This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mou... See more...

Aliases for ZNF235 Gene

Aliases for ZNF235 Gene

  • Zinc Finger Protein 235 2 3 4 5
  • Zinc Finger Protein Homologous To Zfp93 In Mouse 2 3
  • Zinc Finger Protein 93 Homolog 3 4
  • Zinc Finger Protein HZF6 3 4
  • Zinc Finger Protein 270 3 4
  • ANF270 2 3
  • ZNF270 3 4
  • Zfp-93 3 4
  • ZFP93 3 4
  • HZF6 2 3
  • Zinc Finger Protein Homologous To Mouse Zfp93 3
  • Zinc Finger Protein 6 3
  • ZNF235 5

External Ids for ZNF235 Gene

Previous HGNC Symbols for ZNF235 Gene

  • ZNF270
  • ZFP93

Previous GeneCards Identifiers for ZNF235 Gene

  • GC19M045182
  • GC19M049407
  • GC19M049482
  • GC19M049445
  • GC19M044790
  • GC19M041222
  • GC19M044732

Summaries for ZNF235 Gene

Entrez Gene Summary for ZNF235 Gene

  • This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF235 Gene

ZNF235 (Zinc Finger Protein 235) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF45.

UniProtKB/Swiss-Prot Summary for ZNF235 Gene

Additional gene information for ZNF235 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF235 Gene

Genomics for ZNF235 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF235 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF235 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF235

Top Transcription factor binding sites by QIAGEN in the ZNF235 gene promoter:
  • ISGF-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • p53
  • RORalpha2
  • SRF
  • SRF (504 AA)

Genomic Locations for ZNF235 Gene

Genomic Locations for ZNF235 Gene
chr19:44,228,729-44,305,707
(GRCh38/hg38)
Size:
76,979 bases
Orientation:
Minus strand
chr19:44,732,882-44,809,199
(GRCh37/hg19)
Size:
76,318 bases
Orientation:
Minus strand

Genomic View for ZNF235 Gene

Genes around ZNF235 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF235 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF235 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF235 Gene

Proteins for ZNF235 Gene

  • Protein details for ZNF235 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14590-ZN235_HUMAN
    Recommended name:
    Zinc finger protein 235
    Protein Accession:
    Q14590
    Secondary Accessions:
    • B4DTQ7
    • O14898
    • O14899
    • Q17RR8

    Protein attributes for ZNF235 Gene

    Size:
    738 amino acids
    Molecular mass:
    83977 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF235 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF235 Gene

Post-translational modifications for ZNF235 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF235 Gene

No data available for DME Specific Peptides for ZNF235 Gene

Domains & Families for ZNF235 Gene

Gene Families for ZNF235 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF235 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF235 Gene

GenScript: Design optimal peptide antigens:
  • ZNF235 protein (Q3KRA4_HUMAN)
  • Zinc finger protein HZF6 (ZN235_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14590

UniProtKB/Swiss-Prot:

ZN235_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF235: view

Function for ZNF235 Gene

Molecular function for ZNF235 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF235 Gene

Gene Ontology (GO) - Molecular Function for ZNF235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF235: view
genes like me logo Genes that share phenotypes with ZNF235: view

Animal Models for ZNF235 Gene

MGI Knock Outs for ZNF235:
  • Zfp235 Zfp235<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZNF235 Gene

miRTarBase miRNAs that target ZNF235

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF235

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF235 Gene

Localization for ZNF235 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF235 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF235 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF235: view

Pathways & Interactions for ZNF235 Gene

genes like me logo Genes that share pathways with ZNF235: view

Pathways by source for ZNF235 Gene

2 Reactome pathways for ZNF235 Gene
1 KEGG pathway for ZNF235 Gene

Interacting Proteins for ZNF235 Gene

Gene Ontology (GO) - Biological Process for ZNF235 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF235: view

No data available for SIGNOR curated interactions for ZNF235 Gene

Drugs & Compounds for ZNF235 Gene

No Compound Related Data Available

Transcripts for ZNF235 Gene

mRNA/cDNA for ZNF235 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF235

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF235 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: -
SP3:

Relevant External Links for ZNF235 Gene

GeneLoc Exon Structure for
ZNF235

Expression for ZNF235 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF235 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF235

SOURCE GeneReport for Unigene cluster for ZNF235 Gene:

Hs.613424

Evidence on tissue expression from TISSUES for ZNF235 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF235: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF235 Gene

Orthologs for ZNF235 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF235 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF235 30 31
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF235 30 31
  • 89.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp235 30 17 31
  • 80.36 (n)
OneToMany
Zfp93 31
  • 72 (a)
OneToMany
Zfp108 31
  • 71 (a)
OneToMany
Zfp114 31
  • 70 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC102548230 30
  • 78.52 (n)
Cow
(Bos Taurus)
Mammalia ZNF235 30 31
  • 77.09 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 40 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CABZ01028403.2 31
  • 54 (a)
ManyToMany
si:ch73-138e16.3 31
  • 50 (a)
ManyToMany
CR388165.1 31
  • 50 (a)
ManyToMany
CR388179.1 31
  • 50 (a)
ManyToMany
si:dkey-111k8.6 31
  • 48 (a)
ManyToMany
CR382372.2 31
  • 48 (a)
ManyToMany
CR388206.1 31
  • 48 (a)
ManyToMany
CABZ01079304.1 31
  • 47 (a)
ManyToMany
si:ch211-197e7.2 31
  • 47 (a)
ManyToMany
si:ch73-367f21.6 31
  • 46 (a)
ManyToMany
si:ch73-367f21.4 31
  • 46 (a)
ManyToMany
CABZ01057951.1 31
  • 45 (a)
ManyToMany
BX539307.1 31
  • 45 (a)
ManyToMany
si:ch1073-127d16.1 31
  • 45 (a)
ManyToMany
si:dkey-122c11.10 31
  • 45 (a)
ManyToMany
zgc:162971 31
  • 42 (a)
ManyToMany
blf 31
  • 40 (a)
ManyToMany
si:ch211-202h22.10 31
  • 40 (a)
ManyToMany
zgc:174700 31
  • 40 (a)
ManyToMany
zgc:194336 31
  • 39 (a)
ManyToMany
CU302413.2 31
  • 39 (a)
ManyToMany
zgc:162936 31
  • 36 (a)
ManyToMany
rnh1 31
  • 34 (a)
ManyToMany
si:dkey-182i3.9 31
  • 31 (a)
ManyToMany
si:dkey-182i3.10 31
  • 29 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG18011 31
  • 15 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea tag-146 31
  • 23 (a)
ManyToMany
C27A12.2 31
  • 20 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AZF1 33
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
ManyToMany
Species where no ortholog for ZNF235 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF235 Gene

ENSEMBL:
Gene Tree for ZNF235 (if available)
TreeFam:
Gene Tree for ZNF235 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF235: view image

Paralogs for ZNF235 Gene

Paralogs for ZNF235 Gene

(529) SIMAP similar genes for ZNF235 Gene using alignment to 6 proteins:

  • ZN235_HUMAN
  • K7EKI9_HUMAN
  • K7EL19_HUMAN
  • K7ES94_HUMAN
  • K7ESF8_HUMAN
  • Q3KRA4_HUMAN
genes like me logo Genes that share paralogs with ZNF235: view

Variants for ZNF235 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF235 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2125579 - p.His296Pro

Additional dbSNP identifiers (rs#s) for ZNF235 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF235 Gene

Variant ID Type Subtype PubMed ID
nsv961228 CNV duplication 23825009

Variation tolerance for ZNF235 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF235 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF235

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF235 Gene

Disorders for ZNF235 Gene

No disorders were found for ZNF235 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF235 Gene

Publications for ZNF235 Gene

  1. Analysis of homologous XRCC1-linked zinc-finger gene families in human and mouse: evidence for orthologous genes. (PMID: 9570955) Shannon M … Stubbs L (Genomics 1998) 2 3 4
  2. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. (PMID: 21549307) Rowbotham SP … Mermoud JE (Molecular cell 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3

Products for ZNF235 Gene

Sources for ZNF235 Gene