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Aliases for ZNF250 Gene

Aliases for ZNF250 Gene

  • Zinc Finger Protein 250 2 3 5
  • Zinc Finger Protein 647 2 3 4
  • ZNF647 3 4
  • Zinc Finger Protein (Clone 647) 3
  • ZFP647 3

External Ids for ZNF250 Gene

Previous HGNC Symbols for ZNF250 Gene

  • ZNF647

Previous GeneCards Identifiers for ZNF250 Gene

  • GC00U990513
  • GC08M146078
  • GC08M141218

Summaries for ZNF250 Gene

GeneCards Summary for ZNF250 Gene

ZNF250 (Zinc Finger Protein 250) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot for ZNF250 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF250 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF250 Gene

Genomics for ZNF250 Gene

GeneHancer (GH) Regulatory Elements for ZNF250 Gene

Promoters and enhancers for ZNF250 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144899 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 580.9 +0.7 714 3.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF250 ZNF7 CPSF1 VPS28 RPL8 ZNF16 ZNF251 SHARPIN GPAA1 PARP10
GH08I144455 Enhancer 1.3 Ensembl ENCODE 98.6 +445.9 445859 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I144506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.8 +393.3 393336 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MFSD3 ZNF7 CPSF1 VPS28 ZNF250 ZNF623 ZNF251 ENSG00000254533 LRRC14 ZNF707
GH08I143914 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.7 +965.2 965175 45.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 ZNF623 CPSF1 VPS28 LRRC14
GH08I144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.4 +798.4 798394 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF696 ZNF517 ZNF251 ZNF250 CPSF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF250 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF250 Gene

Genomic Locations for ZNF250 Gene
chr8:144,876,497-144,902,305
(GRCh38/hg38)
Size:
25,809 bases
Orientation:
Minus strand
chr8:146,076,632-146,127,553
(GRCh37/hg19)

Genomic View for ZNF250 Gene

Genes around ZNF250 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF250 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF250 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF250 Gene

Proteins for ZNF250 Gene

  • Protein details for ZNF250 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15622-ZN250_HUMAN
    Recommended name:
    Zinc finger protein 250
    Protein Accession:
    P15622
    Secondary Accessions:
    • D3DWP1
    • Q59HE9
    • Q8N942
    • Q96AH9

    Protein attributes for ZNF250 Gene

    Size:
    560 amino acids
    Molecular mass:
    63468 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA34358.1; Type=Frameshift; Positions=458, 488; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF250 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF250 Gene

Post-translational modifications for ZNF250 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF250 Gene

Domains & Families for ZNF250 Gene

Gene Families for ZNF250 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF250 Gene

Graphical View of Domain Structure for InterPro Entry

P15622

UniProtKB/Swiss-Prot:

ZN250_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF250: view

Function for ZNF250 Gene

Molecular function for ZNF250 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF250 Gene

Gene Ontology (GO) - Molecular Function for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF250: view
genes like me logo Genes that share phenotypes with ZNF250: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF250 Gene

Localization for ZNF250 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF250 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF250 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF250: view

Pathways & Interactions for ZNF250 Gene

SuperPathways for ZNF250 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF250: view

Pathways by source for ZNF250 Gene

2 Reactome pathways for ZNF250 Gene

Gene Ontology (GO) - Biological Process for ZNF250 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF250: view

No data available for SIGNOR curated interactions for ZNF250 Gene

Drugs & Compounds for ZNF250 Gene

No Compound Related Data Available

Transcripts for ZNF250 Gene

Unigene Clusters for ZNF250 Gene

Zinc finger protein 250:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF250 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: - -

Relevant External Links for ZNF250 Gene

GeneLoc Exon Structure for
ZNF250
ECgene alternative splicing isoforms for
ZNF250

Expression for ZNF250 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF250 Gene

Protein differential expression in normal tissues from HIPED for ZNF250 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF250 Gene



Protein tissue co-expression partners for ZNF250 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF250 Gene:

ZNF250

SOURCE GeneReport for Unigene cluster for ZNF250 Gene:

Hs.532277

Evidence on tissue expression from TISSUES for ZNF250 Gene

  • Nervous system(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZNF250: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF250 Gene

Orthologs for ZNF250 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF250 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF250 33 34
  • 99.82 (n)
rat
(Rattus norvegicus)
Mammalia Zfp647 33
  • 84.24 (n)
mouse
(Mus musculus)
Mammalia Zfp647 33 16 34
  • 82.52 (n)
dog
(Canis familiaris)
Mammalia ZNF250 33 34
  • 77.51 (n)
cow
(Bos Taurus)
Mammalia ZNF250 33
  • 77.13 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADR1 36
Species where no ortholog for ZNF250 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF250 Gene

ENSEMBL:
Gene Tree for ZNF250 (if available)
TreeFam:
Gene Tree for ZNF250 (if available)

Paralogs for ZNF250 Gene

(534) SIMAP similar genes for ZNF250 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF250 Gene

genes like me logo Genes that share paralogs with ZNF250: view

Variants for ZNF250 Gene

Sequence variations from dbSNP and Humsavar for ZNF250 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000031593 -- 144,880,272(-) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000076720 -- 144,899,331(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000110741 -- 144,876,664(-) T/C downstream_transcript_variant
rs1000346632 -- 144,886,795(-) C/A intron_variant
rs1000518875 -- 144,901,123(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF250 Gene

Variant ID Type Subtype PubMed ID
nsv1031737 CNV gain 25217958
nsv469809 CNV loss 16826518
nsv612969 CNV loss 21841781
nsv6450 CNV insertion 18451855

Variation tolerance for ZNF250 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF250 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF250

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF250 Gene

Disorders for ZNF250 Gene

Additional Disease Information for ZNF250

No disorders were found for ZNF250 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF250 Gene

Publications for ZNF250 Gene

  1. The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues. (PMID: 20346131) Lorenz P … Thiesen HJ (BMC genomics 2010) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF250 Gene

Sources for ZNF250 Gene

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