Aliases for ZNF260 Gene

Aliases for ZNF260 Gene

  • Zinc Finger Protein 260 2 3 4 5
  • Zfp-260 3 4
  • ZFP260 3 4
  • OZRF1 3
  • PEX1 3

External Ids for ZNF260 Gene

Previous GeneCards Identifiers for ZNF260 Gene

  • GC19M041695
  • GC19M037001
  • GC19M033470
  • GC19M036676
  • GC19M036708
  • GC19M040546
  • GC19M040975
  • GC19M041396
  • GC19M036892
  • GC19M036909
  • GC19M037447
  • GC19M037787
  • GC19M038085
  • GC19M038373
  • GC19M038666
  • GC19M040156

Summaries for ZNF260 Gene

GeneCards Summary for ZNF260 Gene

ZNF260 (Zinc Finger Protein 260) is a Protein Coding gene. Diseases associated with ZNF260 include Testicular Leukemia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF568.

UniProtKB/Swiss-Prot Summary for ZNF260 Gene

  • Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).

Additional gene information for ZNF260 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF260 Gene

Genomics for ZNF260 Gene

GeneHancer (GH) Regulatory Elements for ZNF260 Gene

Promoters and enhancers for ZNF260 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF260 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF260

Top Transcription factor binding sites by QIAGEN in the ZNF260 gene promoter:
  • Egr-2
  • FAC1
  • FOXO4
  • IRF-7A
  • MRF-2
  • Pax-4a
  • RORalpha2
  • RREB-1
  • STAT6

Genomic Locations for ZNF260 Gene

Genomic Locations for ZNF260 Gene
chr19:36,510,687-36,528,346
(GRCh38/hg38)
Size:
17,660 bases
Orientation:
Minus strand
chr19:37,001,589-37,019,562
(GRCh37/hg19)
Size:
17,974 bases
Orientation:
Minus strand

Genomic View for ZNF260 Gene

Genes around ZNF260 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF260 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF260 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF260 Gene

Proteins for ZNF260 Gene

  • Protein details for ZNF260 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCT1-ZN260_HUMAN
    Recommended name:
    Zinc finger protein 260
    Protein Accession:
    Q3ZCT1
    Secondary Accessions:
    • Q0VF43

    Protein attributes for ZNF260 Gene

    Size:
    412 amino acids
    Molecular mass:
    47222 Da
    Quaternary structure:
    • Binds DNA. Interacts with GATA4 (By similarity).

neXtProt entry for ZNF260 Gene

Post-translational modifications for ZNF260 Gene

  • Ubiquitination at Lys204
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF260 Gene

Domains & Families for ZNF260 Gene

Gene Families for ZNF260 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF260 Gene

Suggested Antigen Peptide Sequences for ZNF260 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 260 (ZN260_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3ZCT1

UniProtKB/Swiss-Prot:

ZN260_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF260: view

Function for ZNF260 Gene

Molecular function for ZNF260 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by activation of alpha1-adrenergic receptors.

Phenotypes From GWAS Catalog for ZNF260 Gene

Gene Ontology (GO) - Molecular Function for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF260: view
genes like me logo Genes that share phenotypes with ZNF260: view

Animal Models for ZNF260 Gene

MGI Knock Outs for ZNF260:
  • Zfp260 Zfp260<tm1b(NCOM)Mfgc>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF260 Gene

Localization for ZNF260 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF260 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF260 gene
Compartment Confidence
nucleus 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF260: view

Pathways & Interactions for ZNF260 Gene

PathCards logo

SuperPathways for ZNF260 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF260 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZNF260: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF260 Gene

Drugs & Compounds for ZNF260 Gene

No Compound Related Data Available

Transcripts for ZNF260 Gene

mRNA/cDNA for ZNF260 Gene

7 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF260 Gene

No ASD Table

Relevant External Links for ZNF260 Gene

GeneLoc Exon Structure for
ZNF260

Expression for ZNF260 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF260 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF260

SOURCE GeneReport for Unigene cluster for ZNF260 Gene:

Hs.18103

Evidence on tissue expression from TISSUES for ZNF260 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF260: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF260 Gene

Orthologs for ZNF260 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF260 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF260 31 30
  • 99.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF260 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF260 30
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Zfp260 17 31 30
  • 84.36 (n)
rat
(Rattus norvegicus)
Mammalia LOC102549115 30
  • 83.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF146 31
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11398 31
  • 22 (a)
OneToMany
Species where no ortholog for ZNF260 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF260 Gene

ENSEMBL:
Gene Tree for ZNF260 (if available)
TreeFam:
Gene Tree for ZNF260 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF260: view image

Paralogs for ZNF260 Gene

Paralogs for ZNF260 Gene

(501) SIMAP similar genes for ZNF260 Gene using alignment to 2 proteins:

  • ZN260_HUMAN
  • L8E9K3_HUMAN

Pseudogenes.org Pseudogenes for ZNF260 Gene

genes like me logo Genes that share paralogs with ZNF260: view

Variants for ZNF260 Gene

Additional dbSNP identifiers (rs#s) for ZNF260 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF260 Gene

Variant ID Type Subtype PubMed ID
esv3583371 CNV loss 25503493
esv3644261 CNV loss 21293372
esv3644262 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv833816 CNV gain 17160897
nsv833817 CNV loss 17160897

Variation tolerance for ZNF260 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF260 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF260

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF260 Gene

Disorders for ZNF260 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF260 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF260

genes like me logo Genes that share disorders with ZNF260: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF260 Gene

Publications for ZNF260 Gene

  1. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling. (PMID: 16166646) Debrus S … Nemer M (Molecular and cellular biology 2005) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for ZNF260 Gene