This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010] See more...

Aliases for ZNF275 Gene

Aliases for ZNF275 Gene

  • Zinc Finger Protein 275 2 3 4 5
  • ZNF275 5

External Ids for ZNF275 Gene

Previous GeneCards Identifiers for ZNF275 Gene

  • GC0XP146763
  • GC0XP149081
  • GC0XP150161
  • GC0XP151040
  • GC0XP151031
  • GC0XP152093
  • GC0XP152252
  • GC0XP152599
  • GC0XP141258

Summaries for ZNF275 Gene

Entrez Gene Summary for ZNF275 Gene

  • This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]

GeneCards Summary for ZNF275 Gene

ZNF275 (Zinc Finger Protein 275) is a Protein Coding gene. Diseases associated with ZNF275 include Colorblindness, Partial, Protan Series and Sialuria. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF497.

UniProtKB/Swiss-Prot Summary for ZNF275 Gene

Additional gene information for ZNF275 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF275 Gene

Genomics for ZNF275 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF275 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ153334 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 619.5 +0.9 913 3.4 PRDM10 BACH1 JUND MTA2 RBFOX2 POLR2A ZNF24 PATZ1 HDAC1 ZNF341 ZNF275 MIR12129 ZFP92
GH0XJ153379 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas 17.3 +47.0 46954 3.4 CREB1 RFX1 JUND ZIC2 PKNOX1 REST HDAC1 ZNF311 FOXJ2 EP300 ZNF275 HCFC1 piR-39227-005 LOC105373379 ZFP92
GH0XJ153305 Enhancer 0.5 Ensembl 18.9 -27.1 -27146 3.2 ZNF341 OSR2 USF1 ZFHX2 ZMYM3 EGR2 ESRRA ZNF275 HSALNG0140744 PNMA6F ENSG00000278803
GH0XJ153409 Enhancer 0.7 Ensembl 12.5 +75.8 75754 0.2 GATAD2A SOX13 ZBTB26 FOXA2 TFDP1 KDM6A SAP130 GABPB1 SMAD4 HNF4A HSALNG0140752 ZFP92 ZNF275 PNMA6E RF00017-8799 RN7SL667P lnc-PNMA6E-2
GH0XJ153369 Enhancer 0.5 ENCODE 16.6 +36.9 36932 2.5 ATF2 NR2F2 BHLHE40 ATF4 ZNF589 ATF3 PRDM10 ZNF275 piR-39227-005 LOC105373379 ZFP92
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF275 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF275

Top Transcription factor binding sites by QIAGEN in the ZNF275 gene promoter:
  • c-Ets-1
  • E47
  • E4BP4
  • FOXD1
  • HSF1 (long)
  • HSF1short
  • LHX3b
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ZNF275 Gene

Genomic Locations for ZNF275 Gene
chrX:153,334,147-153,360,110
(GRCh38/hg38)
Size:
25,964 bases
Orientation:
Plus strand
chrX:152,599,613-152,625,568
(GRCh37/hg19)
Size:
25,956 bases
Orientation:
Plus strand

Genomic View for ZNF275 Gene

Genes around ZNF275 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF275 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF275 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF275 Gene

Proteins for ZNF275 Gene

  • Protein details for ZNF275 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSD4-ZN275_HUMAN
    Recommended name:
    Zinc finger protein 275
    Protein Accession:
    Q9NSD4
    Secondary Accessions:
    • A6NE92

    Protein attributes for ZNF275 Gene

    Size:
    429 amino acids
    Molecular mass:
    48443 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF275 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF275 Gene

Post-translational modifications for ZNF275 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF275 Gene

No data available for DME Specific Peptides for ZNF275 Gene

Domains & Families for ZNF275 Gene

Gene Families for ZNF275 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF275 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF275 Gene

GenScript: Design optimal peptide antigens:
  • ZNF275 protein (A6NE92_HUMAN)
  • cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275 (A6NFS0_HUMAN)
  • Zinc finger protein 275 (ZN275_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NSD4

UniProtKB/Swiss-Prot:

ZN275_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF275: view

Function for ZNF275 Gene

Molecular function for ZNF275 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF275 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF275: view
genes like me logo Genes that share phenotypes with ZNF275: view

Animal Models for ZNF275 Gene

MGI Knock Outs for ZNF275:
  • Zfp275 Zfp275<tm1.1(NCOM)Mfgc>

Animal Model Products

CRISPR Products

miRNA for ZNF275 Gene

miRTarBase miRNAs that target ZNF275

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF275

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF275 Gene

Localization for ZNF275 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF275 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF275 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF275 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF275: view

Pathways & Interactions for ZNF275 Gene

PathCards logo

SuperPathways for ZNF275 Gene

genes like me logo Genes that share pathways with ZNF275: view

Pathways by source for ZNF275 Gene

1 KEGG pathway for ZNF275 Gene

Gene Ontology (GO) - Biological Process for ZNF275 Gene

None

No data available for SIGNOR curated interactions for ZNF275 Gene

Drugs & Compounds for ZNF275 Gene

No Compound Related Data Available

Transcripts for ZNF275 Gene

mRNA/cDNA for ZNF275 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF275

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF275 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for ZNF275 Gene

GeneLoc Exon Structure for
ZNF275

Expression for ZNF275 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF275 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF275 Gene

This gene is overexpressed in Adrenal Gland (x8.3).

Protein differential expression in normal tissues from HIPED for ZNF275 Gene

This gene is overexpressed in Bone (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF275 Gene



Protein tissue co-expression partners for ZNF275 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF275

SOURCE GeneReport for Unigene cluster for ZNF275 Gene:

Hs.348963
genes like me logo Genes that share expression patterns with ZNF275: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF275 Gene

Orthologs for ZNF275 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF275 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF275 30 31
  • 99.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp275 30 17 31
  • 85.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF275 30
  • 85.36 (n)
Rat
(Rattus norvegicus)
Mammalia Zfp275 30
  • 85.17 (n)
Dog
(Canis familiaris)
Mammalia ZNF275 30 31
  • 82.53 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10959 32
  • 37 (a)
Worm
(Caenorhabditis elegans)
Secernentea F35H8.3 32
  • 36 (a)
Species where no ortholog for ZNF275 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ZNF275 Gene

ENSEMBL:
Gene Tree for ZNF275 (if available)
TreeFam:
Gene Tree for ZNF275 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF275: view image

Paralogs for ZNF275 Gene

(491) SIMAP similar genes for ZNF275 Gene using alignment to 4 proteins:

  • ZN275_HUMAN
  • A6NE92_HUMAN
  • A6NFS0_HUMAN
  • J3KQX9_HUMAN
genes like me logo Genes that share paralogs with ZNF275: view

Variants for ZNF275 Gene

Additional dbSNP identifiers (rs#s) for ZNF275 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF275 Gene

Variant ID Type Subtype PubMed ID
esv2740626 CNV deletion 23290073
esv2740627 CNV deletion 23290073
esv33199 CNV gain+loss 17666407
esv3575021 CNV loss 25503493
nsv472361 CNV novel sequence insertion 20440878
nsv480110 CNV novel sequence insertion 20440878
nsv480323 CNV novel sequence insertion 20440878
nsv480571 CNV novel sequence insertion 20440878
nsv481055 CNV novel sequence insertion 20440878
nsv481604 CNV novel sequence insertion 20440878
nsv481629 CNV novel sequence insertion 20440878

Variation tolerance for ZNF275 Gene

Gene Damage Index Score: 0.43; 9.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF275 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF275

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF275 Gene

Disorders for ZNF275 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF275 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colorblindness, partial, protan series
  • cbp
sialuria
  • infantile sialic acid storage disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF275

genes like me logo Genes that share disorders with ZNF275: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF275 Gene

Publications for ZNF275 Gene

  1. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PMID: 10854409) Mallon AM … Brown SD (Genome research 2000) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF275 Gene

Sources for ZNF275 Gene