Aliases for ZNF263 Gene

Aliases for ZNF263 Gene

  • Zinc Finger Protein 263 2 3 4 5
  • Zinc Finger Protein With KRAB And SCAN Domains 12 3 4
  • Zinc Finger Protein FPM315 3 4
  • ZKSCAN12 3 4
  • FPM315 3 4
  • ZSCAN44 3

External Ids for ZNF263 Gene

Previous GeneCards Identifiers for ZNF263 Gene

  • GC16P003354
  • GC16P003333
  • GC16P003273
  • GC16P003319
  • GC16P003272
  • GC16P003774
  • GC16P003852
  • GC16P003902
  • GC16P003299
  • GC16P003335
  • GC16P003344
  • GC16P003403
  • GC16P003453
  • GC16P003484
  • GC16P003572
  • GC16P003619

Summaries for ZNF263 Gene

GeneCards Summary for ZNF263 Gene

ZNF263 (Zinc Finger Protein 263) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZKSCAN4.

UniProtKB/Swiss-Prot Summary for ZNF263 Gene

  • Might play an important role in basic cellular processes as a transcriptional repressor.

Additional gene information for ZNF263 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF263 Gene

Genomics for ZNF263 Gene

GeneHancer (GH) Regulatory Elements for ZNF263 Gene

Promoters and enhancers for ZNF263 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF263 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF263

Top Transcription factor binding sites by QIAGEN in the ZNF263 gene promoter:
  • AML1a
  • ATF-2
  • c-Jun
  • C/EBPbeta

Genomic Locations for ZNF263 Gene

Genomic Locations for ZNF263 Gene
chr16:3,263,800-3,301,401
(GRCh38/hg38)
Size:
37,602 bases
Orientation:
Plus strand
chr16:3,313,743-3,351,401
(GRCh37/hg19)
Size:
37,659 bases
Orientation:
Plus strand

Genomic View for ZNF263 Gene

Genes around ZNF263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF263 Gene

Proteins for ZNF263 Gene

  • Protein details for ZNF263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14978-ZN263_HUMAN
    Recommended name:
    Zinc finger protein 263
    Protein Accession:
    O14978
    Secondary Accessions:
    • B2R634
    • O43387
    • Q96H95

    Protein attributes for ZNF263 Gene

    Size:
    683 amino acids
    Molecular mass:
    77299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF263 Gene

Post-translational modifications for ZNF263 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF263 Gene

Domains & Families for ZNF263 Gene

Gene Families for ZNF263 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF263 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF263 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57935, highly similar to Zinc finger protein 263 (B4DI05_HUMAN)
  • Zinc finger protein 263, isoform CRA_a (D3DUC1_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 12 (ZN263_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14978

UniProtKB/Swiss-Prot:

ZN263_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF263: view

Function for ZNF263 Gene

Molecular function for ZNF263 Gene

UniProtKB/Swiss-Prot Function:
Might play an important role in basic cellular processes as a transcriptional repressor.
GENATLAS Biochemistry:
zinc finger protein 263

Phenotypes From GWAS Catalog for ZNF263 Gene

Gene Ontology (GO) - Molecular Function for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS,IEA 9256059
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNF263: view
genes like me logo Genes that share phenotypes with ZNF263: view

Animal Model Products

CRISPR Products

miRNA for ZNF263 Gene

miRTarBase miRNAs that target ZNF263
Targeted motifs for ZNF263 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF263
  • Consensus sequence: CNGTCCTCCC Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF263

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF263 Gene

Localization for ZNF263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF263 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF263 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitotic spindle (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF263: view

Pathways & Interactions for ZNF263 Gene

PathCards logo

SuperPathways for ZNF263 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF263: view

Pathways by source for ZNF263 Gene

2 Reactome pathways for ZNF263 Gene

Gene Ontology (GO) - Biological Process for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19887448
GO:0006355 regulation of transcription, DNA-templated IEA,TAS 9256059
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF263: view

No data available for SIGNOR curated interactions for ZNF263 Gene

Drugs & Compounds for ZNF263 Gene

No Compound Related Data Available

Transcripts for ZNF263 Gene

mRNA/cDNA for ZNF263 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF263

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF263 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - - - -
SP3: - -
SP4: - - - - -

Relevant External Links for ZNF263 Gene

GeneLoc Exon Structure for
ZNF263

Expression for ZNF263 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF263 Gene

Protein differential expression in normal tissues from HIPED for ZNF263 Gene

This gene is overexpressed in Nasal epithelium (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF263 Gene



Protein tissue co-expression partners for ZNF263 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF263

SOURCE GeneReport for Unigene cluster for ZNF263 Gene:

Hs.611475

mRNA Expression by UniProt/SwissProt for ZNF263 Gene:

O14978-ZN263_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Evidence on tissue expression from TISSUES for ZNF263 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF263: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF263 Gene

Orthologs for ZNF263 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF263 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF263 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF263 31 30
  • 90.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF263 31 30
  • 89.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp263 17 31 30
  • 84.74 (n)
rat
(Rattus norvegicus)
Mammalia Zfp263 30
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF263 31
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 32 (a)
OneToMany
-- 31
  • 31 (a)
OneToMany
Species where no ortholog for ZNF263 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF263 Gene

ENSEMBL:
Gene Tree for ZNF263 (if available)
TreeFam:
Gene Tree for ZNF263 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF263: view image

Paralogs for ZNF263 Gene

(520) SIMAP similar genes for ZNF263 Gene using alignment to 9 proteins:

  • ZN263_HUMAN
  • B4DI05_HUMAN
  • D3DUC1_HUMAN
  • I3L0N0_HUMAN
  • I3L2X3_HUMAN
  • I3L393_HUMAN
  • I3L4C4_HUMAN
  • I3L538_HUMAN
  • I3NI39_HUMAN
genes like me logo Genes that share paralogs with ZNF263: view

Variants for ZNF263 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF263 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
711958 Benign: not provided 3,298,985(+) T/C MISSENSE_VARIANT
711959 Benign: not provided 3,300,180(+) G/C SYNONYMOUS_VARIANT
768743 Benign: not provided 3,300,078(+) T/C SYNONYMOUS_VARIANT
rs220379 - p.Cys310Ser
rs34236132 - p.Val534Ile

Additional dbSNP identifiers (rs#s) for ZNF263 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF263 Gene

Variant ID Type Subtype PubMed ID
esv3892760 CNV loss 25118596
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958

Variation tolerance for ZNF263 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF263 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF263

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF263 Gene

Disorders for ZNF263 Gene

Additional Disease Information for ZNF263

No disorders were found for ZNF263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF263 Gene

Publications for ZNF263 Gene

  1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. (PMID: 9256059) Yokoyama M … Fukushima A (Biochimica et biophysica acta 1997) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54

Products for ZNF263 Gene

Sources for ZNF263 Gene