Aliases for ZNF251 Gene

Aliases for ZNF251 Gene

  • Zinc Finger Protein 251 2 3 4 5
  • ZNF251 5

External Ids for ZNF251 Gene

Previous GeneCards Identifiers for ZNF251 Gene

  • GC00U990512
  • GC08M145951
  • GC08M145561
  • GC08M145917
  • GC08M141061
  • GC08M145946
  • GC08M144722

Summaries for ZNF251 Gene

GeneCards Summary for ZNF251 Gene

ZNF251 (Zinc Finger Protein 251) is a Protein Coding gene. Diseases associated with ZNF251 include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF568.

UniProtKB/Swiss-Prot Summary for ZNF251 Gene

Additional gene information for ZNF251 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF251 Gene

Genomics for ZNF251 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF251 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J144753 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 600.7 +1.3 1291 3.1 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 SIX5 POLR2A JUND ZNF251 lnc-ZNF251-1 RPL8 CPSF1 VPS28 ZNF7 ADCK5 SLC52A2 ZNF16 COMMD5
GH08J144756 Enhancer 0.7 ENCODE 600.7 -1.1 -1056 1.4 CTCF IKZF1 GABPA REST RAD21 IKZF2 RFX1 FOXK2 SMC3 ZBTB17 ZNF251 lnc-ZNF251-1 RPL8 HSALNG0069460 LOC107986986 ZNF34
GH08J144455 Enhancer 1 ENCODE 174 +300.0 299971 1.6 HNRNPL CREB1 ATF7 ZNF629 LEF1 IKZF1 KDM1A ZNF692 POLR2A ZNF174 lnc-TONSL-3 ZNF251 ZNF7 ZNF623 LRRC14 ZNF250 CPSF1 ZNF16 VPS28 ZNF517
GH08J144785 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 39.5 -33.4 -33411 9.1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 REST ZNF512 RPL8 ZNF34 piR-58885-002 ZNF7 CPSF1 VPS28 ZNF250 ZNF251 ENSG00000255182 LRRC14
GH08J144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 38 +652.4 652350 4.3 SP1 HNRNPL CREB1 PRDM10 ZNF629 REST SIX5 LEF1 IKZF1 ZNF692 MAF1 SHARPIN ZNF623 ZNF7 ZNF517 ZNF16 ZNF251 ZNF250 ZNF696 LRRC14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF251 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF251

Top Transcription factor binding sites by QIAGEN in the ZNF251 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • c-Myc
  • Max1
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1

Genomic Locations for ZNF251 Gene

Genomic Locations for ZNF251 Gene
35,511 bases
Minus strand
35,509 bases
Minus strand

Genomic View for ZNF251 Gene

Genes around ZNF251 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF251 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF251 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF251 Gene

Proteins for ZNF251 Gene

  • Protein details for ZNF251 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 251
    Protein Accession:
    Secondary Accessions:
    • Q2M219

    Protein attributes for ZNF251 Gene

    671 amino acids
    Molecular mass:
    75763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF251 Gene

Post-translational modifications for ZNF251 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF251 Gene

No data available for DME Specific Peptides for ZNF251 Gene

Domains & Families for ZNF251 Gene

Gene Families for ZNF251 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF251 Gene

Suggested Antigen Peptide Sequences for ZNF251 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 251 (ZN251_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF251: view

Function for ZNF251 Gene

Molecular function for ZNF251 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF251 Gene

Gene Ontology (GO) - Molecular Function for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF251: view
genes like me logo Genes that share phenotypes with ZNF251: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF251

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF251 Gene

Localization for ZNF251 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF251 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF251 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF251: view

Pathways & Interactions for ZNF251 Gene

PathCards logo

SuperPathways for ZNF251 Gene

genes like me logo Genes that share pathways with ZNF251: view

Pathways by source for ZNF251 Gene

1 KEGG pathway for ZNF251 Gene

Gene Ontology (GO) - Biological Process for ZNF251 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF251: view

No data available for SIGNOR curated interactions for ZNF251 Gene

Drugs & Compounds for ZNF251 Gene

No Compound Related Data Available

Transcripts for ZNF251 Gene

mRNA/cDNA for ZNF251 Gene

10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF251

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF251 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP4: -

Relevant External Links for ZNF251 Gene

GeneLoc Exon Structure for

Expression for ZNF251 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF251 Gene

Protein differential expression in normal tissues from HIPED for ZNF251 Gene

This gene is overexpressed in Urine (35.6) and Adrenal (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF251 Gene

Protein tissue co-expression partners for ZNF251 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF251

SOURCE GeneReport for Unigene cluster for ZNF251 Gene:


Evidence on tissue expression from TISSUES for ZNF251 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF251: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF251 Gene

Orthologs for ZNF251 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF251 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF251 30 31
  • 99.21 (n)
(Rattus norvegicus)
Mammalia Zfp251 30
  • 77.71 (n)
(Mus musculus)
Mammalia Zfp251 30 17 31
  • 76.85 (n)
(Bos Taurus)
Mammalia -- 31
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 31 (a)
Species where no ortholog for ZNF251 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF251 Gene

Gene Tree for ZNF251 (if available)
Gene Tree for ZNF251 (if available)
Evolutionary constrained regions (ECRs) for ZNF251: view image

Paralogs for ZNF251 Gene

Paralogs for ZNF251 Gene

(512) SIMAP similar genes for ZNF251 Gene using alignment to 3 proteins:

  • ZN251_HUMAN
  • L0R6U9_HUMAN Pseudogenes for ZNF251 Gene

genes like me logo Genes that share paralogs with ZNF251: view

Variants for ZNF251 Gene

Additional dbSNP identifiers (rs#s) for ZNF251 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF251 Gene

Variant ID Type Subtype PubMed ID
esv3619140 CNV gain 21293372
nsv428208 CNV gain 18775914
nsv522459 CNV loss 19592680

Variation tolerance for ZNF251 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF251 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF251 Gene

Disorders for ZNF251 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF251 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary, 1
  • rccp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF251

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF251: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF251 Gene

Publications for ZNF251 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZNF251 Gene

Sources for ZNF251 Gene