Aliases for ZNF280D Gene

Aliases for ZNF280D Gene

  • Zinc Finger Protein 280D 2 3 4 5
  • ZNF634 2 3 4
  • Suppressor Of Hairy Wing Homolog 4 3 4
  • Zinc Finger Protein 634 3 4
  • SUHW4 3 4
  • Suppressor Of Hairy Wing Homolog 4 (Drosophila) 2
  • FLJ20086 2
  • KIAA1584 4
  • ZNF280D 5

External Ids for ZNF280D Gene

Previous HGNC Symbols for ZNF280D Gene

  • SUHW4

Previous GeneCards Identifiers for ZNF280D Gene

  • GC15M054710
  • GC15M056922
  • GC15M033745

Summaries for ZNF280D Gene

GeneCards Summary for ZNF280D Gene

ZNF280D (Zinc Finger Protein 280D) is a Protein Coding gene. Diseases associated with ZNF280D include Dyslexia. An important paralog of this gene is ENSG00000285253.

UniProtKB/Swiss-Prot Summary for ZNF280D Gene

Gene Wiki entry for ZNF280D Gene

Additional gene information for ZNF280D Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF280D Gene

Genomics for ZNF280D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF280D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J056731 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.1 1136 3.1 RNF2 ARHGAP35 SP1 HNRNPL TFE3 KDM1A BACH1 ZHX2 JUND LARP7 ZNF280D lnc-MNS1-9 RFX7 LINC00926 ENSG00000274667 ENSG00000285253 MNS1
GH15J056737 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 605.1 -3.2 -3216 2.2 GATAD2A PRDM10 ZNF629 LEF1 IKZF1 JUND MTA2 PKNOX1 POLR2A RXRB ZNF280D LINC00926 FJ601666-028 ENSG00000285253 TCF12
GH15J056734 Enhancer 0.3 ENCODE 600.7 -0.6 -572 0.2 STAT1 TRIM28 ZNF280D lnc-MNS1-9 FJ601666-028 ENSG00000285253 TCF12
GH15J056704 Promoter 0.3 EPDnew 600.3 +29.9 29916 0.1 ZNF280D lnc-MNS1-8 ENSG00000274667 ENSG00000285253 MNS1
GH15J056693 Promoter 0.3 EPDnew 600.3 +40.9 40948 0.1 lnc-MNS1-8 ZNF280D lnc-MNS1-7 ENSG00000285253 MNS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF280D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF280D

Top Transcription factor binding sites by QIAGEN in the ZNF280D gene promoter:
  • Bach1
  • E2F
  • E2F-1
  • Egr-1
  • Egr-3
  • Egr-4
  • POU3F1
  • YY1

Genomic Locations for ZNF280D Gene

Genomic Locations for ZNF280D Gene
103,911 bases
Minus strand
288,396 bases
Minus strand

Genomic View for ZNF280D Gene

Genes around ZNF280D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280D Gene

Proteins for ZNF280D Gene

  • Protein details for ZNF280D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 280D
    Protein Accession:
    Secondary Accessions:
    • A1L495
    • B2RMT6
    • Q6MZM6
    • Q6N085
    • Q6P2R6
    • Q7Z6J5
    • Q9H0U5
    • Q9HCI8
    • Q9NXS0

    Protein attributes for ZNF280D Gene

    979 amino acids
    Molecular mass:
    109285 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13410.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAE46003.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF280D Gene

neXtProt entry for ZNF280D Gene

Post-translational modifications for ZNF280D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF280D Gene

Domains & Families for ZNF280D Gene

Gene Families for ZNF280D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF280D Gene


Suggested Antigen Peptide Sequences for ZNF280D Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 280D (Q7Z6J5_HUMAN)
  • Zinc finger protein 634 (Z280D_HUMAN)
genes like me logo Genes that share domains with ZNF280D: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF280D Gene

Function for ZNF280D Gene

Molecular function for ZNF280D Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Phenotypes From GWAS Catalog for ZNF280D Gene

Gene Ontology (GO) - Molecular Function for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280D: view

Phenotypes for ZNF280D Gene

genes like me logo Genes that share phenotypes with ZNF280D: view

Animal Model Products

CRISPR Products

miRNA for ZNF280D Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280D Gene

Localization for ZNF280D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280D gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF280D: view

Pathways & Interactions for ZNF280D Gene

PathCards logo

SuperPathways for ZNF280D Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF280D: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280D Gene

Drugs & Compounds for ZNF280D Gene

No Compound Related Data Available

Transcripts for ZNF280D Gene

mRNA/cDNA for ZNF280D Gene

19 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280D

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280D Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP5: -

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP4: - -

Relevant External Links for ZNF280D Gene

GeneLoc Exon Structure for

Expression for ZNF280D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF280D Gene

Protein differential expression in normal tissues from HIPED for ZNF280D Gene

This gene is overexpressed in Fetal Brain (24.8), Plasma (20.8), and Pancreatic juice (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF280D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF280D

SOURCE GeneReport for Unigene cluster for ZNF280D Gene:


Evidence on tissue expression from TISSUES for ZNF280D Gene

  • Nervous system(4.8)
  • Skin(4.3)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ZNF280D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280D Gene

Orthologs for ZNF280D Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF280D 30 31
  • 99.63 (n)
(Canis familiaris)
Mammalia ZNF280D 30 31
  • 92.47 (n)
(Bos Taurus)
Mammalia ZNF280D 30 31
  • 91.37 (n)
(Rattus norvegicus)
Mammalia Zfp280d 30
  • 83.8 (n)
(Mus musculus)
Mammalia Zfp280d 30 17 31
  • 83.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 67 (a)
(Gallus gallus)
Aves ZNF280D 30
  • 71.45 (n)
-- 31
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf280d 30
  • 61.52 (n)
(Danio rerio)
Actinopterygii znf280d 30 31
  • 53.92 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta row 31
  • 14 (a)
(Caenorhabditis elegans)
Secernentea F37D6.2 31
  • 21 (a)
Species where no ortholog for ZNF280D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZNF280D Gene

Gene Tree for ZNF280D (if available)
Gene Tree for ZNF280D (if available)
Evolutionary constrained regions (ECRs) for ZNF280D: view image

Paralogs for ZNF280D Gene

(4) SIMAP similar genes for ZNF280D Gene using alignment to 5 proteins:

  • Z280D_HUMAN
  • H0YL38_HUMAN
  • H0YN90_HUMAN
  • Q7Z6J5_HUMAN
genes like me logo Genes that share paralogs with ZNF280D: view

Variants for ZNF280D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF280D Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs12900729 - p.Gly785Ala
rs12900993 - p.Ala778Val
rs12901843 - p.Lys781Ile
rs28620278 - p.Val568Ile

Additional dbSNP identifiers (rs#s) for ZNF280D Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF280D Gene

Variant ID Type Subtype PubMed ID
esv2661684 CNV deletion 23128226
esv2749732 CNV deletion 23290073
esv3636598 CNV loss 21293372
esv3892699 CNV gain 25118596
nsv1041239 CNV gain 25217958
nsv1133217 CNV tandem duplication 24896259
nsv569576 CNV loss 21841781

Variation tolerance for ZNF280D Gene

Residual Variation Intolerance Score: 6.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF280D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280D Gene

Disorders for ZNF280D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF280D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF280D

genes like me logo Genes that share disorders with ZNF280D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF280D Gene

Publications for ZNF280D Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. (PMID: 30948266) Lee SH … Mayr C (Molecular cell 2019) 3

Products for ZNF280D Gene

Sources for ZNF280D Gene