ZNF236 Gene (Protein Coding)

Zinc Finger Protein 236

GC18P076822
GIFtS:
33
See more...

Aliases for ZNF236 Gene

Aliases for ZNF236 Gene

  • Zinc Finger Protein 236 2 3 4 5
  • Regulated By Glucose 3
  • ZNF236A 3
  • ZNF236B 3
  • ZNF236 5

External Ids for ZNF236 Gene

Previous GeneCards Identifiers for ZNF236 Gene

  • GC18P074159
  • GC18P074689
  • GC18P074299
  • GC18P072663
  • GC18P074536
  • GC18P071217

Summaries for ZNF236 Gene

GeneCards Summary for ZNF236 Gene

ZNF236 (Zinc Finger Protein 236) is a Protein Coding gene. Diseases associated with ZNF236 include Type 1 Diabetes Mellitus 6 and Chromosome 18Q Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot Summary for ZNF236 Gene

Additional gene information for ZNF236 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF236 Gene

Genomics for ZNF236 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF236 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF236 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF236

Genomic Locations for ZNF236 Gene

Latest Assembly
chr18:76,822,550-76,972,901
(GRCh38/hg38)
Size:
150,352 bases
Orientation:
Plus strand

Previous Assembly
chr18:74,534,513-74,684,857
(GRCh37/hg19 by Entrez Gene)
Size:
150,345 bases
Orientation:
Plus strand

chr18:74,534,563-74,682,683
(GRCh37/hg19 by Ensembl)
Size:
148,121 bases
Orientation:
Plus strand

Genomic View for ZNF236 Gene

Genes around ZNF236 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF236 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF236 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF236 Gene

Proteins for ZNF236 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for ZNF236 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL36-ZN236_HUMAN
    Recommended name:
    Zinc finger protein 236
    Protein Accession:
    Q9UL36
    Secondary Accessions:
    • B2RTX9
    • Q9UL37

    Protein attributes for ZNF236 Gene

    Size:
    1845 amino acids
    Molecular mass:
    203704 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ZNF236 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF236 Gene

Protein Expression for ZNF236 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF236 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF236 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF236 Gene

Domains & Families for ZNF236 Gene

Gene Families for ZNF236 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF236 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF236 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 236 (ZN236_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL36

UniProtKB/Swiss-Prot:

ZN236_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF236: view

Function for ZNF236 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for ZNF236 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 236,(glucose regulated Kruppel-like),ubiquitously expressed

Phenotypes From GWAS Catalog for ZNF236 Gene

Gene Ontology (GO) - Molecular Function for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF236: view
genes like me logo Genes that share phenotypes with ZNF236: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF236

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF236 Gene

Localization for ZNF236 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF236 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF236 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF236: view

Pathways & Interactions for ZNF236 Gene

PathCards logo

SuperPathways for ZNF236 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF236 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0071333 cellular response to glucose stimulus IEP 9299475
genes like me logo Genes that share ontologies with ZNF236: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF236 Gene

Drugs & Compounds for ZNF236 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for ZNF236 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for ZNF236 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF236

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF236 Gene

No ASD Table

Relevant External Links for ZNF236 Gene

GeneLoc Exon Structure for
ZNF236

Expression for ZNF236 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF236 Gene

mRNA expression in normal human tissues for ZNF236 Gene
mRNA expression by BioGPS for ZNF236 GenemRNA expression by GTEx for ZNF236 Gene

Protein differential expression in normal tissues from HIPED for ZNF236 Gene

This gene is overexpressed in Frontal cortex (57.9) and Kidney (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF236 Gene



Protein tissue co-expression partners for ZNF236 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF236

SOURCE GeneReport for Unigene cluster for ZNF236 Gene:

Hs.719137

mRNA Expression by UniProt/SwissProt for ZNF236 Gene:

Q9UL36-ZN236_HUMAN
Tissue specificity: Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.

Evidence on tissue expression from TISSUES for ZNF236 Gene

  • Kidney(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNF236: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF236 Gene

Orthologs for ZNF236 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF236 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF236 30 31
  • 99.29 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ZNF236 30
  • 86.71 (n)
-- 31
  • 17 (a)
 ManyToMany
Rat
(Rattus norvegicus)
 Mammalia Zfp236 30
  • 83.79 (n)
Mouse
(Mus musculus)
 Mammalia Zfp236 30 17 31
  • 83.39 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ZNF236 31
  • 82 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ZNF236 31
  • 80 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ZNF236 30 31
  • 79.92 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves ZNF236 30 31
  • 74.84 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ZNF236 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia znf236 30
  • 70.44 (n)
Str.17000 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5283 30
Zebrafish
(Danio rerio)
 Actinopterygii znf236 31
  • 56 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FZF1 31
  • 23 (a)
 OneToMany
Species where no ortholog for ZNF236 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF236 Gene

ENSEMBL:
Gene Tree for ZNF236 (if available)
TreeFam:
Gene Tree for ZNF236 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF236: view image

Paralogs for ZNF236 Gene

(98) SIMAP similar genes for ZNF236 Gene using alignment to 3 proteins:

  • ZN236_HUMAN
  • J3QQL1_HUMAN
  • J9JID5_HUMAN
genes like me logo Genes that share paralogs with ZNF236: view

No data available for Paralogs for ZNF236 Gene

Variants for ZNF236 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF236 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs111932063 Benign: not provided 76,928,075(+) G/T
NM_007345.3(ZNF236):c.4557G>T (p.Gly1519=) 		SYNONYMOUS
rs113817245 Benign: not provided 76,956,014(+) G/A
NM_007345.3(ZNF236):c.4938G>A (p.Pro1646=) 		SYNONYMOUS
rs139451924 Likely Benign: not provided 76,880,165(+) C/T
NM_007345.3(ZNF236):c.1031C>T (p.Ser344Leu) 		MISSENSE
rs147362673 Likely Benign: not provided 76,927,412(+) A/C
NM_007345.3(ZNF236):c.4303A>C (p.Ile1435Leu) 		MISSENSE
rs151294291 Likely Benign: not provided 76,899,136(+) G/A
NM_007345.3(ZNF236):c.1802G>A (p.Arg601His) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF236 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF236 Gene

Variant ID Type Subtype PubMed ID
dgv1644n106 CNV duplication 24896259
dgv1645n106 CNV deletion 24896259
dgv1932e59 CNV duplication 20981092
esv2547601 CNV insertion 19546169
esv2588513 CNV deletion 19546169
esv2625456 CNV insertion 19546169
esv2717388 CNV deletion 23290073
esv2717421 CNV deletion 23290073
esv2717422 CNV deletion 23290073
esv2717423 CNV deletion 23290073
esv3331506 CNV duplication 20981092
esv3345401 CNV duplication 20981092
esv3376995 CNV insertion 20981092
esv3447107 CNV duplication 20981092
esv3555703 CNV deletion 23714750
esv3643197 CNV loss 21293372
esv3643199 CNV loss 21293372
nsv1056690 CNV gain 25217958
nsv1063632 CNV gain 25217958
nsv1071865 CNV deletion 25765185
nsv1077850 CNV duplication 25765185
nsv1129606 CNV tandem duplication 24896259
nsv1129608 CNV tandem duplication 24896259
nsv1130687 CNV deletion 24896259
nsv1135059 CNV deletion 24896259
nsv1140142 CNV insertion 24896259
nsv1143794 CNV deletion 24896259
nsv1146345 CNV duplication 26484159
nsv1152371 CNV deletion 26484159
nsv2363 CNV insertion 18451855
nsv477637 CNV novel sequence insertion 20440878
nsv960288 CNV duplication 23825009

Variation tolerance for ZNF236 Gene

Residual Variation Intolerance Score: 1.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF236 Gene

Human Gene Mutation Database (HGMD)
ZNF236
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF236

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF236 Gene

Disorders for ZNF236 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF236 Gene - From: COP

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 6
  • t1d6
chromosome 18q deletion syndrome
  • chromosome 18q- syndrome
cleft palate, isolated
  • cpi
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF236

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF236: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF236 Gene

Publications for ZNF236 Gene

  1. Cloning and characterization of ZNF236, a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23. (PMID: 10458916) Holmes DI … Mason RM (Genomics 1999) 2 3 4
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  3. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough CW … Bowden DW (Human genetics 2009) 3 41
  4. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

ExternalLinks

View latest publications for ZNF236 gene in Mastermind

Products for ZNF236 Gene

Sources for ZNF236 Gene