ZNF24 Gene (Protein Coding)

Zinc Finger Protein 24

GC18M035332
GIFtS:
40

Aliases for ZNF24 Gene

Aliases for ZNF24 Gene

  • Zinc Finger Protein 24 2 3 4 5
  • Zinc Finger And SCAN Domain-Containing Protein 3 3 4
  • Retinoic Acid Suppression Protein A 3 4
  • Zinc Finger Protein 24 (KOX 17) 2 3
  • Zinc Finger Protein KOX17 3 4
  • Zinc Finger Protein 191 3 4
  • ZNF191 3 4
  • ZSCAN3 3 4
  • KOX17 3 4
  • RSG-A 3 4
  • Zfp191 3

External Ids for ZNF24 Gene

Previous HGNC Symbols for ZNF24 Gene

  • ZNF191

Previous GeneCards Identifiers for ZNF24 Gene

  • GC18M032950
  • GC18M032735
  • GC18M032722
  • GC18M031167
  • GC18M031169
  • GC18M032912
  • GC18M029771

Summaries for ZNF24 Gene

GeneCards Summary for ZNF24 Gene

ZNF24 (Zinc Finger Protein 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZKSCAN1.

UniProtKB/Swiss-Prot Summary for ZNF24 Gene

  • Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.

Gene Wiki entry for ZNF24 Gene

Additional gene information for ZNF24 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF24 Gene

Genomics for ZNF24 Gene

GeneHancer (GH) Regulatory Elements for ZNF24 Gene

Promoters and enhancers for ZNF24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF24 gene promoter:
  • AML1a
  • ATF-2
  • GATA-1
  • GATA-2
  • GATA-3
  • Olf-1
  • Pax-6
  • YY1

Genomic Locations for ZNF24 Gene

Genomic Locations for ZNF24 Gene
chr18:35,332,214-35,345,482
(GRCh38/hg38)
Size:
13,269 bases
Orientation:
Minus strand
chr18:32,912,176-32,925,446
(GRCh37/hg19)
Size:
13,271 bases
Orientation:
Minus strand

Genomic View for ZNF24 Gene

Genes around ZNF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF24 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF24 Gene

Proteins for ZNF24 Gene

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  • Protein details for ZNF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17028-ZNF24_HUMAN
    Recommended name:
    Zinc finger protein 24
    Protein Accession:
    P17028
    Secondary Accessions:
    • O14754
    • Q53YE4
    • Q6ICR5
    • Q8IZN4

    Protein attributes for ZNF24 Gene

    Size:
    368 amino acids
    Molecular mass:
    42155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZNF24 Gene

    Alternative splice isoforms for ZNF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF24 Gene

Protein Expression for ZNF24 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF24 Gene

Other Protein References for ZNF24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF24 Gene

Domains & Families for ZNF24 Gene

Gene Families for ZNF24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF24 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF24 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX17 (ZNF24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17028

UniProtKB/Swiss-Prot:

ZNF24_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF24: view

Function for ZNF24 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for ZNF24 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.
GENATLAS Biochemistry:
zinc finger protein 24 (KOX17) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF24 Gene

Gene Ontology (GO) - Molecular Function for ZNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 11532988
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ZNF24: view
genes like me logo Genes that share phenotypes with ZNF24: view

Animal Models for ZNF24 Gene

MGI Knock Outs for ZNF24:

Animal Model Products

CRISPR Products

miRNA for ZNF24 Gene

miRTarBase miRNAs that target ZNF24

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF24 Gene

Localization for ZNF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF24 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF24 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
genes like me logo Genes that share ontologies with ZNF24: view

Pathways & Interactions for ZNF24 Gene

PathCards logo

SuperPathways for ZNF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042552 myelination ISS,IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 10585455
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 11532988
genes like me logo Genes that share ontologies with ZNF24: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF24 Gene

Drugs & Compounds for ZNF24 Gene

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  1. Drug

(1) Drugs for ZNF24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2741
genes like me logo Genes that share compounds with ZNF24: view

Transcripts for ZNF24 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for ZNF24 Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(388) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF24

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for ZNF24 Gene

GeneLoc Exon Structure for
ZNF24
ECgene alternative splicing isoforms for
ZNF24

Expression for ZNF24 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF24 Gene

mRNA expression in normal human tissues for ZNF24 Gene
mRNA expression by BioGPS for ZNF24 GenemRNA expression by GTEx for ZNF24 Gene

Protein differential expression in normal tissues from HIPED for ZNF24 Gene

This gene is overexpressed in Blymphocyte (13.2), CD8 Tcells (11.9), NK cells (10.6), and Lung (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF24 Gene



Protein tissue co-expression partners for ZNF24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF24 Gene:

ZNF24

SOURCE GeneReport for Unigene cluster for ZNF24 Gene:

Hs.514802

mRNA Expression by UniProt/SwissProt for ZNF24 Gene:

P17028-ZNF24_HUMAN
Tissue specificity: Expressed in many tissues except in heart.

Evidence on tissue expression from TISSUES for ZNF24 Gene

  • Bone marrow(4.3)
  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ZNF24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF24 Gene

Orthologs for ZNF24 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF24 33 32
  • 99.82 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZNF24 33 32
  • 94.66 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ZNF24 33 32
  • 93.66 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Zfp191 33 32
  • 89.04 (n)
 OneToOne
Zfp24 17
rat
(Rattus norvegicus)
 Mammalia Zfp191 32
  • 88.95 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZNF24 33
  • 69 (a)
 OneToOne
Species where no ortholog for ZNF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF24 Gene

ENSEMBL:
Gene Tree for ZNF24 (if available)
TreeFam:
Gene Tree for ZNF24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF24: view image

Paralogs for ZNF24 Gene

Paralogs for ZNF24 Gene

(276) SIMAP similar genes for ZNF24 Gene using alignment to 4 proteins:

  • ZNF24_HUMAN
  • K7EPL1_HUMAN
  • K7EPZ8_HUMAN
  • K7EQP8_HUMAN
genes like me logo Genes that share paralogs with ZNF24: view

Variants for ZNF24 Gene

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Sequence variations from dbSNP and Humsavar for ZNF24 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000058747 -- 35,342,547(-) T/C intron_variant
rs1000654799 -- 35,333,692(-) G/A/T 3_prime_UTR_variant
rs1000661020 -- 35,343,735(-) A/G intron_variant
rs1000948362 -- 35,343,473(-) G/A intron_variant
rs1001008754 -- 35,343,986(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF24 Gene

Variant ID Type Subtype PubMed ID
nsv1059793 CNV gain 25217958

Variation tolerance for ZNF24 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF24 Gene

Human Gene Mutation Database (HGMD)
ZNF24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF24 Gene

Disorders for ZNF24 Gene

Additional Disease Information for ZNF24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF24 Gene

Publications for ZNF24 Gene

  1. Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24. (PMID: 24224020) Li JZ … Zhang JP (PloS one 2013) 3 4 56
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 43 56
  3. A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor. (PMID: 19463170) Li J … Zhang J (BMC genomics 2009) 3 23 56
  4. Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors. (PMID: 19544452) Khalfallah O … Nardelli J (Stem cells (Dayton, Ohio) 2009) 3 23 56
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 56

ExternalLinks

View latest publications for ZNF24 gene in Mastermind

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