Aliases for ZNF281 Gene

Aliases for ZNF281 Gene

  • Zinc Finger Protein 281 2 3 4 5
  • GC-Box-Binding Zinc Finger Protein 1 3 4
  • Zinc Finger DNA-Binding Protein 99 3 4
  • Transcription Factor ZBP-99 3 4
  • ZNP-99 Transcription Factor 3
  • ZBP-99 3
  • ZNP-99 3
  • ZBP99 4
  • GZP1 4

External Ids for ZNF281 Gene

Previous GeneCards Identifiers for ZNF281 Gene

  • GC01M198105
  • GC01M195834
  • GC01M196842
  • GC01M197664
  • GC01M197663
  • GC01M197107
  • GC01M198642
  • GC01M200375
  • GC01M171541

Summaries for ZNF281 Gene

GeneCards Summary for ZNF281 Gene

ZNF281 (Zinc Finger Protein 281) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF148.

UniProtKB/Swiss-Prot Summary for ZNF281 Gene

  • Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

Gene Wiki entry for ZNF281 Gene

Additional gene information for ZNF281 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF281 Gene

Genomics for ZNF281 Gene

GeneHancer (GH) Regulatory Elements for ZNF281 Gene

Promoters and enhancers for ZNF281 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J200408 Promoter/Enhancer 2.4 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.9 -943 5.6 HNRNPK ZNF217 NRF1 POLR2G PHF8 PHB2 TEAD4 ZNF10 ZIC2 POLR2A ZNF281 piR-46641 ENSG00000230623 lnc-NR5A2-10
GH01J200361 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 35.5 +47.2 47201 1.9 YY1 SPI1 FOXA1 ZNF770 ZNF281 ENSG00000230623 TMEM9 RF00017-433 HSALNG0009585 lnc-NR5A2-7 LINC00862
GH01J200371 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +35.7 35705 6.7 EP300 FOXK2 ZNF217 ZSCAN5C TCF12 NCOR1 FOS ZNF639 KDM6A TCF7 ZNF281 ENSG00000230623 HSALNG0009585 RF00017-433 LINC00862
GH01J200351 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 15 +57.5 57498 2.5 FOS POLR2A ZNF384 IRF1 IRF2 EZH2 GATA3 PKNOX1 CTCF PRDM1 ZNF281 LINC00862 DDX59 RF00017-433 ENSG00000230623 HSALNG0009585 lnc-NR5A2-7
GH01J200314 Enhancer 1.3 UCNEbase Ensembl ENCODE 11.5 +98.1 98072 6.8 TCF12 POLR2G KDM6A TEAD1 ZSCAN9 CEBPB MAFF SIX5 SAP130 FOSL2 ZNF281 ENSG00000273093 RF00017-432 LINC00862
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF281 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF281

Top Transcription factor binding sites by QIAGEN in the ZNF281 gene promoter:
  • c-Myc
  • C/EBPalpha
  • FOXJ2
  • FOXJ2 (long isoform)
  • Lmo2
  • Max1
  • Nkx2-5
  • Pax-4a
  • STAT5A

Genomic Locations for ZNF281 Gene

Genomic Locations for ZNF281 Gene
chr1:200,404,940-200,410,058
(GRCh38/hg38)
Size:
5,119 bases
Orientation:
Minus strand
chr1:200,374,068-200,379,184
(GRCh37/hg19)
Size:
5,117 bases
Orientation:
Minus strand

Genomic View for ZNF281 Gene

Genes around ZNF281 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF281 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF281 Gene

Proteins for ZNF281 Gene

  • Protein details for ZNF281 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X9-ZN281_HUMAN
    Recommended name:
    Zinc finger protein 281
    Protein Accession:
    Q9Y2X9
    Secondary Accessions:
    • A6NF48
    • B3KMX2
    • Q5RKW5
    • Q9NY92

    Protein attributes for ZNF281 Gene

    Size:
    895 amino acids
    Molecular mass:
    96915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70967.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF281 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF281 Gene

Post-translational modifications for ZNF281 Gene

  • Ubiquitination at Lys539, Lys661, and Lys840
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF281 Gene

No data available for DME Specific Peptides for ZNF281 Gene

Domains & Families for ZNF281 Gene

Gene Families for ZNF281 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF281 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF281 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 281 (Q5RKW5_HUMAN)
  • Zinc finger DNA-binding protein 99 (ZN281_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2X9

UniProtKB/Swiss-Prot:

ZN281_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF281: view

Function for ZNF281 Gene

Molecular function for ZNF281 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
GENATLAS Biochemistry:
zinc finger protein 281,regulating ornithine decarboxylase gene (ODC) expression,major transcript,highly expressed in placenta,adult kidney,liver,lymphocytes,binding to thhe GC rich promoter element of gastrin and ODC

Phenotypes From GWAS Catalog for ZNF281 Gene

Gene Ontology (GO) - Molecular Function for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10448078
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 10448078
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF281: view
genes like me logo Genes that share phenotypes with ZNF281: view

Animal Models for ZNF281 Gene

MGI Knock Outs for ZNF281:

Animal Model Products

CRISPR Products

miRNA for ZNF281 Gene

miRTarBase miRNAs that target ZNF281

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF281

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF281 Gene

Localization for ZNF281 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF281 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF281 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 10448078
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF281: view

Pathways & Interactions for ZNF281 Gene

PathCards logo

SuperPathways for ZNF281 Gene

genes like me logo Genes that share pathways with ZNF281: view

Pathways by source for ZNF281 Gene

2 BioSystems pathways for ZNF281 Gene

Gene Ontology (GO) - Biological Process for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10448078
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0010172 embryonic body morphogenesis ISS --
GO:0010629 negative regulation of gene expression IMP 10448078
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF281: view

No data available for SIGNOR curated interactions for ZNF281 Gene

Drugs & Compounds for ZNF281 Gene

No Compound Related Data Available

Transcripts for ZNF281 Gene

mRNA/cDNA for ZNF281 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF281

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF281 Gene

No ASD Table

Relevant External Links for ZNF281 Gene

GeneLoc Exon Structure for
ZNF281

Expression for ZNF281 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF281 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF281 Gene

This gene is overexpressed in Brain (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF281 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF281

SOURCE GeneReport for Unigene cluster for ZNF281 Gene:

Hs.59757

Evidence on tissue expression from TISSUES for ZNF281 Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF281: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF281 Gene

Orthologs for ZNF281 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF281 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF281 31 30
  • 99.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp281 17 31 30
  • 94.35 (n)
rat
(Rattus norvegicus)
Mammalia Zfp281 30
  • 93.61 (n)
dog
(Canis familiaris)
Mammalia ZNF281 30
  • 91.45 (n)
cow
(Bos Taurus)
Mammalia ZNF281 31 30
  • 89.09 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF281 31
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF281 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF281 31 30
  • 83.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF281 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf281 30
  • 67.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30049 30
zebrafish
(Danio rerio)
Actinopterygii LOC100005963 30
  • 57.59 (n)
ZNF281 (2 of 2) 31
  • 39 (a)
OneToMany
ZNF281 (1 of 2) 31
  • 36 (a)
OneToMany
Species where no ortholog for ZNF281 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF281 Gene

ENSEMBL:
Gene Tree for ZNF281 (if available)
TreeFam:
Gene Tree for ZNF281 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF281: view image

Paralogs for ZNF281 Gene

genes like me logo Genes that share paralogs with ZNF281: view

Variants for ZNF281 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF281 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
711738 Benign: not provided 200,407,966(-) T/C SYNONYMOUS_VARIANT
VAR_035576 A breast cancer sample p.Ile527Thr

Additional dbSNP identifiers (rs#s) for ZNF281 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF281 Gene

Variant ID Type Subtype PubMed ID
nsv548990 CNV loss 21841781

Variation tolerance for ZNF281 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF281 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF281 Gene

Disorders for ZNF281 Gene

Additional Disease Information for ZNF281

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF281 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF281 Gene

Publications for ZNF281 Gene

  1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. (PMID: 10448078) Law DJ … Merchant JL (Biochemical and biophysical research communications 1999) 2 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. (PMID: 12771217) Zhang X … Zehner ZE (Nucleic acids research 2003) 3 4 54
  5. Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. (PMID: 10405178) Lisowsky T … Cantatore P (FEBS letters 1999) 3 4 54

Products for ZNF281 Gene

Sources for ZNF281 Gene