Aliases for ZNF267 Gene

Aliases for ZNF267 Gene

  • Zinc Finger Protein 267 2 3 4 5
  • Zinc Finger Protein HZF2 3 4
  • HZF2 2 3
  • Zinc Finger Protein 2 3
  • Zinc Finger (C2H2) 3
  • ZNF267 5

External Ids for ZNF267 Gene

Previous GeneCards Identifiers for ZNF267 Gene

  • GC16P030966
  • GC16P032222
  • GC16P031723
  • GC16P031760
  • GC16P031633
  • GC16P031792
  • GC16P029445

Summaries for ZNF267 Gene

GeneCards Summary for ZNF267 Gene

ZNF267 (Zinc Finger Protein 267) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF836.

UniProtKB/Swiss-Prot Summary for ZNF267 Gene

Gene Wiki entry for ZNF267 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF267 Gene

Genomics for ZNF267 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF267 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J031873 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 627.8 +2.4 2360 6.7 SP1 GATAD2A PRDM10 ZNF629 ZNF692 POLR2A RCOR2 BACH1 FOS LARP7 ZNF267 piR-52249 ARMC5 CLUHP3 ENSG00000259950 lnc-C16orf58-12 TP53TG3D
GH16J031879 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 20.5 +6.7 6734 2 ZNF629 RFX1 LEF1 IKZF1 ZNF692 POLR2A BACH1 JUND ZIC2 PKNOX1 ZNF267 ARMC5 CLUHP3 piR-52249 ENSG00000259950 lnc-C16orf58-12 TP53TG3D
GH16J031868 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.1 -4.0 -4030 2.4 CTCF PRDM10 ZNF629 PRDM1 REST RAD21 IKZF2 TRIM22 YY1 IRF3 ENSG00000259874 lnc-C16orf58-11 ZNF267 CLUHP3 ARMC5 lnc-ZNF267-2 VN1R3
GH16J031894 Enhancer 0.4 FANTOM5 dbSUPER 6.6 +20.8 20773 0.4 ENSG00000259950 LOC100422713 lnc-C16orf58-12 ZNF267 CLUHP3 piR-52249 TP53TG3D
GH16J031871 Promoter/Enhancer 0.8 Ensembl dbSUPER 0.7 -2.2 -2206 0.4 ZNF316 MAFF MAFK EMSY ENSG00000259874 lnc-C16orf58-11 CLUHP3 ZNF267 VN1R3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF267 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF267

Top Transcription factor binding sites by QIAGEN in the ZNF267 gene promoter:
  • AML1a
  • C/EBPalpha
  • En-1
  • GATA-1
  • Gfi-1
  • HTF
  • MRF-2
  • Nkx2-5
  • p53
  • XBP-1

Genomic Locations for ZNF267 Gene

Genomic Locations for ZNF267 Gene
43,551 bases
Plus strand
43,590 bases
Plus strand

Genomic View for ZNF267 Gene

Genes around ZNF267 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF267 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF267 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF267 Gene

Proteins for ZNF267 Gene

  • Protein details for ZNF267 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 267
    Protein Accession:
    Secondary Accessions:
    • A0JNZ9
    • Q8NE41
    • Q9NRJ0

    Protein attributes for ZNF267 Gene

    743 amino acids
    Molecular mass:
    87376 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF267 Gene

Post-translational modifications for ZNF267 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF267 Gene

No data available for DME Specific Peptides for ZNF267 Gene

Domains & Families for ZNF267 Gene

Gene Families for ZNF267 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF267 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF267 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein HZF2 (ZN267_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF267: view

Function for ZNF267 Gene

Molecular function for ZNF267 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0003700 DNA-binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF267: view
genes like me logo Genes that share phenotypes with ZNF267: view

Animal Model Products

CRISPR Products

miRNA for ZNF267 Gene

miRTarBase miRNAs that target ZNF267

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF267

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF267 Gene

Localization for ZNF267 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF267 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF267 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF267: view

Pathways & Interactions for ZNF267 Gene

genes like me logo Genes that share pathways with ZNF267: view

Pathways by source for ZNF267 Gene

2 Reactome pathways for ZNF267 Gene
1 KEGG pathway for ZNF267 Gene

Gene Ontology (GO) - Biological Process for ZNF267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS 7865130
genes like me logo Genes that share ontologies with ZNF267: view

No data available for SIGNOR curated interactions for ZNF267 Gene

Drugs & Compounds for ZNF267 Gene

No Compound Related Data Available

Transcripts for ZNF267 Gene

mRNA/cDNA for ZNF267 Gene

13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF267

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF267 Gene

No ASD Table

Relevant External Links for ZNF267 Gene

GeneLoc Exon Structure for

Expression for ZNF267 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF267 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF267 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF267 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF267 Gene

Protein tissue co-expression partners for ZNF267 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF267

SOURCE GeneReport for Unigene cluster for ZNF267 Gene:

genes like me logo Genes that share expression patterns with ZNF267: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF267 Gene

Orthologs for ZNF267 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF267 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF267 30 31
  • 99.46 (n)
(Mus musculus)
Mammalia D3Ertd254e 30
  • 60.59 (n)
Gm19965 31
  • 26 (a)
Zfp267 17
(Rattus norvegicus)
Mammalia LOC100359945 30
  • 59.36 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
-- 31
  • 43 (a)
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Kr-h1 32
  • 47 (a)
CG18262 32
  • 46 (a)
Cf2 32
  • 45 (a)
CG3281 32
  • 37 (a)
CG17612 32
  • 30 (a)
Species where no ortholog for ZNF267 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF267 Gene

Gene Tree for ZNF267 (if available)
Gene Tree for ZNF267 (if available)
Evolutionary constrained regions (ECRs) for ZNF267: view image

Paralogs for ZNF267 Gene

Paralogs for ZNF267 Gene

(510) SIMAP similar genes for ZNF267 Gene using alignment to 5 proteins:

  • ZN267_HUMAN
  • I3L4I6_HUMAN Pseudogenes for ZNF267 Gene

genes like me logo Genes that share paralogs with ZNF267: view

Variants for ZNF267 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF267 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs3850114 - p.Cys350Tyr
rs7202455 - p.Met257Val

Additional dbSNP identifiers (rs#s) for ZNF267 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF267 Gene

Variant ID Type Subtype PubMed ID
dgv50e203 CNV gain+loss 21179565
esv2375355 CNV deletion 18987734
esv2640928 CNV deletion 19546169
esv2666562 CNV deletion 23128226
esv29641 CNV loss 19812545
esv3570465 CNV gain 25503493
esv3638413 CNV loss 21293372
nsv1113783 CNV deletion 24896259
nsv428325 CNV gain+loss 18775914
nsv475846 CNV novel sequence insertion 20440878
nsv833196 CNV gain 17160897

Variation tolerance for ZNF267 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF267 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF267 Gene

Disorders for ZNF267 Gene

No disorders were found for ZNF267 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF267 Gene

Publications for ZNF267 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4
  2. Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y. (PMID: 15814297) Hu K … Schnabl B (Biochimica et biophysica acta 2005) 3 23
  3. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. (PMID: 16054593) Schnabl B … Schölmerich J (Biochemical and biophysical research communications 2005) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZNF267 Gene

Sources for ZNF267 Gene