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Aliases for ZNF276 Gene
Aliases for ZNF276 Gene
External Ids for ZNF276 Gene
- HGNC: 23330
- Entrez Gene: 92822
- Ensembl: ENSG00000158805
- OMIM: 608460
- UniProtKB: Q8N554
Previous HGNC Symbols for ZNF276 Gene
- ZFP276
Previous GeneCards Identifiers for ZNF276 Gene
- GC16P088315
- GC16P089788
- GC16P075482
Summaries for ZNF276 Gene
GeneCards Summary for ZNF276 Gene
ZNF276 (Zinc Finger Protein 276) is a Protein Coding gene. Diseases associated with ZNF276 include Fanconi Anemia, Complementation Group A. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF692.
UniProtKB/Swiss-Prot Summary for ZNF276 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF276 Gene
- HGNC(23330)
- Entrez Gene(92822)
- Ensembl(ENSG00000158805)
- OMIM(608460)
- UniProtKB(Q8N554)
- Open Targets Platform(ENSG00000158805)
- Search for ZNF276 at DataMed
- Search for ZNF276 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF276 Gene
Genomics for ZNF276 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ZNF276 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF276 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF276
- Top Transcription factor binding sites by QIAGEN in the ZNF276 gene promoter:
-
- AML1a
- CP2
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
Genomic Locations for ZNF276 Gene
Genomic Locations for ZNF276 Gene
- chr16:89,720,368-89,740,925
- (GRCh38/hg38)
- Size:
- 20,558 bases
- Orientation:
- Plus strand
- chr16:89,786,808-89,807,333
- (GRCh37/hg19)
- Size:
- 20,526 bases
- Orientation:
- Plus strand
Genomic View for ZNF276 Gene
Genes around ZNF276 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by HGNC
- 16q24.3 by Entrez Gene
- 16q24.3 by Ensembl
ZNF276 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF276 Gene
Proteins for ZNF276 Gene
-
Protein details for ZNF276 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N554-ZN276_HUMAN
- Recommended name:
- Zinc finger protein 276
- Protein Accession:
- Q8N554
- Q0VGA1
- Q2TBE8
- Q3B7H7
Protein attributes for ZNF276 Gene
- Size:
- 614 amino acids
- Molecular mass:
- 67219 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32781.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAI10349.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for ZNF276 Gene
Post-translational modifications for ZNF276 Gene
Other Protein References for ZNF276 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF276
- Invitrogen Antibodies for ZNF276 (AFLGC-ZNF276)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF276
Protein Products
-
OriGene Purified Proteins for ZNF276
- Search Origene for MassSpec and Protein Over-expression Lysates for ZNF276
- Origene Custom Protein Services for ZNF276
- antibodies-online: Show 3 available ZNF276 Proteins ranked by validation data
- Compare Top ZNF276 Proteins
-
Quality Products:
-
Abcam proteins for ZNF276
No data available for DME Specific Peptides for ZNF276 Gene
Domains & Families for ZNF276 Gene
Gene Families for ZNF276 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF276 Gene
- InterPro:
- Blocks:
-
- Aspartate carbamoyltransferase, regulatory chain, C-terminal
- Zinc finger, AD-type
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF276 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ77809 (A8K186_HUMAN)
- Zinc finger protein 477 (ZN276_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF276 Gene
Function for ZNF276 Gene
Molecular function for ZNF276 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF276 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF276 Gene
- GenomeRNAi human phenotypes for ZNF276:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF276 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF276
miRNA for ZNF276 Gene
- miRTarBase miRNAs that target ZNF276
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for ZNF276 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF276
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF276
Cell Line Products
-
Horizon Cell Lines for ZNF276
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF276 Gene
Localization for ZNF276 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF276 Gene
- Nucleus. Chromosome, centromere, kinetochore.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
- Cytosol (2)
- Nucleoli (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA,IDA | 20813266 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for ZNF276 Gene
Interacting Proteins for ZNF276 Gene
Selected Interacting proteins:
Q8N554-ZN276_HUMAN
ENSP00000415836
for ZNF276 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ZNF276
No data available for Pathways by source and SIGNOR curated interactions for ZNF276 Gene
Transcripts for ZNF276 Gene
mRNA/cDNA for ZNF276 Gene
- 2 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000289816 4589 nts (view in UCSC)
- ENST00000443381 4628 nts (view in UCSC)
- ENST00000561536 1947 nts (view in UCSC)
- ENST00000562530 1826 nts (view in UCSC)
- ENST00000563541 588 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF276 - Select products 50% OFF >
- * ZNF276 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF276
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF276
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF276
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF276
- Browse OriGene Inhibitory RNA Products For ZNF276
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF276
Clone Products
- Applied Biological Materials (abm): Clones for ZNF276 - Select products 50% OFF >
- * ZNF276 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF276
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF276
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for ZNF276 Gene
- GeneLoc Exon Structure for
- ZNF276
Expression for ZNF276 Gene
This gene is overexpressed in Colon muscle (22.5), Peripheral blood mononuclear cells (16.0), Pancreatic juice (10.6), and Bone (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF276 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF276
SOURCE GeneReport for Unigene cluster for ZNF276 Gene:
Hs.290154Evidence on tissue expression from TISSUES for ZNF276 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ZNF276
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF276 Gene
Orthologs for ZNF276 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ZNF276 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ZNF276 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ZNF276 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Zfp276 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Zfp276 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ZNF276 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF276 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ZNF276 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ZNF276 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf276 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:171673 31 |
|
ManyToMany | |
| im:7141269 31 |
|
ManyToMany | |||
| Dr.19956 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for ZNF276 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ZNF276 Gene
- ENSEMBL:
- Gene Tree for ZNF276 (if available)
- TreeFam:
- Gene Tree for ZNF276 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF276: view image
Paralogs for ZNF276 Gene
Paralogs for ZNF276 Gene
- ZNF692 5
- PRDM10 5
- ZNF653 5
- ZFP91-CNTF 5
- ZFP91 5
- HIC1 5
- ZBTB20 5
- ZBTB7C 5
- HIC2 5
- ZNF451 5
- ZBTB16 5
- ZNF296 5
- ZNF410 5
- ZNF384 5
- PRDM1 5
- MTF1 5
- ZNF148 5
- ZBTB1 5
- ZNF362 5
- ZNF281 5
- PRDM6 5
- PRDM14 5
- ZBTB18 5
- PATZ1 5
- ZNF76 5
- ZBTB45 5
- MAZ 5
- ZBTB42 5
- ZNF143 5
- SNAI3 5
- SCRT1 5
- SNAI2 5
- ZBTB32 5
- SCRT2 5
- VEZF1 5
- ZNF575 5
- SNAI1 5
- ENSG00000267477 5
(15) SIMAP similar genes for ZNF276 Gene using alignment to 7 proteins:
- ZN276_HUMAN
- A8K186_HUMAN
- H3BPJ6_HUMAN
- H3BPT7_HUMAN
- H3BTK0_HUMAN
- H3BTT0_HUMAN
- I6L9I3_HUMAN
Variants for ZNF276 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF276 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 641764 | Likely Pathogenic: Fanconi anemia | 89,738,693(+) | CA/C | FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 645069 | Uncertain Significance: Fanconi anemia | 89,739,261(+) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 645201 | Uncertain Significance: Fanconi anemia | 89,739,281(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 648627 | Uncertain Significance: Fanconi anemia | 89,738,898(+) | A/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT | |
| 649207 | Uncertain Significance: Fanconi anemia | 89,739,249(+) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv387e201 | CNV | deletion | 23290073 |
| dgv517e199 | CNV | deletion | 23128226 |
| dgv872e212 | CNV | loss | 25503493 |
| dgv873e212 | CNV | loss | 25503493 |
| dgv874e212 | CNV | loss | 25503493 |
| dgv875e212 | CNV | loss | 25503493 |
| esv1401930 | CNV | insertion | 17803354 |
| esv1995159 | CNV | deletion | 18987734 |
| esv25585 | CNV | loss | 19812545 |
| esv2672413 | CNV | deletion | 23128226 |
| esv2715199 | CNV | deletion | 23290073 |
| esv2762221 | CNV | gain+loss | 21179565 |
| esv3572253 | CNV | gain | 25503493 |
| nsv1152934 | CNV | deletion | 26484159 |
| nsv1931 | CNV | insertion | 18451855 |
| nsv428331 | CNV | gain+loss | 18775914 |
| nsv457623 | CNV | gain | 19166990 |
| nsv457624 | CNV | loss | 19166990 |
| nsv482951 | CNV | loss | 15286789 |
| nsv509639 | CNV | insertion | 20534489 |
| nsv516241 | CNV | loss | 19592680 |
| nsv573743 | CNV | gain | 21841781 |
| nsv573744 | CNV | loss | 21841781 |
| nsv833330 | CNV | loss | 17160897 |
| nsv833331 | CNV | gain+loss | 17160897 |
| nsv952079 | CNV | deletion | 24416366 |
| nsv958046 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.20;
52.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF276 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF276
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF276 Gene
Disorders for ZNF276 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi anemia, complementation group a |
|
|
Search ZNF276 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF276
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF276 Gene
Publications for ZNF276 Gene
- The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 2 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. (PMID: 14605947) Wong JCY … Buchwald M (Journal of human genetics 2003) 3 4
- Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. (PMID: 10936049) Wong JC … Buchwald M (Genomics 2000) 2 3
ExternalLinks
Products for ZNF276 Gene
- Custom Antibody Services
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- antibodies-online: Show 16 available ZNF276 Antibodies ranked by validation data
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- antibodies-online: Show 3 available ZNF276 Proteins ranked by validation data
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- Quality Products:
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZNF276
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Sources for ZNF276 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
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