Aliases for ZNF25 Gene

Aliases for ZNF25 Gene

  • Zinc Finger Protein 25 2 3 4 5
  • Zinc Finger Protein 25 (KOX 19) 2 3
  • Zinc Finger Protein KOX19 3 4
  • KOX19 3 4
  • Zfp9 3

External Ids for ZNF25 Gene

Previous GeneCards Identifiers for ZNF25 Gene

  • GC10U990058
  • GC10M038389
  • GC10M038242
  • GC10M038122
  • GC10M038278
  • GC10M038238

Summaries for ZNF25 Gene

GeneCards Summary for ZNF25 Gene

ZNF25 (Zinc Finger Protein 25) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot Summary for ZNF25 Gene

Additional gene information for ZNF25 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF25 Gene

Genomics for ZNF25 Gene

GeneHancer (GH) Regulatory Elements for ZNF25 Gene

Promoters and enhancers for ZNF25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J037975 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 517.3 +0.7 680 2.6 HNRNPK ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G PHF8 SIX5 ZFX ZNF25 ZNF248 ZNF25-DT ZNF33A ZNF37A piR-57460-054
GH10J038009 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 24.5 -33.9 -33933 3 ZNF217 SIN3A TCF12 NRF1 POLR2G GTF2E2 PHF8 SIX5 ZFX ZNF639 ZNF33A ZNF25 ZNF25-DT SEPTIN7P9 HSD17B7P2 RNU6-795P
GH10J037854 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.8 +120.0 119979 4 SIN3A NRF1 TCF12 POLR2G SP1 PHF8 ZFX ZNF639 ZIC2 POLR2A ENSG00000236514 ZNF248 CICP9 ZNF25 ZNF33A SEPTIN7P9 ZNF25-DT HSD17B7P2 lnc-ZNF25-2
GH10J037860 Enhancer 1.1 FANTOM5 Ensembl ENCODE 12.8 +116.1 116080 1 ZSCAN5C TEAD1 FOXA2 OSR2 WT1 FOS SRF JUND ZNF335 HOMEZ ZNF248 ZNF25 ZNF37CP
GH10J038093 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.4 -117.5 -117521 2.6 ZNF217 NRF1 TCF12 POLR2G PHF8 SIX5 ZFX ZIC2 POLR2A ZBTB26 ZNF37A ENSG00000283930 lnc-ZNF33A-6 ENSG00000272983 HSD17B7P2 ZNF248 ZNF25 SLC9B1P3 piR-38423-004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF25

Top Transcription factor binding sites by QIAGEN in the ZNF25 gene promoter:
  • ATF
  • ATF-2
  • c-Myc
  • CRE-BP1
  • GCNF-1
  • GCNF-2
  • Max
  • USF-1
  • USF1
  • XBP-1

Genomic Locations for ZNF25 Gene

Genomic Locations for ZNF25 Gene
chr10:37,949,572-37,976,980
(GRCh38/hg38)
Size:
27,409 bases
Orientation:
Minus strand
chr10:38,238,500-38,265,561
(GRCh37/hg19)
Size:
27,062 bases
Orientation:
Minus strand

Genomic View for ZNF25 Gene

Genes around ZNF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF25 Gene

Proteins for ZNF25 Gene

  • Protein details for ZNF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17030-ZNF25_HUMAN
    Recommended name:
    Zinc finger protein 25
    Protein Accession:
    P17030
    Secondary Accessions:
    • A9Z1X5
    • Q8IYE3
    • Q8NDD6
    • Q96MU2

    Protein attributes for ZNF25 Gene

    Size:
    456 amino acids
    Molecular mass:
    53545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36038.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF25 Gene

Post-translational modifications for ZNF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF25 Gene

Domains & Families for ZNF25 Gene

Gene Families for ZNF25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF25 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF25 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 25 (B1AKS7_HUMAN)
  • Zinc finger protein KOX19 (ZNF25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17030

UniProtKB/Swiss-Prot:

ZNF25_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF25: view

Function for ZNF25 Gene

Molecular function for ZNF25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 25 (KOX19) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF25 Gene

Gene Ontology (GO) - Molecular Function for ZNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF25: view
genes like me logo Genes that share phenotypes with ZNF25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF25 Gene

Localization for ZNF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF25 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF25: view

Pathways & Interactions for ZNF25 Gene

genes like me logo Genes that share pathways with ZNF25: view

Pathways by source for ZNF25 Gene

2 Reactome pathways for ZNF25 Gene
1 KEGG pathway for ZNF25 Gene

Gene Ontology (GO) - Biological Process for ZNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF25: view

No data available for SIGNOR curated interactions for ZNF25 Gene

Drugs & Compounds for ZNF25 Gene

No Compound Related Data Available

Transcripts for ZNF25 Gene

mRNA/cDNA for ZNF25 Gene

19 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF25

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for ZNF25 Gene

GeneLoc Exon Structure for
ZNF25

Expression for ZNF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF25

SOURCE GeneReport for Unigene cluster for ZNF25 Gene:

Hs.499429

Evidence on tissue expression from TISSUES for ZNF25 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ZNF25: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF25 Gene

Orthologs for ZNF25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF25 31 30
  • 99.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF25 31 30
  • 87.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF25 31 30
  • 87.48 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp9 30
  • 82.56 (n)
mouse
(Mus musculus)
Mammalia Zfp9 17 31 30
  • 81.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
OneToMany
Species where no ortholog for ZNF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF25 Gene

ENSEMBL:
Gene Tree for ZNF25 (if available)
TreeFam:
Gene Tree for ZNF25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF25: view image

Paralogs for ZNF25 Gene

(519) SIMAP similar genes for ZNF25 Gene using alignment to 2 proteins:

  • ZNF25_HUMAN
  • B1AKS7_HUMAN
genes like me logo Genes that share paralogs with ZNF25: view

Variants for ZNF25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF25 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
VAR_035567 A breast cancer sample p.Glu21Lys
VAR_035568 A breast cancer sample p.Asp81Gly
rs1208606 - p.Asn453Lys

Additional dbSNP identifiers (rs#s) for ZNF25 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF25 Gene

Variant ID Type Subtype PubMed ID
nsv1040704 CNV gain 25217958

Variation tolerance for ZNF25 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF25 Gene

Disorders for ZNF25 Gene

Additional Disease Information for ZNF25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF25 Gene

Publications for ZNF25 Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A … Ponder BA (Nucleic acids research 1993) 2 3 23 54
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. (PMID: 1639412) Rousseau-Merck MF … Thiesen HJ (Genomics 1992) 2 3 54

Products for ZNF25 Gene

Sources for ZNF25 Gene