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Aliases for ZNF239 Gene

Aliases for ZNF239 Gene

  • Zinc Finger Protein 239 2 3 3 5
  • Zinc Finger Protein HOK-2 3 4
  • Zinc Finger Protein MOK-2 3 4
  • MOK2 3 4
  • Zinc Finger Protein (C2H2) Homologous To Mouse MOK-2 3
  • HOK-2 3
  • HOK2 4

External Ids for ZNF239 Gene

Previous GeneCards Identifiers for ZNF239 Gene

  • GC10M043340
  • GC10M043826
  • GC10M043335
  • GC10M043371
  • GC10M044051
  • GC10M040579

Summaries for ZNF239 Gene

Entrez Gene Summary for ZNF239 Gene

  • MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZNF239 Gene

ZNF239 (Zinc Finger Protein 239) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA binding. An important paralog of this gene is ZNF214.

UniProtKB/Swiss-Prot for ZNF239 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF239 Gene

Additional gene information for ZNF239 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF239 Gene

Genomics for ZNF239 Gene

GeneHancer (GH) Regulatory Elements for ZNF239 Gene

Promoters and enhancers for ZNF239 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J043572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 670.1 -0.2 -185 3.9 CLOCK ARNT SIN3A YY1 ZNF766 CBX5 ZNF213 E2F8 ZNF143 KLF13 ZNF239 ZNF32-AS2 BMS1 ZNF33B ZNF32-AS1 ZNF487 CAP1P2
GH10J043392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +172.9 172929 18.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HNRNPF RASGEF1A BMS1 EIF3LP2 ZNF32-AS2 HNRNPA3P1 ZNF37BP ZNF33B ZNF32-AS1 ZNF32
GH10J042781 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.1 +791.9 791857 2.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 BMS1 GC10M042779 HNRNPF EIF3LP2 ENSG00000273008 ZNF32-AS2 ZNF32-AS1 ZNF37BP RSU1P1 CUBNP1
GH10J043416 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +155.1 155075 6.1 CLOCK MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A LOC105378272 GC10P043423 BMS1 ZNF32-AS2 EIF3LP2 ZNF33B ZNF239 ENSG00000259869 HNRNPF CSGALNACT2
GH10J043585 Enhancer 0.4 ENCODE 19 -12.0 -11987 2.2 PHF21A RXRA GABPB1 ZNF239 CAP1P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF239 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF239 gene promoter:
  • IRF-1

Genomic Locations for ZNF239 Gene

Genomic Locations for ZNF239 Gene
chr10:43,556,344-43,574,618
(GRCh38/hg38)
Size:
18,275 bases
Orientation:
Minus strand
chr10:44,051,792-44,070,066
(GRCh37/hg19)
Size:
18,275 bases
Orientation:
Minus strand

Genomic View for ZNF239 Gene

Genes around ZNF239 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF239 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF239 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF239 Gene

Proteins for ZNF239 Gene

  • Protein details for ZNF239 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16600-ZN239_HUMAN
    Recommended name:
    Zinc finger protein 239
    Protein Accession:
    Q16600
    Secondary Accessions:
    • Q5T1G9
    • Q8TAS5

    Protein attributes for ZNF239 Gene

    Size:
    458 amino acids
    Molecular mass:
    51591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF239 Gene

Post-translational modifications for ZNF239 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF239 Gene

Domains & Families for ZNF239 Gene

Gene Families for ZNF239 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF239 Gene

Suggested Antigen Peptide Sequences for ZNF239 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16600

UniProtKB/Swiss-Prot:

ZN239_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF239: view

Function for ZNF239 Gene

Molecular function for ZNF239 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
Kruppel zinc finger protein 239,murine Mok2 homolog

Gene Ontology (GO) - Molecular Function for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP 11278819
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP 11278819
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding TAS 9121460
genes like me logo Genes that share ontologies with ZNF239: view
genes like me logo Genes that share phenotypes with ZNF239: view

Animal Model Products

miRNA for ZNF239 Gene

miRTarBase miRNAs that target ZNF239

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF239 Gene

Localization for ZNF239 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF239 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF239 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF239: view

Pathways & Interactions for ZNF239 Gene

SuperPathways for ZNF239 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF239 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11278819
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF239: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF239 Gene

Drugs & Compounds for ZNF239 Gene

No Compound Related Data Available

Transcripts for ZNF239 Gene

Unigene Clusters for ZNF239 Gene

Zinc finger protein 239:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF239 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - -

Relevant External Links for ZNF239 Gene

GeneLoc Exon Structure for
ZNF239
ECgene alternative splicing isoforms for
ZNF239

Expression for ZNF239 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF239 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF239 Gene:

ZNF239

SOURCE GeneReport for Unigene cluster for ZNF239 Gene:

Hs.25040

Evidence on tissue expression from TISSUES for ZNF239 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF239: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF239 Gene

Orthologs for ZNF239 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF239 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF239 34 33
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF239 34 33
  • 86.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp239 16 34 33
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia ZNF239 34 33
  • 83.66 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX649556.2 34
  • 52 (a)
ManyToMany
si:ch211-178j18.2 34
  • 49 (a)
ManyToMany
BX548067.3 34
  • 49 (a)
ManyToMany
BX950868.2 34
  • 49 (a)
ManyToMany
BX324003.4 34
  • 49 (a)
ManyToMany
si:ch211-208f21.2 34
  • 48 (a)
ManyToMany
BX901892.1 34
  • 48 (a)
ManyToMany
BX276122.1 34
  • 48 (a)
ManyToMany
si:dkey-3p4.8 34
  • 48 (a)
ManyToMany
CR388052.2 34
  • 48 (a)
ManyToMany
zgc:173619 34 34
  • 47 (a)
ManyToMany
si:dkey-156j15.1 34
  • 47 (a)
ManyToMany
zgc:173620 34
  • 47 (a)
ManyToMany
BX537137.1 34
  • 47 (a)
ManyToMany
CR759907.4 34
  • 47 (a)
ManyToMany
si:ch211-231i17.4 34
  • 46 (a)
ManyToMany
CABZ01028403.3 34
  • 46 (a)
ManyToMany
CABZ01001466.1 34
  • 45 (a)
ManyToMany
si:dkey-7j22.4 34
  • 45 (a)
ManyToMany
BX927193.1 34
  • 45 (a)
ManyToMany
si:ch211-209j12.3 34
  • 45 (a)
ManyToMany
BX842593.1 34
  • 45 (a)
ManyToMany
si:dkey-285e18.6 34
  • 44 (a)
ManyToMany
BX511066.4 34
  • 44 (a)
ManyToMany
si:dkey-28i19.1 34
  • 44 (a)
ManyToMany
si:dkey-146c18.5 34
  • 42 (a)
ManyToMany
CABZ01017733.1 34
  • 39 (a)
ManyToMany
CU138542.1 34
  • 39 (a)
ManyToMany
si:dkey-264f17.4 34
  • 36 (a)
ManyToMany
si:ch211-79k12.2 34
  • 25 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2120 35
  • 35 (a)
CG1832 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eor-1 34
  • 11 (a)
OneToMany
Species where no ortholog for ZNF239 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF239 Gene

ENSEMBL:
Gene Tree for ZNF239 (if available)
TreeFam:
Gene Tree for ZNF239 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF239: view image

Paralogs for ZNF239 Gene

(487) SIMAP similar genes for ZNF239 Gene using alignment to 1 proteins:

  • ZN239_HUMAN

Pseudogenes.org Pseudogenes for ZNF239 Gene

genes like me logo Genes that share paralogs with ZNF239: view

Variants for ZNF239 Gene

Sequence variations from dbSNP and Humsavar for ZNF239 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000296369 -- 43,562,506(-) G/A intron_variant
rs1000340574 -- 43,575,542(-) G/C upstream_transcript_variant
rs1000374779 -- 43,575,906(-) G/A upstream_transcript_variant
rs1000667401 -- 43,569,697(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000851307 -- 43,554,029(-) G/A downstream_transcript_variant

Variation tolerance for ZNF239 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF239 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF239

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF239 Gene

Disorders for ZNF239 Gene

Additional Disease Information for ZNF239

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF239 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF239 Gene

Publications for ZNF239 Gene

  1. Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins. (PMID: 8587123) Ernoult-Lange M … Kress M (Journal of molecular evolution 1995) 2 3 4 58
  2. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei SF … Deng HW (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PMID: 17760566) Dreuillet C … Ernoult-Lange M (Biology of the cell 2008) 3 22 58
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58

Products for ZNF239 Gene

Sources for ZNF239 Gene