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Aliases for ZNF266 Gene

Aliases for ZNF266 Gene

  • Zinc Finger Protein 266 2 3 5
  • Zinc Finger Protein HZF1 3 4
  • Zinc Finger Protein 1 3
  • KIAA2007 4
  • HZF1 3

External Ids for ZNF266 Gene

Previous GeneCards Identifiers for ZNF266 Gene

  • GC19M009644
  • GC19M009745
  • GC19M009368
  • GC19M009267
  • GC19M009523
  • GC19M009104

Summaries for ZNF266 Gene

Entrez Gene Summary for ZNF266 Gene

  • This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF266 Gene

ZNF266 (Zinc Finger Protein 266) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF426.

UniProtKB/Swiss-Prot for ZNF266 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF266 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF266 Gene

Genomics for ZNF266 Gene

GeneHancer (GH) Regulatory Elements for ZNF266 Gene

Promoters and enhancers for ZNF266 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I009434 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 659.6 +0.1 98 2.4 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF266 LOC105372269 GC19P009427
GH19I009418 Promoter 0.5 EPDnew 550.4 +17.0 16978 0.1 ZNF266 GC19P009427 ENSG00000283108
GH19I009406 Promoter/Enhancer 1.3 Ensembl ENCODE 127.2 +28.6 28577 1.6 HDAC1 PKNOX1 ATF1 ZBTB40 CBX5 E2F8 ATF7 CREM SP3 NCOA1 ENSG00000283108 ZNF266 ICAM1 PIR33278
GH19I009323 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 79.2 +111.4 111418 2.1 PKNOX1 ATF1 ARID4B SIN3A BRCA1 YY1 GTF3C2 POLR2B KLF7 FOS ZNF559 GC19M009325 PIR42397 ZNF559-ZNF177 PIR62532 ZNF266 GC19M009317
GH19I010415 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 52.9 -981.1 -981068 2 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC PDE4A LOC100419831 ZNF266 KRI1 ILF3 RAVER1 FBXL12 PPAN ZNF561 DNMT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF266 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF266 gene promoter:

Genomic Locations for ZNF266 Gene

Genomic Locations for ZNF266 Gene
23,153 bases
Minus strand

Genomic View for ZNF266 Gene

Genes around ZNF266 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF266 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF266 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF266 Gene

Proteins for ZNF266 Gene

  • Protein details for ZNF266 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 266
    Protein Accession:
    Secondary Accessions:
    • A0AV90
    • A4FU85
    • Q6IQ07
    • Q6U8A5
    • Q8IVG3
    • Q8WVX1
    • Q96SX9

    Protein attributes for ZNF266 Gene

    549 amino acids
    Molecular mass:
    62116 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK027480; Type=Erroneous termination; Positions=536; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK027480; Type=Frameshift; Positions=461; Evidence={ECO:0000305}; Sequence=BAC23104.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF266 Gene

Post-translational modifications for ZNF266 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF266 Gene

Domains & Families for ZNF266 Gene

Gene Families for ZNF266 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF266 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF266: view

Function for ZNF266 Gene

Molecular function for ZNF266 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF266 Gene

Gene Ontology (GO) - Molecular Function for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF266: view
genes like me logo Genes that share phenotypes with ZNF266: view

Animal Models for ZNF266 Gene

MGI Knock Outs for ZNF266:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF266 Gene

Localization for ZNF266 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF266 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF266 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (4)
  • Nucleus (2)
  • Rods & Rings (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF266: view

Pathways & Interactions for ZNF266 Gene

SuperPathways for ZNF266 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF266: view

Pathways by source for ZNF266 Gene

2 Reactome pathways for ZNF266 Gene

Gene Ontology (GO) - Biological Process for ZNF266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF266: view

No data available for SIGNOR curated interactions for ZNF266 Gene

Drugs & Compounds for ZNF266 Gene

No Compound Related Data Available

Transcripts for ZNF266 Gene

Unigene Clusters for ZNF266 Gene

Zinc finger protein 266:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF266 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - -
SP9: - - - - - - - - - -
SP10: -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - -
SP15: - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - -

ExUns: 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP16: - - -

Relevant External Links for ZNF266 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF266 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF266 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF266 Gene:


SOURCE GeneReport for Unigene cluster for ZNF266 Gene:


Evidence on tissue expression from TISSUES for ZNF266 Gene

  • Nervous system(4.6)
  • Skin(4.3)
  • Eye(4.1)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with ZNF266: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF266 Gene

Orthologs for ZNF266 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF266 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF266 33 34
  • 99.27 (n)
(Mus musculus)
Mammalia Zfp266 33 16
  • 65.91 (n)
Zfp846 34
  • 43 (a)
(Rattus norvegicus)
Mammalia Zfp266 33
  • 65.4 (n)
(Canis familiaris)
Mammalia -- 34
  • 46 (a)
(Bos Taurus)
Mammalia -- 34
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10274 35
  • 38 (a)
D19A 35
  • 34 (a)
Species where no ortholog for ZNF266 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF266 Gene

Gene Tree for ZNF266 (if available)
Gene Tree for ZNF266 (if available)

Paralogs for ZNF266 Gene

Paralogs for ZNF266 Gene

(467) SIMAP similar genes for ZNF266 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF266: view

Variants for ZNF266 Gene

Sequence variations from dbSNP and Humsavar for ZNF266 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000051022 -- 9,433,810(-) A/C intron_variant
rs1000112821 -- 9,420,207(-) G/T 5_prime_UTR_variant
rs1000181362 -- 9,425,905(-) G/T intron_variant
rs1000236665 -- 9,412,574(-) T/ 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000364053 -- 9,425,278(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF266 Gene

Variant ID Type Subtype PubMed ID
nsv2412 CNV deletion 18451855

Variation tolerance for ZNF266 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF266 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF266 Gene

Disorders for ZNF266 Gene

Additional Disease Information for ZNF266

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF266 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF266 Gene

Publications for ZNF266 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4 58
  2. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PMID: 19763908) Deng MJ … Zhang JW (Molecular biotechnology 2010) 3 22 58
  3. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PMID: 20601676) Fransen K … Weersma RK (Human molecular genetics 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF266 Gene

Sources for ZNF266 Gene

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