This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for t... See more...

Aliases for ZNF266 Gene

Aliases for ZNF266 Gene

  • Zinc Finger Protein 266 2 3 4 5
  • Zinc Finger Protein HZF1 3 4
  • HZF1 2 3
  • Zinc Finger Protein 1 3
  • KIAA2007 4
  • ZNF266 5

External Ids for ZNF266 Gene

Previous GeneCards Identifiers for ZNF266 Gene

  • GC19M009644
  • GC19M009745
  • GC19M009368
  • GC19M009384
  • GC19M009267
  • GC19M009523
  • GC19M009104

Summaries for ZNF266 Gene

Entrez Gene Summary for ZNF266 Gene

  • This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF266 Gene

ZNF266 (Zinc Finger Protein 266) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF560.

UniProtKB/Swiss-Prot Summary for ZNF266 Gene

Additional gene information for ZNF266 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF266 Gene

Genomics for ZNF266 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF266 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009434 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 709.5 +0.2 178 2.8 CREB1 GATAD2A CTCF ATF7 ZNF629 NFKBIZ ZNF692 POLR2A JUND FOXA1 ZNF266 LOC105372269 lnc-ZNF266-2 HE855992 ZNF177
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 96.5 -985.3 -985338 10.6 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PDE4A CDC37 ILF3 ZNF266 KRI1 LOC100419831 DNMT1 RAVER1 FBXL12 PPAN
GH19J009418 Promoter 0.3 EPDnew 600.4 +17.0 16978 0.1 ZNF266 HE855992 LOC112268250 ZNF177
GH19J009406 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 127.2 +28.3 28277 2.2 IKZF1 GABPA PKNOX1 PATZ1 NR2C1 HDAC1 MGA SP2 CBX3 NKRF ENSG00000283108 LOC112268250 ZNF266 ICAM1 ZNF177
GH19J009323 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 79.2 +111.3 111277 3 BRCA1 SP1 CTCF PRDM10 IKZF1 POLR2A FOXA1 PHF21A RBFOX2 PKNOX1 ZNF559 NONHSAG024732.2 ZNF559-ZNF177 piR-39487 piR-49398 ZNF177 ZNF266 lnc-ZNF177-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF266 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF266

Top Transcription factor binding sites by QIAGEN in the ZNF266 gene promoter:
  • Nkx6-1

Genomic Locations for ZNF266 Gene

Genomic Locations for ZNF266 Gene
chr19:9,412,426-9,435,578
(GRCh38/hg38)
Size:
23,153 bases
Orientation:
Minus strand
chr19:9,523,271-9,546,254
(GRCh37/hg19)
Size:
22,984 bases
Orientation:
Minus strand

Genomic View for ZNF266 Gene

Genes around ZNF266 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF266 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF266 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF266 Gene

Proteins for ZNF266 Gene

  • Protein details for ZNF266 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14584-ZN266_HUMAN
    Recommended name:
    Zinc finger protein 266
    Protein Accession:
    Q14584
    Secondary Accessions:
    • A0AV90
    • A4FU85
    • Q6IQ07
    • Q6U8A5
    • Q8IVG3
    • Q8WVX1
    • Q96SX9

    Protein attributes for ZNF266 Gene

    Size:
    549 amino acids
    Molecular mass:
    62116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK027480; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AK027480; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAC23104.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF266 Gene

Post-translational modifications for ZNF266 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF266 Gene

Domains & Families for ZNF266 Gene

Gene Families for ZNF266 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF266 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF266 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein HZF1 (ZN266_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14584

UniProtKB/Swiss-Prot:

ZN266_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF266: view

Function for ZNF266 Gene

Molecular function for ZNF266 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF266 Gene

Gene Ontology (GO) - Molecular Function for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF266: view
genes like me logo Genes that share phenotypes with ZNF266: view

Animal Models for ZNF266 Gene

MGI Knock Outs for ZNF266:
  • Zfp266 Zfp266<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF266

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF266 Gene

Localization for ZNF266 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF266 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF266 gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (4)
  • Nucleoplasm (2)
  • Rods & Rings (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF266: view

Pathways & Interactions for ZNF266 Gene

PathCards logo

SuperPathways for ZNF266 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF266: view

Pathways by source for ZNF266 Gene

2 Reactome pathways for ZNF266 Gene

Gene Ontology (GO) - Biological Process for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF266: view

No data available for SIGNOR curated interactions for ZNF266 Gene

Drugs & Compounds for ZNF266 Gene

No Compound Related Data Available

Transcripts for ZNF266 Gene

mRNA/cDNA for ZNF266 Gene

30 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF266

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF266 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - -
SP8:
SP9: - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - -
SP14:
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -

ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - -
SP17:

Relevant External Links for ZNF266 Gene

GeneLoc Exon Structure for
ZNF266

Expression for ZNF266 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF266 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF266

SOURCE GeneReport for Unigene cluster for ZNF266 Gene:

Hs.656185

Evidence on tissue expression from TISSUES for ZNF266 Gene

  • Nervous system(4.6)
  • Skin(4.4)
  • Eye(4.1)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with ZNF266: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF266 Gene

Orthologs for ZNF266 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF266 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF266 30 31
  • 99.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp266 30 17
  • 65.91 (n)
Zfp846 31
  • 43 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Zfp266 30
  • 65.4 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 46 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 36 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG10274 32
  • 38 (a)
D19A 32
  • 34 (a)
Species where no ortholog for ZNF266 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF266 Gene

ENSEMBL:
Gene Tree for ZNF266 (if available)
TreeFam:
Gene Tree for ZNF266 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF266: view image

Paralogs for ZNF266 Gene

(467) SIMAP similar genes for ZNF266 Gene using alignment to 2 proteins:

  • ZN266_HUMAN
  • K7EQP7_HUMAN
genes like me logo Genes that share paralogs with ZNF266: view

Variants for ZNF266 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF266 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10515 - p.Pro519Leu

Additional dbSNP identifiers (rs#s) for ZNF266 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF266 Gene

Variant ID Type Subtype PubMed ID
nsv2412 CNV deletion 18451855

Variation tolerance for ZNF266 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF266 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF266

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF266 Gene

Disorders for ZNF266 Gene

Additional Disease Information for ZNF266

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF266 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF266 Gene

Publications for ZNF266 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4
  2. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PMID: 19763908) Deng MJ … Zhang JW (Molecular biotechnology 2010) 3 23
  3. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PMID: 20601676) Fransen K … Weersma RK (Human molecular genetics 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZNF266 Gene

  • Signalway Proteins for ZNF266

Sources for ZNF266 Gene