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Aliases for ZNF251 Gene

Aliases for ZNF251 Gene

  • Zinc Finger Protein 251 2 3 5

External Ids for ZNF251 Gene

Previous GeneCards Identifiers for ZNF251 Gene

  • GC00U990512
  • GC08M145951
  • GC08M145561
  • GC08M145917
  • GC08M141061
  • GC08M145946

Summaries for ZNF251 Gene

GeneCards Summary for ZNF251 Gene

ZNF251 (Zinc Finger Protein 251) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot for ZNF251 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF251 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF251 Gene

Genomics for ZNF251 Gene

GeneHancer (GH) Regulatory Elements for ZNF251 Gene

Promoters and enhancers for ZNF251 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144753 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.3 1270 3 PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B E2F8 ZNF251 RPL8 CPSF1 VPS28 ZNF7 ADCK5 SLC52A2 ZNF16 COMMD5 PARP10
GH08I144756 Enhancer 0.9 Ensembl ENCODE 550.8 -1.1 -1056 1.4 ELF3 CTCF SAP130 TEAD4 ARID4B SIN3A ZBTB7B RAD21 FOXK2 POLR2A ZNF251 RPL8 LOC105375805
GH08I144455 Enhancer 1.3 Ensembl ENCODE 190 +300.0 299971 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I143914 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.2 +819.3 819287 45.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 ZNF623 CPSF1 VPS28 LRRC14
GH08I144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.3 +652.5 652506 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF696 ZNF517 ZNF251 ZNF250 CPSF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF251 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF251 gene promoter:

Genomic Locations for ZNF251 Gene

Genomic Locations for ZNF251 Gene
35,511 bases
Minus strand

Genomic View for ZNF251 Gene

Genes around ZNF251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF251 Gene

Proteins for ZNF251 Gene

  • Protein details for ZNF251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 251
    Protein Accession:
    Secondary Accessions:
    • Q2M219

    Protein attributes for ZNF251 Gene

    671 amino acids
    Molecular mass:
    75763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF251 Gene

Post-translational modifications for ZNF251 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF251 Gene

No data available for DME Specific Peptides for ZNF251 Gene

Domains & Families for ZNF251 Gene

Gene Families for ZNF251 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF251 Gene

Suggested Antigen Peptide Sequences for ZNF251 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF251: view

Function for ZNF251 Gene

Molecular function for ZNF251 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF251 Gene

Gene Ontology (GO) - Molecular Function for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF251: view
genes like me logo Genes that share phenotypes with ZNF251: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF251 Gene

Localization for ZNF251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF251 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF251 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF251: view

Pathways & Interactions for ZNF251 Gene

SuperPathways for ZNF251 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF251: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF251 Gene

Drugs & Compounds for ZNF251 Gene

No Compound Related Data Available

Transcripts for ZNF251 Gene

Unigene Clusters for ZNF251 Gene

Zinc finger protein 251:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP4: -

Relevant External Links for ZNF251 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF251 Gene

Protein differential expression in normal tissues from HIPED for ZNF251 Gene

This gene is overexpressed in Urine (35.6) and Adrenal (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF251 Gene

Protein tissue co-expression partners for ZNF251 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF251 Gene:


SOURCE GeneReport for Unigene cluster for ZNF251 Gene:


Evidence on tissue expression from TISSUES for ZNF251 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF251: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF251 Gene

Orthologs for ZNF251 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF251 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF251 33 34
  • 99.21 (n)
(Rattus norvegicus)
Mammalia Zfp251 33
  • 77.71 (n)
(Mus musculus)
Mammalia Zfp251 33 16 34
  • 76.85 (n)
(Bos Taurus)
Mammalia -- 34
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 31 (a)
Species where no ortholog for ZNF251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF251 Gene

Gene Tree for ZNF251 (if available)
Gene Tree for ZNF251 (if available)

Paralogs for ZNF251 Gene

(512) SIMAP similar genes for ZNF251 Gene using alignment to 3 proteins: Pseudogenes for ZNF251 Gene

genes like me logo Genes that share paralogs with ZNF251: view

Variants for ZNF251 Gene

Sequence variations from dbSNP and Humsavar for ZNF251 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000093074 -- 144,744,017(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000254132 -- 144,755,702(-) A/T upstream_transcript_variant
rs1000431339 -- 144,750,185(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000488759 -- 144,752,428(-) T/C intron_variant
rs1000520994 -- 144,744,513(-) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF251 Gene

Variant ID Type Subtype PubMed ID
esv3619140 CNV gain 21293372
nsv428208 CNV gain 18775914
nsv522459 CNV loss 19592680

Variation tolerance for ZNF251 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF251 Gene

Disorders for ZNF251 Gene

Additional Disease Information for ZNF251

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF251 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF251 Gene

Publications for ZNF251 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2. (PMID: 27337956) Li Q … Xiong W (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58

Products for ZNF251 Gene

Sources for ZNF251 Gene

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