Aliases for ZNF28 Gene

Aliases for ZNF28 Gene

  • Zinc Finger Protein 28 2 3 4 5
  • KOX24 2 3 4
  • Zinc Finger Protein KOX24 3 4
  • Zinc Finger Protein 28 (KOX 24) 2
  • DKFZp781D0275 2
  • ZNF28 5

External Ids for ZNF28 Gene

Previous GeneCards Identifiers for ZNF28 Gene

  • GC19U990097
  • GC19M053665
  • GC19M057981
  • GC19M057995
  • GC19M057992
  • GC19M053300
  • GC19M049628

Summaries for ZNF28 Gene

GeneCards Summary for ZNF28 Gene

ZNF28 (Zinc Finger Protein 28) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF600.

UniProtKB/Swiss-Prot Summary for ZNF28 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF28 Gene

Genomics for ZNF28 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF28 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF28 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF28

Top Transcription factor binding sites by QIAGEN in the ZNF28 gene promoter:
  • CUTL1
  • FOXD1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • NF-kappaB
  • NF-kappaB1
  • Olf-1
  • RelA

Genomic Locations for ZNF28 Gene

Latest Assembly
60,193 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
24,226 bases
Minus strand

(GRCh37/hg19 by Ensembl)
60,192 bases
Minus strand

Genomic View for ZNF28 Gene

Genes around ZNF28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF28 Gene

Proteins for ZNF28 Gene

  • Protein details for ZNF28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 28
    Protein Accession:
    Secondary Accessions:
    • A8KAK9
    • B4E3G0
    • B9EIK7
    • Q5H9V1
    • Q5HYM9
    • Q6ZML9
    • Q6ZN56

    Protein attributes for ZNF28 Gene

    718 amino acids
    Molecular mass:
    83658 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18706.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF28 Gene


neXtProt entry for ZNF28 Gene

Post-translational modifications for ZNF28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF28 Gene

Domains & Families for ZNF28 Gene

Gene Families for ZNF28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF28 Gene

  • C2H2-type zinc finger signature

Suggested Antigen Peptide Sequences for ZNF28 Gene

GenScript: Design optimal peptide antigens:
  • ZNF28 protein (Q6NSH2_HUMAN)
  • Zinc finger protein KOX24 (ZNF28_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF28: view

Function for ZNF28 Gene

Molecular function for ZNF28 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 28 (KOX24) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF28 Gene

Gene Ontology (GO) - Molecular Function for ZNF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF28: view
genes like me logo Genes that share phenotypes with ZNF28: view

miRNA for ZNF28 Gene

miRTarBase miRNAs that target ZNF28

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF28

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF28 Gene

Localization for ZNF28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF28 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF28 Gene

Pathways & Interactions for ZNF28 Gene

PathCards logo

SuperPathways for ZNF28 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF28: view

Pathways by source for ZNF28 Gene

2 Reactome pathways for ZNF28 Gene

Gene Ontology (GO) - Biological Process for ZNF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF28: view

No data available for SIGNOR curated interactions for ZNF28 Gene

Drugs & Compounds for ZNF28 Gene

No Compound Related Data Available

Transcripts for ZNF28 Gene

mRNA/cDNA for ZNF28 Gene

14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF28

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF28 Gene

No ASD Table

Relevant External Links for ZNF28 Gene

GeneLoc Exon Structure for

Expression for ZNF28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF28 Gene

Protein differential expression in normal tissues from HIPED for ZNF28 Gene

This gene is overexpressed in Plasma (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF28 Gene

Protein tissue co-expression partners for ZNF28 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF28

SOURCE GeneReport for Unigene cluster for ZNF28 Gene:


Evidence on tissue expression from TISSUES for ZNF28 Gene

  • Nervous system(4.5)
  • Spleen(2.6)
  • Lung(2.5)
  • Lymph node(2.4)
  • Blood(2.4)
  • Heart(2.3)
  • Liver(2.3)
  • Thyroid gland(2.3)
  • Intestine(2.2)
  • Eye(2.2)
  • Pancreas(2.2)
  • Bone marrow(2.1)
  • Adrenal gland(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZNF28: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF28 Gene

Orthologs for ZNF28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF28 30 31
  • 98.84 (n)
(Canis familiaris)
Mammalia -- 31
  • 53 (a)
(Bos Taurus)
Mammalia -- 31
  • 41 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Aef1 32
  • 53 (a)
Kr-h1 32
  • 47 (a)
CG12299 32
  • 43 (a)
CG15436 32
  • 40 (a)
crol 32
  • 40 (a)
CG5245 32
  • 40 (a)
CG8319 32
  • 36 (a)
CG11247 32
  • 36 (a)
CG2129 32
  • 31 (a)
CG7386 32
  • 31 (a)
CG17612 32
  • 29 (a)
CG3941 32
  • 29 (a)
CG8388 32
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y55F3AM.14 32
  • 37 (a)
Species where no ortholog for ZNF28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF28 Gene

Gene Tree for ZNF28 (if available)
Gene Tree for ZNF28 (if available)
Evolutionary constrained regions (ECRs) for ZNF28: view image

Paralogs for ZNF28 Gene

Paralogs for ZNF28 Gene

(651) SIMAP similar genes for ZNF28 Gene using alignment to 6 proteins:

  • C9K0H3_HUMAN
  • M0R0U4_HUMAN
  • Q6NSH2_HUMAN Pseudogenes for ZNF28 Gene

genes like me logo Genes that share paralogs with ZNF28: view

Variants for ZNF28 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF28 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs74870761 Benign: not provided 52,801,534(-) T/C
NM_006969.5(ZNF28):c.311A>G (p.Asp104Gly)
rs79157402 Benign: not provided 52,799,895(-) G/A
NM_006969.5(ZNF28):c.1950C>T (p.Leu650=)
rs10417163 - p.Lys465Gln
rs13382164 - p.Arg179Gly
rs8107444 - p.Met524Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF28 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF28 Gene

Variant ID Type Subtype PubMed ID
dgv148n111 CNV duplication 26073780
dgv3629n100 CNV loss 25217958
dgv3630n100 CNV loss 25217958
dgv3631n100 CNV gain 25217958
dgv3632n100 CNV gain+loss 25217958
dgv529e201 CNV deletion 23290073
dgv6527n54 CNV gain 21841781
dgv660e199 CNV deletion 23128226
dgv74e203 CNV gain+loss 21179565
esv1004256 CNV deletion 20482838
esv1009469 CNV deletion 20482838
esv1010802 CNV loss 20482838
esv1065813 CNV insertion 17803354
esv1979870 CNV deletion 18987734
esv2013773 CNV deletion 18987734
esv21942 CNV gain 19812545
esv2445065 CNV deletion 19546169
esv2464403 CNV loss 19546169
esv2671531 CNV deletion 23128226
esv2673863 CNV deletion 23128226
esv2676843 CNV deletion 23128226
esv2718786 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718796 CNV deletion 23290073
esv2718798 CNV deletion 23290073
esv2718799 CNV deletion 23290073
esv2718801 CNV deletion 23290073
esv2758768 CNV gain+loss 17122850
esv28948 CNV loss 19812545
esv3556576 CNV deletion 23714750
esv3556577 CNV deletion 23714750
esv3574676 CNV gain 25503493
esv3583512 CNV loss 25503493
esv3644719 CNV gain 21293372
esv3644722 CNV loss 21293372
esv3644723 CNV loss 21293372
esv3644724 CNV loss 21293372
esv3644725 CNV gain 21293372
esv3893234 CNV gain 25118596
esv3893235 CNV loss 25118596
esv999313 CNV loss 20482838
nsv1057118 CNV gain 25217958
nsv1060163 CNV loss 25217958
nsv1060555 CNV gain 25217958
nsv1066762 CNV gain 25217958
nsv1067557 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1140479 CNV deletion 24896259
nsv1147763 CNV deletion 26484159
nsv458746 CNV gain 19166990
nsv458747 CNV gain 19166990
nsv509752 CNV insertion 20534489
nsv528436 CNV loss 19592680
nsv580030 CNV gain 21841781
nsv580034 CNV gain 21841781
nsv580035 CNV loss 21841781
nsv817858 CNV gain 17921354
nsv828617 CNV loss 20364138
nsv828618 CNV loss 20364138
nsv828619 CNV gain 20364138
nsv833875 CNV loss 17160897
nsv961240 CNV duplication 23825009
nsv9743 CNV loss 18304495
nsv9744 CNV gain 18304495

Variation tolerance for ZNF28 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF28 Gene

Disorders for ZNF28 Gene

Additional Disease Information for ZNF28

No disorders were found for ZNF28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF28 Gene

Publications for ZNF28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZNF28 Gene

Sources for ZNF28 Gene