This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011] See more...

Aliases for ZNF280C Gene

Aliases for ZNF280C Gene

  • Zinc Finger Protein 280C 2 3 4 5
  • ZNF633 2 3 4
  • Zinc Finger Protein Proximal To RAD Eighteen 2 3
  • Suppressor Of Hairy Wing Homolog 3 3 4
  • Zinc Finger Protein 633 3 4
  • SUHW3 3 4
  • ZPET 2 3
  • Suppressor Of Hairy Wing Homolog 3 (Drosophila) 2
  • FLJ20095 2
  • ZNF280C 5

External Ids for ZNF280C Gene

Previous HGNC Symbols for ZNF280C Gene

  • SUHW3

Previous GeneCards Identifiers for ZNF280C Gene

  • GC0XM129166
  • GC0XM129336
  • GC0XM118731

Summaries for ZNF280C Gene

Entrez Gene Summary for ZNF280C Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF280C Gene

ZNF280C (Zinc Finger Protein 280C) is a Protein Coding gene. Diseases associated with ZNF280C include Exudative Vitreoretinopathy 1. An important paralog of this gene is ZNF280D.

UniProtKB/Swiss-Prot Summary for ZNF280C Gene

Additional gene information for ZNF280C Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF280C Gene

Genomics for ZNF280C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF280C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF280C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF280C

Top Transcription factor binding sites by QIAGEN in the ZNF280C gene promoter:
  • Brachyury
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-4a
  • Pbx1a
  • TGIF
  • YY1

Genomic Locations for ZNF280C Gene

Genomic Locations for ZNF280C Gene
chrX:130,202,707-130,268,899
(GRCh38/hg38)
Size:
66,193 bases
Orientation:
Minus strand
chrX:129,336,673-129,402,922
(GRCh37/hg19)
Size:
66,250 bases
Orientation:
Minus strand

Genomic View for ZNF280C Gene

Genes around ZNF280C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280C Gene

Proteins for ZNF280C Gene

  • Protein details for ZNF280C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND82-Z280C_HUMAN
    Recommended name:
    Zinc finger protein 280C
    Protein Accession:
    Q8ND82
    Secondary Accessions:
    • A8K2V8
    • Q9NXR3

    Protein attributes for ZNF280C Gene

    Size:
    737 amino acids
    Molecular mass:
    83096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF280C Gene

Post-translational modifications for ZNF280C Gene

  • Ubiquitination at Lys689
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF280C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280C Gene

Domains & Families for ZNF280C Gene

Gene Families for ZNF280C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF280C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF280C Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 280C (Q9UJJ2_HUMAN)
  • Zinc finger protein 633 (Z280C_HUMAN)
genes like me logo Genes that share domains with ZNF280C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF280C Gene

Function for ZNF280C Gene

Molecular function for ZNF280C Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Phenotypes From GWAS Catalog for ZNF280C Gene

Gene Ontology (GO) - Molecular Function for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 27705803
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280C: view
genes like me logo Genes that share phenotypes with ZNF280C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280C Gene

Localization for ZNF280C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280C gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF280C: view

Pathways & Interactions for ZNF280C Gene

PathCards logo

SuperPathways for ZNF280C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF280C: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280C Gene

Drugs & Compounds for ZNF280C Gene

No Compound Related Data Available

Transcripts for ZNF280C Gene

mRNA/cDNA for ZNF280C Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280C

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2: -

Relevant External Links for ZNF280C Gene

GeneLoc Exon Structure for
ZNF280C

Expression for ZNF280C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF280C Gene

Protein differential expression in normal tissues from HIPED for ZNF280C Gene

This gene is overexpressed in Testis (28.7), Peripheral blood mononuclear cells (26.0), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF280C Gene



Protein tissue co-expression partners for ZNF280C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF280C

SOURCE GeneReport for Unigene cluster for ZNF280C Gene:

Hs.308418

Evidence on tissue expression from TISSUES for ZNF280C Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with ZNF280C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280C Gene

Orthologs for ZNF280C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF280C 30
  • 98.58 (n)
Dog
(Canis familiaris)
Mammalia ZNF280C 30 31
  • 85.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF280C 30 31
  • 78.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp280c 30 17 31
  • 78.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp280c 30
  • 77.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 61 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 43 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii znf280d 31
  • 35 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta row 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F37D6.2 31
  • 18 (a)
OneToMany
Species where no ortholog for ZNF280C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF280C Gene

ENSEMBL:
Gene Tree for ZNF280C (if available)
TreeFam:
Gene Tree for ZNF280C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF280C: view image

Paralogs for ZNF280C Gene

(3) SIMAP similar genes for ZNF280C Gene using alignment to 2 proteins:

  • Z280C_HUMAN
  • Q9UJJ2_HUMAN
genes like me logo Genes that share paralogs with ZNF280C: view

Variants for ZNF280C Gene

Additional dbSNP identifiers (rs#s) for ZNF280C Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF280C Gene

Variant ID Type Subtype PubMed ID
dgv2425e212 CNV loss 25503493
dgv2426e212 CNV gain 25503493
esv3368010 CNV insertion 20981092
esv3577252 CNV gain 25503493
nsv528290 CNV gain 19592680

Variation tolerance for ZNF280C Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF280C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF280C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF280C Gene

Disorders for ZNF280C Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF280C Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 1
  • evr1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF280C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF280C Gene

Publications for ZNF280C Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF280C Gene

Sources for ZNF280C Gene