Aliases for ZNF257 Gene

Aliases for ZNF257 Gene

  • Zinc Finger Protein 257 2 3 4 5
  • BMZF-4 2 3 4
  • Bone Marrow Zinc Finger 4 3 4
  • BMZF4 3 4
  • ZNF257 5

External Ids for ZNF257 Gene

Previous GeneCards Identifiers for ZNF257 Gene

  • GC19P022683
  • GC19P022564
  • GC19P022011
  • GC19P022027
  • GC19P022235
  • GC19P021773
  • GC19P022127
  • GC19P022326

Summaries for ZNF257 Gene

GeneCards Summary for ZNF257 Gene

ZNF257 (Zinc Finger Protein 257) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF92.

UniProtKB/Swiss-Prot Summary for ZNF257 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF257 Gene

Genomics for ZNF257 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF257 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J022051 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 616.7 +0.3 271 2.2 PKNOX1 PBX2 GTF2F1 MGA ZFX SP2 POLR2A TAF9B EP400 SIN3A ZNF257 ENSG00000269504 BNIP3P29 ZNF208 piR-43105-335 ZNF676
GH19J022010 Promoter 0.9 EPDnew Ensembl 10.4 -42.2 -42229 2 PKNOX1 PRDM10 GABPB1 ZNF208 ZNF257 BNIP3P29 ZNF676 BNIP3P28 lnc-ZNF257-2 ZNF43
GH19J021158 Enhancer 0.7 Ensembl 9.9 -893.7 -893729 2.2 IKZF1 HDAC1 SOX6 TCF12 ZNF140 JUND FOXK2 HDAC2 PHB2 TRIM24 ZNF100 ZNF708 RPL7AP10 ENSG00000268119 ZNF66 ZNF43 ZNF257 ENSG00000268081 ZNF493 MTDHP3
GH19J022429 Enhancer 0.2 FANTOM5 2.3 +375.2 375173 0.3 ZNF208 ZNF98 ZNF257 ZNF492 ZNF676 ENSG00000269796 piR-48209-340 lnc-ZNF492-2 NONHSAG045689.2-002 ZNF729
GH19J022541 Enhancer 0.2 FANTOM5 1.7 +489.5 489504 0.2 L13714-233 ZNF98 ZNF257 ZNF492 LINC01233 lnc-ZNF492-2 NONHSAG045689.2-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF257 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF257

Genomic Locations for ZNF257 Gene

Genomic Locations for ZNF257 Gene
39,051 bases
Plus strand
39,029 bases
Plus strand

Genomic View for ZNF257 Gene

Genes around ZNF257 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF257 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF257 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF257 Gene

Proteins for ZNF257 Gene

  • Protein details for ZNF257 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 257
    Protein Accession:
    Secondary Accessions:
    • B3KPS4
    • E9PG34
    • Q8NE34

    Protein attributes for ZNF257 Gene

    563 amino acids
    Molecular mass:
    65779 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF257 Gene


neXtProt entry for ZNF257 Gene

Post-translational modifications for ZNF257 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF257 Gene

Domains & Families for ZNF257 Gene

Gene Families for ZNF257 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF257 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF257 Gene

GenScript: Design optimal peptide antigens:
  • Bone marrow zinc finger 4 (ZN257_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF257: view

Function for ZNF257 Gene

Molecular function for ZNF257 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF257 Gene

Gene Ontology (GO) - Molecular Function for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF257: view
genes like me logo Genes that share phenotypes with ZNF257: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF257

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF257 Gene

Localization for ZNF257 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF257 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF257 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF257: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF257 Gene

Pathways & Interactions for ZNF257 Gene

genes like me logo Genes that share pathways with ZNF257: view

Pathways by source for ZNF257 Gene

2 Reactome pathways for ZNF257 Gene
1 KEGG pathway for ZNF257 Gene

Interacting Proteins for ZNF257 Gene

Gene Ontology (GO) - Biological Process for ZNF257 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
genes like me logo Genes that share ontologies with ZNF257: view

No data available for SIGNOR curated interactions for ZNF257 Gene

Drugs & Compounds for ZNF257 Gene

No Compound Related Data Available

Transcripts for ZNF257 Gene

mRNA/cDNA for ZNF257 Gene

9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF257

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF257 Gene

No ASD Table

Relevant External Links for ZNF257 Gene

GeneLoc Exon Structure for

Expression for ZNF257 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF257 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF257

SOURCE GeneReport for Unigene cluster for ZNF257 Gene:


Evidence on tissue expression from TISSUES for ZNF257 Gene

  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ZNF257: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF257 Gene

Orthologs for ZNF257 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF257 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF257 31
  • 99 (a)
(Bos Taurus)
Mammalia -- 31
  • 54 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
-- 31
  • 41 (a)
(Mus musculus)
Mammalia Zfp429 31
  • 43 (a)
(Canis familiaris)
Mammalia -- 31
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
-- 31
  • 43 (a)
-- 31
  • 41 (a)
-- 31
  • 37 (a)
-- 31
  • 33 (a)
-- 31
  • 33 (a)
-- 31
  • 33 (a)
-- 31
  • 30 (a)
Species where no ortholog for ZNF257 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF257 Gene

Gene Tree for ZNF257 (if available)
Gene Tree for ZNF257 (if available)
Evolutionary constrained regions (ECRs) for ZNF257: view image

Paralogs for ZNF257 Gene

(522) SIMAP similar genes for ZNF257 Gene using alignment to 5 proteins:

  • ZN257_HUMAN
  • M0R0N1_HUMAN
  • M0R321_HUMAN Pseudogenes for ZNF257 Gene

genes like me logo Genes that share paralogs with ZNF257: view

Variants for ZNF257 Gene

Additional dbSNP identifiers (rs#s) for ZNF257 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF257 Gene

Variant ID Type Subtype PubMed ID
dgv3471n100 CNV gain 25217958
dgv3472n100 CNV loss 25217958
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv513e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
dgv70e203 CNV loss 21179565
esv2718335 CNV deletion 23290073
esv2758750 CNV gain+loss 17122850
esv3352646 CNV insertion 20981092
esv34340 CNV loss 17911159
esv3583307 CNV loss 25503493
esv3643941 CNV loss 21293372
esv3893183 CNV gain 25118596
esv4924 OTHER complex 18987735
nsv1055550 CNV loss 25217958
nsv1061327 CNV gain 25217958
nsv1063115 CNV gain 25217958
nsv1063392 CNV loss 25217958
nsv1112317 CNV deletion 24896259
nsv436253 CNV deletion 17901297
nsv436853 CNV insertion 17901297
nsv436857 CNV insertion 17901297
nsv469674 CNV loss 16826518
nsv470135 CNV loss 18288195
nsv520741 CNV loss 19592680
nsv525240 CNV gain 19592680
nsv578972 CNV loss 21841781
nsv578973 CNV loss 21841781
nsv7306 OTHER inversion 18451855
nsv833785 CNV gain 17160897
nsv961196 CNV duplication 23825009

Variation tolerance for ZNF257 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF257 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF257 Gene

Disorders for ZNF257 Gene

Additional Disease Information for ZNF257

No disorders were found for ZNF257 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF257 Gene

Publications for ZNF257 Gene

  1. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3
  4. Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript. (PMID: 26427027) Puig M … Cáceres M (PLoS genetics 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF257 Gene

Sources for ZNF257 Gene