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Aliases for ZNF276 Gene

Aliases for ZNF276 Gene

  • Zinc Finger Protein 276 2 3 5
  • Zinc Finger Protein 477 3 4
  • Centromere Protein Z 2 3
  • Zinc Finger, AD-Type 2 3
  • Zfp-276 3 4
  • ZFP276 3 4
  • CENP-Z 3 4
  • ZNF477 3 4
  • Zinc Finger Protein 276 Homolog (Mouse) 2
  • Zinc Finger Protein 276 Homolog 3
  • CENPZ 3
  • ZADT 3

External Ids for ZNF276 Gene

Previous HGNC Symbols for ZNF276 Gene

  • ZFP276

Previous GeneCards Identifiers for ZNF276 Gene

  • GC16P088315
  • GC16P089788
  • GC16P075482

Summaries for ZNF276 Gene

GeneCards Summary for ZNF276 Gene

ZNF276 (Zinc Finger Protein 276) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF653.

UniProtKB/Swiss-Prot for ZNF276 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF276 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF276 Gene

Genomics for ZNF276 Gene

GeneHancer (GH) Regulatory Elements for ZNF276 Gene

Promoters and enhancers for ZNF276 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I089717 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.2 +0.9 858 7.5 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 VPS9D1 ZNF276 AFG3L1P CDK10 LOC101927863 ENSG00000268218 ACSF3 ANKRD11 MC1R TCF25
GH16I089480 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -233.4 -233441 12 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 ANKRD11 SPG7 ZNF778 ZC3H18 AFG3L1P MC1R ENSG00000259877 RPL13 TCF25 RNU6-430P
GH16I089216 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 -502.9 -502880 2.6 PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ENSG00000259877 PIR52460 ZNF778 AFG3L1P TCF25 CDK10 TRAPPC2L PIEZO1 CTU2 ZNF276
GH16I089686 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -32.9 -32884 2.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF207 CDK10 LINC02166 DPEP1 VPS9D1 ZNF276 FANCA PIR59284
GH16I089832 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +115.6 115604 6.6 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 BRCA1 ZNF48 CDK10 SPIRE2 ACSF3 TUBB3 GALNS VPS9D1 ZNF276 ANKRD11 SNORD68 FANCA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF276 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF276 gene promoter:

Genomic Locations for ZNF276 Gene

Genomic Locations for ZNF276 Gene
chr16:89,720,195-89,740,925
(GRCh38/hg38)
Size:
20,731 bases
Orientation:
Plus strand
chr16:89,786,808-89,807,333
(GRCh37/hg19)

Genomic View for ZNF276 Gene

Genes around ZNF276 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF276 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF276 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF276 Gene

Proteins for ZNF276 Gene

  • Protein details for ZNF276 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N554-ZN276_HUMAN
    Recommended name:
    Zinc finger protein 276
    Protein Accession:
    Q8N554
    Secondary Accessions:
    • Q0VGA1
    • Q2TBE8
    • Q3B7H7

    Protein attributes for ZNF276 Gene

    Size:
    614 amino acids
    Molecular mass:
    67219 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32781.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI10349.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF276 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF276 Gene

Post-translational modifications for ZNF276 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF276 Gene

Domains & Families for ZNF276 Gene

Gene Families for ZNF276 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF276 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF276: view

No data available for UniProtKB/Swiss-Prot for ZNF276 Gene

Function for ZNF276 Gene

Molecular function for ZNF276 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF276 Gene

Gene Ontology (GO) - Molecular Function for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF276: view

Phenotypes for ZNF276 Gene

GenomeRNAi human phenotypes for ZNF276:
genes like me logo Genes that share phenotypes with ZNF276: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF276 Gene

Localization for ZNF276 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF276 Gene

Nucleus. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF276 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA,IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZNF276: view

Pathways & Interactions for ZNF276 Gene

SuperPathways for ZNF276 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF276: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF276 Gene

Drugs & Compounds for ZNF276 Gene

No Compound Related Data Available

Transcripts for ZNF276 Gene

Unigene Clusters for ZNF276 Gene

Zinc finger protein 276:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF276 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:
SP8: -
SP9:
SP10:

Relevant External Links for ZNF276 Gene

GeneLoc Exon Structure for
ZNF276
ECgene alternative splicing isoforms for
ZNF276

Expression for ZNF276 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF276 Gene

Protein differential expression in normal tissues from HIPED for ZNF276 Gene

This gene is overexpressed in Colon muscle (22.5), Peripheral blood mononuclear cells (16.0), Pancreatic juice (10.6), and Bone (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF276 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF276 Gene:

ZNF276

SOURCE GeneReport for Unigene cluster for ZNF276 Gene:

Hs.290154

Evidence on tissue expression from TISSUES for ZNF276 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF276: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF276 Gene

Orthologs for ZNF276 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF276 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF276 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia ZNF276 33 34
  • 85.66 (n)
cow
(Bos Taurus)
Mammalia ZNF276 33 34
  • 82.61 (n)
rat
(Rattus norvegicus)
Mammalia Zfp276 33
  • 82.56 (n)
mouse
(Mus musculus)
Mammalia Zfp276 33 16 34
  • 81.75 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF276 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF276 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF276 33 34
  • 70.15 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF276 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf276 33
  • 59.65 (n)
zebrafish
(Danio rerio)
Actinopterygii im:7141269 34
  • 19 (a)
ManyToMany
zgc:171673 34
  • 19 (a)
ManyToMany
Dr.19956 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
OneToMany
Species where no ortholog for ZNF276 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF276 Gene

ENSEMBL:
Gene Tree for ZNF276 (if available)
TreeFam:
Gene Tree for ZNF276 (if available)

Paralogs for ZNF276 Gene

Paralogs for ZNF276 Gene

genes like me logo Genes that share paralogs with ZNF276: view

Variants for ZNF276 Gene

Sequence variations from dbSNP and Humsavar for ZNF276 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1060501882 uncertain-significance, Fanconi anemia 89,739,187(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1060501887 likely-pathogenic, Fanconi anemia 89,738,881(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs11649210 benign, likely-benign, not specified, Fanconi anemia 89,740,825(+) C/A/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1230 benign, Fanconi anemia 89,738,447(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs139478274 uncertain-significance, Fanconi anemia 89,738,917(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF276 Gene

Variant ID Type Subtype PubMed ID
dgv387e201 CNV deletion 23290073
dgv517e199 CNV deletion 23128226
dgv872e212 CNV loss 25503493
dgv873e212 CNV loss 25503493
dgv874e212 CNV loss 25503493
dgv875e212 CNV loss 25503493
esv1401930 CNV insertion 17803354
esv1995159 CNV deletion 18987734
esv25585 CNV loss 19812545
esv2672413 CNV deletion 23128226
esv2715199 CNV deletion 23290073
esv2762221 CNV gain+loss 21179565
esv3572253 CNV gain 25503493
nsv1152934 CNV deletion 26484159
nsv1931 CNV insertion 18451855
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv457624 CNV loss 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv516241 CNV loss 19592680
nsv573743 CNV gain 21841781
nsv573744 CNV loss 21841781
nsv833330 CNV loss 17160897
nsv833331 CNV gain+loss 17160897
nsv952079 CNV deletion 24416366
nsv958046 CNV deletion 24416366

Variation tolerance for ZNF276 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF276 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF276

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF276 Gene

Disorders for ZNF276 Gene

Additional Disease Information for ZNF276

No disorders were found for ZNF276 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF276 Gene

Publications for ZNF276 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. (PMID: 14605947) Wong JC … Buchwald M (Journal of human genetics 2003) 3 4 58
  5. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. (PMID: 10936049) Wong JC … Buchwald M (Genomics 2000) 2 3 58

Products for ZNF276 Gene

Sources for ZNF276 Gene

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