Aliases for ZNF276 Gene
Aliases for ZNF276 Gene
External Ids for ZNF276 Gene
- HGNC: 23330
- Entrez Gene: 92822
- Ensembl: ENSG00000158805
- OMIM: 608460
- UniProtKB: Q8N554
Previous HGNC Symbols for ZNF276 Gene
- ZFP276
Previous GeneCards Identifiers for ZNF276 Gene
- GC16P088315
- GC16P089788
- GC16P075482
Summaries for ZNF276 Gene
GeneCards Summary for ZNF276 Gene
ZNF276 (Zinc Finger Protein 276) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF653.
UniProtKB/Swiss-Prot for ZNF276 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF276 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF276 Gene
Genomics for ZNF276 Gene
GeneHancer (GH) Regulatory Elements for ZNF276 Gene
Promoters and enhancers for ZNF276 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF276 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZNF276 gene promoter:
Regulatory Element Products
Genomic Locations for ZNF276 Gene
Genomic Locations for ZNF276 Gene
- chr16:89,720,195-89,740,925
- (GRCh38/hg38)
- Size:
- 20,731 bases
- Orientation:
- Plus strand
- chr16:89,786,808-89,807,333
- (GRCh37/hg19)
Genomic View for ZNF276 Gene
Genes around ZNF276 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by Ensembl
- 16q24.3 by Entrez Gene
- 16q24.3 by HGNC
ZNF276 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF276 Gene
Proteins for ZNF276 Gene
-
Protein details for ZNF276 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N554-ZN276_HUMAN
- Recommended name:
- Zinc finger protein 276
- Protein Accession:
- Q8N554
- Q0VGA1
- Q2TBE8
- Q3B7H7
Protein attributes for ZNF276 Gene
- Size:
- 614 amino acids
- Molecular mass:
- 67219 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32781.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI10349.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for ZNF276 Gene
Post-translational modifications for ZNF276 Gene
No Post-translational modifications
Other Protein References for ZNF276 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF276
-
Abcam antibodies for ZNF276
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- Search GeneTex for Antibodies for ZNF276
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZNF276
Protein Products
-
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- antibodies-online: Search results for 3 available ZNF276 Proteins ranked by validation data
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-
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-
Abcam proteins for ZNF276
Assay Products
No data available for DME Specific Peptides for ZNF276 Gene
Domains & Families for ZNF276 Gene
Gene Families for ZNF276 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF276 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF276 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZNF276 Gene
Function for ZNF276 Gene
Molecular function for ZNF276 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF276 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF276 Gene
- GenomeRNAi human phenotypes for ZNF276:
Animal Model Products
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-
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miRNA for ZNF276 Gene
- miRTarBase miRNAs that target ZNF276
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF276 Gene
Localization for ZNF276 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF276 Gene
- Nucleus. Chromosome, centromere, kinetochore.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
- Cytosol (2)
- Nucleoli (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IEA,IDA | 20813266 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for ZNF276 Gene
No Data Available
Interacting Proteins for ZNF276 Gene
Selected Interacting proteins:
ENSP00000415836
Q8N554-ZN276_HUMAN
for ZNF276 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF276 Gene
Transcripts for ZNF276 Gene
mRNA/cDNA for ZNF276 Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (105) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF276 Gene
- Zinc finger protein 276:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF276
- genomics-online: gRNA clones - Search results for available ZNF276 gene related products
- Applied Biological Materials CRISPR for ZNF276
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF276
- GenScript: Design CRISPR guide RNA sequences for ZNF276
miRNA Products
- Search ViGene Biosciences for ZNF276
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZNF276
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- genomics-online: shRNA clones - Search results for available ZNF276 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF276 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF276
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF276
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF276 gene related products
- orf clones - Search results for available ZNF276 gene related products
- Applied Biological Materials Clones for ZNF276
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
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| SP10: |
Expression for ZNF276 Gene
This gene is overexpressed in Colon muscle (22.5), Peripheral blood mononuclear cells (16.0), Pancreatic juice (10.6), and Bone (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF276 Gene
NURSA nuclear receptor signaling pathways regulating expression of ZNF276 Gene:
ZNF276SOURCE GeneReport for Unigene cluster for ZNF276 Gene:
Hs.290154Evidence on tissue expression from TISSUES for ZNF276 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ZNF276
- genomics-online: primer clones - Search results for available ZNF276 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF276 Gene
Orthologs for ZNF276 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF276 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF276 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF276 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfp276 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp276 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF276 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF276 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF276 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZNF276 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | znf276 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | im:7141269 34 |
|
ManyToMany | |
| zgc:171673 34 |
|
ManyToMany | |||
| Dr.19956 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ZNF276 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF276 Gene
Paralogs for ZNF276 Gene
(15) SIMAP similar genes for ZNF276 Gene using alignment to 7 proteins:
Variants for ZNF276 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1060501882 | uncertain-significance, Fanconi anemia | 89,739,187(+) | C/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1060501887 | likely-pathogenic, Fanconi anemia | 89,738,881(+) | C/T | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs11649210 | benign, likely-benign, not specified, Fanconi anemia | 89,740,825(+) | C/A/G/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1230 | benign, Fanconi anemia | 89,738,447(+) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs139478274 | uncertain-significance, Fanconi anemia | 89,738,917(+) | G/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv958046 | CNV | deletion | 24416366 |
| nsv952079 | CNV | deletion | 24416366 |
| nsv833331 | CNV | gain+loss | 17160897 |
| nsv833330 | CNV | loss | 17160897 |
| nsv573744 | CNV | loss | 21841781 |
| nsv573743 | CNV | gain | 21841781 |
| nsv516241 | CNV | loss | 19592680 |
| nsv509639 | CNV | insertion | 20534489 |
| nsv482951 | CNV | loss | 15286789 |
| nsv457624 | CNV | loss | 19166990 |
| nsv457623 | CNV | gain | 19166990 |
| nsv428331 | CNV | gain+loss | 18775914 |
| nsv1931 | CNV | insertion | 18451855 |
| nsv1152934 | CNV | deletion | 26484159 |
| esv3572253 | CNV | gain | 25503493 |
| esv2762221 | CNV | gain+loss | 21179565 |
| esv2715199 | CNV | deletion | 23290073 |
| esv2672413 | CNV | deletion | 23128226 |
| esv25585 | CNV | loss | 19812545 |
| esv1995159 | CNV | deletion | 18987734 |
| esv1401930 | CNV | insertion | 17803354 |
| dgv875e212 | CNV | loss | 25503493 |
| dgv874e212 | CNV | loss | 25503493 |
| dgv873e212 | CNV | loss | 25503493 |
| dgv872e212 | CNV | loss | 25503493 |
| dgv517e199 | CNV | deletion | 23128226 |
| dgv387e201 | CNV | deletion | 23290073 |
Residual Variation Intolerance Score:
68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.20;
52.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF276 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF276
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF276 Gene
Disorders for ZNF276 Gene
Additional Disease Information for ZNF276
No disorders were found for ZNF276 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF276 Gene
Publications for ZNF276 Gene
- The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. (PMID: 14605947) Wong JC … Buchwald M (Journal of human genetics 2003) 3 4 58
- Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. (PMID: 10936049) Wong JC … Buchwald M (Genomics 2000) 2 3 58
Products for ZNF276 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 38 available ZNF276 Antibodies ranked by validation data
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Sources for ZNF276 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
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