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Aliases for ZNF280B Gene

Aliases for ZNF280B Gene

  • Zinc Finger Protein 280B 2 3 5
  • Zinc Finger Protein 279 2 3 4
  • Suppressor Of Hairy Wing Homolog 2 3 4
  • Zinc Finger Protein 632 3 4
  • 5OY11.1 3 4
  • ZNF279 3 4
  • ZNF632 3 4
  • SUHW2 3 4
  • Suppressor Of Hairy Wing Homolog 2 (Drosophila) 2
  • D87009.C22.3 3

External Ids for ZNF280B Gene

Previous HGNC Symbols for ZNF280B Gene

  • ZNF279
  • SUHW2

Previous GeneCards Identifiers for ZNF280B Gene

  • GC22M021168
  • GC22M022838
  • GC22M005797

Summaries for ZNF280B Gene

Entrez Gene Summary for ZNF280B Gene

  • The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

GeneCards Summary for ZNF280B Gene

ZNF280B (Zinc Finger Protein 280B) is a Protein Coding gene. An important paralog of this gene is ZNF280A.

UniProtKB/Swiss-Prot for ZNF280B Gene

  • May function as a transcription factor.

Additional gene information for ZNF280B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280B Gene

Genomics for ZNF280B Gene

GeneHancer (GH) Regulatory Elements for ZNF280B Gene

Promoters and enhancers for ZNF280B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I022507 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 556.1 +0.6 592 1.6 MLX ZNF133 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 ZNF143 FOS ZNF280B ZDHHC8P1 ENSG00000273342 IGLV5-37 ENSG00000226595 IGL
GH22I023248 Enhancer 1 Ensembl ENCODE dbSUPER 4.3 -739.3 -739314 1 ELF3 GATAD2A RFX1 ZNF140 GABPA RFX5 ZNF600 HOMEZ IGLV5-52 ENSG00000234630 ENSG00000272779 SMARCB1 RSPH14 RAB36 ZNF70 ENSG00000272578 ENSG00000232545 FBXW4P1
GH22I022487 Enhancer 0.7 ENCODE 5.6 +20.8 20796 1.2 BACH1 CEBPG IRF9 POLR2B MTA3 CBFA2T2 TRIM24 KDM4B ZNF740 CEBPB TOP3B PPIL2 ENSG00000272779 IGLV5-52 ENSG00000234630 ENSG00000225544 ZNF280B IGLV5-37 ENSG00000226595 IGL
GH22I022924 Enhancer 0.7 FANTOM5 dbSUPER 4.7 -415.9 -415874 0.2 MCM7 ETS2 ID3 LOC105372947 RSPH14 IGLV7-43 ZNF280B PIR39792 LOC105372948
GH22I022506 Enhancer 0.4 FANTOM5 6.5 +2.3 2310 0.4 ETS2 ZNF280B ENSG00000226595 IGL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF280B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF280B gene promoter:

Genomic Locations for ZNF280B Gene

Genomic Locations for ZNF280B Gene
chr22:22,484,421-22,509,187
(GRCh38/hg38)
Size:
24,767 bases
Orientation:
Minus strand
chr22:22,838,767-22,863,505
(GRCh37/hg19)

Genomic View for ZNF280B Gene

Genes around ZNF280B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280B Gene

Proteins for ZNF280B Gene

  • Protein details for ZNF280B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YH2-Z280B_HUMAN
    Recommended name:
    Zinc finger protein 280B
    Protein Accession:
    Q86YH2

    Protein attributes for ZNF280B Gene

    Size:
    543 amino acids
    Molecular mass:
    61584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF280B Gene

Post-translational modifications for ZNF280B Gene

No Post-translational modifications

Other Protein References for ZNF280B Gene

No data available for DME Specific Peptides for ZNF280B Gene

Domains & Families for ZNF280B Gene

Gene Families for ZNF280B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF280B Gene

Suggested Antigen Peptide Sequences for ZNF280B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF280B: view

No data available for UniProtKB/Swiss-Prot for ZNF280B Gene

Function for ZNF280B Gene

Molecular function for ZNF280B Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Phenotypes From GWAS Catalog for ZNF280B Gene

Gene Ontology (GO) - Molecular Function for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280B: view
genes like me logo Genes that share phenotypes with ZNF280B: view

Animal Model Products

CRISPR Products

miRNA for ZNF280B Gene

miRTarBase miRNAs that target ZNF280B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF280B Gene

Localization for ZNF280B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280B gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

Pathways & Interactions for ZNF280B Gene

SuperPathways for ZNF280B Gene

No Data Available

Interacting Proteins for ZNF280B Gene

Gene Ontology (GO) - Biological Process for ZNF280B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF280B: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280B Gene

Drugs & Compounds for ZNF280B Gene

No Compound Related Data Available

Transcripts for ZNF280B Gene

Unigene Clusters for ZNF280B Gene

Zinc finger protein 280B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280B Gene

No ASD Table

Relevant External Links for ZNF280B Gene

GeneLoc Exon Structure for
ZNF280B
ECgene alternative splicing isoforms for
ZNF280B

Expression for ZNF280B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF280B Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280B Gene

This gene is overexpressed in Testis (x11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF280B Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF280B Gene:

ZNF280B

SOURCE GeneReport for Unigene cluster for ZNF280B Gene:

Hs.43834
genes like me logo Genes that share expression patterns with ZNF280B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280B Gene

Orthologs for ZNF280B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF280B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF280B 33
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia ZNF280B 33
  • 87.61 (n)
cow
(Bos Taurus)
Mammalia ZNF280B 33
  • 85.99 (n)
mouse
(Mus musculus)
Mammalia Zfp280b 33 16
  • 76.05 (n)
rat
(Rattus norvegicus)
Mammalia Zfp280b 33
  • 72.42 (n)
Species where no ortholog for ZNF280B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF280B Gene

ENSEMBL:
Gene Tree for ZNF280B (if available)
TreeFam:
Gene Tree for ZNF280B (if available)

Paralogs for ZNF280B Gene

Paralogs for ZNF280B Gene

(4) SIMAP similar genes for ZNF280B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF280B: view

Variants for ZNF280B Gene

Sequence variations from dbSNP and Humsavar for ZNF280B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000189032 -- 22,498,411(-) A/C intron_variant
rs1000208161 -- 22,492,059(-) T/C intron_variant
rs1000237709 -- 22,500,713(-) G/T intron_variant
rs1000237927 -- 22,492,404(-) G/C intron_variant
rs1000363589 -- 22,504,276(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF280B Gene

Variant ID Type Subtype PubMed ID
nsv459548 CNV loss 19166990
nsv469735 CNV loss 16826518
nsv474491 CNV novel sequence insertion 20440878
nsv459546 CNV loss 19166990
nsv459539 CNV loss 19166990
nsv459538 CNV loss 19166990
nsv459450 CNV loss 19166990
nsv459421 CNV gain 19166990
nsv438338 CNV loss 16468122
nsv1063128 CNV gain+loss 25217958
nsv1060145 CNV gain 25217958
nsv1059960 CNV loss 25217958
esv3893451 CNV loss 25118596
esv3647368 CNV loss 21293372
esv3647367 CNV loss 21293372
esv3568289 CNV loss 25503493
esv33016 CNV gain 17666407
esv2422480 CNV deletion 17116639
esv1007524 CNV gain 20482838
dgv826e214 CNV loss 21293372
dgv8015n54 CNV loss 21841781
dgv8014n54 CNV loss 21841781
dgv8013n54 CNV loss 21841781
dgv8012n54 CNV loss 21841781
dgv8011n54 CNV loss 21841781
dgv8010n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8004n54 CNV loss 21841781
dgv731n67 CNV loss 20364138
dgv558n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv556n27 CNV loss 19166990
dgv555n27 CNV loss 19166990
dgv551n27 CNV loss 19166990
dgv550n27 CNV loss 19166990
dgv548n27 CNV loss 19166990
dgv4511n100 CNV gain 25217958
dgv4510n100 CNV loss 25217958
dgv4507n100 CNV loss 25217958
dgv4506n100 CNV loss 25217958
dgv4505n100 CNV loss 25217958
dgv39n64 CNV loss 17921354
dgv38n64 CNV loss 17921354
dgv23n14 CNV loss 18776910
nsv834150 CNV loss 17160897
nsv834149 CNV loss 17160897
nsv828979 CNV gain+loss 20364138
nsv828977 CNV loss 20364138
nsv821694 CNV loss 15273396
nsv819428 CNV gain 19587683
nsv817958 CNV gain 17921354
nsv817957 CNV gain 17921354
nsv817956 CNV loss 17921354
nsv817953 CNV gain 17921354
nsv817937 CNV loss 17921354
nsv7350 OTHER inversion 18451855
nsv588472 CNV loss 21841781
nsv588470 CNV loss 21841781
nsv588469 CNV loss 21841781
nsv588468 CNV loss 21841781
nsv588431 CNV loss 21841781
nsv588348 CNV gain 21841781
nsv526328 CNV gain 19592680
nsv514963 CNV gain+loss 21397061
nsv511072 OTHER complex 20534489
nsv508727 CNV insertion 20534489
nsv481271 CNV novel sequence insertion 20440878
nsv481189 CNV novel sequence insertion 20440878
nsv479962 CNV novel sequence insertion 20440878
nsv479817 CNV novel sequence insertion 20440878

Variation tolerance for ZNF280B Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF280B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF280B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280B Gene

Disorders for ZNF280B Gene

Additional Disease Information for ZNF280B

No disorders were found for ZNF280B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280B Gene

Publications for ZNF280B Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 2 3 4 58
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 44 58
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58

Products for ZNF280B Gene

Sources for ZNF280B Gene

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