Aliases for ZNF280A Gene
Aliases for ZNF280A Gene
External Ids for ZNF280A Gene
- HGNC: 18597
- Entrez Gene: 129025
- Ensembl: ENSG00000169548
- UniProtKB: P59817
Previous HGNC Symbols for ZNF280A Gene
- ZNF280
- SUHW1
Previous GeneCards Identifiers for ZNF280A Gene
- GC22M021198
- GC22M022868
- GC22M005826
Summaries for ZNF280A Gene
-
This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]
GeneCards Summary for ZNF280A Gene
ZNF280A (Zinc Finger Protein 280A) is a Protein Coding gene. An important paralog of this gene is ZNF280B.
UniProtKB/Swiss-Prot for ZNF280A Gene
-
May function as a transcription factor.
Additional gene information for ZNF280A Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF280A Gene
Genomics for ZNF280A Gene
GeneHancer (GH) Regulatory Elements for ZNF280A Gene
Promoters and enhancers for ZNF280A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22I022520 | Promoter/Enhancer | 1.3 | EPDnew ENCODE | 550.8 | -0.1 | -52 | 0.2 | ELF3 PKNOX1 FOXA2 ARID4B ZNF48 GATA2 RBM34 THAP11 ZNF263 CEBPB | ZNF280A PIR39122 IGL | |
| GH22I022394 | Enhancer | 1 | Ensembl ENCODE | 11.9 | +123.9 | 123906 | 3.7 | FOXA2 RAD21 THRB RFX5 RARA SLC30A9 FOS MCM3 SP5 MCM5 | IGLV7-43 IGLVI-42 IGLVVII-41-1 TOP3B ENSG00000272779 IGLV5-52 ENSG00000234630 ZNF280A PPIL2 IGL | |
| GH22I022486 | Enhancer | 0.4 | ENCODE | 12.5 | +33.3 | 33287 | 0.2 | ZNF639 POLR2A | ZNF280A ENSG00000226595 ZNF280B IGL | |
| GH22I022546 | Enhancer | 0.7 | ENCODE dbSUPER | 0.3 | -26.3 | -26323 | 0.1 | POLR2A MAX TSC22D4 MYC RELA | PIR39122 ZNF280A IGL |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF280A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZNF280A gene promoter:
Regulatory Element Products
Genomic Locations for ZNF280A Gene
Genomic Locations for ZNF280A Gene
- chr22:22,513,736-22,520,281
- (GRCh38/hg38)
- Size:
- 6,546 bases
- Orientation:
- Minus strand
- chr22:22,868,060-22,874,613
- (GRCh37/hg19)
Genomic View for ZNF280A Gene
Genes around ZNF280A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by Ensembl
- 22q11.22 by Entrez Gene
- 22q11.22 by HGNC
ZNF280A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF280A Gene
Proteins for ZNF280A Gene
-
Protein details for ZNF280A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59817-Z280A_HUMAN
- Recommended name:
- Zinc finger protein 280A
- Protein Accession:
- P59817
Protein attributes for ZNF280A Gene
- Size:
- 542 amino acids
- Molecular mass:
- 60816 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF280A Gene
Post-translational modifications for ZNF280A Gene
No Post-translational modifications
Other Protein References for ZNF280A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF280A
-
Abcam antibodies for ZNF280A
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-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF280A
Protein Products
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Quality Products:
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-
Abcam proteins for ZNF280A
Assay Products
No data available for DME Specific Peptides for ZNF280A Gene
Domains & Families for ZNF280A Gene
Gene Families for ZNF280A Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF280A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF280A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZNF280A Gene
Function for ZNF280A Gene
Molecular function for ZNF280A Gene
- UniProtKB/Swiss-Prot Function:
- May function as a transcription factor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF280A Gene
- GenomeRNAi human phenotypes for ZNF280A:
Animal Model Products
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-
-
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CRISPR Products
-
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-
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF280A gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF280A
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF280A Gene
Localization for ZNF280A Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF280A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for ZNF280A Gene
No Data Available
Interacting Proteins for ZNF280A Gene
Selected Interacting proteins:
ENSP00000302855
P59817-Z280A_HUMAN
for ZNF280A Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF280A Gene
Transcripts for ZNF280A Gene
mRNA/cDNA for ZNF280A Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF280A Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF280A
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF280A
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF280A gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ZNF280A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF280A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF280A gene related products
- orf clones - Search results for available ZNF280A gene related products
- Applied Biological Materials Clones for ZNF280A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZNF280A Gene
mRNA differential expression in normal tissues according to GTEx for ZNF280A Gene
This gene is overexpressed in Adrenal Gland (x34.3) and Testis (x5.0).
This gene is overexpressed in Breast (68.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF280A Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF280A Gene:
ZNF280ASOURCE GeneReport for Unigene cluster for ZNF280A Gene:
Hs.178665Primer Products
-
OriGene qPCR primer pairs for ZNF280A
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280A Gene
Orthologs for ZNF280A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF280A 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF280A 33 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF280A 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | znf280d 34 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | row 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F37D6.2 34 |
|
OneToMany |
- Species where no ortholog for ZNF280A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for ZNF280A Gene
Variants for ZNF280A Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000277935 | -- | 22,519,104(-) | A/G | intron_variant | |
| rs1000873439 | -- | 22,517,155(-) | C/T | intron_variant | |
| rs1001326753 | -- | 22,517,356(-) | G/A | intron_variant | |
| rs1001955195 | -- | 22,515,312(-) | C/G | coding_sequence_variant, missense_variant | |
| rs1002004419 | -- | 22,521,520(-) | T/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
18.44;
98.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF280A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF280A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280A Gene
Disorders for ZNF280A Gene
Additional Disease Information for ZNF280A
No disorders were found for ZNF280A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280A Gene
Publications for ZNF280A Gene
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
Products for ZNF280A Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 27 available ZNF280A Antibodies ranked by validation data
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Sources for ZNF280A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems