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Aliases for ZNF280C Gene

Aliases for ZNF280C Gene

  • Zinc Finger Protein 280C 2 3 5
  • Suppressor Of Hairy Wing Homolog 3 3 4
  • Zinc Finger Protein 633 3 4
  • ZNF633 3 4
  • SUHW3 3 4
  • Suppressor Of Hairy Wing Homolog 3 (Drosophila) 2

External Ids for ZNF280C Gene

Previous HGNC Symbols for ZNF280C Gene

  • SUHW3

Previous GeneCards Identifiers for ZNF280C Gene

  • GC0XM129166
  • GC0XM129336
  • GC0XM118731

Summaries for ZNF280C Gene

Entrez Gene Summary for ZNF280C Gene

  • This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZNF280C Gene

ZNF280C (Zinc Finger Protein 280C) is a Protein Coding gene. An important paralog of this gene is ZNF280D.

UniProtKB/Swiss-Prot for ZNF280C Gene

  • May function as a transcription factor.

Additional gene information for ZNF280C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280C Gene

Genomics for ZNF280C Gene

GeneHancer (GH) Regulatory Elements for ZNF280C Gene

Promoters and enhancers for ZNF280C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI130267 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.5 +0.8 810 2.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF280C BCORL1 RBMX2 GC0XP130243
GH0XI129770 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.3 +489.3 489310 17.9 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 IRF4 YY1 TCF12 ZNF766 GATA2 SASH3 ZNF280C BCORL1 XPNPEP2 UTP14A SLC25A14 OCRL ELF4 ENSG00000240143 ZDHHC9
GH0XI130170 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 20.5 +96.4 96370 4.4 PKNOX1 ATF1 POLR2B ZNF766 ATF7 RUNX3 ZNF592 MEF2D ATF4 MAFF RAB33A ZNF280C RBMX2 BCORL1 UTP14A ELF4 GC0XP130201
GH0XI130108 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 16.2 +158.7 158670 4.3 HDGF ATF1 ARNT SIN3A GLIS2 FOS ATF7 RUNX3 ZNF202 ZNF592 ELF4 ZNF280C BCORL1 RBMX2 AIFM1 GC0XP130039
GH0XI130117 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +149.2 149200 4.6 ATF1 SIN3A ZNF2 ZBTB7B POLR2B GLIS2 ARID2 ZNF143 FOS ATF7 ZNF280C AIFM1 RAB33A ELF4 RBMX2 BCORL1 SASH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF280C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF280C gene promoter:

Genomic Locations for ZNF280C Gene

Genomic Locations for ZNF280C Gene
66,370 bases
Minus strand

Genomic View for ZNF280C Gene

Genes around ZNF280C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280C Gene

Proteins for ZNF280C Gene

  • Protein details for ZNF280C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 280C
    Protein Accession:
    Secondary Accessions:
    • A8K2V8
    • Q9NXR3

    Protein attributes for ZNF280C Gene

    737 amino acids
    Molecular mass:
    83096 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF280C Gene

Post-translational modifications for ZNF280C Gene

  • Ubiquitination at isoforms=689
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF280C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280C Gene

Domains & Families for ZNF280C Gene

Gene Families for ZNF280C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF280C Gene

Suggested Antigen Peptide Sequences for ZNF280C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF280C: view

No data available for UniProtKB/Swiss-Prot for ZNF280C Gene

Function for ZNF280C Gene

Molecular function for ZNF280C Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 27705803
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280C: view

Phenotypes for ZNF280C Gene

genes like me logo Genes that share phenotypes with ZNF280C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280C Gene

Localization for ZNF280C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280C gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280C: view

Pathways & Interactions for ZNF280C Gene

SuperPathways for ZNF280C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280C: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280C Gene

Drugs & Compounds for ZNF280C Gene

No Compound Related Data Available

Transcripts for ZNF280C Gene

mRNA/cDNA for ZNF280C Gene

Unigene Clusters for ZNF280C Gene

Zinc finger protein 280C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP2: -

Relevant External Links for ZNF280C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF280C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF280C Gene

Protein differential expression in normal tissues from HIPED for ZNF280C Gene

This gene is overexpressed in Testis (28.7), Peripheral blood mononuclear cells (26.0), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF280C Gene

Protein tissue co-expression partners for ZNF280C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF280C Gene:


SOURCE GeneReport for Unigene cluster for ZNF280C Gene:


Evidence on tissue expression from TISSUES for ZNF280C Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with ZNF280C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280C Gene

Orthologs for ZNF280C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF280C 33
  • 98.58 (n)
(Canis familiaris)
Mammalia ZNF280C 33 34
  • 85.77 (n)
(Bos Taurus)
Mammalia ZNF280C 33 34
  • 78.6 (n)
(Mus musculus)
Mammalia Zfp280c 33 16 34
  • 78.29 (n)
(Rattus norvegicus)
Mammalia Zfp280c 33
  • 77.78 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
(Gallus gallus)
Aves -- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
(Danio rerio)
Actinopterygii znf280d 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta row 34
  • 12 (a)
(Caenorhabditis elegans)
Secernentea F37D6.2 34
  • 18 (a)
Species where no ortholog for ZNF280C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF280C Gene

Gene Tree for ZNF280C (if available)
Gene Tree for ZNF280C (if available)

Paralogs for ZNF280C Gene

Paralogs for ZNF280C Gene

(3) SIMAP similar genes for ZNF280C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF280C: view

Variants for ZNF280C Gene

Sequence variations from dbSNP and Humsavar for ZNF280C Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000093010 -- 130,241,959(-) G/C intron_variant
rs1000106782 -- 130,217,405(-) G/A intron_variant
rs1000137707 -- 130,237,031(-) C/T intron_variant
rs1000139424 -- 130,217,129(-) A/G intron_variant
rs1000240238 -- 130,208,899(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280C Gene

Variant ID Type Subtype PubMed ID
dgv2425e212 CNV loss 25503493
dgv2426e212 CNV gain 25503493
esv3368010 CNV insertion 20981092
esv3577252 CNV gain 25503493
nsv528290 CNV gain 19592680

Variation tolerance for ZNF280C Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF280C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280C Gene

Disorders for ZNF280C Gene

Additional Disease Information for ZNF280C

No disorders were found for ZNF280C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280C Gene

Publications for ZNF280C Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF280C Gene

Sources for ZNF280C Gene

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