Aliases for ZNF256 Gene

Aliases for ZNF256 Gene

  • Zinc Finger Protein 256 2 3 4 5
  • BMZF-3 2 3 4
  • Bone Marrow Zinc Finger 3 3 4
  • BMZF3 3 4
  • ZNF256 5

External Ids for ZNF256 Gene

Previous GeneCards Identifiers for ZNF256 Gene

  • GC19M059282
  • GC19M058905
  • GC19M063123
  • GC19M063143
  • GC19M063144
  • GC19M058452
  • GC19M054763

Summaries for ZNF256 Gene

GeneCards Summary for ZNF256 Gene

ZNF256 (Zinc Finger Protein 256) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF418.

UniProtKB/Swiss-Prot Summary for ZNF256 Gene

  • Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.

Additional gene information for ZNF256 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF256 Gene

Genomics for ZNF256 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF256 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF256 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF256

Top Transcription factor binding sites by QIAGEN in the ZNF256 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-3
  • LCR-F1

Genomic Locations for ZNF256 Gene

Genomic Locations for ZNF256 Gene
chr19:57,940,833-57,947,706
(GRCh38/hg38)
Size:
6,874 bases
Orientation:
Minus strand
chr19:58,452,201-58,459,077
(GRCh37/hg19)
Size:
6,877 bases
Orientation:
Minus strand

Genomic View for ZNF256 Gene

Genes around ZNF256 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF256 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF256 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF256 Gene

Proteins for ZNF256 Gene

  • Protein details for ZNF256 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2P7-ZN256_HUMAN
    Recommended name:
    Zinc finger protein 256
    Protein Accession:
    Q9Y2P7
    Secondary Accessions:
    • B2RA92
    • Q53Y85
    • Q9BV71

    Protein attributes for ZNF256 Gene

    Size:
    627 amino acids
    Molecular mass:
    71871 Da
    Quaternary structure:
    • Interacts with TRIM28.

    Alternative splice isoforms for ZNF256 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF256 Gene

Post-translational modifications for ZNF256 Gene

  • Ubiquitination at Lys447
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF256 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF256 Gene

Domains & Families for ZNF256 Gene

Gene Families for ZNF256 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF256 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF256 Gene

GenScript: Design optimal peptide antigens:
  • Bone marrow zinc finger 3 (ZN256_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2P7

UniProtKB/Swiss-Prot:

ZN256_HUMAN :
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF256: view

Function for ZNF256 Gene

Molecular function for ZNF256 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.
UniProtKB/Swiss-Prot Induction:
By GDNF/glial cell line-derived neurotrophic factor.

Phenotypes From GWAS Catalog for ZNF256 Gene

Gene Ontology (GO) - Molecular Function for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS --
GO:0005515 protein binding IPI 18060868
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF256: view
genes like me logo Genes that share phenotypes with ZNF256: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF256

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF256 Gene

Localization for ZNF256 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF256 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF256 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18060868
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF256: view

Pathways & Interactions for ZNF256 Gene

genes like me logo Genes that share pathways with ZNF256: view

Pathways by source for ZNF256 Gene

2 Reactome pathways for ZNF256 Gene
1 KEGG pathway for ZNF256 Gene

Gene Ontology (GO) - Biological Process for ZNF256 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 18060868
genes like me logo Genes that share ontologies with ZNF256: view

No data available for SIGNOR curated interactions for ZNF256 Gene

Drugs & Compounds for ZNF256 Gene

No Compound Related Data Available

Transcripts for ZNF256 Gene

mRNA/cDNA for ZNF256 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF256

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF256 Gene

No ASD Table

Relevant External Links for ZNF256 Gene

GeneLoc Exon Structure for
ZNF256

Expression for ZNF256 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF256 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF256

SOURCE GeneReport for Unigene cluster for ZNF256 Gene:

Hs.596242

Evidence on tissue expression from TISSUES for ZNF256 Gene

  • Bone marrow(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZNF256: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF256 Gene

Orthologs for ZNF256 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF256 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF256 30 31
  • 99.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC491462 30
  • 69.21 (n)
Cow
(Bos Taurus)
Mammalia LOC509810 30
  • 67.85 (n)
Species where no ortholog for ZNF256 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF256 Gene

ENSEMBL:
Gene Tree for ZNF256 (if available)
TreeFam:
Gene Tree for ZNF256 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF256: view image

Paralogs for ZNF256 Gene

(438) SIMAP similar genes for ZNF256 Gene using alignment to 3 proteins:

  • ZN256_HUMAN
  • L8E7T8_HUMAN
  • M0R2X0_HUMAN

Pseudogenes.org Pseudogenes for ZNF256 Gene

genes like me logo Genes that share paralogs with ZNF256: view

Variants for ZNF256 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF256 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs953619 - p.Phe304Ile

Additional dbSNP identifiers (rs#s) for ZNF256 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF256 Gene

Variant ID Type Subtype PubMed ID
esv3644913 CNV gain 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF256 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF256 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF256

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF256 Gene

Disorders for ZNF256 Gene

No disorders were found for ZNF256 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF256 Gene

Publications for ZNF256 Gene

  1. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. (PMID: 18060868) Suzuki C … Takahashi M (Biochemical and biophysical research communications 2008) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF256 Gene

  • Signalway Proteins for ZNF256

Sources for ZNF256 Gene