Aliases for ZNF26 Gene

Aliases for ZNF26 Gene

  • Zinc Finger Protein 26 2 3 4 5
  • KOX20 2 3 4
  • Zinc Finger Protein KOX20 3 4
  • Zinc Finger Protein 26 (KOX 20) 2
  • Epididymis Luminal Protein 179 3
  • FLJ20755 2
  • HEL-179 3
  • ZNF26 5

External Ids for ZNF26 Gene

Previous GeneCards Identifiers for ZNF26 Gene

  • GC12P131066
  • GC12P133116
  • GC12P131825
  • GC12P131393
  • GC12P132173
  • GC12P132073
  • GC12P133563
  • GC12P130343

Summaries for ZNF26 Gene

GeneCards Summary for ZNF26 Gene

ZNF26 (Zinc Finger Protein 26) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF268.

UniProtKB/Swiss-Prot Summary for ZNF26 Gene

Additional gene information for ZNF26 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF26 Gene

Genomics for ZNF26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF26

Top Transcription factor binding sites by QIAGEN in the ZNF26 gene promoter:
  • AhR
  • Arnt

Genomic Locations for ZNF26 Gene

Genomic Locations for ZNF26 Gene
chr12:132,986,365-133,032,952
(GRCh38/hg38)
Size:
46,588 bases
Orientation:
Plus strand
chr12:133,562,951-133,589,154
(GRCh37/hg19)
Size:
26,204 bases
Orientation:
Plus strand

Genomic View for ZNF26 Gene

Genes around ZNF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF26 Gene

Proteins for ZNF26 Gene

  • Protein details for ZNF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17031-ZNF26_HUMAN
    Recommended name:
    Zinc finger protein 26
    Protein Accession:
    P17031
    Secondary Accessions:
    • Q86X57
    • Q9NWL3

    Protein attributes for ZNF26 Gene

    Size:
    533 amino acids
    Molecular mass:
    61282 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08211.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91367.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF26 Gene

Post-translational modifications for ZNF26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF26 Gene

Domains & Families for ZNF26 Gene

Gene Families for ZNF26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF26 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF26 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX20 (ZNF26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17031

UniProtKB/Swiss-Prot:

ZNF26_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF26: view

Function for ZNF26 Gene

Molecular function for ZNF26 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 26 (KOX20) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF26 Gene

Gene Ontology (GO) - Molecular Function for ZNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF26: view

Phenotypes for ZNF26 Gene

GenomeRNAi human phenotypes for ZNF26:
genes like me logo Genes that share phenotypes with ZNF26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF26 Gene

Localization for ZNF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF26 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF26: view

Pathways & Interactions for ZNF26 Gene

genes like me logo Genes that share pathways with ZNF26: view

Pathways by source for ZNF26 Gene

2 Reactome pathways for ZNF26 Gene
1 KEGG pathway for ZNF26 Gene

Gene Ontology (GO) - Biological Process for ZNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF26: view

No data available for SIGNOR curated interactions for ZNF26 Gene

Drugs & Compounds for ZNF26 Gene

No Compound Related Data Available

Transcripts for ZNF26 Gene

mRNA/cDNA for ZNF26 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF26

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF26 Gene

No ASD Table

Relevant External Links for ZNF26 Gene

GeneLoc Exon Structure for
ZNF26

Expression for ZNF26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF26 Gene

Protein differential expression in normal tissues from HIPED for ZNF26 Gene

This gene is overexpressed in Skin (59.3) and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF26 Gene



Protein tissue co-expression partners for ZNF26 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF26

SOURCE GeneReport for Unigene cluster for ZNF26 Gene:

Hs.489608
genes like me logo Genes that share expression patterns with ZNF26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF26 Gene

Orthologs for ZNF26 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF26 30 31
  • 99.65 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia ZNF26 30
  • 87.51 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 29 (a)
ManyToMany
Species where no ortholog for ZNF26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF26 Gene

ENSEMBL:
Gene Tree for ZNF26 (if available)
TreeFam:
Gene Tree for ZNF26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF26: view image

Paralogs for ZNF26 Gene

Paralogs for ZNF26 Gene

(541) SIMAP similar genes for ZNF26 Gene using alignment to 4 proteins:

  • ZNF26_HUMAN
  • F5GZ77_HUMAN
  • F5H2P7_HUMAN
  • F5H6R4_HUMAN
genes like me logo Genes that share paralogs with ZNF26: view

Variants for ZNF26 Gene

Additional dbSNP identifiers (rs#s) for ZNF26 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF26 Gene

Variant ID Type Subtype PubMed ID
dgv1590n100 CNV gain 25217958
dgv1591n100 CNV gain 25217958
dgv219n27 CNV gain 19166990
dgv3059n54 CNV gain 21841781
dgv330e199 CNV deletion 23128226
dgv917n106 CNV deletion 24896259
esv2759923 CNV loss 17122850
esv2763013 CNV gain 21179565
nsv1054709 CNV loss 25217958
nsv1054933 CNV gain 25217958
nsv1071081 CNV deletion 25765185
nsv438246 CNV loss 16468122
nsv455813 CNV gain 19166990
nsv470336 CNV gain 18288195
nsv525745 CNV gain 19592680
nsv561142 CNV gain 21841781

Additional Variant Information for ZNF26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for ZNF26 Gene

Disorders for ZNF26 Gene

No disorders were found for ZNF26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF26 Gene

Publications for ZNF26 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4
  4. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. (PMID: 30745168) Wang B … Liu Y (EBioMedicine 2019) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for ZNF26 Gene

  • Signalway Proteins for ZNF26

Sources for ZNF26 Gene