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This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]
ZNF280A (Zinc Finger Protein 280A) is a Protein Coding gene. An important paralog of this gene is ZNF280B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF280A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF280A 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ZNF280A 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | znf280d 31 |
|
OneToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | row 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F37D6.2 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs16989015 | - | p.Leu276Phe | |||
rs361580 | - | p.Tyr137Ser | |||
rs361666 | - | p.Arg488Ser | |||
rs361762 | - | p.Phe486Leu | |||
rs361959 | - | p.Lys71Asn |
No disorders were found for ZNF280A Gene.