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF282 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF282 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF282 34
  • 45 (a)
OneToOne
Species where no ortholog for ZNF282 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF282 Gene

ENSEMBL:
Gene Tree for ZNF282 (if available)
TreeFam:
Gene Tree for ZNF282 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF282: view image

Paralogs for ZNF282 Gene

Paralogs for ZNF282 Gene

(321) SIMAP similar genes for ZNF282 Gene using alignment to 4 proteins:

  • ZN282_HUMAN
  • B4DRI5_HUMAN
  • Q05BY5_HUMAN
  • Q7Z2V4_HUMAN
genes like me logo Genes that share paralogs with ZNF282: view

Variants for ZNF282 Gene

Sequence variations from dbSNP and Humsavar for ZNF282 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000085495 -- 149,214,460(+) A/G intron_variant
rs1000201914 -- 149,211,609(+) G/C intron_variant
rs1000275525 -- 149,211,421(+) T/C intron_variant
rs1000520422 -- 149,216,424(+) T/G intron_variant
rs1000532732 -- 149,210,312(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF282 Gene

Variant ID Type Subtype PubMed ID
dgv11712n54 CNV loss 21841781
nsv465196 CNV loss 19166990
nsv518773 CNV loss 19592680

Variation tolerance for ZNF282 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF282 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF282

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF282 Gene

Disorders for ZNF282 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF282 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF282

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF282: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF282 Gene

Publications for ZNF282 Gene

  1. HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. (PMID: 9396811) Okumura K … Igarashi H (Nucleic acids research 1997) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF282 Gene

Sources for ZNF282 Gene

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