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Aliases for ZNF264 Gene

Aliases for ZNF264 Gene

  • Zinc Finger Protein 264 2 3 5
  • KIAA0412 4

External Ids for ZNF264 Gene

Previous GeneCards Identifiers for ZNF264 Gene

  • GC19P058601
  • GC19P058156
  • GC19P062378
  • GC19P062394
  • GC19P057702
  • GC19P054015

Summaries for ZNF264 Gene

Entrez Gene Summary for ZNF264 Gene

  • This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZNF264 Gene

ZNF264 (Zinc Finger Protein 264) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot for ZNF264 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF264 Gene

Additional gene information for ZNF264 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF264 Gene

Genomics for ZNF264 Gene

GeneHancer (GH) Regulatory Elements for ZNF264 Gene

Promoters and enhancers for ZNF264 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057190 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 561.9 +0.3 308 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 CBX5 ZNF207 ZNF143 KLF7 ZNF264 ZNF548 ZNF417 ZNF134 ZNF274 AURKC ZNF773 ZNF550 ZIM3 ZNF805
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 81.3 -596.0 -596039 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 68 +991.8 991757 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I057809 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 50.1 +621.7 621739 7.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF552 TRIM28 ZNF264 ZNF805 ZNF543 ENSG00000269867 ZNF134 ZNF587 ZNF324B ZNF586
GH19I057239 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 43.8 +49.7 49669 2.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 ZNF805 ZNF264 ZNF543 ZNF274 ZNF548 ZNF417 AURKC ZNF471 ZNF134 ZNF550
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF264 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF264 gene promoter:

Genomic Locations for ZNF264 Gene

Genomic Locations for ZNF264 Gene
31,368 bases
Plus strand

Genomic View for ZNF264 Gene

Genes around ZNF264 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF264 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF264 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF264 Gene

Proteins for ZNF264 Gene

  • Protein details for ZNF264 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 264
    Protein Accession:
    Secondary Accessions:
    • A8K8Y9
    • Q9P1V0

    Protein attributes for ZNF264 Gene

    627 amino acids
    Molecular mass:
    70587 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA24842.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF264 Gene

Post-translational modifications for ZNF264 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF264 Gene

No data available for DME Specific Peptides for ZNF264 Gene

Domains & Families for ZNF264 Gene

Gene Families for ZNF264 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF264 Gene

Suggested Antigen Peptide Sequences for ZNF264 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF264: view

Function for ZNF264 Gene

Molecular function for ZNF264 Gene

GENATLAS Biochemistry:
Kruppel-related zinc finger protein 264 ,Kruppel related
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF264 Gene

Gene Ontology (GO) - Molecular Function for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF264: view
genes like me logo Genes that share phenotypes with ZNF264: view

Animal Model Products

CRISPR Products

miRNA for ZNF264 Gene

miRTarBase miRNAs that target ZNF264
Targeted motifs for ZNF264 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF264
  • Consensus sequence: RGGGCACTAACY Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF264 Gene

Localization for ZNF264 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF264 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF264 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF264: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF264 Gene

Pathways & Interactions for ZNF264 Gene

SuperPathways for ZNF264 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF264: view

Pathways by source for ZNF264 Gene

2 Reactome pathways for ZNF264 Gene

Gene Ontology (GO) - Biological Process for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF264: view

No data available for SIGNOR curated interactions for ZNF264 Gene

Drugs & Compounds for ZNF264 Gene

No Compound Related Data Available

Transcripts for ZNF264 Gene

Unigene Clusters for ZNF264 Gene

Zinc finger protein 264:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF264 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for ZNF264 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF264 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF264 Gene

Protein differential expression in normal tissues from HIPED for ZNF264 Gene

This gene is overexpressed in CD8 Tcells (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF264 Gene

Protein tissue co-expression partners for ZNF264 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF264 Gene:


SOURCE GeneReport for Unigene cluster for ZNF264 Gene:


mRNA Expression by UniProt/SwissProt for ZNF264 Gene:

Tissue specificity: Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.

Evidence on tissue expression from TISSUES for ZNF264 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF264: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF264 Gene

Orthologs for ZNF264 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF264 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF264 33 34
  • 99.2 (n)
(Canis familiaris)
Mammalia ZNF264 33 34
  • 85.62 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
(Danio rerio)
Actinopterygii si:dkey-7j22.3 34
  • 52 (a)
CU138542.3 34
  • 43 (a)
Species where no ortholog for ZNF264 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF264 Gene

Gene Tree for ZNF264 (if available)
Gene Tree for ZNF264 (if available)

Paralogs for ZNF264 Gene

Paralogs for ZNF264 Gene

(499) SIMAP similar genes for ZNF264 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF264: view

Variants for ZNF264 Gene

Sequence variations from dbSNP and Humsavar for ZNF264 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000200469 -- 57,190,972(+) G/T upstream_transcript_variant
rs1000206519 -- 57,195,919(+) A/G intron_variant
rs1000223729 -- 57,203,983(+) G/A intron_variant
rs1000328406 -- 57,195,987(+) A/T intron_variant
rs1000411689 -- 57,201,397(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF264 Gene

Variant ID Type Subtype PubMed ID
dgv1093e212 CNV loss 25503493
dgv1094e212 CNV loss 25503493
esv2662848 CNV deletion 23128226
esv2663783 CNV deletion 23128226
esv3644896 CNV gain 21293372
esv3644897 CNV loss 21293372
esv3644898 CNV loss 21293372
esv3893256 CNV loss 25118596
nsv1064109 CNV gain 25217958
nsv580400 CNV gain 21841781

Variation tolerance for ZNF264 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF264 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF264 Gene

Disorders for ZNF264 Gene

Additional Disease Information for ZNF264

No disorders were found for ZNF264 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF264 Gene

Publications for ZNF264 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF264 Gene

Sources for ZNF264 Gene

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