Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information... See more...

Aliases for ZNF254 Gene

Aliases for ZNF254 Gene

  • Zinc Finger Protein 254 2 3 4 5
  • Zinc Finger Protein 539 2 3 4
  • HD-ZNF1 2 3 4
  • BMZF-5 2 3 4
  • Hematopoietic Cell-Derived Zinc Finger Protein 1 3 4
  • Bone Marrow Zinc Finger 5 3 4
  • ZNF539 3 4
  • ZNF91L 3 4
  • Zinc Finger Protein 91-Like 4
  • CTD-2017D11.1 3
  • ZNF254 5
  • BMZF5 4

External Ids for ZNF254 Gene

Previous HGNC Symbols for ZNF254 Gene

  • ZNF91L
  • ZNF539

Previous GeneCards Identifiers for ZNF254 Gene

  • GC19U990156
  • GC19P024605
  • GC19P023992
  • GC19P024061
  • GC19P024048
  • GC19P024269
  • GC19P023824
  • GC19P024217
  • GC19P023833
  • GC19P024034

Summaries for ZNF254 Gene

Entrez Gene Summary for ZNF254 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF254 Gene

ZNF254 (Zinc Finger Protein 254) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF726.

UniProtKB/Swiss-Prot Summary for ZNF254 Gene

Additional gene information for ZNF254 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF254 Gene

Genomics for ZNF254 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF254 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J024086 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.2 +54.5 54494 3 SP1 CREB1 REST ZNF692 POLR2A BACH1 LARP7 DDX20 ZNF143 PKNOX1 ZNF254 piR-34822-161 BNIP3P40 lnc-ZNF681-5 ENSG00000268362
GH19J024032 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas 602 +1.0 952 3.7 SP1 HNRNPL CREB1 REST ZNF629 IKZF1 ZNF692 POLR2A LARP7 ZIC2 ZNF254 ENSG00000268362 MN297578
GH19J023762 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 -270.4 -270404 4.8 SP1 TEAD4 PRDM10 IKZF1 ZNF692 ZHX2 POLR2A HDAC1 ZNF600 YY1 ENSG00000233836 RPSAP58 lnc-ZNF726-5 ZNF254 ENSG00000268362 LINC01224 IPO5P1 ZNF681
GH19J023685 Promoter/Enhancer 1.6 EPDnew ENCODE CraniofacialAtlas 15.8 -346.8 -346760 3.1 SP1 REST POLR2A FOS ZHX2 LARP7 ZNF143 PHF21A RBFOX2 PKNOX1 ZNF675 ENSG00000233836 ENSG00000268362 ZNF254 ZNF91 piR-30449-075
GH19J023824 Enhancer 0.7 ENCODE 10.7 -209.3 -209261 0.2 CTCF PKNOX1 NR2C1 GABPA SOX6 CBX3 MTA3 ESR1 ZNF316 TRIM28 ZNF254 piR-61223-009 BNIP3P39 ENSG00000267924 RPSAP58 lnc-ZNF726-5 ENSG00000233836 ZNF726
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF254 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF254

Genomic Locations for ZNF254 Gene

Genomic Locations for ZNF254 Gene
chr19:24,033,405-24,129,968
(GRCh38/hg38)
Size:
96,564 bases
Orientation:
Plus strand
chr19:24,216,276-24,312,654
(GRCh37/hg19)
Size:
96,379 bases
Orientation:
Plus strand

Genomic View for ZNF254 Gene

Genes around ZNF254 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF254 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF254 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF254 Gene

Proteins for ZNF254 Gene

  • Protein details for ZNF254 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75437-ZN254_HUMAN
    Recommended name:
    Zinc finger protein 254
    Protein Accession:
    O75437
    Secondary Accessions:
    • A4QPC0
    • Q86XL7

    Protein attributes for ZNF254 Gene

    Size:
    659 amino acids
    Molecular mass:
    77160 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF254 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF254 Gene

Post-translational modifications for ZNF254 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF254 Gene

Domains & Families for ZNF254 Gene

Gene Families for ZNF254 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF254 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF254 Gene

GenScript: Design optimal peptide antigens:
  • ZNF254 protein (Q7Z2R1_HUMAN)
  • Zinc finger protein 91-like (ZN254_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75437

UniProtKB/Swiss-Prot:

ZN254_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF254: view

Function for ZNF254 Gene

Molecular function for ZNF254 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein254

Phenotypes From GWAS Catalog for ZNF254 Gene

Gene Ontology (GO) - Molecular Function for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF254: view
genes like me logo Genes that share phenotypes with ZNF254: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF254

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF254 Gene

Localization for ZNF254 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF254 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF254 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF254: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF254 Gene

Pathways & Interactions for ZNF254 Gene

genes like me logo Genes that share pathways with ZNF254: view

Pathways by source for ZNF254 Gene

2 Reactome pathways for ZNF254 Gene
1 KEGG pathway for ZNF254 Gene

Gene Ontology (GO) - Biological Process for ZNF254 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 10585455
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF254: view

No data available for SIGNOR curated interactions for ZNF254 Gene

Drugs & Compounds for ZNF254 Gene

No Compound Related Data Available

Transcripts for ZNF254 Gene

mRNA/cDNA for ZNF254 Gene

9 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF254

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF254 Gene

No ASD Table

Relevant External Links for ZNF254 Gene

GeneLoc Exon Structure for
ZNF254

Expression for ZNF254 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF254 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF254

SOURCE GeneReport for Unigene cluster for ZNF254 Gene:

Hs.729302

Evidence on tissue expression from TISSUES for ZNF254 Gene

  • Blood(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF254: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF254 Gene

Orthologs for ZNF254 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF254 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF254 30 31
  • 99.44 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp493 31
  • 59 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 56 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 39 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF254 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF254 Gene

ENSEMBL:
Gene Tree for ZNF254 (if available)
TreeFam:
Gene Tree for ZNF254 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF254: view image

Paralogs for ZNF254 Gene

Paralogs for ZNF254 Gene

(565) SIMAP similar genes for ZNF254 Gene using alignment to 5 proteins:

  • ZN254_HUMAN
  • F5H2M4_HUMAN
  • M0QZY2_HUMAN
  • M0R2X5_HUMAN
  • Q7Z2R1_HUMAN

Pseudogenes.org Pseudogenes for ZNF254 Gene

genes like me logo Genes that share paralogs with ZNF254: view

Variants for ZNF254 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF254 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs12611425 - p.Lys537Asn
rs17854260 - p.Asp93Gly
rs2446056 - p.Val594Ile
rs2925930 - p.Thr457Ala
rs403356 - p.Ala386Thr

Additional dbSNP identifiers (rs#s) for ZNF254 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF254 Gene

Variant ID Type Subtype PubMed ID
dgv3481n100 CNV gain 25217958
dgv657e214 CNV loss 21293372
esv2662304 CNV deletion 23128226
esv2670676 CNV deletion 23128226
esv2751784 CNV gain 17911159
esv3428234 OTHER inversion 20981092
esv3556222 CNV deletion 23714750
esv3583316 CNV loss 25503493
esv3644032 CNV loss 21293372
esv3644033 CNV gain 21293372
esv3644035 CNV loss 21293372
esv3644036 CNV gain 21293372
esv3644038 CNV gain 21293372
esv3644039 CNV gain 21293372
esv3644040 CNV loss 21293372
esv3644041 CNV loss 21293372
esv3644042 CNV gain 21293372
esv3644043 CNV loss 21293372
esv3644045 CNV gain 21293372
esv3893187 CNV gain 25118596
esv993002 CNV insertion 20482838
nsv1057291 CNV loss 25217958
nsv1057420 CNV gain 25217958
nsv1062848 CNV loss 25217958
nsv1109183 CNV deletion 24896259
nsv1134778 CNV deletion 24896259
nsv1147498 CNV deletion 26484159
nsv479744 CNV novel sequence insertion 20440878
nsv524183 CNV gain 19592680
nsv579077 CNV gain 21841781
nsv579078 CNV gain 21841781
nsv579079 CNV loss 21841781
nsv833791 CNV loss 17160897
nsv833793 CNV gain+loss 17160897
nsv961203 CNV duplication 23825009
nsv978798 CNV duplication 23825009

Variation tolerance for ZNF254 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF254 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF254

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF254 Gene

Disorders for ZNF254 Gene

No disorders were found for ZNF254 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF254 Gene

Publications for ZNF254 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR. (PMID: 12821146) Dooley TP … Davis RL (Biochemical and biophysical research communications 2003) 3 23
  4. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. (PMID: 10585455) Han ZG … Chen Z (The Journal of biological chemistry 1999) 3 4
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for ZNF254 Gene

Sources for ZNF254 Gene