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Aliases for ZNF263 Gene

Aliases for ZNF263 Gene

  • Zinc Finger Protein 263 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 12 3 4
  • Zinc Finger Protein FPM315 3 4
  • ZKSCAN12 3 4
  • FPM315 3 4
  • ZSCAN44 3

External Ids for ZNF263 Gene

Previous GeneCards Identifiers for ZNF263 Gene

  • GC16P003354
  • GC16P003333
  • GC16P003273
  • GC16P003319
  • GC16P003272
  • GC16P003299
  • GC16P003335
  • GC16P003344
  • GC16P003403
  • GC16P003453

Summaries for ZNF263 Gene

GeneCards Summary for ZNF263 Gene

ZNF263 (Zinc Finger Protein 263) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZKSCAN5.

UniProtKB/Swiss-Prot for ZNF263 Gene

  • Might play an important role in basic cellular processes as a transcriptional repressor.

Additional gene information for ZNF263 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF263 Gene

Genomics for ZNF263 Gene

GeneHancer (GH) Regulatory Elements for ZNF263 Gene

Promoters and enhancers for ZNF263 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I003281 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.8 +19.8 19782 3.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF263 ZNF75A TIGD7 CLUAP1 ZNF213-AS1 MTCO1P28 FLYWCH1 MTND1P8 ZSCAN32 MMP25
GH16I003262 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 570.4 +0.1 108 2.8 CLOCK DMAP1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 ZNF263 LINC00921 ZNF75A CREBBP ZNF597 ZNF205 ENSG00000261938 AMDHD2 ZNF213-AS1 ERVK13-1
GH16I003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 89.4 -241.5 -241497 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 E4F1 SRRM2 TSC2 ERVK13-1 ZNF75A
GH16I002266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 76.1 -995.6 -995588 3.2 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RNPS1 LOC106660606 GC16M002266 GC16M002267 ZNF263 ENSG00000260051 ENSG00000261505 E4F1 AMDHD2 TSC2
GH16I004252 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 43.2 +989.8 989849 1.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LINC01569 LOC105371063 CREBBP ZNF500 ZNF263 ENSG00000261938 ZNF597 ZNF75A UBN1 ANKS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF263 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF263 gene promoter:

Genomic Locations for ZNF263 Gene

Genomic Locations for ZNF263 Gene
37,602 bases
Plus strand

Genomic View for ZNF263 Gene

Genes around ZNF263 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF263 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF263 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF263 Gene

Proteins for ZNF263 Gene

  • Protein details for ZNF263 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 263
    Protein Accession:
    Secondary Accessions:
    • B2R634
    • O43387
    • Q96H95

    Protein attributes for ZNF263 Gene

    683 amino acids
    Molecular mass:
    77299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF263 Gene

Post-translational modifications for ZNF263 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF263 Gene

Domains & Families for ZNF263 Gene

Gene Families for ZNF263 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF263: view

Function for ZNF263 Gene

Molecular function for ZNF263 Gene

GENATLAS Biochemistry:
zinc finger protein 263
UniProtKB/Swiss-Prot Function:
Might play an important role in basic cellular processes as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF263 Gene

Gene Ontology (GO) - Molecular Function for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS,IEA 9256059
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZNF263: view
genes like me logo Genes that share phenotypes with ZNF263: view

Animal Model Products

CRISPR Products

miRNA for ZNF263 Gene

miRTarBase miRNAs that target ZNF263
Targeted motifs for ZNF263 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF263
  • Consensus sequence: CNGTCCTCCC Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF263 Gene

Localization for ZNF263 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF263 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF263 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitotic spindle (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF263: view

Pathways & Interactions for ZNF263 Gene

SuperPathways for ZNF263 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF263: view

Pathways by source for ZNF263 Gene

2 Reactome pathways for ZNF263 Gene

Gene Ontology (GO) - Biological Process for ZNF263 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 19887448
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,TAS 9256059
GO:0045892 negative regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF263: view

No data available for SIGNOR curated interactions for ZNF263 Gene

Drugs & Compounds for ZNF263 Gene

No Compound Related Data Available

Transcripts for ZNF263 Gene

Unigene Clusters for ZNF263 Gene

Zinc finger protein 263:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF263 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP2: - - - -
SP3: - -
SP4: - - - - -

Relevant External Links for ZNF263 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF263 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF263 Gene

Protein differential expression in normal tissues from HIPED for ZNF263 Gene

This gene is overexpressed in Nasal epithelium (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF263 Gene

Protein tissue co-expression partners for ZNF263 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF263 Gene:


SOURCE GeneReport for Unigene cluster for ZNF263 Gene:


mRNA Expression by UniProt/SwissProt for ZNF263 Gene:

Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Evidence on tissue expression from TISSUES for ZNF263 Gene

  • Nervous system(4.6)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF263: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF263 Gene

Orthologs for ZNF263 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF263 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF263 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia ZNF263 33 34
  • 90.53 (n)
(Bos Taurus)
Mammalia ZNF263 33 34
  • 89.51 (n)
(Mus musculus)
Mammalia Zfp263 33 16 34
  • 84.74 (n)
(Rattus norvegicus)
Mammalia Zfp263 33
  • 83.33 (n)
(Monodelphis domestica)
Mammalia ZNF263 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
-- 34
  • 31 (a)
Species where no ortholog for ZNF263 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF263 Gene

Gene Tree for ZNF263 (if available)
Gene Tree for ZNF263 (if available)

Paralogs for ZNF263 Gene

(520) SIMAP similar genes for ZNF263 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF263: view

Variants for ZNF263 Gene

Sequence variations from dbSNP and Humsavar for ZNF263 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000184372 -- 3,292,719(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000360526 -- 3,287,300(+) C/T intron_variant
rs1000455546 -- 3,287,204(+) G/A intron_variant
rs1000743295 -- 3,294,549(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000762091 -- 3,294,088(+) G/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF263 Gene

Variant ID Type Subtype PubMed ID
esv3892760 CNV loss 25118596
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958

Variation tolerance for ZNF263 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF263 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF263 Gene

Disorders for ZNF263 Gene

Additional Disease Information for ZNF263

No disorders were found for ZNF263 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF263 Gene

Publications for ZNF263 Gene

  1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. (PMID: 9256059) Yokoyama M … Fukushima A (Biochimica et biophysica acta 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. (PMID: 28473536) Yin Y … Taipale J (Science (New York, N.Y.) 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF263 Gene

Sources for ZNF263 Gene

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