This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014] See more...

Aliases for ZNF280A Gene

Aliases for ZNF280A Gene

  • Zinc Finger Protein 280A 2 3 4 5
  • Suppressor Of Hairy Wing Homolog 1 3 4
  • Zinc Finger Protein 636 3 4
  • Zinc Finger Protein 280 2 3
  • 3'OY11.1 3 4
  • ZNF280 3 4
  • ZNF636 3 4
  • SUHW1 3 4
  • Suppressor Of Hairy Wing Homolog 1 (Drosophila) 2

External Ids for ZNF280A Gene

Previous HGNC Symbols for ZNF280A Gene

  • ZNF280
  • SUHW1

Previous GeneCards Identifiers for ZNF280A Gene

  • GC22M021198
  • GC22M022868
  • GC22M005826

Summaries for ZNF280A Gene

Entrez Gene Summary for ZNF280A Gene

  • This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF280A Gene

ZNF280A (Zinc Finger Protein 280A) is a Protein Coding gene. An important paralog of this gene is ZNF280B.

UniProtKB/Swiss-Prot Summary for ZNF280A Gene

Additional gene information for ZNF280A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF280A Gene

Genomics for ZNF280A Gene

GeneHancer (GH) Regulatory Elements for ZNF280A Gene

Promoters and enhancers for ZNF280A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J022520 Promoter/Enhancer 1.1 EPDnew ENCODE 500.7 -0.1 -52 0.2 USF1 POLR2G NCOR1 PHF8 ZNF263 RBM34 TCF7 RBM25 RAD51 FOXA2 ZNF280A piR-46123 lnc-ZNF280B-6 IGL lnc-IGLL5-1
GH22J022519 Promoter 0.9 Ensembl 500.7 +0.5 480 0.8 POLR2G NCOR1 PHF8 RBM34 TCF7 SIN3A TBP TRIM28 POLR2A STAT5A ZNF280A RF01210-248 lnc-ZNF280B-6 IGL lnc-IGLL5-1
GH22J022394 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.9 +123.9 123880 4 CTCF RFX1 SKI MCM3 NEUROD1 FOXA2 FOS RAD21 FOSL2 RFX5 IGLV7-43 IGLVI-42 IGLVVII-41-1 RF00952-006 lnc-VPREB1-26 IGLL5 TOP3B ZNF280A IGLV5-52 PI4KAP2
GH22J022578 Enhancer 0.8 Ensembl 12.3 -59.1 -59127 0.9 NRF1 TSC22D4 MYC CTBP1 MCM3 MAX ATF3 KLF13 NFE2 FOSL1 IGLV2-34 RF00952-010 lnc-GGTLC2-13 ZNF280A GNAZ TOP3B ENSG00000223999 IGLV2-23 IGLV3-24 IGLV3-22
GH22J022446 Enhancer 0.5 Ensembl 12.6 +73.5 73480 1.6 TSC22D4 MCM3 ZNF341 MCM7 ZBTB5 BRF2 SAP30 PRDM10 HDAC6 ENSG00000230821 LOC100736412 piR-48209-470 ZNF280A IGLV5-52 PI4KAP2 TOP3B ZNF280B IGL lnc-IGLL5-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF280A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF280A

Top Transcription factor binding sites by QIAGEN in the ZNF280A gene promoter:
  • AhR
  • AML1a
  • HOXA9
  • HOXA9B
  • Meis-1
  • PPAR-alpha

Genomic Locations for ZNF280A Gene

Genomic Locations for ZNF280A Gene
chr22:22,513,736-22,520,281
(GRCh38/hg38)
Size:
6,546 bases
Orientation:
Minus strand
chr22:22,868,060-22,874,613
(GRCh37/hg19)
Size:
6,554 bases
Orientation:
Minus strand

Genomic View for ZNF280A Gene

Genes around ZNF280A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF280A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF280A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF280A Gene

Proteins for ZNF280A Gene

  • Protein details for ZNF280A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59817-Z280A_HUMAN
    Recommended name:
    Zinc finger protein 280A
    Protein Accession:
    P59817

    Protein attributes for ZNF280A Gene

    Size:
    542 amino acids
    Molecular mass:
    60816 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF280A Gene

Post-translational modifications for ZNF280A Gene

No Post-translational modifications

Other Protein References for ZNF280A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF280A Gene

Domains & Families for ZNF280A Gene

Gene Families for ZNF280A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF280A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF280A Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 636 (Z280A_HUMAN)
genes like me logo Genes that share domains with ZNF280A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF280A Gene

Function for ZNF280A Gene

Molecular function for ZNF280A Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor.

Gene Ontology (GO) - Molecular Function for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF280A: view
genes like me logo Genes that share phenotypes with ZNF280A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF280A Gene

Localization for ZNF280A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF280A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF280A gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF280A: view

Pathways & Interactions for ZNF280A Gene

PathCards logo

SuperPathways for ZNF280A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF280A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF280A: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF280A Gene

Drugs & Compounds for ZNF280A Gene

No Compound Related Data Available

Transcripts for ZNF280A Gene

mRNA/cDNA for ZNF280A Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF280A

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF280A Gene

No ASD Table

Relevant External Links for ZNF280A Gene

GeneLoc Exon Structure for
ZNF280A

Expression for ZNF280A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF280A Gene

mRNA differential expression in normal tissues according to GTEx for ZNF280A Gene

This gene is overexpressed in Adrenal Gland (x34.3) and Testis (x5.0).

Protein differential expression in normal tissues from HIPED for ZNF280A Gene

This gene is overexpressed in Breast (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF280A Gene



Protein tissue co-expression partners for ZNF280A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF280A

SOURCE GeneReport for Unigene cluster for ZNF280A Gene:

Hs.178665
genes like me logo Genes that share expression patterns with ZNF280A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF280A Gene

Orthologs for ZNF280A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF280A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF280A 31 30
  • 98.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF280A 30
  • 74.71 (n)
cow
(Bos Taurus)
Mammalia ZNF280A 31 30
  • 73.77 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 30 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 25 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii znf280d 31
  • 22 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta row 31
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F37D6.2 31
  • 16 (a)
OneToMany
Species where no ortholog for ZNF280A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF280A Gene

ENSEMBL:
Gene Tree for ZNF280A (if available)
TreeFam:
Gene Tree for ZNF280A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF280A: view image

Paralogs for ZNF280A Gene

(4) SIMAP similar genes for ZNF280A Gene using alignment to 1 proteins:

  • Z280A_HUMAN

Pseudogenes.org Pseudogenes for ZNF280A Gene

genes like me logo Genes that share paralogs with ZNF280A: view

Variants for ZNF280A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF280A Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs16989015 - p.Leu276Phe
rs361580 - p.Tyr137Ser
rs361666 - p.Arg488Ser
rs361762 - p.Phe486Leu
rs361959 - p.Lys71Asn

Additional dbSNP identifiers (rs#s) for ZNF280A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF280A Gene

Variant ID Type Subtype PubMed ID
dgv23n14 CNV loss 18776910
dgv38n64 CNV loss 17921354
dgv39n64 CNV loss 17921354
dgv4505n100 CNV loss 25217958
dgv4506n100 CNV loss 25217958
dgv4507n100 CNV loss 25217958
dgv4510n100 CNV loss 25217958
dgv4511n100 CNV gain 25217958
dgv548n27 CNV loss 19166990
dgv550n27 CNV loss 19166990
dgv551n27 CNV loss 19166990
dgv555n27 CNV loss 19166990
dgv556n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv558n27 CNV loss 19166990
dgv560n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv8004n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8010n54 CNV loss 21841781
dgv8011n54 CNV loss 21841781
dgv8012n54 CNV loss 21841781
dgv8014n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv826e214 CNV loss 21293372
esv1007524 CNV gain 20482838
esv2422480 CNV deletion 17116639
esv33016 CNV gain 17666407
esv3568289 CNV loss 25503493
esv3575435 CNV gain 25503493
esv3647368 CNV loss 21293372
nsv1059960 CNV loss 25217958
nsv1060145 CNV gain 25217958
nsv1063128 CNV gain+loss 25217958
nsv194 CNV insertion 15895083
nsv3571 CNV insertion 18451855
nsv433336 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459421 CNV gain 19166990
nsv459539 CNV loss 19166990
nsv459548 CNV loss 19166990
nsv469735 CNV loss 16826518
nsv508727 CNV insertion 20534489
nsv511072 OTHER complex 20534489
nsv514963 CNV gain+loss 21397061
nsv526328 CNV gain 19592680
nsv588348 CNV gain 21841781
nsv588469 CNV loss 21841781
nsv588470 CNV loss 21841781
nsv588472 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817957 CNV gain 17921354
nsv819428 CNV gain 19587683
nsv821694 CNV loss 15273396
nsv828977 CNV loss 20364138
nsv828979 CNV gain+loss 20364138
nsv834149 CNV loss 17160897
nsv834150 CNV loss 17160897

Variation tolerance for ZNF280A Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.44; 98.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF280A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF280A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF280A Gene

Disorders for ZNF280A Gene

Additional Disease Information for ZNF280A

No disorders were found for ZNF280A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF280A Gene

Publications for ZNF280A Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 54

Products for ZNF280A Gene

Sources for ZNF280A Gene