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Aliases for ZNF254 Gene

Aliases for ZNF254 Gene

  • Zinc Finger Protein 254 2 3 5
  • Zinc Finger Protein 539 2 3 4
  • Hematopoietic Cell-Derived Zinc Finger Protein 1 3 4
  • Bone Marrow Zinc Finger 5 3 4
  • HD-ZNF1 3 4
  • ZNF91L 3 4
  • ZNF539 3 4
  • BMZF-5 3 4
  • Zinc Finger Protein 91-Like 4
  • CTD-2017D11.1 3
  • BMZF5 4

External Ids for ZNF254 Gene

Previous HGNC Symbols for ZNF254 Gene

  • ZNF91L
  • ZNF539

Previous GeneCards Identifiers for ZNF254 Gene

  • GC19U990156
  • GC19P024605
  • GC19P023992
  • GC19P024061
  • GC19P024048
  • GC19P024269
  • GC19P023824
  • GC19P024217
  • GC19P023833

Summaries for ZNF254 Gene

Entrez Gene Summary for ZNF254 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF254 Gene

ZNF254 (Zinc Finger Protein 254) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF726.

UniProtKB/Swiss-Prot for ZNF254 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF254 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF254 Gene

Genomics for ZNF254 Gene

GeneHancer (GH) Regulatory Elements for ZNF254 Gene

Promoters and enhancers for ZNF254 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I024032 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 552.1 +0.5 536 2.9 PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF48 YY1 POLR2B ATF7 SP3 ZNF254 ENSG00000268362 GC19P024035 GC19M024028 GC19P024019
GH19I024086 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.2 +54.1 54094 2.2 HDGF PKNOX1 ATF1 SIN3A YY1 POLR2B ZNF207 ZNF143 FOS ATF7 ZNF254 ENSG00000279425 BNIP3P40
GH19I024047 Promoter 0.6 EPDnew 550.4 +14.2 14173 0.1 ZNF366 ZNF254 ENSG00000268362 GC19M024028 ENSG00000279425 GC19P024019
GH19I023685 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.8 -346.8 -346760 3.1 PKNOX1 ATF1 SMAD1 ZFP64 ARID4B SIN3A ZNF48 YY1 GTF3C2 POLR2B ZNF675 ZNF91 ENSG00000233836 ENSG00000268362 ZNF254 BNIP3P40 GC19P023634
GH19I023824 Enhancer 0.7 ENCODE 10.7 -209.3 -209261 0.2 CTCF MEIS2 PKNOX1 ZBTB40 RAD21 TCF12 MTA3 ZNF316 CBX5 POLR2A ZNF254 GC19P023828 BNIP3P39 ENSG00000267924 RPSAP58 ENSG00000233836
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF254 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF254 Gene

Genomic Locations for ZNF254 Gene
96,564 bases
Plus strand

Genomic View for ZNF254 Gene

Genes around ZNF254 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF254 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF254 Gene

Proteins for ZNF254 Gene

  • Protein details for ZNF254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 254
    Protein Accession:
    Secondary Accessions:
    • A4QPC0
    • Q86XL7

    Protein attributes for ZNF254 Gene

    659 amino acids
    Molecular mass:
    77160 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF254 Gene


neXtProt entry for ZNF254 Gene

Post-translational modifications for ZNF254 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF254 Gene

Domains & Families for ZNF254 Gene

Gene Families for ZNF254 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF254 Gene

Suggested Antigen Peptide Sequences for ZNF254 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF254: view

Function for ZNF254 Gene

Molecular function for ZNF254 Gene

GENATLAS Biochemistry:
zinc finger protein254
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF254 Gene

Gene Ontology (GO) - Molecular Function for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF254: view
genes like me logo Genes that share phenotypes with ZNF254: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF254 Gene

Localization for ZNF254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF254 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF254 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF254: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF254 Gene

Pathways & Interactions for ZNF254 Gene

SuperPathways for ZNF254 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF254: view

Pathways by source for ZNF254 Gene

2 Reactome pathways for ZNF254 Gene

Gene Ontology (GO) - Biological Process for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 10585455
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF254: view

No data available for SIGNOR curated interactions for ZNF254 Gene

Drugs & Compounds for ZNF254 Gene

No Compound Related Data Available

Transcripts for ZNF254 Gene

Unigene Clusters for ZNF254 Gene

Zinc finger protein 254:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF254 Gene

No ASD Table

Relevant External Links for ZNF254 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF254 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF254 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF254 Gene:


SOURCE GeneReport for Unigene cluster for ZNF254 Gene:


Evidence on tissue expression from TISSUES for ZNF254 Gene

  • Blood(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF254: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF254 Gene

Orthologs for ZNF254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF254 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF254 33 34
  • 99.44 (n)
(Mus musculus)
Mammalia Zfp493 34
  • 59 (a)
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
-- 34
  • 41 (a)
(Canis familiaris)
Mammalia -- 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
-- 34
  • 45 (a)
-- 34
  • 41 (a)
-- 34
  • 39 (a)
-- 34
  • 36 (a)
-- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 30 (a)
Species where no ortholog for ZNF254 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF254 Gene

Gene Tree for ZNF254 (if available)
Gene Tree for ZNF254 (if available)

Paralogs for ZNF254 Gene

(565) SIMAP similar genes for ZNF254 Gene using alignment to 5 proteins: Pseudogenes for ZNF254 Gene

genes like me logo Genes that share paralogs with ZNF254: view

Variants for ZNF254 Gene

Sequence variations from dbSNP and Humsavar for ZNF254 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000043260 -- 24,032,527(+) A/C upstream_transcript_variant
rs1000044442 -- 24,129,696(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000068731 -- 24,117,026(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000077972 -- 24,053,839(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000097765 -- 24,129,725(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF254 Gene

Variant ID Type Subtype PubMed ID
nsv978798 CNV duplication 23825009
nsv961203 CNV duplication 23825009
nsv833793 CNV gain+loss 17160897
nsv833791 CNV loss 17160897
nsv579079 CNV loss 21841781
nsv579078 CNV gain 21841781
nsv579077 CNV gain 21841781
nsv524183 CNV gain 19592680
nsv479744 CNV novel sequence insertion 20440878
nsv1147498 CNV deletion 26484159
nsv1134778 CNV deletion 24896259
nsv1109183 CNV deletion 24896259
nsv1062848 CNV loss 25217958
nsv1057420 CNV gain 25217958
nsv1057291 CNV loss 25217958
esv993002 CNV insertion 20482838
esv3893187 CNV gain 25118596
esv3644045 CNV gain 21293372
esv3644043 CNV loss 21293372
esv3644042 CNV gain 21293372
esv3644041 CNV loss 21293372
esv3644040 CNV loss 21293372
esv3644039 CNV gain 21293372
esv3644038 CNV gain 21293372
esv3644036 CNV gain 21293372
esv3644035 CNV loss 21293372
esv3644033 CNV gain 21293372
esv3644032 CNV loss 21293372
esv3583316 CNV loss 25503493
esv3556222 CNV deletion 23714750
esv3428234 OTHER inversion 20981092
esv2751784 CNV gain 17911159
esv2670676 CNV deletion 23128226
esv2662304 CNV deletion 23128226
dgv657e214 CNV loss 21293372
dgv3481n100 CNV gain 25217958

Variation tolerance for ZNF254 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF254 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF254 Gene

Disorders for ZNF254 Gene

Additional Disease Information for ZNF254

No disorders were found for ZNF254 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF254 Gene

Publications for ZNF254 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR. (PMID: 12821146) Dooley TP … Davis RL (Biochemical and biophysical research communications 2003) 3 22 58
  4. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF254 Gene

Sources for ZNF254 Gene

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