ZNF239 Gene (Protein Coding)

Zinc Finger Protein 239

GC10M043557
GIFtS:
35
MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008] See more...

Aliases for ZNF239 Gene

Aliases for ZNF239 Gene

  • Zinc Finger Protein 239 2 3 4 5
  • MOK2 2 3 4
  • Zinc Finger Protein HOK-2 3 4
  • Zinc Finger Protein MOK-2 3 4
  • HOK-2 2 3
  • Zinc Finger Protein (C2H2) Homologous To Mouse MOK-2 3
  • ZNF239 5
  • HOK2 4

External Ids for ZNF239 Gene

Previous GeneCards Identifiers for ZNF239 Gene

  • GC10M043340
  • GC10M043520
  • GC10M043826
  • GC10M043335
  • GC10M043371
  • GC10M044051
  • GC10M040579

Summaries for ZNF239 Gene

Entrez Gene Summary for ZNF239 Gene

  • MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF239 Gene

ZNF239 (Zinc Finger Protein 239) is a Protein Coding gene. Diseases associated with ZNF239 include Cardiomyopathy, Dilated, 1H. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA binding. An important paralog of this gene is ZNF229.

UniProtKB/Swiss-Prot Summary for ZNF239 Gene

Gene Wiki entry for ZNF239 Gene

Additional gene information for ZNF239 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF239 Gene

Genomics for ZNF239 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF239 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF239 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF239

Top Transcription factor binding sites by QIAGEN in the ZNF239 gene promoter:
  • IRF-1

Genomic Locations for ZNF239 Gene

Genomic Locations for ZNF239 Gene
chr10:43,554,516-43,574,619
(GRCh38/hg38)
Size:
20,104 bases
Orientation:
Minus strand
chr10:44,051,792-44,070,066
(GRCh37/hg19)
Size:
18,275 bases
Orientation:
Minus strand

Genomic View for ZNF239 Gene

Genes around ZNF239 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF239 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF239 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF239 Gene

Proteins for ZNF239 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF239 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16600-ZN239_HUMAN
    Recommended name:
    Zinc finger protein 239
    Protein Accession:
    Q16600
    Secondary Accessions:
    • Q5T1G9
    • Q8TAS5

    Protein attributes for ZNF239 Gene

    Size:
    458 amino acids
    Molecular mass:
    51591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF239 Gene

Post-translational modifications for ZNF239 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF239 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF239 Gene

Domains & Families for ZNF239 Gene

Gene Families for ZNF239 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF239 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF239 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein MOK-2 (ZN239_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16600

UniProtKB/Swiss-Prot:

ZN239_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF239: view

Function for ZNF239 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF239 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
Kruppel zinc finger protein 239,murine Mok2 homolog

Phenotypes From GWAS Catalog for ZNF239 Gene

Gene Ontology (GO) - Molecular Function for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP 11278819
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IMP 11278819
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 9121460
GO:0003723 RNA binding TAS 9121460
genes like me logo Genes that share ontologies with ZNF239: view
genes like me logo Genes that share phenotypes with ZNF239: view

Animal Model Products

CRISPR Products

miRNA for ZNF239 Gene

miRTarBase miRNAs that target ZNF239

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF239

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF239 Gene

Localization for ZNF239 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF239 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF239 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF239: view

Pathways & Interactions for ZNF239 Gene

PathCards logo

SuperPathways for ZNF239 Gene

No Data Available

SIGNOR curated interactions for ZNF239 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11278819
genes like me logo Genes that share ontologies with ZNF239: view

No data available for Pathways by source for ZNF239 Gene

Drugs & Compounds for ZNF239 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF239 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF239 Gene

11 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF239

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF239 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - -

Relevant External Links for ZNF239 Gene

GeneLoc Exon Structure for
ZNF239

Expression for ZNF239 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF239 Gene

mRNA expression in normal human tissues for ZNF239 Gene
mRNA expression by GTEx for ZNF239 GenemRNA expression by BioGPS for ZNF239 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF239

SOURCE GeneReport for Unigene cluster for ZNF239 Gene:

Hs.25040

Evidence on tissue expression from TISSUES for ZNF239 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF239: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF239 Gene

Orthologs for ZNF239 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF239 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF239 30 31
  • 99.56 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZNF239 30 31
  • 86.87 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Zfp239 30 17 31
  • 86.13 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZNF239 30 31
  • 83.66 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 25 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 33 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii BX649556.2 31
  • 52 (a)
 ManyToMany
si:ch211-178j18.2 31
  • 49 (a)
 ManyToMany
BX548067.3 31
  • 49 (a)
 ManyToMany
BX950868.2 31
  • 49 (a)
 ManyToMany
BX324003.4 31
  • 49 (a)
 ManyToMany
si:ch211-208f21.2 31
  • 48 (a)
 ManyToMany
BX901892.1 31
  • 48 (a)
 ManyToMany
BX276122.1 31
  • 48 (a)
 ManyToMany
si:dkey-3p4.8 31
  • 48 (a)
 ManyToMany
CR388052.2 31
  • 48 (a)
 ManyToMany
zgc:173619 31 31
  • 47 (a)
 ManyToMany
si:dkey-156j15.1 31
  • 47 (a)
 ManyToMany
zgc:173620 31
  • 47 (a)
 ManyToMany
BX537137.1 31
  • 47 (a)
 ManyToMany
CR759907.4 31
  • 47 (a)
 ManyToMany
si:ch211-231i17.4 31
  • 46 (a)
 ManyToMany
CABZ01028403.3 31
  • 46 (a)
 ManyToMany
CABZ01001466.1 31
  • 45 (a)
 ManyToMany
si:dkey-7j22.4 31
  • 45 (a)
 ManyToMany
BX927193.1 31
  • 45 (a)
 ManyToMany
si:ch211-209j12.3 31
  • 45 (a)
 ManyToMany
BX842593.1 31
  • 45 (a)
 ManyToMany
si:dkey-285e18.6 31
  • 44 (a)
 ManyToMany
BX511066.4 31
  • 44 (a)
 ManyToMany
si:dkey-28i19.1 31
  • 44 (a)
 ManyToMany
si:dkey-146c18.5 31
  • 42 (a)
 ManyToMany
CABZ01017733.1 31
  • 39 (a)
 ManyToMany
CU138542.1 31
  • 39 (a)
 ManyToMany
si:dkey-264f17.4 31
  • 36 (a)
 ManyToMany
si:ch211-79k12.2 31
  • 25 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG2120 32
  • 35 (a)
CG1832 31
  • 20 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea eor-1 31
  • 11 (a)
 OneToMany
Species where no ortholog for ZNF239 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF239 Gene

ENSEMBL:
Gene Tree for ZNF239 (if available)
TreeFam:
Gene Tree for ZNF239 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF239: view image

Paralogs for ZNF239 Gene

Paralogs for ZNF239 Gene

(487) SIMAP similar genes for ZNF239 Gene using alignment to 1 proteins:

  • ZN239_HUMAN

Pseudogenes.org Pseudogenes for ZNF239 Gene

genes like me logo Genes that share paralogs with ZNF239: view

Variants for ZNF239 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF239 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1128865 - p.Asp266Glu
rs2230660 - p.Ala172Gly
rs2230661 - p.Cys209Gly

Additional dbSNP identifiers (rs#s) for ZNF239 Gene

Variation tolerance for ZNF239 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF239 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF239

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF239 Gene

Disorders for ZNF239 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF239 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1h
  • cmd1h
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF239

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF239: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF239 Gene

Publications for ZNF239 Gene

  1. Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins. (PMID: 8587123) Ernoult-Lange M … Kress M (Journal of molecular evolution 1995) 2 3 4
  2. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei SF … Deng HW (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011) 3 41
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PMID: 17760566) Dreuillet C … Ernoult-Lange M (Biology of the cell 2008) 3 23
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41

ExternalLinks

View latest publications for ZNF239 gene in Mastermind

Products for ZNF239 Gene

  • Signalway Proteins for ZNF239

Sources for ZNF239 Gene