This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010] See more...

Aliases for ZNF264 Gene

Aliases for ZNF264 Gene

  • Zinc Finger Protein 264 2 3 4 5
  • KIAA0412 2 4
  • ZNF264 5

External Ids for ZNF264 Gene

Previous GeneCards Identifiers for ZNF264 Gene

  • GC19P058601
  • GC19P058156
  • GC19P062378
  • GC19P062394
  • GC19P057702
  • GC19P054015

Summaries for ZNF264 Gene

Entrez Gene Summary for ZNF264 Gene

  • This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZNF264 Gene

ZNF264 (Zinc Finger Protein 264) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF805.

UniProtKB/Swiss-Prot Summary for ZNF264 Gene

Gene Wiki entry for ZNF264 Gene

Additional gene information for ZNF264 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF264 Gene

Genomics for ZNF264 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF264 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF264 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF264

Top Transcription factor binding sites by QIAGEN in the ZNF264 gene promoter:
  • FAC1
  • GATA-1
  • GATA-2
  • GATA-3
  • Hlf
  • Meis-1a
  • Meis-1b
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for ZNF264 Gene

Genomic Locations for ZNF264 Gene
chr19:57,191,500-57,222,846
(GRCh38/hg38)
Size:
31,347 bases
Orientation:
Plus strand
chr19:57,702,868-57,734,214
(GRCh37/hg19)
Size:
31,347 bases
Orientation:
Plus strand

Genomic View for ZNF264 Gene

Genes around ZNF264 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF264 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF264 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF264 Gene

Proteins for ZNF264 Gene

  • Protein details for ZNF264 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43296-ZN264_HUMAN
    Recommended name:
    Zinc finger protein 264
    Protein Accession:
    O43296
    Secondary Accessions:
    • A8K8Y9
    • Q9P1V0

    Protein attributes for ZNF264 Gene

    Size:
    627 amino acids
    Molecular mass:
    70587 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24842.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF264 Gene

Post-translational modifications for ZNF264 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF264 Gene

No data available for DME Specific Peptides for ZNF264 Gene

Domains & Families for ZNF264 Gene

Gene Families for ZNF264 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF264 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF264 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 264, isoform CRA_a (Q14C61_HUMAN)
  • Zinc finger protein 264 (ZN264_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43296

UniProtKB/Swiss-Prot:

ZN264_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF264: view

Function for ZNF264 Gene

Molecular function for ZNF264 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
Kruppel-related zinc finger protein 264 ,Kruppel related

Phenotypes From GWAS Catalog for ZNF264 Gene

Gene Ontology (GO) - Molecular Function for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 28514442
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF264: view
genes like me logo Genes that share phenotypes with ZNF264: view

Animal Model Products

CRISPR Products

miRNA for ZNF264 Gene

miRTarBase miRNAs that target ZNF264
Targeted motifs for ZNF264 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF264
  • Consensus sequence: RGGGCACTAACY Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF264

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF264 Gene

Localization for ZNF264 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF264 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF264 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF264: view

Pathways & Interactions for ZNF264 Gene

genes like me logo Genes that share pathways with ZNF264: view

Pathways by source for ZNF264 Gene

2 Reactome pathways for ZNF264 Gene
1 KEGG pathway for ZNF264 Gene

Gene Ontology (GO) - Biological Process for ZNF264 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF264: view

No data available for SIGNOR curated interactions for ZNF264 Gene

Drugs & Compounds for ZNF264 Gene

No Compound Related Data Available

Transcripts for ZNF264 Gene

mRNA/cDNA for ZNF264 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF264

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF264 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for ZNF264 Gene

GeneLoc Exon Structure for
ZNF264

Expression for ZNF264 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF264 Gene

Protein differential expression in normal tissues from HIPED for ZNF264 Gene

This gene is overexpressed in CD8 Tcells (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF264 Gene



Protein tissue co-expression partners for ZNF264 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF264

SOURCE GeneReport for Unigene cluster for ZNF264 Gene:

Hs.515634

mRNA Expression by UniProt/SwissProt for ZNF264 Gene:

O43296-ZN264_HUMAN
Tissue specificity: Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.

Evidence on tissue expression from TISSUES for ZNF264 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF264: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF264 Gene

Orthologs for ZNF264 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF264 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF264 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF264 30 31
  • 85.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-7j22.3 31
  • 52 (a)
ManyToMany
CU138542.3 31
  • 43 (a)
ManyToMany
Species where no ortholog for ZNF264 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF264 Gene

ENSEMBL:
Gene Tree for ZNF264 (if available)
TreeFam:
Gene Tree for ZNF264 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF264: view image

Paralogs for ZNF264 Gene

(499) SIMAP similar genes for ZNF264 Gene using alignment to 6 proteins:

  • ZN264_HUMAN
  • M0QXF3_HUMAN
  • M0QZJ4_HUMAN
  • M0QZT5_HUMAN
  • M0R146_HUMAN
  • Q14C61_HUMAN
genes like me logo Genes that share paralogs with ZNF264: view

Variants for ZNF264 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF264 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2074858 - p.Arg181Thr
rs917340 - p.Arg183His

Additional dbSNP identifiers (rs#s) for ZNF264 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF264 Gene

Variant ID Type Subtype PubMed ID
dgv1093e212 CNV loss 25503493
dgv1094e212 CNV loss 25503493
esv2662848 CNV deletion 23128226
esv2663783 CNV deletion 23128226
esv3644896 CNV gain 21293372
esv3644897 CNV loss 21293372
esv3644898 CNV loss 21293372
esv3893256 CNV loss 25118596
nsv1064109 CNV gain 25217958
nsv580400 CNV gain 21841781

Variation tolerance for ZNF264 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF264 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF264

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF264 Gene

Disorders for ZNF264 Gene

Additional Disease Information for ZNF264

No disorders were found for ZNF264 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF264 Gene

Publications for ZNF264 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF264 Gene

Sources for ZNF264 Gene