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Aliases for ZNF28 Gene

Aliases for ZNF28 Gene

  • Zinc Finger Protein 28 2 3 5
  • Zinc Finger Protein KOX24 3 4
  • KOX24 3 4
  • Zinc Finger Protein 28 (KOX 24) 2

External Ids for ZNF28 Gene

Previous GeneCards Identifiers for ZNF28 Gene

  • GC19U990097
  • GC19M053665
  • GC19M057981
  • GC19M057995
  • GC19M057992
  • GC19M053300
  • GC19M049628

Summaries for ZNF28 Gene

GeneCards Summary for ZNF28 Gene

ZNF28 (Zinc Finger Protein 28) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF888.

UniProtKB/Swiss-Prot for ZNF28 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF28 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF28 Gene

Genomics for ZNF28 Gene

GeneHancer (GH) Regulatory Elements for ZNF28 Gene

Promoters and enhancers for ZNF28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052820 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 573.1 +36.1 36051 1.5 HDGF BCOR HDAC1 MXI1 SAP130 ZNF266 SIN3A NFXL1 E4F1 E2F1 ZNF28 ZNF600 ZNF701 ZNF845 ZNF808 ENSG00000269001 ZNF350 ZNF160 ENSG00000268970 ZNF836
GH19I052856 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 560.7 -0.1 -89 1.8 HDAC1 ELF3 ATF1 TAF9B ARID4B SIN3A ZNF48 ZNF335 POLR2B EGR1 ZNF468 ZNF28 ZNF320 GC19M052864
GH19I052137 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 31.2 +718.0 717968 3.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF616 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577
GH19I052637 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 18.9 +219.4 219379 2.2 HDGF SMAD1 ARID4B SIN3A POLR2B E2F8 ATF7 SP3 NCOA1 ZNF518A ZNF83 ZNF701 ZNF600 ZNF845 ZNF28 ZNF808 ENSG00000269001 ZNF350 ZNF160 ENSG00000268970
GH19I052687 Promoter/Enhancer 1.5 Ensembl ENCODE 18.5 +167.7 167708 4.3 HDGF PKNOX1 ATF1 SMAD1 ARNT ZNF48 POLR2B ZNF766 GLIS2 E2F8 ZNF83 ZNF28 ZNF525 ENSG00000269825 ZNF766 ZNF701 ZNF845 ZNF160 ZNF350 ZNF137P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF28 gene promoter:

Genomic Locations for ZNF28 Gene

Genomic Locations for ZNF28 Gene
chr19:52,797,408-52,857,600
(GRCh38/hg38)
Size:
60,193 bases
Orientation:
Minus strand
chr19:53,300,661-53,360,853
(GRCh37/hg19)

Genomic View for ZNF28 Gene

Genes around ZNF28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF28 Gene

Proteins for ZNF28 Gene

  • Protein details for ZNF28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17035-ZNF28_HUMAN
    Recommended name:
    Zinc finger protein 28
    Protein Accession:
    P17035
    Secondary Accessions:
    • A8KAK9
    • B4E3G0
    • B9EIK7
    • Q5H9V1
    • Q5HYM9
    • Q6ZML9
    • Q6ZN56

    Protein attributes for ZNF28 Gene

    Size:
    718 amino acids
    Molecular mass:
    83658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18706.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF28 Gene

Post-translational modifications for ZNF28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF28 Gene

Domains & Families for ZNF28 Gene

Gene Families for ZNF28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17035

UniProtKB/Swiss-Prot:

ZNF28_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF28: view

Function for ZNF28 Gene

Molecular function for ZNF28 Gene

GENATLAS Biochemistry:
zinc finger protein 28 (KOX24) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF28 Gene

Gene Ontology (GO) - Molecular Function for ZNF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF28: view
genes like me logo Genes that share phenotypes with ZNF28: view

Animal Model Products

CRISPR Products

miRNA for ZNF28 Gene

miRTarBase miRNAs that target ZNF28

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF28 Gene

Localization for ZNF28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF28 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF28 Gene

Pathways & Interactions for ZNF28 Gene

SuperPathways for ZNF28 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF28: view

Pathways by source for ZNF28 Gene

2 Reactome pathways for ZNF28 Gene

Interacting Proteins for ZNF28 Gene

Gene Ontology (GO) - Biological Process for ZNF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF28: view

No data available for SIGNOR curated interactions for ZNF28 Gene

Drugs & Compounds for ZNF28 Gene

No Compound Related Data Available

Transcripts for ZNF28 Gene

Unigene Clusters for ZNF28 Gene

Zinc finger protein 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF28 Gene

No ASD Table

Relevant External Links for ZNF28 Gene

GeneLoc Exon Structure for
ZNF28
ECgene alternative splicing isoforms for
ZNF28

Expression for ZNF28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF28 Gene

Protein differential expression in normal tissues from HIPED for ZNF28 Gene

This gene is overexpressed in Plasma (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF28 Gene



Protein tissue co-expression partners for ZNF28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF28 Gene:

ZNF28

SOURCE GeneReport for Unigene cluster for ZNF28 Gene:

Hs.732407

Evidence on tissue expression from TISSUES for ZNF28 Gene

  • Nervous system(4.5)
  • Spleen(2.6)
  • Lung(2.5)
  • Blood(2.4)
  • Lymph node(2.4)
  • Heart(2.3)
  • Liver(2.3)
  • Thyroid gland(2.3)
  • Eye(2.2)
  • Intestine(2.2)
  • Pancreas(2.2)
  • Adrenal gland(2.1)
  • Bone marrow(2.1)
  • Muscle(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with ZNF28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF28 Gene

Orthologs for ZNF28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF28 33 34
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 53 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aef1 35
  • 53 (a)
Kr-h1 35
  • 47 (a)
CG12299 35
  • 43 (a)
CG15436 35
  • 40 (a)
CG5245 35
  • 40 (a)
crol 35
  • 40 (a)
CG11247 35
  • 36 (a)
CG8319 35
  • 36 (a)
CG2129 35
  • 31 (a)
CG7386 35
  • 31 (a)
CG17612 35
  • 29 (a)
CG3941 35
  • 29 (a)
CG8388 35
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 35
  • 37 (a)
Species where no ortholog for ZNF28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ZNF28 Gene

ENSEMBL:
Gene Tree for ZNF28 (if available)
TreeFam:
Gene Tree for ZNF28 (if available)

Paralogs for ZNF28 Gene

(651) SIMAP similar genes for ZNF28 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for ZNF28 Gene

genes like me logo Genes that share paralogs with ZNF28: view

Variants for ZNF28 Gene

Sequence variations from dbSNP and Humsavar for ZNF28 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000023557 -- 52,797,426(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000077423 -- 52,797,694(-) A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000097013 -- 52,798,556(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000150928 -- 52,798,254(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000457592 -- 52,823,011(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF28 Gene

Variant ID Type Subtype PubMed ID
dgv148n111 CNV duplication 26073780
dgv3629n100 CNV loss 25217958
dgv3630n100 CNV loss 25217958
dgv3631n100 CNV gain 25217958
dgv3632n100 CNV gain+loss 25217958
dgv529e201 CNV deletion 23290073
dgv6527n54 CNV gain 21841781
dgv660e199 CNV deletion 23128226
dgv74e203 CNV gain+loss 21179565
esv1004256 CNV deletion 20482838
esv1009469 CNV deletion 20482838
esv1010802 CNV loss 20482838
esv1065813 CNV insertion 17803354
esv1979870 CNV deletion 18987734
esv2013773 CNV deletion 18987734
esv21942 CNV gain 19812545
esv2445065 CNV deletion 19546169
esv2464403 CNV loss 19546169
esv2671531 CNV deletion 23128226
esv2673863 CNV deletion 23128226
esv2676843 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718798 CNV deletion 23290073
esv2718799 CNV deletion 23290073
esv2718801 CNV deletion 23290073
esv2758768 CNV gain+loss 17122850
esv28948 CNV loss 19812545
esv3556576 CNV deletion 23714750
esv3556577 CNV deletion 23714750
esv3574676 CNV gain 25503493
esv3583512 CNV loss 25503493
esv3644719 CNV gain 21293372
esv3644722 CNV loss 21293372
esv3644723 CNV loss 21293372
esv3644724 CNV loss 21293372
esv3644725 CNV gain 21293372
esv3893234 CNV gain 25118596
esv3893235 CNV loss 25118596
esv999313 CNV loss 20482838
nsv1057118 CNV gain 25217958
nsv1060163 CNV loss 25217958
nsv1060555 CNV gain 25217958
nsv1066762 CNV gain 25217958
nsv1067557 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv1147763 CNV deletion 26484159
nsv458746 CNV gain 19166990
nsv458747 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv528436 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580034 CNV gain 21841781
nsv580035 CNV loss 21841781
nsv817858 CNV gain 17921354
nsv828617 CNV loss 20364138
nsv828618 CNV loss 20364138
nsv828619 CNV gain 20364138
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009
nsv9743 CNV loss 18304495
nsv9744 CNV gain 18304495

Variation tolerance for ZNF28 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF28

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF28 Gene

Disorders for ZNF28 Gene

Additional Disease Information for ZNF28

No disorders were found for ZNF28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF28 Gene

Publications for ZNF28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ZNF28 Gene

Sources for ZNF28 Gene

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