Aliases for ZNF274 Gene
External Ids for ZNF274 Gene
Previous GeneCards Identifiers for ZNF274 Gene
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZNF274 Gene
ZNF274 (Zinc Finger Protein 274) is a Protein Coding gene. Diseases associated with ZNF274 include Anemia, Congenital Dyserythropoietic, Type Iv and Hypoparathyroidism, Sensorineural Deafness, And Renal Disease. Among its related pathways are Gene Expression and p75(NTR)-mediated signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZSCAN32.
UniProtKB/Swiss-Prot Summary for ZNF274 Gene
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).