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This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014] See more...
Aliases for ZNF280A Gene
Aliases for ZNF280A Gene
External Ids for ZNF280A Gene
- HGNC: 18597
- Entrez Gene: 129025
- Ensembl: ENSG00000169548
- UniProtKB: P59817
Previous HGNC Symbols for ZNF280A Gene
- ZNF280
- SUHW1
Previous GeneCards Identifiers for ZNF280A Gene
- GC22M021198
- GC22M022868
- GC22M005826
Summaries for ZNF280A Gene
-
This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]
GeneCards Summary for ZNF280A Gene
ZNF280A (Zinc Finger Protein 280A) is a Protein Coding gene. An important paralog of this gene is ZNF280B.
UniProtKB/Swiss-Prot Summary for ZNF280A Gene
-
May function as a transcription factor.
Additional gene information for ZNF280A Gene
- HGNC(18597)
- Entrez Gene(129025)
- Ensembl(ENSG00000169548)
- UniProtKB(P59817)
- Open Targets Platform(ENSG00000169548)
- Search for ZNF280A at DataMed
- Search for ZNF280A at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF280A Gene
Genomics for ZNF280A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF280A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF280A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF280A
- Top Transcription factor binding sites by QIAGEN in the ZNF280A gene promoter:
-
- AhR
- AML1a
- HOXA9
- HOXA9B
- Meis-1
- PPAR-alpha
Genomic Locations for ZNF280A Gene
Genomic Locations for ZNF280A Gene
- chr22:22,513,736-22,520,270
- (GRCh38/hg38)
- Size:
- 6,535 bases
- Orientation:
- Minus strand
- chr22:22,868,060-22,874,613
- (GRCh37/hg19)
- Size:
- 6,554 bases
- Orientation:
- Minus strand
Genomic View for ZNF280A Gene
Genes around ZNF280A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by HGNC
- 22q11.22 by Entrez Gene
- 22q11.22 by Ensembl
ZNF280A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF280A Gene
Proteins for ZNF280A Gene
-
Protein details for ZNF280A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59817-Z280A_HUMAN
- Recommended name:
- Zinc finger protein 280A
- Protein Accession:
- P59817
Protein attributes for ZNF280A Gene
- Size:
- 542 amino acids
- Molecular mass:
- 60816 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF280A Gene
Post-translational modifications for ZNF280A Gene
No Post-translational modifications
Other Protein References for ZNF280A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SUHW1 Polyclonal Antibody and Immunotag™ SUHW1 Antibody
- Novus Biologicals Antibodies for ZNF280A
-
Abcam antibodies for ZNF280A
- Invitrogen Antibodies for ZNF280A (AFLGC-ZNF280A)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF280A
- Sino Biological Antibodies for ZNF280A
Protein Products
-
OriGene Purified Proteins for ZNF280A
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF280A
- Origene Custom Protein Services for ZNF280A
- antibodies-online: Show 3 available ZNF280A Proteins ranked by validation data
- Compare Top ZNF280A Proteins
-
Quality Products:
-
Abcam proteins for ZNF280A
No data available for DME Specific Peptides for ZNF280A Gene
Domains & Families for ZNF280A Gene
Gene Families for ZNF280A Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF280A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF280A Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger protein 636 (Z280A_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF280A Gene
Function for ZNF280A Gene
Molecular function for ZNF280A Gene
- UniProtKB/Swiss-Prot Function:
- May function as a transcription factor.
Phenotypes From GWAS Catalog for ZNF280A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF280A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF280A - Select products 50% OFF >
- * ZNF280A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for ZNF280A
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF280A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF280A
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF280A - Select products 50% OFF >
- * ZNF280A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for ZNF280A
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Cell Line Products
-
Horizon Cell Lines for ZNF280A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF280A Gene
Localization for ZNF280A Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF280A Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
Pathways & Interactions for ZNF280A Gene
Interacting Proteins for ZNF280A Gene
Selected Interacting proteins:
P59817-Z280A_HUMAN
ENSP00000302855
for ZNF280A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZNF280A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for ZNF280A Gene
Transcripts for ZNF280A Gene
mRNA/cDNA for ZNF280A Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000302097 2148 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF280A - Select products 50% OFF >
- * ZNF280A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF280A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF280A
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF280A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF280A
- Browse OriGene Inhibitory RNA Products For ZNF280A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280A
Clone Products
- Applied Biological Materials (abm): Clones for ZNF280A - Select products 50% OFF >
- * ZNF280A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF280A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF280A
Relevant External Links for ZNF280A Gene
- GeneLoc Exon Structure for
- ZNF280A
Expression for ZNF280A Gene
mRNA differential expression in normal tissues according to GTEx for ZNF280A Gene
This gene is overexpressed in Adrenal Gland (x34.3) and Testis (x5.0).
This gene is overexpressed in Breast (68.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF280A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF280A
SOURCE GeneReport for Unigene cluster for ZNF280A Gene:
Hs.178665Primer Products
-
OriGene qPCR primer pairs for ZNF280A
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280A Gene
Orthologs for ZNF280A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF280A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF280A 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | ZNF280A 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | znf280d 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | row 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F37D6.2 31 |
|
OneToMany |
- Species where no ortholog for ZNF280A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ZNF280A Gene
- ENSEMBL:
- Gene Tree for ZNF280A (if available)
- TreeFam:
- Gene Tree for ZNF280A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF280A: view image
Paralogs for ZNF280A Gene
Paralogs for ZNF280A Gene
(4) SIMAP similar genes for ZNF280A Gene using alignment to 1 proteins:
- Z280A_HUMAN
Pseudogenes.org Pseudogenes for ZNF280A Gene
Variants for ZNF280A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF280A Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16989015 | - | p.Leu276Phe | |||
| rs361580 | - | p.Tyr137Ser | |||
| rs361666 | - | p.Arg488Ser | |||
| rs361762 | - | p.Phe486Leu | |||
| rs361959 | - | p.Lys71Asn |
Residual Variation Intolerance Score:
89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
18.44;
98.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF280A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF280A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280A Gene
Disorders for ZNF280A Gene
Additional Disease Information for ZNF280A
No disorders were found for ZNF280A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280A Gene
Publications for ZNF280A Gene
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 2 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
ExternalLinks
Products for ZNF280A Gene
- Custom Antibody Services
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- OriGene qPCR primer pairs for ZNF280A
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- Invitrogen Antibodies for ZNF280A (AFLGC-ZNF280A)
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- VectorBuilder Viral vectors for ZNF280A (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 10 available ZNF280A Antibodies ranked by validation data
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Sources for ZNF280A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB