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Aliases for ZNF273 Gene

Aliases for ZNF273 Gene

  • Zinc Finger Protein 273 2 3 3 5
  • Zinc Finger Protein HZF9 3 4
  • Zinc Finger Protein 9 3
  • HZF9 3

External Ids for ZNF273 Gene

Previous GeneCards Identifiers for ZNF273 Gene

  • GC07P062915
  • GC07P063027
  • GC07P063785
  • GC07P063686
  • GC07P063087
  • GC07P063808
  • GC07P064001
  • GC07P064330
  • GC07P060743

Summaries for ZNF273 Gene

Entrez Gene Summary for ZNF273 Gene

  • This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF273 Gene

ZNF273 (Zinc Finger Protein 273) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF254.

UniProtKB/Swiss-Prot for ZNF273 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF273 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF273 Gene

Genomics for ZNF273 Gene

GeneHancer (GH) Regulatory Elements for ZNF273 Gene

Promoters and enhancers for ZNF273 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J064902 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 657.5 +33.3 33272 2.3 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF273 EEF1DP4 ZNF117 GTF2IP14 LOC441239 VN1R42P
GH07J064792 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.2 -76.0 -76029 2.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B ZNF138 ZNF273 EEF1DP4 GABPAP GTF2IP14 ERV3-1 ZNF107 ENSG00000234338 ENSG00000277206
GH07J064887 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.2 +18.5 18495 1.9 CTCF ZNF792 SAP130 SUZ12 ARID4B SIN3A RAD21 ZNF48 GATAD1 IKZF5 LOC441239 EEF1DP4 ZNF273 ZNF117 ENSG00000234338
GH07J064995 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 3.9 +131.7 131713 11.8 MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 RCOR2 ZNF117 CCT6P3 GTF2IP14 ERV3-1 INTS4P1 CCT6P1 ZNF736 VKORC1L1 ENSG00000227113 GUSB
GH07J064947 Enhancer 0.9 Ensembl dbSUPER 7.8 +77.4 77429 0.8 CTCF KLF1 ZFP64 ZIC2 ZNF48 ZNF205 CHAMP1 ZFHX2 GLIS2 PRDM10 LOC105375328 VKORC1L1 ZNF273 PIR39696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF273 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF273 gene promoter:
  • GATA-1
  • E47
  • Hand1
  • GR
  • GR-alpha

Genomic Locations for ZNF273 Gene

Genomic Locations for ZNF273 Gene
62,068 bases
Plus strand
61,406 bases
Plus strand

Genomic View for ZNF273 Gene

Genes around ZNF273 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF273 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF273 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF273 Gene

Proteins for ZNF273 Gene

  • Protein details for ZNF273 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 273
    Protein Accession:
    Secondary Accessions:
    • B3KQZ5
    • Q6P3V4

    Protein attributes for ZNF273 Gene

    569 amino acids
    Molecular mass:
    64971 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF273 Gene


neXtProt entry for ZNF273 Gene

Post-translational modifications for ZNF273 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF273 Gene

Domains & Families for ZNF273 Gene

Gene Families for ZNF273 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF273 Gene

Suggested Antigen Peptide Sequences for ZNF273 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF273: view

Function for ZNF273 Gene

Molecular function for ZNF273 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF273 Gene

Gene Ontology (GO) - Molecular Function for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF273: view
genes like me logo Genes that share phenotypes with ZNF273: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF273 Gene

Localization for ZNF273 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF273 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF273 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF273: view

Pathways & Interactions for ZNF273 Gene

SuperPathways for ZNF273 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF273: view

Pathways by source for ZNF273 Gene

2 Reactome pathways for ZNF273 Gene

Gene Ontology (GO) - Biological Process for ZNF273 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF273: view

No data available for SIGNOR curated interactions for ZNF273 Gene

Drugs & Compounds for ZNF273 Gene

No Compound Related Data Available

Transcripts for ZNF273 Gene

Unigene Clusters for ZNF273 Gene

Zinc finger protein 273:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF273 Gene

No ASD Table

Relevant External Links for ZNF273 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF273 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF273 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF273 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.9), Brain - Cerebellum (x4.8), Skin - Sun Exposed (Lower leg) (x4.5), and Brain - Cerebellar Hemisphere (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF273 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF273 Gene:


SOURCE GeneReport for Unigene cluster for ZNF273 Gene:


Evidence on tissue expression from TISSUES for ZNF273 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF273: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF273 Gene

Orthologs for ZNF273 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF273 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF273 34 33
  • 99.47 (n)
(Mus musculus)
Mammalia Zfp493 34
  • 59 (a)
(Bos Taurus)
Mammalia -- 34
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
-- 34
  • 37 (a)
(Canis familiaris)
Mammalia -- 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 33 (a)
-- 34
  • 31 (a)
-- 34
  • 30 (a)
-- 34
  • 30 (a)
-- 34
  • 30 (a)
Species where no ortholog for ZNF273 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF273 Gene

Gene Tree for ZNF273 (if available)
Gene Tree for ZNF273 (if available)
Evolutionary constrained regions (ECRs) for ZNF273: view image

Paralogs for ZNF273 Gene

(535) SIMAP similar genes for ZNF273 Gene using alignment to 4 proteins:

  • ZN273_HUMAN
  • E9PL30_HUMAN
  • Q96HL5_HUMAN
genes like me logo Genes that share paralogs with ZNF273: view

Variants for ZNF273 Gene

Sequence variations from dbSNP and Humsavar for ZNF273 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000007024 -- 64,915,091(+) A/G intron_variant
rs1000034218 -- 64,932,074(+) A/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000070898 -- 64,915,632(+) G/A intron_variant
rs1000148153 -- 64,894,595(+) /C genic_upstream_transcript_variant, intron_variant
rs1000197860 -- 64,893,125(+) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF273 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv226e55 CNV loss 17911159
dgv3575n106 CNV deletion 24896259
esv2422405 CNV duplication 17116639
esv2677316 CNV deletion 23128226
esv3541778 CNV deletion 23714750
nsv1018967 CNV gain 25217958
nsv1019180 CNV loss 25217958
nsv1022042 CNV gain 25217958
nsv1026390 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv508457 CNV deletion 20534489
nsv510085 OTHER sequence alteration 20534489
nsv607312 CNV gain 21841781
nsv970504 CNV duplication 23825009
nsv981497 CNV duplication 23825009

Variation tolerance for ZNF273 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.21; 90.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF273 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF273 Gene

Disorders for ZNF273 Gene

Additional Disease Information for ZNF273

No disorders were found for ZNF273 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF273 Gene

Publications for ZNF273 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF273 Gene

Sources for ZNF273 Gene

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