Aliases for ZNF276 Gene

Aliases for ZNF276 Gene

  • Zinc Finger Protein 276 2 3 4 5
  • CENP-Z 2 3 4
  • ZNF477 2 3 4
  • Zinc Finger Protein 477 3 4
  • Centromere Protein Z 2 3
  • Zinc Finger, AD-Type 2 3
  • ZFP276 3 4
  • CENPZ 2 3
  • ZADT 2 3
  • Zinc Finger Protein 276 Homolog (Mouse) 2
  • Zinc Finger Protein 276 Homolog 3
  • MGC45417 2
  • Zfp-276 4
  • ZNF276 5

External Ids for ZNF276 Gene

Previous HGNC Symbols for ZNF276 Gene

  • ZFP276

Previous GeneCards Identifiers for ZNF276 Gene

  • GC16P088315
  • GC16P089788
  • GC16P075482

Summaries for ZNF276 Gene

GeneCards Summary for ZNF276 Gene

ZNF276 (Zinc Finger Protein 276) is a Protein Coding gene. Diseases associated with ZNF276 include Fanconi Anemia, Complementation Group A. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF692.

UniProtKB/Swiss-Prot Summary for ZNF276 Gene

Additional gene information for ZNF276 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF276 Gene

Genomics for ZNF276 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF276 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF276 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF276

Top Transcription factor binding sites by QIAGEN in the ZNF276 gene promoter:
  • AML1a
  • CP2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2

Genomic Locations for ZNF276 Gene

Genomic Locations for ZNF276 Gene
chr16:89,720,368-89,740,925
(GRCh38/hg38)
Size:
20,558 bases
Orientation:
Plus strand
chr16:89,786,808-89,807,333
(GRCh37/hg19)
Size:
20,526 bases
Orientation:
Plus strand

Genomic View for ZNF276 Gene

Genes around ZNF276 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF276 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF276 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF276 Gene

Proteins for ZNF276 Gene

  • Protein details for ZNF276 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N554-ZN276_HUMAN
    Recommended name:
    Zinc finger protein 276
    Protein Accession:
    Q8N554
    Secondary Accessions:
    • Q0VGA1
    • Q2TBE8
    • Q3B7H7

    Protein attributes for ZNF276 Gene

    Size:
    614 amino acids
    Molecular mass:
    67219 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32781.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAI10349.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF276 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF276 Gene

Post-translational modifications for ZNF276 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF276 Gene

Domains & Families for ZNF276 Gene

Gene Families for ZNF276 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF276 Gene

InterPro:
Blocks:
  • Aspartate carbamoyltransferase, regulatory chain, C-terminal
  • Zinc finger, AD-type
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF276 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77809 (A8K186_HUMAN)
  • Zinc finger protein 477 (ZN276_HUMAN)
genes like me logo Genes that share domains with ZNF276: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF276 Gene

Function for ZNF276 Gene

Molecular function for ZNF276 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF276 Gene

Gene Ontology (GO) - Molecular Function for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF276: view

Phenotypes for ZNF276 Gene

genes like me logo Genes that share phenotypes with ZNF276: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF276

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF276 Gene

Localization for ZNF276 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF276 Gene

Nucleus. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF276 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF276 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with ZNF276: view

Pathways & Interactions for ZNF276 Gene

PathCards logo

SuperPathways for ZNF276 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF276 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF276 Gene

Drugs & Compounds for ZNF276 Gene

No Compound Related Data Available

Transcripts for ZNF276 Gene

mRNA/cDNA for ZNF276 Gene

2 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF276

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF276 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:
SP8: -
SP9:
SP10:

Relevant External Links for ZNF276 Gene

GeneLoc Exon Structure for
ZNF276

Expression for ZNF276 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF276 Gene

Protein differential expression in normal tissues from HIPED for ZNF276 Gene

This gene is overexpressed in Colon muscle (22.5), Peripheral blood mononuclear cells (16.0), Pancreatic juice (10.6), and Bone (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF276 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF276

SOURCE GeneReport for Unigene cluster for ZNF276 Gene:

Hs.290154

Evidence on tissue expression from TISSUES for ZNF276 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF276: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF276 Gene

Orthologs for ZNF276 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF276 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF276 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF276 30 31
  • 85.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF276 30 31
  • 82.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp276 30
  • 82.56 (n)
Mouse
(Mus musculus)
Mammalia Zfp276 30 17 31
  • 81.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF276 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF276 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF276 30 31
  • 70.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF276 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf276 30
  • 59.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:171673 31
  • 19 (a)
ManyToMany
im:7141269 31
  • 19 (a)
ManyToMany
Dr.19956 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
OneToMany
Species where no ortholog for ZNF276 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF276 Gene

ENSEMBL:
Gene Tree for ZNF276 (if available)
TreeFam:
Gene Tree for ZNF276 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF276: view image

Paralogs for ZNF276 Gene

(15) SIMAP similar genes for ZNF276 Gene using alignment to 7 proteins:

  • ZN276_HUMAN
  • A8K186_HUMAN
  • H3BPJ6_HUMAN
  • H3BPT7_HUMAN
  • H3BTK0_HUMAN
  • H3BTT0_HUMAN
  • I6L9I3_HUMAN
genes like me logo Genes that share paralogs with ZNF276: view

Variants for ZNF276 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF276 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
641764 Likely Pathogenic: Fanconi anemia 89,738,693(+) CA/C FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
645069 Uncertain Significance: Fanconi anemia 89,739,261(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
645201 Uncertain Significance: Fanconi anemia 89,739,281(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
648627 Uncertain Significance: Fanconi anemia 89,738,898(+) A/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
649207 Uncertain Significance: Fanconi anemia 89,739,249(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF276 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF276 Gene

Variant ID Type Subtype PubMed ID
dgv387e201 CNV deletion 23290073
dgv517e199 CNV deletion 23128226
dgv872e212 CNV loss 25503493
dgv873e212 CNV loss 25503493
dgv874e212 CNV loss 25503493
dgv875e212 CNV loss 25503493
esv1401930 CNV insertion 17803354
esv1995159 CNV deletion 18987734
esv25585 CNV loss 19812545
esv2672413 CNV deletion 23128226
esv2715199 CNV deletion 23290073
esv2762221 CNV gain+loss 21179565
esv3572253 CNV gain 25503493
nsv1152934 CNV deletion 26484159
nsv1931 CNV insertion 18451855
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv457624 CNV loss 19166990
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv516241 CNV loss 19592680
nsv573743 CNV gain 21841781
nsv573744 CNV loss 21841781
nsv833330 CNV loss 17160897
nsv833331 CNV gain+loss 17160897
nsv952079 CNV deletion 24416366
nsv958046 CNV deletion 24416366

Variation tolerance for ZNF276 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF276 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF276

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF276 Gene

Disorders for ZNF276 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF276 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanca
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF276: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF276 Gene

Publications for ZNF276 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. (PMID: 14605947) Wong JCY … Buchwald M (Journal of human genetics 2003) 3 4
  5. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. (PMID: 10936049) Wong JC … Buchwald M (Genomics 2000) 2 3

Products for ZNF276 Gene

Sources for ZNF276 Gene