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Aliases for ZNF280D Gene

Aliases for ZNF280D Gene

  • Zinc Finger Protein 280D 2 3 5
  • Suppressor Of Hairy Wing Homolog 4 3 4
  • Zinc Finger Protein 634 3 4
  • ZNF634 3 4
  • SUHW4 3 4
  • Suppressor Of Hairy Wing Homolog 4 (Drosophila) 2
  • KIAA1584 4

External Ids for ZNF280D Gene

Previous HGNC Symbols for ZNF280D Gene

  • SUHW4

Previous GeneCards Identifiers for ZNF280D Gene

  • GC15M054710
  • GC15M056922
  • GC15M033745

Summaries for ZNF280D Gene

GeneCards Summary for ZNF280D Gene

ZNF280D (Zinc Finger Protein 280D) is a Protein Coding gene. Diseases associated with ZNF280D include Dyslexia. An important paralog of this gene is ZNF280C.

UniProtKB/Swiss-Prot for ZNF280D Gene

  • May function as a transcription factor.

Gene Wiki entry for ZNF280D Gene

Additional gene information for ZNF280D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280D Gene

Genomics for ZNF280D Gene

GeneHancer (GH) Regulatory Elements for ZNF280D Gene

Promoters and enhancers for ZNF280D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I056917 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.6 -561 4.1 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZNF610 TCF12 ZNF280D LOC145783 LINC00926 RFX7 GC15M057429
GH15I056731 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 559.8 +185.6 185621 3.1 SIN3A FEZF1 DMAP1 YY1 ZNF766 CBX5 ZNF143 SP3 ZHX2 MXD4 ZNF280D RFX7 TEX9 LINC00926 ENSG00000274667 GC15M057422
GH15I056717 Promoter 0.5 EPDnew 550.1 +200.8 200787 0.1 ZNF280D ENSG00000274667 ENSG00000276696
GH15I056037 Enhancer 1.5 FANTOM5 Ensembl ENCODE 48.6 +877.6 877590 6.5 PKNOX1 CLOCK FOXA2 MLX FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF280D RSL24D1 TEX9 PYGO1 PRTG RFX7 MNS1 TCF12 PIGBOS1 RN7SL568P
GH15I056885 Promoter/Enhancer 1.6 Ensembl ENCODE 11.6 +31.2 31188 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF207 PIR32785 TCF12 ZNF280D LINC00926 LOC105370833 LOC145783
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF280D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF280D gene promoter:

Genomic Locations for ZNF280D Gene

Genomic Locations for ZNF280D Gene
288,396 bases
Minus strand

Genomic View for ZNF280D Gene

Genes around ZNF280D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280D Gene

Proteins for ZNF280D Gene

  • Protein details for ZNF280D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 280D
    Protein Accession:
    Secondary Accessions:
    • A1L495
    • B2RMT6
    • Q6MZM6
    • Q6N085
    • Q6P2R6
    • Q7Z6J5
    • Q9H0U5
    • Q9HCI8
    • Q9NXS0

    Protein attributes for ZNF280D Gene

    979 amino acids
    Molecular mass:
    109285 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13410.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAE46003.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF280D Gene

neXtProt entry for ZNF280D Gene

Post-translational modifications for ZNF280D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF280D Gene

Domains & Families for ZNF280D Gene

Gene Families for ZNF280D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF280D Gene

Suggested Antigen Peptide Sequences for ZNF280D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF280D: view

No data available for UniProtKB/Swiss-Prot for ZNF280D Gene

Function for ZNF280D Gene

Molecular function for ZNF280D Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Phenotypes From GWAS Catalog for ZNF280D Gene

Gene Ontology (GO) - Molecular Function for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

Phenotypes for ZNF280D Gene

GenomeRNAi human phenotypes for ZNF280D:
genes like me logo Genes that share phenotypes with ZNF280D: view

Animal Model Products

CRISPR Products

miRNA for ZNF280D Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280D Gene

Localization for ZNF280D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280D gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

Pathways & Interactions for ZNF280D Gene

SuperPathways for ZNF280D Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280D Gene

Drugs & Compounds for ZNF280D Gene

No Compound Related Data Available

Transcripts for ZNF280D Gene

Unigene Clusters for ZNF280D Gene

Zinc finger protein 280D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP5: -

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP4: - -

Relevant External Links for ZNF280D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF280D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF280D Gene

Protein differential expression in normal tissues from HIPED for ZNF280D Gene

This gene is overexpressed in Fetal Brain (24.8), Plasma (20.8), and Pancreatic juice (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF280D Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF280D Gene:


SOURCE GeneReport for Unigene cluster for ZNF280D Gene:


Evidence on tissue expression from TISSUES for ZNF280D Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with ZNF280D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280D Gene

Orthologs for ZNF280D Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF280D 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia ZNF280D 33 34
  • 92.47 (n)
(Bos Taurus)
Mammalia ZNF280D 33 34
  • 91.37 (n)
(Rattus norvegicus)
Mammalia Zfp280d 33
  • 83.8 (n)
(Mus musculus)
Mammalia Zfp280d 33 16 34
  • 83.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
(Gallus gallus)
Aves ZNF280D 33
  • 71.45 (n)
-- 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf280d 33
  • 61.52 (n)
(Danio rerio)
Actinopterygii znf280d 33 34
  • 53.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta row 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea F37D6.2 34
  • 21 (a)
Species where no ortholog for ZNF280D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF280D Gene

Gene Tree for ZNF280D (if available)
Gene Tree for ZNF280D (if available)

Paralogs for ZNF280D Gene

Paralogs for ZNF280D Gene

(4) SIMAP similar genes for ZNF280D Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF280D: view

Variants for ZNF280D Gene

Sequence variations from dbSNP and Humsavar for ZNF280D Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000017458 -- 56,714,578(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000045104 -- 56,673,900(-) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000049994 -- 56,714,335(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000083120 -- 56,684,598(-) G/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000114549 -- 56,637,164(-) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280D Gene

Variant ID Type Subtype PubMed ID
esv2661684 CNV deletion 23128226
esv2749732 CNV deletion 23290073
esv3636598 CNV loss 21293372
esv3892699 CNV gain 25118596
nsv1041239 CNV gain 25217958
nsv1133217 CNV tandem duplication 24896259
nsv569576 CNV loss 21841781

Variation tolerance for ZNF280D Gene

Residual Variation Intolerance Score: 6.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF280D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280D Gene

Disorders for ZNF280D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF280D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF280D

genes like me logo Genes that share disorders with ZNF280D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF280D Gene

Publications for ZNF280D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. (PMID: 25755297) Xiao Z … Vertegaal AC (Molecular & cellular proteomics : MCP 2015) 4 58

Products for ZNF280D Gene

Sources for ZNF280D Gene

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